 Off-Label Use
"Off-Label Use" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The practice of prescribing or using a drug outside the scope of the drug's official approved label as designated by a regulatory agency concerning the treatment of a particular disease or condition.
| Descriptor ID |
D056687
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| MeSH Number(s) |
E02.319.307.500
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| Concept/Terms |
Off-Label Use- Off-Label Use
- Off Label Use
- Off-Label Uses
- Use, Off-Label
- Uses, Off-Label
- Unlabeled Indication
- Indication, Unlabeled
- Indications, Unlabeled
- Unlabeled Indications
- Off-Label Prescribing
- Off Label Prescribing
- Off-Label Prescribings
- Prescribing, Off-Label
- Prescribings, Off-Label
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Below are MeSH descriptors whose meaning is more general than "Off-Label Use".
Below are MeSH descriptors whose meaning is more specific than "Off-Label Use".
This graph shows the total number of publications written about "Off-Label Use" by people in this website by year, and whether "Off-Label Use" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 2 | 0 | 2 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 1 | 2 | | 2016 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Off-Label Use" by people in Profiles.
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Cobey S, Larremore DB, Grad YH, Lipsitch M. Concerns about SARS-CoV-2 evolution should not hold back efforts to expand vaccination. Nat Rev Immunol. 2021 05; 21(5):330-335.
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Smieliauskas F, Sharma H, Hurley C, de Souza JA, Shih YT. State insurance mandates and off-label use of chemotherapy. Health Econ. 2018 01; 27(1):e55-e70.
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Devlin JW, Smithburger P, Kane JM, Fraser GL, Skrobik Y. Intended and Unintended Consequences of Constraining Clinician Prescribing: The Case of Antipsychotics. Crit Care Med. 2016 10; 44(10):1805-7.
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Huang M, Briceño V, Lam SK, Luerssen TG, Jea A. Survey of the Effectiveness of Internet Information on Patient Education for Bone Morphogenetic Protein. World Neurosurg. 2016 Mar; 87:613-8.
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McClellan MB, Daniel GW, Dickson D, Perlmutter J, Berger DP, Miller V, Nussbaum S, Malin J, Romine MH, Schilsky RL. Improving evidence developed from population-level experience with targeted agents. Clin Pharmacol Ther. 2015 May; 97(5):478-87.
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Aronsohn A, Reau N, Jensen D. Preparing for the uncertain yet inevitable: off-label combinations of antiviral agents in hepatitis C virus. Hepatology. 2014 May; 59(5):1688-91.
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Conti RM, Bernstein AC, Villaflor VM, Schilsky RL, Rosenthal MB, Bach PB. Prevalence of off-label use and spending in 2010 among patent-protected chemotherapies in a population-based cohort of medical oncologists. J Clin Oncol. 2013 Mar 20; 31(9):1134-9.
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Aronsohn A, Muir AJ, Swan T, Jensen D. Is the HCV pipeline heading in the right direction? Gastroenterology. 2013 Mar; 144(3):482-5.
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de Souza JA, Polite B, Perkins M, Meropol NJ, Ratain MJ, Newcomer LN, Alexander GC. Unsupported off-label chemotherapy in metastatic colon cancer. BMC Health Serv Res. 2012 Dec 29; 12:481.
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Graziul C, Gibbons R, Alexander GC. Association between the commercial characteristics of psychotropic drugs and their off-label use. Med Care. 2012 Nov; 50(11):940-7.
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