"Integrin alpha Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
| Descriptor ID |
D039001
|
| MeSH Number(s) |
D12.776.543.750.705.408.100
|
| Concept/Terms |
Integrin alpha Chains- Integrin alpha Chains
- alpha Chains, Integrin
- Integrin alpha Subunits
- alpha Integrins
- Integrins, alpha
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha Chains".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha Chains".
This graph shows the total number of publications written about "Integrin alpha Chains" by people in this website by year, and whether "Integrin alpha Chains" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 2 | 2 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Integrin alpha Chains" by people in Profiles.
-
Recruitment of CD103+ dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy. Sci Adv. 2019 12; 5(12):eaay1357.
-
Negligible Role for Deletion Mediated by cDC1 in CD8+ T Cell Tolerance. J Immunol. 2019 05 01; 202(9):2628-2635.
-
Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy. Cancer Cell. 2017 05 08; 31(5):711-723.e4.
-
Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nat Commun. 2016 12 22; 7:13894.
-
PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells. J Immunol. 2015 Jun 15; 194(12):5801-11.
-
?d Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice. Gastroenterology. 2015 Jun; 148(7):1417-26.
-
Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection. PLoS Pathog. 2013 Jan; 9(1):e1003115.
-
Cross-presenting CD103+ dendritic cells are protected from influenza virus infection. J Clin Invest. 2012 Nov; 122(11):4037-47.
-
Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature. 2012 Oct 25; 490(7421):502-7.
-
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity. 2012 Feb 24; 36(2):276-87.