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Jay Koyner

InstitutionUniversity of Chicago
AddressChicago IL 60637
Phone+1 (773) 702-4842
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    Collapse Overview 
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    Jay L. Koyner, MD, is an Associate Professor of Medicine in the Section of Nephrology at the University of Chicago. He completed his undergraduate degree in Biophysics at The Johns Hopkins University. He then went on to complete medical school at the State University of New York at Stony Brook where he awarded a degree with distinction in research following completion of a Howard Hughes Medical Institute Research Fellowship. Dr. Koyner completed his internal medicine and nephrology training at the University of Chicago, where he currently serves as the Medical Director of the Inpatient Dialysis Unit and Director of ICU Nephrology. He is an expert in the care of patients at risk for and diagnosed with acute kidney injury (AKI) . He is spoken nationally and internationally on AKI and a variety of topics in the field of Critical Care Nephrology. Over the last decade he has served many roles for the American Society of Nephrology, including being a member of the Acute Kidney Injury Advisory Group, Co-Director of the Critical Care Nephrology pre-course (2014 to 2018), Co-Editor of the Nephrology Self-Assessment Program (NephSAP) for Acute Kidney Injury and Critical Care Nephrology (2016 to 2019) and currently he sits on the Scientific Advisory Board of the National Kidney Foundation. He has served on the editorial review board of the Clinical Journal of the American Society of Nephrology, The American Journal of Nephrology and Advances in Chronic Kidney Disease. In addition to being a dedicated clinician educator, Dr. Koyner’s critical care nephrology research interests have focused on the utilization of plasma and urine biomarkers to improve patient risk stratification and outcomes in the setting of AKI. He has contributed to several multicenter studies investigating biomarkers of AKI, including the TRIBE-AKI study, the Furosemide Stress Test study and several industry sponsored investigations. More recently he has begun developing and implementing an electronic health record derived AKI risk score, with the goal of improving the care of patients at high risk for the development of severe hospital acquired AKI. He has published over 90 peer-reviewed articles and book chapters on AKI and the care of patients with kidney injury in the ICU.

    Collapse Biography 
    Collapse education and training
    The Johns Hopkins University , Baltimore, MDBA06/1996Biophysics
    Stony Brook School of Medicine , Stony Brook, NYMD05-2001Medicine
    The University of Chicago, Chicago 06/2004Internal Medicine
    The University of Chicago, Chicago. IL06/2006Nephrology
    Collapse awards and honors
    2019Mid-Career Award , American Society of Nephrology

    Collapse Research 
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    R01DK126933     (CHURPEK, MATTHEW MICHAEL;KOYNER, JAY L)Aug 1, 2021 - Jul 31, 2026
    Using Machine Learning for Early Recognition and Personalized Treatment of Acute Kidney Injury
    Role: Principal Investigator

    R21DK113420     (KOYNER, JAY L)Aug 1, 2018 - Jul 31, 2021
    An Early Real-Time Electronic Health Record Risk Algorithm for the Prevention and Treatment of Acute Kidney Injury: A Randomized Trial of an Early Standardized, Personalized Nephrology Intervention
    Role: Principal Investigator

    K23DK081616     (KOYNER, JAY L)Apr 1, 2009 - Mar 31, 2014
    The Role of Cystatin C in Acute Kidney Injury
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Raina R, Nada A, Shah R, Aly H, Kadatane S, Abitbol C, Aggarwal M, Koyner J, Neyra J, Sethi SK. Artificial intelligence in early detection and prediction of pediatric/neonatal acute kidney injury: current status and future directions. Pediatr Nephrol. 2023 Oct 27. PMID: 37889281.
      Citations:    Fields:    
    2. Baeseman L, Gunning S, Koyner JL. Biomarker Enrichment in Sepsis Associated Acute Kidney Injury: Finding High-Risk Patients in the ICU. Am J Nephrol. 2023 Oct 16. PMID: 37844555.
      Citations:    Fields:    
    3. Kashani KB, Koyner JL. Digital health utilities in acute kidney injury management. Curr Opin Crit Care. 2023 12 01; 29(6):542-550. PMID: 37861196.
      Citations:    Fields:    Translation:Humans
    4. Rossiter A, La A, Koyner JL, Forni LG. New biomarkers in acute kidney injury. Crit Rev Clin Lab Sci. 2023 Sep 05; 1-22. PMID: 37668397.
      Citations:    Fields:    
    5. Kashani KB, Awdishu L, Bagshaw SM, Barreto EF, Claure-Del Granado R, Evans BJ, Forni LG, Ghosh E, Goldstein SL, Kane-Gill SL, Koola J, Koyner JL, Liu M, Murugan R, Nadkarni GN, Neyra JA, Ninan J, Ostermann M, Pannu N, Rashidi P, Ronco C, Rosner MH, Selby NM, Shickel B, Singh K, Soranno DE, Sutherland SM, Bihorac A, Mehta RL. Digital health and acute kidney injury: consensus report of the 27th Acute Disease Quality Initiative workgroup. Nat Rev Nephrol. 2023 Aug 14. PMID: 37580570.
      Citations: 1     Fields:    
    6. Zarbock A, Koyner JL, Gomez H, Pickkers P, Forni L, ADQI group . Sepsis-associated acute kidney injury - treatment standard. Nephrol Dial Transplant. 2023 Jul 03. PMID: 37401137.
      Citations: 2     Fields:    
    7. Bohorquez H, Koyner JL, Jones CR. Intraoperative Renal Replacement Therapy in Orthotopic Liver Transplantation. Adv Kidney Dis Health. 2023 07; 30(4):378-386. PMID: 37657884.
      Citations:    Translation:Humans
    8. La AM, Gunning S, Trevino SA, Kunczt A, Forni LG, Swamy V, Zarbock A, Groboske S, Leung EKY, Yeo KJ, Koyner JL. Real-World Use of AKI Biomarkers: A Quality Improvement Project Using Urinary Tissue Inhibitor Metalloprotease-2 and Insulin-Like Growth Factor Binding Protein 7 ([TIMP-2]*[IGFBP7]). Am J Nephrol. 2023; 54(7-8):281-290. PMID: 37356428.
      Citations:    Fields:    Translation:Humans
    9. Mazer CD, Siadati-Fini N, Myjavec A, Brown CD, Koyner JL, Boening A, Engelman DT, Larsson TE, Renfurm R, Thielmann M, Lamy A, Ronco C, Boehm J, Wirth F, de Varennes B, Noiseux N, Laflamme M, von Groote T, Zarbock A. Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microglobulin in subjects at high risk for acute kidney injury following open-chest cardiac surgery (AKITA trial). BMJ Open. 2023 04 06; 13(4):e068363. PMID: 37024249; PMCID: PMC10410810.
      Citations:    Fields:    Translation:HumansCellsCTClinical Trials
    10. Kellum JA, Chawla L, Forni LG, Koyner JL, Meersch M, Weiss R, Gerss J, Albert F, Gruber J, von Groote T, Zarbock A. Predicting the Development of Renal Replacement Therapy Indications by Combining the Furosemide Stress Test and Chemokine (C-C Motif) Ligand 14 in a Cohort of Postsurgical Patients. Crit Care Med. 2023 Aug 01; 51(8):1033-1042. PMID: 36988335; PMCID: PMC10335738.
      Citations: 2     Fields:    Translation:Humans
    11. Koyner JL, Mackey RH, Rosenthal NA, Carabuena LA, Kampf JP, Echeverri J, McPherson P, Blackowicz MJ, Rodriguez T, Sanghani AR, Textoris J. Health Care Resource Utilization and Costs of Persistent Severe Acute Kidney Injury (PS-AKI) Among Hospitalized Stage 2/3 AKI Patients. Kidney360. 2023 03 01; 4(3):316-325. PMID: 36996299; PMCID: PMC10103312.
      Citations:    Fields:    Translation:Humans
    12. Prowle JR, Artigas A, Bagshaw SM, Forni LG, Heung M, Hoste E, Marlies O, Koyner JL, Chawla L, Kellum JA, Kampf JP, Kwan T, McPherson P. Serial Urinary C-C Motif Chemokine Ligand 14 and Risk of Persistent Severe Acute Kidney Injury. Crit Care Explor. 2023 Mar; 5(3):e0870. PMID: 36875557; PMCID: PMC9981369.
      Citations: 1     
    13. Nadim MK, Pickkers P, Gomez H, Bell S, Joannidis M, Kashani K, Koyner JL, Pannu N, Bagshaw SM, Bellomo R, Deep A, De Rosa S, Perez-Fernandez X, Husain-Syed F, Kane-Gill SL, Kelly Y, Mehta RL, Murray PT, Ostermann M, Prowle J, Ricci Z, See EJ, Schneider A, Soranno DE, Tolwani A, Villa G, Ronco C, Forni LG, Zarbock A, Meersch M, Reis T, Rimmelé T, Cantaluppi V. Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup. Nat Rev Nephrol. 2023 06; 19(6):401-417. PMID: 36823168.
      Citations: 17     Fields:    Translation:Humans
    14. Koyner JL, Mackey RH, Rosenthal NA, Carabuena LA, Rodriguez T, Sanghani A, Textoris J, Kampf JP, McPherson P. Outcomes, Healthcare Resource Utilization, and Costs of Overall, Community-Acquired, and Hospital-Acquired Acute Kidney Injury in COVID-19 Patients. J Health Econ Outcomes Res. 2023; 10(1):31-40. PMID: 36852155; PMCID: PMC9961448.
    15. Bajaj T, Koyner JL. Cautious Optimism: Artificial Intelligence and Acute Kidney Injury. Clin J Am Soc Nephrol. 2023 Jan 30. PMID: 36795027; PMCID: PMC10278802.
      Citations:    Fields:    
    16. Liu K, Koyner JL, Heung M, Vijayan A. Care of the Hospitalized Patients with Kidney Failure during COVID-19 Pandemic: Lessons Learned. Clin J Am Soc Nephrol. 2023 Jan 30. PMID: 36795034; PMCID: PMC10356130.
      Citations:    Fields:    
    17. Vasquez-Rios G, Moledina DG, Jia Y, McArthur E, Mansour SG, Thiessen-Philbrook H, Shlipak MG, Koyner JL, Garg AX, Parikh CR, Coca SG, TRIBE-AKI Consortium. Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study. J Cardiothorac Surg. 2022 Dec 25; 17(1):338. PMID: 36567329; PMCID: PMC9790121.
      Citations: 1     Fields:    Translation:Humans
    18. Neyra JA, Chen J, Bagshaw SM, Koyner JL. Risk Classification and Subphenotyping of Acute Kidney Injury: Concepts and Methodologies. Semin Nephrol. 2022 Dec 02; 151285. PMID: 36470740.
      Citations:    Fields:    
    19. Koyner JL, Mackey RH, Rosenthal NA, Carabuena LA, Kampf JP, Rodriguez T, Sanghani A, Echeverri J, McPherson P, Blackowicz MJ, Textoris J. Clinical Outcomes of Persistent Severe Acute Kidney Injury among Patients with Kidney Disease Improving Global Outcomes Stage 2 or 3 Acute Kidney Injury. Am J Nephrol. 2022; 53(11-12):816-825. PMID: 36450235.
      Citations:    Fields:    Translation:Humans
    20. Yang L, Li J, Wei W, Yi C, Pu Y, Zhang L, Cui T, Ma L, Zhang J, Koyner J, Zhao Y, Fu P. Kidney health in the COVID-19 pandemic: An umbrella review of meta-analyses and systematic reviews. Front Public Health. 2022; 10:963667. PMID: 36172213; PMCID: PMC9511113.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    21. Bajaj T, Koyner JL. Artificial Intelligence in Acute Kidney Injury Prediction. Adv Chronic Kidney Dis. 2022 09; 29(5):450-460. PMID: 36253028; PMCID: PMC10259199.
      Citations:    Fields:    Translation:Humans
    22. Bagshaw SM, Koyner JL, Schulman IH, Mathis MR, Bernholz J, Coca S, Gallagher M, Liu KD, Mehta RL, Pirracchio R, Ryan A, Steubl D, Stockbridge N, Erlandsson F, Turan A, Wilson FP, Bokoch MP, Casey JD, Rossignol P, Legrand M, Harhay MO, Gaudry S, Zarbock A. Optimizing the Design and Analysis of Future AKI Trials. J Am Soc Nephrol. 2022 08; 33(8):1459-1470. PMID: 35831022; PMCID: PMC9342638.
      Citations: 7     Fields:    Translation:Humans
    23. Forni LG, Joannidis M, Artigas A, Bell M, Hoste E, Joannes-Boyau O, Kashani K, Koyner J, Shi J, Ostermann M, Chawla LS, Kellum JA, Sapphire Investigators, Rimmele T. Characterising acute kidney injury: The complementary roles of biomarkers of renal stress and renal function. J Crit Care. 2022 10; 71:154066. PMID: 35696851.
      Citations: 2     Fields:    Translation:Humans
    24. Koyner JL, Chawla LS, Bihorac A, Gunnerson KJ, Schroeder R, Demirjian S, Hodgson L, Frey JA, Wilber ST, Kampf JP, Kwan T, McPherson P, Kellum JA. Performance of a Standardized Clinical Assay for Urinary C-C Motif Chemokine Ligand 14 (CCL14) for Persistent Severe Acute Kidney Injury. Kidney360. 2022 07 28; 3(7):1158-1168. PMID: 35919538; PMCID: PMC9337886.
      Citations: 7     Fields:    Translation:Humans
    25. Pearson SD, Koyner JL, Patel BK. Management of Respiratory Failure: Ventilator Management 101 and Noninvasive Ventilation. Clin J Am Soc Nephrol. 2022 04; 17(4):572-580. PMID: 35273008; PMCID: PMC8993478.
      Citations:    Fields:    Translation:Humans
    26. Koyner JL, Echeverri J, Harenski K, Priyanka P, Kellum JA, Ethgen O, Zarbock A. Early versus delayed initiation of renal replacement therapy in cardiac-surgery associated acute kidney injury: an economic perspective. J Crit Care. 2022 06; 69:153977. PMID: 35183893.
      Citations: 1     Fields:    Translation:Humans
    27. Schurle A, Koyner JL. CSA-AKI: Incidence, Epidemiology, Clinical Outcomes, and Economic Impact. J Clin Med. 2021 Dec 08; 10(24). PMID: 34945041; PMCID: PMC8706363.
      Citations: 6     
    28. Bihorac A, Goldstein SL, Kashani KB, Menon S, Nadkarni GN, Neyra JA, Pannu NI, Singh K, Cerda J, Koyner JL, Soranno DE. Artificial Intelligence for AKI!Now: Let's Not Await Plato's Utopian Republic. Kidney360. 2022 02 24; 3(2):376-381. PMID: 35373136; PMCID: PMC8967630.
      Citations: 3     Fields:    Translation:Humans
    29. Kapp ME, Fogo AB, Roufouse C, Najafian B, Radhakrishnan J, Mohan S, Miller SE, D'Agati VD, Silberzweig J, Barbar T, Gopalan T, Srivatana V, Mokrzycki MH, Benstein JA, Ng YH, Lentine KL, Aggarwal V, Perl J, Salenger P, Koyner JL, Josephson MA, Heung M, Velez JC, Ikizler A, Vijayan A, William P, Thajudeen B, Slepian MJ. Renal Considerations in COVID-19: Biology, Pathology, and Pathophysiology. ASAIO J. 2021 10 01; 67(10):1087-1096. PMID: 34191753; PMCID: PMC8478105.
      Citations: 2     Fields:    Translation:HumansCells
    30. La A, Koyner JL. Urine Sediment Exam Provides More Diagnostic Information in AKI than Novel Urinary Biomarkers: CON. Kidney360. 2022 04 28; 3(4):600-603. PMID: 35721617; PMCID: PMC9136909.
      Citations:    Fields:    Translation:Humans
    31. Ostermann M, Koyner JL. Extracorporeal Blood Purification Is Appropriate in Critically Ill Patients with COVID-19 and Multiorgan Failure: COMMENTARY. Kidney360. 2022 03 31; 3(3):423-425. PMID: 35583415; PMCID: PMC9034803.
      Citations: 1     Fields:    Translation:HumansCells
    32. Koyner JL. Sepsis and Kidney Injury. Contrib Nephrol. 2021; 199:56-70. PMID: 34343994.
      Citations: 4     Fields:    Translation:Humans
    33. Legrand M, Bell S, Forni L, Joannidis M, Koyner JL, Liu K, Cantaluppi V. Pathophysiology of COVID-19-associated acute kidney injury. Nat Rev Nephrol. 2021 11; 17(11):751-764. PMID: 34226718; PMCID: PMC8256398.
      Citations: 151     Fields:    Translation:Humans
    34. Menez S, Ju W, Menon R, Moledina DG, Thiessen Philbrook H, McArthur E, Jia Y, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Coca SG, Garg AX, Bomback AS, Kellum JA, Kretzler M, Parikh CR, Translational Research Investigating Biomarker Endpoints in AKI (TRIBE-AKI) Consortium and the Kidne. Urinary EGF and MCP-1 and risk of CKD after cardiac surgery. JCI Insight. 2021 06 08; 6(11). PMID: 33974569; PMCID: PMC8262289.
      Citations: 14     Fields:    Translation:Humans
    35. Prowle JR, Forni LG, Bell M, Edwards M, Grams ME, Grocott MPW, Liu KD, McIlroy D, Murray PT, Ostermann M, Bagshaw SM, Bartz R, Bell S, Bihorac A, Gan TJ, Hobson CE, Joannidis M, Koyner JL, Levett DZH, Mehta RL, Miller TE, Mythen MG, Nadim MK, Pearse RM, Rimmele T, Ronco C, Shaw AD, Kellum JA, Chew MS, Zarbock A. Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative. Nat Rev Nephrol. 2021 09; 17(9):605-618. PMID: 33976395; PMCID: PMC8367817.
      Citations: 37     Fields:    Translation:Humans
    36. Verhoef PA, Kannan S, Sturgill JL, Tucker EW, Morris PE, Miller AC, Sexton TR, Koyner JL, Hejal R, Brakenridge SC, Moldawer LL, Hotchkiss RS, Blood TM, Mazer MB, Bolesta S, Alexander SA, Armaignac DL, Shein SL, Jones C, Hoemann CD, Doctor A, Friess SH, Parker RI, Rotta AT, Remy KE. Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research. Crit Care Explor. 2021 Mar; 3(3):e0374. PMID: 33786450; PMCID: PMC7994036.
      Citations: 13     
    37. Mistry NS, Koyner JL. Artificial Intelligence in Acute Kidney Injury: From Static to Dynamic Models. Adv Chronic Kidney Dis. 2021 01; 28(1):74-82. PMID: 34389139; PMCID: PMC8371697.
      Citations: 7     Fields:    Translation:Humans
    38. Kohn OF, Plascencia M, Taylor Y, Koyner JL. Novel Use of Premixed Dialysate Bags during Water Supply Interruption in Acute Hospital Setting. Kidney360. 2021 02 25; 2(2):339-343. PMID: 35373022; PMCID: PMC8740998.
      Citations:    Fields:    Translation:HumansCells
    39. Koyner JL, Haines RW, Bouchard J. Individualized acute kidney injury after care. Curr Opin Crit Care. 2020 12; 26(6):581-589. PMID: 33027144; PMCID: PMC8016399.
      Citations: 2     Fields:    Translation:Humans
    40. Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, Koyner JL, Legrand M, Lumlertgul N, Mohan S, Pannu N, Peng Z, Perez-Fernandez XL, Pickkers P, Prowle J, Reis T, Srisawat N, Tolwani A, Vijayan A, Villa G, Yang L, Ronco C, Kellum JA, Rimmelé T, Zarbock A. Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol. 2020 Dec; 16(12):765. PMID: 33139940; PMCID: PMC7605735.
      Citations: 6     Fields:    
    41. Moledina DG, Belliveau O, Yamamoto Y, Arora T, Carey KA, Churpek M, Martin M, Partridge CM, Mansour SG, Parikh CR, Koyner JL, Wilson FP. Variation in Best Practice Measures in Patients With Severe Hospital-Acquired Acute Kidney Injury: A Multicenter Study. Am J Kidney Dis. 2021 04; 77(4):547-549. PMID: 33075389; PMCID: PMC8672301.
      Citations: 8     Fields:    Translation:Humans
    42. Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, Koyner JL, Legrand M, Lumlertgul N, Mohan S, Pannu N, Peng Z, Perez-Fernandez XL, Pickkers P, Prowle J, Reis T, Srisawat N, Tolwani A, Vijayan A, Villa G, Yang L, Ronco C, Kellum JA, Rimmelé T, Zarbock A. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol. 2020 12; 16(12):747-764. PMID: 33060844; PMCID: PMC7561246.
      Citations: 276     Fields:    Translation:HumansCells
    43. Gunning S, Koyner JL. Not All Sepsis-Associated Acute Kidney Injury Is the Same: There May Be an App for That. Clin J Am Soc Nephrol. 2020 11 06; 15(11):1543-1545. PMID: 33034570; PMCID: PMC7646237.
      Citations: 1     Fields:    Translation:Humans
    44. Koyner JL. Subclinical Acute Kidney Injury Is Acute Kidney Injury and Should Not Be Ignored. Am J Respir Crit Care Med. 2020 09 15; 202(6):786-787. PMID: 32640167; PMCID: PMC7491389.
      Citations: 5     Fields:    Translation:Humans
    45. Liu KD, Forni LG, Heung M, Wu VC, Kellum JA, Mehta RL, Ronco C, Kashani K, Rosner MH, Haase M, Koyner JL, Acute Disease Quality Initiative Investigators. Quality of Care for Acute Kidney Disease: Current Knowledge Gaps and Future Directions. Kidney Int Rep. 2020 Oct; 5(10):1634-1642. PMID: 33102955; PMCID: PMC7569680.
      Citations: 9     
    46. Churpek MM, Carey KA, Edelson DP, Singh T, Astor BC, Gilbert ER, Winslow C, Shah N, Afshar M, Koyner JL. Internal and External Validation of a Machine Learning Risk Score for Acute Kidney Injury. JAMA Netw Open. 2020 08 03; 3(8):e2012892. PMID: 32780123; PMCID: PMC7420241.
      Citations: 32     Fields:    Translation:Humans
    47. Koyner JL, Basu RK, Ronco C, Zarbock A. The impact of biomarkers of acute kidney injury on individual patient care. Nephrol Dial Transplant. 2020 08 01; 35(8):1295-1305. PMID: 31725154; PMCID: PMC7828472.
      Citations: 13     Fields:    Translation:Humans
    48. Menez S, Moledina DG, Garg AX, Thiessen-Philbrook H, McArthur E, Jia Y, Liu C, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Wilson FP, Coca SG, Parikh CR. Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery. Kidney Int. 2021 03; 99(3):716-724. PMID: 32721447; PMCID: PMC8077034.
      Citations: 15     Fields:    Translation:Humans
    49. Gunning S, Kutuby F, Rose R, Trevino S, Song T, Koyner JL. Fluid Overload and Mortality in Patients with Severe Acute Kidney Injury and Extracorporeal Membrane Oxygenation. Kidney360. 2020 04 30; 1(4):232-240. PMID: 35372918; PMCID: PMC8809269.
      Citations:    Fields:    Translation:Humans
    50. Hoste E, Bihorac A, Al-Khafaji A, Ortega LM, Ostermann M, Haase M, Zacharowski K, Wunderink R, Heung M, Lissauer M, Self WH, Koyner JL, Honore PM, Prowle JR, Joannidis M, Forni LG, Kampf JP, McPherson P, Kellum JA, Chawla LS, RUBY Investigators. Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study. Intensive Care Med. 2020 05; 46(5):943-953. PMID: 32025755; PMCID: PMC7210248.
      Citations: 60     Fields:    Translation:Humans
    51. Lieske JC, Kashani K, Kellum J, Koyner J, Mehta R, Parikh CR. Use of Biomarkers to Detect and Manage Acute Kidney Injury: Has Progress Stalled? Clin Chem. 2020 02 01; 66(2):271-276. PMID: 32040587.
      Citations: 4     Fields:    Translation:Humans
    52. Patel DM, Thiessen-Philbrook H, Brown JR, McArthur E, Moledina DG, Mansour SG, Shlipak MG, Koyner JL, Kavsak P, Whitlock RP, Everett AD, Malenka DJ, Garg AX, Coca SG, Parikh CR. Association of plasma-soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgery. Am Heart J. 2020 02; 220:253-263. PMID: 31911262; PMCID: PMC7008086.
      Citations: 5     Fields:    Translation:Humans
    53. McCullough PA, Ostermann M, Forni LG, Bihorac A, Koyner JL, Chawla LS, Shi J, Kampf JP, McPherson P, Kellum JA, the Sapphire Investigators. Serial Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 and the Prognosis for Acute Kidney Injury over the Course of Critical Illness. Cardiorenal Med. 2019; 9(6):358-369. PMID: 31618746.
      Citations: 6     Fields:    Translation:Humans
    54. Koyner J, Bakris G. Kidney injury is not prevented by hydration alone. Eur Heart J. 2019 10 07; 40(38):3179-3181. PMID: 31263876.
      Citations:    Fields:    Translation:Humans
    55. Joannidis M, Forni LG, Haase M, Koyner J, Shi J, Kashani K, Chawla LS, Kellum JA, Sapphire Investigators. Use of Cell Cycle Arrest Biomarkers in Conjunction With Classical Markers of Acute Kidney Injury. Crit Care Med. 2019 10; 47(10):e820-e826. PMID: 31343478; PMCID: PMC6750148.
      Citations: 23     Fields:    Translation:Humans
    56. Moledina DG, Mansour SG, Jia Y, Obeid W, Thiessen-Philbrook H, Koyner JL, McArthur E, Garg AX, Wilson FP, Shlipak MG, Coca SG, Parikh CR. Association of T Cell-Derived Inflammatory Cytokines With Acute Kidney Injury and Mortality After Cardiac Surgery. Kidney Int Rep. 2019 Dec; 4(12):1689-1697. PMID: 31844805; PMCID: PMC6895592.
      Citations: 10     
    57. Guzzi LM, Binnall B, Engelman DT, Forni L, Germain MJ, Gluck E, Koyner JL, Reddy VS, Ronco C, Textoris J, Kellum JA, Bergler T, Göcze I, Joannidis M, Rimmelé T, Zarbock A. Clinical use of [TIMP-2]•[IGFBP7] biomarker testing to assess risk of acute kidney injury in critical care: guidance from an expert panel. Crit Care. 2019 06 20; 23(1):225. PMID: 31221200; PMCID: PMC6585126.
      Citations: 28     Fields:    Translation:Humans
    58. Rosner MH, Haase M, Lewington AJP, O'Donoghue DJ, Wilson FP, Nadim MK, Silver SA, Ostermann M, Mehta RL, Kane-Gill SL, Ding X, Pickkers P, Bihorac A, Siew ED, Barreto EF, Macedo E, Kellum JA, Tolwani AJ, Ronco C, Juncos LA, Rewa OG, Bagshaw SM, Mottes TA, Koyner JL, Liu KD, Forni LG, Heung M, Wu VC, Kashani K, Palevsky PM, Zarbock A. Quality Improvement Goals for Acute Kidney Injury. Clin J Am Soc Nephrol. 2019 06 07; 14(6):941-953. PMID: 31101671; PMCID: PMC6556737.
      Citations: 76     Fields:    Translation:HumansPHPublic Health
    59. Rewa OG, Bagshaw SM, Wang X, Wald R, Smith O, Shapiro J, McMahon B, Liu KD, Trevino SA, Chawla LS, Koyner JL. The furosemide stress test for prediction of worsening acute kidney injury in critically ill patients: A multicenter, prospective, observational study. J Crit Care. 2019 08; 52:109-114. PMID: 31035185; PMCID: PMC8704439.
      Citations: 19     Fields:    Translation:Humans
    60. Mansour SG, Zhang WR, Moledina DG, Coca SG, Jia Y, Thiessen-Philbrook H, McArthur E, Inoue K, Koyner JL, Shlipak MG, Wilson FP, Garg AX, Ishibe S, Parikh CR, TRIBE-AKI Consortium. The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery. Am J Kidney Dis. 2019 07; 74(1):36-46. PMID: 30955944; PMCID: PMC6591032.
      Citations: 20     Fields:    Translation:Humans
    61. Borden BA, Lee SM, Danahey K, Galecki P, Patrick-Miller L, Siegler M, Sorrentino MJ, Sacro Y, Davis AM, Rubin DT, Lipstreuer K, Polonsky TS, Nanda R, Harper WR, Koyner JL, Burnet DL, Stadler WM, Kavitt RT, Meltzer DO, Ratain MJ, O'Donnell PH. Patient-provider communications about pharmacogenomic results increase patient recall of medication changes. Pharmacogenomics J. 2019 12; 19(6):528-537. PMID: 30713337; PMCID: PMC6980369.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    62. Borden BA, Galecki P, Wellmann R, Danahey K, Lee SM, Patrick-Miller L, Sorrentino MJ, Nanda R, Koyner JL, Polonsky TS, Stadler WM, Mulcahy C, Kavitt RT, Ratain MJ, Meltzer DO, O'Donnell PH. Assessment of provider-perceived barriers to clinical use of pharmacogenomics during participation in an institutional implementation study. Pharmacogenet Genomics. 2019 02; 29(2):31-38. PMID: 30531377.
      Citations: 11     Fields:    Translation:Humans
    63. Poston JT, Koyner JL. Sepsis associated acute kidney injury. BMJ. 2019 Jan 09; 364:k4891. PMID: 30626586; PMCID: PMC6890472.
      Citations: 234     Fields:    Translation:Humans
    64. Koyner JL, Hoste EAJ, Kellum JA, Zarbock A. Update on Perioperative Acute Kidney Injury. Anesth Analg. 2018 11; 127(5):1236-1245. PMID: 30138176.
      Citations: 41     Fields:    Translation:Humans
    65. Chen LX, Demirjian S, Udani SM, Trevino SA, Murray PT, Koyner JL. Cytokine Clearances in Critically Ill Patients on Continuous Renal Replacement Therapy. Blood Purif. 2018; 46(4):315-322. PMID: 30107381.
      Citations: 7     Fields:    Translation:Humans
    66. Koyner JL, Carey KA, Edelson DP, Churpek MM. The Development of a Machine Learning Inpatient Acute Kidney Injury Prediction Model. Crit Care Med. 2018 07; 46(7):1070-1077. PMID: 29596073.
      Citations: 111     Fields:    Translation:Humans
    67. Nadim MK, Forni LG, Bihorac A, Hobson C, Shaw A, Arnaoutakis GJ, Ding X, Engelman DT, Gasparovic H, Gasparovic V, Herzog CA, Kashani K, Katz N, Liu KD, Mehta RL, Ostermann M, Pannu N, Pickkers P, Price S, Rich JB, Sajja LR, Weaver FA, Ronco C, Kellum JA, Koyner JL, Ricci Z, Zarbock A. Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group. J Am Heart Assoc. 2018 06 01; 7(11). PMID: 29858368; PMCID: PMC6015369.
      Citations: 76     Fields:    Translation:Humans
    68. Jelinek MJ, Lee SM, Wyche Okpareke A, Wing C, Koyner JL, Murray PT, Stadler WM, O' Donnell PH. Predicting Acute Renal Injury in Cancer Patients Receiving Cisplatin Using Urinary Neutrophil Gelatinase-Associated Lipocalin and Cystatin C. Clin Transl Sci. 2018 07; 11(4):420-427. PMID: 29691991; PMCID: PMC6039203.
      Citations: 4     Fields:    Translation:Humans
    69. Ostermann M, Chawla LS, Forni LG, Kane-Gill SL, Kellum JA, Koyner J, Murray PT, Ronco C, Goldstein SL, ADQI 16 workgroup. Drug management in acute kidney disease - Report of the Acute Disease Quality Initiative XVI meeting. Br J Clin Pharmacol. 2018 02; 84(2):396-403. PMID: 29023830; PMCID: PMC5777429.
      Citations: 22     Fields:    Translation:Humans
    70. Beunders R, Struck J, Wu AHB, Zarbock A, Di Somma S, Mehta RL, Koyner JL, Nadim MK, Maisel AS, Murray PT, Neath SX, Jaffe A, Pickkers P. Proenkephalin (PENK) as a Novel Biomarker for Kidney Function. J Appl Lab Med. 2017 Nov 01; 2(3):400-412. PMID: 33636859.
      Citations: 9     Fields:    
    71. McMahon BA, Koyner JL, Novick T, Menez S, Moran RA, Lonze BE, Desai N, Alasfar S, Borja M, Merritt WT, Ariyo P, Chawla LS, Kraus E. The prognostic value of the furosemide stress test in predicting delayed graft function following deceased donor kidney transplantation. Biomarkers. 2018 Feb; 23(1):61-69. PMID: 29034718; PMCID: PMC6379684.
      Citations: 13     Fields:    Translation:Humans
    72. Meroni R, Simonini M, Casamassima N, Bignami E, Koyner JL. Biomarkers in acute kidney injury: that's all the story? : Discussion on "Have biomarkers failed in acute kidney injury?" Intensive Care Med. 2017 12; 43(12):1931-1932. PMID: 28852797.
      Citations:    Fields:    Translation:Humans
    73. Parikh CR, Puthumana J, Shlipak MG, Koyner JL, Thiessen-Philbrook H, McArthur E, Kerr K, Kavsak P, Whitlock RP, Garg AX, Coca SG. Relationship of Kidney Injury Biomarkers with Long-Term Cardiovascular Outcomes after Cardiac Surgery. J Am Soc Nephrol. 2017 Dec; 28(12):3699-3707. PMID: 28808078; PMCID: PMC5698070.
      Citations: 33     Fields:    Translation:Humans
    74. Koyner JL. Reconfiguring Health Care Delivery to Improve AKI Outcomes. Clin J Am Soc Nephrol. 2017 Aug 07; 12(8):1203-1205. PMID: 28729381; PMCID: PMC5544508.
      Citations: 1     Fields:    
    75. Nadkarni GN, Coca SG, Meisner A, Patel S, Kerr KF, Patel UD, Koyner JL, Garg AX, Philbrook HT, Edelstein CL, Shlipak M, El-Khoury J, Parikh CR, TRIBE-AKI Consortium Investigators. Urinalysis findings and urinary kidney injury biomarker concentrations. BMC Nephrol. 2017 Jul 06; 18(1):218. PMID: 28683730; PMCID: PMC5499057.
      Citations: 7     Fields:    Translation:Humans
    76. O'Donnell PH, Wadhwa N, Danahey K, Borden BA, Lee SM, Hall JP, Klammer C, Hussain S, Siegler M, Sorrentino MJ, Davis AM, Sacro YA, Nanda R, Polonsky TS, Koyner JL, Burnet DL, Lipstreuer K, Rubin DT, Mulcahy C, Strek ME, Harper W, Cifu AS, Polite B, Patrick-Miller L, Yeo KT, Leung E, Volchenboum SL, Altman RB, Olopade OI, Stadler WM, Meltzer DO, Ratain MJ. Pharmacogenomics-Based Point-of-Care Clinical Decision Support Significantly Alters Drug Prescribing. Clin Pharmacol Ther. 2017 Nov; 102(5):859-869. PMID: 28398598; PMCID: PMC5636653.
      Citations: 33     Fields:    Translation:Humans
    77. Wu B, Lewis LD, Harvey RD, Rasmussen E, Gamelin E, Sun YN, Friberg G, Koyner JL, Dowlati A, Maitland ML. A Pharmacokinetic and Safety Study of Trebananib, an Fc-Fusion Peptibody, in Patients With Advanced Solid Tumors and Varying Degrees of Renal Dysfunction. Clin Pharmacol Ther. 2017 Aug; 102(2):313-320. PMID: 28074547.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    78. McMahon BA, Koyner JL. Have biomarkers failed in acute kidney injury? No. Intensive Care Med. 2017 06; 43(6):887-889. PMID: 28439644.
      Citations: 4     Fields:    Translation:Humans
    79. McKillip RP, Borden BA, Galecki P, Ham SA, Patrick-Miller L, Hall JP, Hussain S, Danahey K, Siegler M, Sorrentino MJ, Sacro Y, Davis AM, Rubin DT, Lipstreuer K, Polonsky TS, Nanda R, Harper WR, Koyner JL, Burnet DL, Stadler WM, Ratain MJ, Meltzer DO, O'Donnell PH. Patient Perceptions of Care as Influenced by a Large Institutional Pharmacogenomic Implementation Program. Clin Pharmacol Ther. 2017 07; 102(1):106-114. PMID: 27981566; PMCID: PMC5474215.
      Citations: 10     Fields:    Translation:Humans
    80. Chawla LS, Bellomo R, Bihorac A, Goldstein SL, Siew ED, Bagshaw SM, Bittleman D, Cruz D, Endre Z, Fitzgerald RL, Forni L, Kane-Gill SL, Hoste E, Koyner J, Liu KD, Macedo E, Mehta R, Murray P, Nadim M, Ostermann M, Palevsky PM, Pannu N, Rosner M, Wald R, Ronco C, Kellum JA, Acute Disease Quality Initiative Workgroup 16., Zarbock A. Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup. Nat Rev Nephrol. 2017 04; 13(4):241-257. PMID: 28239173.
      Citations: 445     Fields:    Translation:Humans
    81. Koyner JL, Chawla LS. Use of stress tests in evaluating kidney disease. Curr Opin Nephrol Hypertens. 2017 01; 26(1):31-35. PMID: 27820705.
      Citations: 4     Fields:    Translation:Humans
    82. Askenazi DJ, Heung M, Connor MJ, Basu RK, Doi K, Koyner JL, Bihorac A, Golestaneh L, Vijayan A, Okusa MD, Faubel S, American Society of Nephrology Acute Kidney Injury Advisory Group, Cerdá J. Optimal Role of the Nephrologist in the Intensive Care Unit. Blood Purif. 2017; 43(1-3):68-77. PMID: 27923227; PMCID: PMC5340591.
      Citations: 8     Fields:    Translation:Humans
    83. Koyner JL, Adhikari R, Edelson DP, Churpek MM. Development of a Multicenter Ward-Based AKI Prediction Model. Clin J Am Soc Nephrol. 2016 11 07; 11(11):1935-1943. PMID: 27633727; PMCID: PMC5108182.
      Citations: 47     Fields:    Translation:Humans
    84. Coca SG, Nadkarni GN, Garg AX, Koyner J, Thiessen-Philbrook H, McArthur E, Shlipak MG, Parikh CR, TRIBE-AKI Consortium. First Post-Operative Urinary Kidney Injury Biomarkers and Association with the Duration of AKI in the TRIBE-AKI Cohort. PLoS One. 2016; 11(8):e0161098. PMID: 27537050; PMCID: PMC4990204.
      Citations: 23     Fields:    Translation:Humans
    85. Heung M, Ortega LM, Chawla LS, Wunderink RG, Self WH, Koyner JL, Shi J, Kellum JA, Sapphire and Topaz Investigators. Common chronic conditions do not affect performance of cell cycle arrest biomarkers for risk stratification of acute kidney injury. Nephrol Dial Transplant. 2016 10; 31(10):1633-40. PMID: 27342582; PMCID: PMC5039344.
      Citations: 15     Fields:    Translation:Humans
    86. McMahon BA, Koyner JL. Risk Stratification for Acute Kidney Injury: Are Biomarkers Enough? Adv Chronic Kidney Dis. 2016 05; 23(3):167-78. PMID: 27113693.
      Citations: 17     Fields:    Translation:Humans
    87. Vijayan A, Faubel S, Askenazi DJ, Cerda J, Fissell WH, Heung M, Humphreys BD, Koyner JL, Liu KD, Mour G, Nolin TD, Bihorac A, American Society of Nephrology Acute Kidney Injury Advisory Group. Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment. Am J Kidney Dis. 2016 07; 68(1):19-28. PMID: 26948834; PMCID: PMC4921267.
      Citations: 74     Fields:    Translation:Humans
    88. Park M, Shlipak MG, Thiessen-Philbrook H, Garg AX, Koyner JL, Coca SG, Parikh CR, Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury Consortium. Association of Peak Changes in Plasma Cystatin C and Creatinine With Death After Cardiac Operations. Ann Thorac Surg. 2016 Apr; 101(4):1395-401. PMID: 26921980; PMCID: PMC4803601.
      Citations: 1     Fields:    Translation:Humans
    89. Alreja G, Koyner JL. Acute Kidney Injury: A Modifiable Risk Factor for Cardiovascular Morbidity and Mortality. Am J Nephrol. 2015; 42(4):282-4. PMID: 26496654.
      Citations:    Fields:    Translation:Humans
    90. Koyner JL, Coca SG, Thiessen-Philbrook H, Patel UD, Shlipak MG, Garg AX, Parikh CR, Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury (TRIBE-AKI) Consort, Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury TRIBE-AKI Consortiu. Urine Biomarkers and Perioperative Acute Kidney Injury: The Impact of Preoperative Estimated GFR. Am J Kidney Dis. 2015 Dec; 66(6):1006-14. PMID: 26386737; PMCID: PMC4658239.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    91. Koyner JL, Heung M. Nephrohepatology: Managing the Nexus of Liver and Kidney Interactions. Adv Chronic Kidney Dis. 2015 Sep; 22(5):335-6. PMID: 26311593.
      Citations:    Fields:    Translation:Humans
    92. Chen LX, Koyner JL. Biomarkers in Acute Kidney Injury. Crit Care Clin. 2015 Oct; 31(4):633-48. PMID: 26410134.
      Citations: 16     Fields:    Translation:Humans
    93. Heung M, Faubel S, Watnick S, Cruz DN, Koyner JL, Mour G, Liu KD, Cerda J, Okusa MD, Lukaszewski M, Vijayan A, American Society of Nephrology Acute Kidney Injury Advisory Group. Outpatient Dialysis for Patients with AKI: A Policy Approach to Improving Care. Clin J Am Soc Nephrol. 2015 Oct 07; 10(10):1868-74. PMID: 26220818; PMCID: PMC4594066.
      Citations: 11     Fields:    Translation:Humans
    94. Koyner JL. The Golden Hours of AKI: Is Oxygen Delivery the Key? Clin J Am Soc Nephrol. 2015 Aug 07; 10(8):1311-3. PMID: 26209156; PMCID: PMC4527025.
      Citations: 1     Fields:    Translation:Humans
    95. Liu KD, Cruz DN, Jaber BL, Koyner JL, Heung M, Okusa MD, Faubel S, AKI Advisory Group of the American Society of Nephrology, Cerdá J. Promoting Kidney Function Recovery in Patients with AKI Requiring RRT. Clin J Am Soc Nephrol. 2015 Oct 07; 10(10):1859-67. PMID: 26138260; PMCID: PMC4594060.
      Citations: 47     Fields:    Translation:Humans
    96. Moledina DG, Parikh CR, Garg AX, Thiessen-Philbrook H, Koyner JL, Patel UD, Devarajan P, Shlipak MG, Coca SG, TRIBE-AKI Consortium. Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study. PLoS One. 2015; 10(6):e0129619. PMID: 26053382; PMCID: PMC4460181.
      Citations: 10     Fields:    Translation:Humans
    97. Faubel S, Franch H, Vijayan A, Barron MA, Heung M, Liu KD, Koyner JL, Conner MJ. Preparing for renal replacement therapy in patients with the Ebola virus disease. Blood Purif. 2014; 38(3-4):276-85. PMID: 25675963.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    98. Koyner JL, Davison DL, Brasha-Mitchell E, Chalikonda DM, Arthur JM, Shaw AD, Tumlin JA, Trevino SA, Bennett MR, Kimmel PL, Seneff MG, Chawla LS. Furosemide Stress Test and Biomarkers for the Prediction of AKI Severity. J Am Soc Nephrol. 2015 Aug; 26(8):2023-31. PMID: 25655065; PMCID: PMC4520172.
      Citations: 81     Fields:    Translation:HumansCTClinical Trials
    99. Heung M, Koyner JL. Entanglement of sepsis, chronic kidney disease, and other comorbidities in patients who develop acute kidney injury. Semin Nephrol. 2015 Jan; 35(1):23-37. PMID: 25795497.
      Citations: 9     Fields:    Translation:Humans
    100. Koyner JL, Shaw AD, Chawla LS, Hoste EA, Bihorac A, Kashani K, Haase M, Shi J, Kellum JA, Sapphire Investigators. Tissue Inhibitor Metalloproteinase-2 (TIMP-2)·IGF-Binding Protein-7 (IGFBP7) Levels Are Associated with Adverse Long-Term Outcomes in Patients with AKI. J Am Soc Nephrol. 2015 Jul; 26(7):1747-54. PMID: 25535301; PMCID: PMC4483589.
      Citations: 86     Fields:    Translation:Humans
    101. Koyner JL, Garg AX, Thiessen-Philbrook H, Coca SG, Cantley LG, Peixoto A, Passik CS, Hong K, Parikh CR, TRIBE-AKI Consortium. Adjudication of etiology of acute kidney injury: experience from the TRIBE-AKI multi-center study. BMC Nephrol. 2014 Jul 04; 15:105. PMID: 24996668; PMCID: PMC4091753.
      Citations: 15     Fields:    Translation:HumansCTClinical Trials
    102. Koyner JL, Goldstein SL, Jaber BL, Liu KD, Shea JA, Faubel S, Acute Kidney Injury Advisory Group of the American Society of Nephrology, Cerdá J. The daily burden of acute kidney injury: a survey of U.S. nephrologists on World Kidney Day. Am J Kidney Dis. 2014 Sep; 64(3):394-401. PMID: 24815216.
      Citations: 24     Fields:    Translation:Humans
    103. Bihorac A, Chawla LS, Shaw AD, Al-Khafaji A, Davison DL, Demuth GE, Fitzgerald R, Gong MN, Graham DD, Gunnerson K, Heung M, Jortani S, Kleerup E, Koyner JL, Krell K, Letourneau J, Lissauer M, Miner J, Nguyen HB, Ortega LM, Self WH, Sellman R, Shi J, Straseski J, Szalados JE, Wilber ST, Walker MG, Wilson J, Wunderink R, Zimmerman J, Kellum JA. Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication. Am J Respir Crit Care Med. 2014 Apr 15; 189(8):932-9. PMID: 24559465.
      Citations: 193     Fields:    Translation:Humans
    104. Molnar AO, Parikh CR, Coca SG, Thiessen-Philbrook H, Koyner JL, Shlipak MG, Lee Myers M, Garg AX, TRIBE-AKI Consortium. Association between preoperative statin use and acute kidney injury biomarkers in cardiac surgical procedures. Ann Thorac Surg. 2014 Jun; 97(6):2081-7. PMID: 24725831; PMCID: PMC4068122.
      Citations: 16     Fields:    Translation:Humans
    105. Khan UA, Coca SG, Hong K, Koyner JL, Garg AX, Passik CS, Swaminathan M, Garwood S, Patel UD, Hashim S, Quantz MA, Parikh CR. Blood transfusions are associated with urinary biomarkers of kidney injury in cardiac surgery. J Thorac Cardiovasc Surg. 2014 Aug; 148(2):726-32. PMID: 24820190; PMCID: PMC4104243.
      Citations: 25     Fields:    Translation:HumansCells
    106. Naik A, Akhter SA, Fedson S, Jeevanandam V, Rich JD, Koyner JL. Acute kidney injury and mortality following ventricular assist device implantation. Am J Nephrol. 2014; 39(3):195-203. PMID: 24556808; PMCID: PMC4000722.
      Citations: 4     Fields:    Translation:Humans
    107. Coca SG, Garg AX, Thiessen-Philbrook H, Koyner JL, Patel UD, Krumholz HM, Shlipak MG, Parikh CR, TRIBE-AKI Consortium. Urinary biomarkers of AKI and mortality 3 years after cardiac surgery. J Am Soc Nephrol. 2014 May; 25(5):1063-71. PMID: 24357673; PMCID: PMC4005309.
      Citations: 88     Fields:    Translation:Humans
    108. Ramachandran K, Saikumar J, Bijol V, Koyner JL, Qian J, Betensky RA, Waikar SS, Vaidya VS. Human miRNome profiling identifies microRNAs differentially present in the urine after kidney injury. Clin Chem. 2013 Dec; 59(12):1742-52. PMID: 24153252; PMCID: PMC3870155.
      Citations: 61     Fields:    Translation:Humans
    109. Murray PT, Mehta RL, Shaw A, Ronco C, Endre Z, Kellum JA, Chawla LS, Cruz D, Ince C, Okusa MD, ADQI 10 workgroup. Potential use of biomarkers in acute kidney injury: report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference. Kidney Int. 2014 Mar; 85(3):513-21. PMID: 24107851; PMCID: PMC4198530.
      Citations: 168     Fields:    Translation:Humans
    110. Coca SG, Garg AX, Swaminathan M, Garwood S, Hong K, Thiessen-Philbrook H, Passik C, Koyner JL, Parikh CR, TRIBE-AKI Consortium. Preoperative angiotensin-converting enzyme inhibitors and angiotensin receptor blocker use and acute kidney injury in patients undergoing cardiac surgery. Nephrol Dial Transplant. 2013 Nov; 28(11):2787-99. PMID: 24081864; PMCID: PMC3811062.
      Citations: 36     Fields:    Translation:Humans
    111. Huynh T, Sun B, Li L, Nichols KP, Koyner JL, Ismagilov RF. Chemical analog-to-digital signal conversion based on robust threshold chemistry and its evaluation in the context of microfluidics-based quantitative assays. J Am Chem Soc. 2013 Oct 02; 135(39):14775-83. PMID: 24060606; PMCID: PMC3860884.
      Citations: 2     Fields:    Translation:Humans
    112. Chawla LS, Davison DL, Brasha-Mitchell E, Koyner JL, Arthur JM, Shaw AD, Tumlin JA, Trevino SA, Kimmel PL, Seneff MG. Development and standardization of a furosemide stress test to predict the severity of acute kidney injury. Crit Care. 2013 Sep 20; 17(5):R207. PMID: 24053972; PMCID: PMC4057505.
      Citations: 115     Fields:    Translation:Humans
    113. Lieske JC, Chawla L, Kashani K, Kellum JA, Koyner JL, Mehta RL. Biomarkers for acute kidney injury: where are we today? Where should we go? Clin Chem. 2014 Feb; 60(2):294-300. PMID: 23958848.
      Citations: 13     Fields:    Translation:Humans
    114. McCullough PA, Bouchard J, Waikar SS, Siew ED, Endre ZH, Goldstein SL, Koyner JL, Macedo E, Doi K, Di Somma S, Lewington A, Thadhani R, Chakravarthi R, Ice C, Okusa MD, Duranteau J, Doran P, Yang L, Jaber BL, Meehan S, Kellum JA, Haase M, Murray PT, Cruz D, Maisel A, Bagshaw SM, Chawla LS, Mehta RL, Shaw AD, Ronco C. Implementation of novel biomarkers in the diagnosis, prognosis, and management of acute kidney injury: executive summary from the tenth consensus conference of the Acute Dialysis Quality Initiative (ADQI). Contrib Nephrol. 2013; 182:5-12. PMID: 23689652; PMCID: PMC3856225.
      Citations: 40     Fields:    Translation:Humans
    115. Endre ZH, Kellum JA, Di Somma S, Doi K, Goldstein SL, Koyner JL, Macedo E, Mehta RL, Murray PT. Differential diagnosis of AKI in clinical practice by functional and damage biomarkers: workgroup statements from the tenth Acute Dialysis Quality Initiative Consensus Conference. Contrib Nephrol. 2013; 182:30-44. PMID: 23689654.
      Citations: 54     Fields:    Translation:Humans
    116. Parikh CR, Thiessen-Philbrook H, Garg AX, Kadiyala D, Shlipak MG, Koyner JL, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Coca SG, TRIBE-AKI Consortium. Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery. Clin J Am Soc Nephrol. 2013 Jul; 8(7):1079-88. PMID: 23599408; PMCID: PMC3700701.
      Citations: 119     Fields:    Translation:Humans
    117. Koyner JL, Parikh CR. Clinical utility of biomarkers of AKI in cardiac surgery and critical illness. Clin J Am Soc Nephrol. 2013 Jun; 8(6):1034-42. PMID: 23471130.
      Citations: 49     Fields:    Translation:Humans
    118. Goldstein SL, Jaber BL, Faubel S, Chawla LS, Acute Kidney Injury Advisory Group of American Society of Nephrology. AKI transition of care: a potential opportunity to detect and prevent CKD. Clin J Am Soc Nephrol. 2013 Mar; 8(3):476-83. PMID: 23471414.
      Citations: 82     Fields:    Translation:Humans
    119. Kashani K, Al-Khafaji A, Ardiles T, Artigas A, Bagshaw SM, Bell M, Bihorac A, Birkhahn R, Cely CM, Chawla LS, Davison DL, Feldkamp T, Forni LG, Gong MN, Gunnerson KJ, Haase M, Hackett J, Honore PM, Hoste EA, Joannes-Boyau O, Joannidis M, Kim P, Koyner JL, Laskowitz DT, Lissauer ME, Marx G, McCullough PA, Mullaney S, Ostermann M, Shapiro NI, Shaw AD, Shi J, Sprague AM, Vincent JL, Vinsonneau C, Wagner L, Walker MG, Wilkerson RG, Zacharowski K, Kellum JA, Rimmelé T. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care. 2013 Feb 06; 17(1):R25. PMID: 23388612; PMCID: PMC4057242.
      Citations: 459     Fields:    Translation:HumansCTClinical Trials
    120. Koyner JL, Garg AX, Shlipak MG, Patel UD, Sint K, Hong K, Devarajan P, Edelstein CL, Zappitelli M, Thiessen-Philbrook H, Parikh CR, Translational Research Investigating Biomarker Endpoints in AKI (TRIBE AKI) Consortium. Urinary cystatin C and acute kidney injury after cardiac surgery. Am J Kidney Dis. 2013 May; 61(5):730-8. PMID: 23332602; PMCID: PMC3627833.
      Citations: 23     Fields:    Translation:Humans
    121. Molnar AO, Parikh CR, Sint K, Coca SG, Koyner J, Patel UD, Butrymowicz I, Shlipak M, Garg AX. Association of postoperative proteinuria with AKI after cardiac surgery among patients at high risk. Clin J Am Soc Nephrol. 2012 Nov; 7(11):1749-60. PMID: 22977220; PMCID: PMC3488955.
      Citations: 26     Fields:    Translation:Humans
    122. Spahillari A, Parikh CR, Sint K, Koyner JL, Patel UD, Edelstein CL, Passik CS, Thiessen-Philbrook H, Swaminathan M, Shlipak MG, TRIBE-AKI Consortium. Serum cystatin C- versus creatinine-based definitions of acute kidney injury following cardiac surgery: a prospective cohort study. Am J Kidney Dis. 2012 Dec; 60(6):922-9. PMID: 22809763; PMCID: PMC3496012.
      Citations: 35     Fields:    Translation:Humans
    123. Koyner JL. Assessment and diagnosis of renal dysfunction in the ICU. Chest. 2012 Jun; 141(6):1584-1594. PMID: 22670020; PMCID: PMC3367482.
      Citations: 12     Fields:    Translation:Humans
    124. Koyner JL, Garg AX, Coca SG, Sint K, Thiessen-Philbrook H, Patel UD, Shlipak MG, Parikh CR, TRIBE-AKI Consortium. Biomarkers predict progression of acute kidney injury after cardiac surgery. J Am Soc Nephrol. 2012 May; 23(5):905-14. PMID: 22383693; PMCID: PMC3338298.
      Citations: 124     Fields:    Translation:Humans
    125. Eadon MT, Koyner JL. Autologous creatinine clearance in a case of necrotizing fasciitis and anuria. Am J Nephrol. 2012; 35(3):225-9. PMID: 22343604; PMCID: PMC3711005.
      Citations:    Fields:    Translation:Humans
    126. Patel UD, Garg AX, Krumholz HM, Shlipak MG, Coca SG, Sint K, Thiessen-Philbrook H, Koyner JL, Swaminathan M, Passik CS, Parikh CR, Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI) Consorti. Preoperative serum brain natriuretic peptide and risk of acute kidney injury after cardiac surgery. Circulation. 2012 Mar 20; 125(11):1347-55. PMID: 22322531; PMCID: PMC3312808.
      Citations: 42     Fields:    Translation:HumansCTClinical Trials
    127. Coca SG, Jammalamadaka D, Sint K, Thiessen Philbrook H, Shlipak MG, Zappitelli M, Devarajan P, Hashim S, Garg AX, Parikh CR, Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury Consortium. Preoperative proteinuria predicts acute kidney injury in patients undergoing cardiac surgery. J Thorac Cardiovasc Surg. 2012 Feb; 143(2):495-502. PMID: 22050987; PMCID: PMC3341084.
      Citations: 22     Fields:    Translation:Humans
    128. Murray P, Udani S, Koyner JL. Does renal replacement therapy improve outcome? Controversies in acute kidney injury. Contrib Nephrol. 2011; 174:212-221. PMID: 21921626.
      Citations: 1     Fields:    Translation:Humans
    129. Parikh CR, Coca SG, Thiessen-Philbrook H, Shlipak MG, Koyner JL, Wang Z, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Swaminathan M, Garg AX, TRIBE-AKI Consortium. Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. J Am Soc Nephrol. 2011 Sep; 22(9):1748-57. PMID: 21836143; PMCID: PMC3171945.
      Citations: 260     Fields:    Translation:Humans
    130. Parikh CR, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim RW, Koyner JL, Coca SG, Edelstein CL, Shlipak MG, Garg AX, Krawczeski CD, TRIBE-AKI Consortium. Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery. J Am Soc Nephrol. 2011 Sep; 22(9):1737-47. PMID: 21836147; PMCID: PMC3171944.
      Citations: 163     Fields:    Translation:Humans
    131. Shlipak MG, Coca SG, Wang Z, Devarajan P, Koyner JL, Patel UD, Thiessen-Philbrook H, Garg AX, Parikh CR, TRIBE-AKI Consortium. Presurgical serum cystatin C and risk of acute kidney injury after cardiac surgery. Am J Kidney Dis. 2011 Sep; 58(3):366-73. PMID: 21601336; PMCID: PMC3159705.
      Citations: 35     Fields:    Translation:Humans
    132. Zappitelli M, Krawczeski CD, Devarajan P, Wang Z, Sint K, Thiessen-Philbrook H, Li S, Bennett MR, Ma Q, Shlipak MG, Garg AX, Parikh CR, TRIBE-AKI consortium. Early postoperative serum cystatin C predicts severe acute kidney injury following pediatric cardiac surgery. Kidney Int. 2011 Sep; 80(6):655-62. PMID: 21525851; PMCID: PMC3312809.
      Citations: 48     Fields:    Translation:HumansCTClinical Trials
    133. Devarajan P, Haase-Fielitz A, Bellomo R, Cruz DN, Wagener G, Krawczeski CD, Koyner JL, Murray P, Zappitelli M, Goldstein SL, Makris K, Ronco C, Martensson J, Martling CR, Venge P, Siew E, Ware LB, Ikizler TA, Mertens PR, Haase M. The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J Am Coll Cardiol. 2011 Apr 26; 57(17):1752-61. PMID: 21511111; PMCID: PMC4866647.
      Citations: 274     Fields:    Translation:Humans
    134. Hall IE, Koyner JL, Doshi MD, Marcus RJ, Parikh CR. Urine cystatin C as a biomarker of proximal tubular function immediately after kidney transplantation. Am J Nephrol. 2011; 33(5):407-13. PMID: 21494031; PMCID: PMC3100377.
      Citations: 16     Fields:    Translation:Humans
    135. McMahon BA, Koyner JL, Murray PT. Urinary glutathione S-transferases in the pathogenesis and diagnostic evaluation of acute kidney injury following cardiac surgery: a critical review. Curr Opin Crit Care. 2010 Dec; 16(6):550-5. PMID: 20930627; PMCID: PMC4363992.
      Citations: 13     Fields:    Translation:Humans
    136. Koyner JL, Vaidya VS, Bennett MR, Ma Q, Worcester E, Akhter SA, Raman J, Jeevanandam V, O'Connor MF, Devarajan P, Bonventre JV, Murray PT. Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury. Clin J Am Soc Nephrol. 2010 Dec; 5(12):2154-65. PMID: 20798258; PMCID: PMC2994075.
      Citations: 137     Fields:    Translation:Humans
    137. Udani SM, Koyner JL. The effects of heart failure on renal function. Cardiol Clin. 2010 Aug; 28(3):453-65. PMID: 20621250; PMCID: PMC2904358.
      Citations: 16     Fields:    Translation:HumansAnimals
    138. Koyner JL, Murray PT. Mechanical ventilation and the kidney. Blood Purif. 2010; 29(1):52-68. PMID: 19923815; PMCID: PMC2914396.
      Citations: 37     Fields:    Translation:HumansAnimals
    139. Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A, NGAL Meta-analysis Investigator Group, Haase M. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis. 2009 Dec; 54(6):1012-24. PMID: 19850388.
      Citations: 486     Fields:    Translation:Humans
    140. Udani SM, Koyner JL. Effect of blood pressure lowering on markers of kidney disease progression. Curr Hypertens Rep. 2009 Oct; 11(5):368-74. PMID: 19737454.
      Citations: 2     Fields:    Translation:Humans
    141. Lu JC, Coca SG, Patel UD, Cantley L, Parikh CR, Translational Research Investigating Biomarkers and Endpoints for Acute Kidney Injury (TRIBE-AKI) Co. Searching for genes that matter in acute kidney injury: a systematic review. Clin J Am Soc Nephrol. 2009 Jun; 4(6):1020-31. PMID: 19443624; PMCID: PMC2689876.
      Citations: 33     Fields:    Translation:Humans
    142. Koyner JL, Sher Ali R, Murray PT. Antioxidants. Do they have a place in the prevention or therapy of acute kidney injury? Nephron Exp Nephrol. 2008; 109(4):e109-17. PMID: 18802373.
      Citations: 31     Fields:    Translation:HumansAnimals
    143. Koyner JL, Bennett MR, Worcester EM, Ma Q, Raman J, Jeevanandam V, Kasza KE, O'Connor MF, Konczal DJ, Trevino S, Devarajan P, Murray PT. Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery. Kidney Int. 2008 Oct; 74(8):1059-69. PMID: 18650797; PMCID: PMC2745082.
      Citations: 128     Fields:    
    144. Koyner JL, Murray PT. Mechanical ventilation and lung-kidney interactions. Clin J Am Soc Nephrol. 2008 Mar; 3(2):562-70. PMID: 18256378; PMCID: PMC6631081.
      Citations: 25     Fields:    Translation:Humans
    145. Hitzemann R, Malmanger B, Cooper S, Coulombe S, Reed C, Demarest K, Koyner J, Cipp L, Flint J, Talbot C, Rademacher B, Buck K, McCaughran J. Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation. Genes Brain Behav. 2002 Nov; 1(4):214-22. PMID: 12882366.
      Citations: 25     Fields:    Translation:AnimalsCells
    146. Demarest K, Koyner J, McCaughran J, Cipp L, Hitzemann R, Demarest K, Koyner J, McCaughran J, Cipp L, Hitzemann R. Further characterization and high-resolution mapping of quantitative trait loci for ethanol-induced locomotor activity. Behav Genet. 2001 Jan; 31(1):79-91. PMID: 11529277.
      Citations: 49     Fields:    Translation:Animals
    147. Hitzemann R, Demarest K, Koyner J, Cipp L, Patel N, Rasmussen E, McCaughran J. Effect of genetic cross on the detection of quantitative trait loci and a novel approach to mapping QTLs. Pharmacol Biochem Behav. 2000 Dec; 67(4):767-72. PMID: 11166067.
      Citations: 10     Fields:    Translation:Animals
    148. Koyner J, Demarest K, McCaughran J, Cipp L, Hitzemann R. Identification and time dependence of quantitative trait loci for basal locomotor activity in the BXD recombinant inbred series and a B6D2 F2 intercross. Behav Genet. 2000 May; 30(3):159-70. PMID: 11105390.
      Citations: 14     Fields:    Translation:Animals
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