Directed Molecular Evolution
"Directed Molecular Evolution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The techniques used to produce molecules exhibiting properties that conform to the demands of the experimenter. These techniques combine methods of generating structural changes with methods of selection. They are also used to examine proposed mechanisms of evolution under in vitro selection conditions.
| Descriptor ID |
D019020
|
| MeSH Number(s) |
E05.393.420.175
|
| Concept/Terms |
Directed Molecular Evolution- Directed Molecular Evolution
- Directed Molecular Evolutions
- Evolution, Directed Molecular
- Evolutions, Directed Molecular
- Molecular Evolutions, Directed
- Molecular Evolution, Directed
- Evolution, Molecular, Directed
In Vitro Molecular Evolution- In Vitro Molecular Evolution
- Laboratory Molecular Evolution
- Evolution, Laboratory Molecular
- Evolutions, Laboratory Molecular
- Laboratory Molecular Evolutions
- Molecular Evolution, Laboratory
- Molecular Evolutions, Laboratory
|
Below are MeSH descriptors whose meaning is more general than "Directed Molecular Evolution".
Below are MeSH descriptors whose meaning is more specific than "Directed Molecular Evolution".
This graph shows the total number of publications written about "Directed Molecular Evolution" by people in this website by year, and whether "Directed Molecular Evolution" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 0 | 2 |
| 2007 | 2 | 0 | 2 |
| 2013 | 0 | 2 | 2 |
| 2015 | 1 | 1 | 2 |
| 2018 | 2 | 2 | 4 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Directed Molecular Evolution" by people in Profiles.
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Methods for the directed evolution of biomolecular interactions. Trends Biochem Sci. 2022 05; 47(5):403-416.
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A high-throughput screening method for evolving a demethylase enzyme with improved and new functionalities. Nucleic Acids Res. 2021 03 18; 49(5):e30.
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Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides. Proc Natl Acad Sci U S A. 2020 06 30; 117(26):15148-15159.
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Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection. mBio. 2019 09 17; 10(5).
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Putting Evolution to Work. Cell. 2018 11 29; 175(6):1449-1451.
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Multinucleotide mutations cause false inferences of lineage-specific positive selection. Nat Ecol Evol. 2018 08; 2(8):1280-1288.
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Evolved Cas9 variants with broad PAM compatibility and high DNA specificity. Nature. 2018 04 05; 556(7699):57-63.
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The rate and potential relevance of new mutations in a colonizing plant lineage. PLoS Genet. 2018 02; 14(2):e1007155.
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Whole-Genome Resequencing of Experimental Populations Reveals Polygenic Basis of Egg-Size Variation in Drosophila melanogaster. Mol Biol Evol. 2015 Oct; 32(10):2616-32.
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Evolvability as a function of purifying selection in TEM-1 ß-lactamase. Cell. 2015 Feb 26; 160(5):882-892.