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Luis Ralat

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Research 
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    K99GM095703     (RALAT, LUIS ABEL)Mar 1, 2011 - May 12, 2011
    Biological Role of Two Metalloenzymes: insulin-degrading enzyme and neprilysin
    Role: Principal Investigator

    F32GM087093     (RALAT, LUIS ABEL)Mar 1, 2009 - Feb 29, 2012
    Molecular Insights into the Mechanism and Regulation of Insulin-Degrading Enzyme
    Role: Principal Investigator

    F31GM075387     (RALAT, LUIS ABEL)Aug 15, 2005 - Aug 14, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhou S, Sorokina EM, Harper S, Li H, Ralat L, Dodia C, Speicher DW, Feinstein SI, Fisher AB. Peroxiredoxin 6 homodimerization and heterodimerization with glutathione S-transferase pi are required for its peroxidase but not phospholipase A2 activity. Free Radic Biol Med. 2016 05; 94:145-56. PMID: 26891882; PMCID: PMC4844822.
      Citations: 23     Fields:    Translation:HumansCells
    2. Ralat LA, Kalas V, Zheng Z, Goldman RD, Sosnick TR, Tang WJ. Ubiquitin is a novel substrate for human insulin-degrading enzyme. J Mol Biol. 2011 Feb 25; 406(3):454-66. PMID: 21185309; PMCID: PMC3064465.
      Citations: 19     Fields:    Translation:HumansCells
    3. Ralat LA, Guo Q, Ren M, Funke T, Dickey DM, Potter LR, Tang WJ. Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response. J Biol Chem. 2011 Feb 11; 286(6):4670-9. PMID: 21098034; PMCID: PMC3039328.
      Citations: 33     Fields:    Translation:HumansCells
    4. Ralat LA, Ren M, Schilling AB, Tang WJ. Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation. J Biol Chem. 2009 Dec 04; 284(49):34005-18. PMID: 19808678; PMCID: PMC2797171.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    5. Hulse RE, Ralat LA, Wei-Jen T. Structure, function, and regulation of insulin-degrading enzyme. Vitam Horm. 2009; 80:635-48. PMID: 19251053; PMCID: PMC3656499.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    6. Malito E, Ralat LA, Manolopoulou M, Tsay JL, Wadlington NL, Tang WJ. Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme. Biochemistry. 2008 Dec 02; 47(48):12822-34. PMID: 18986166; PMCID: PMC2652632.
      Citations: 39     Fields:    Translation:HumansCells
    7. Ralat LA, Misquitta SA, Manevich Y, Fisher AB, Colman RF. Characterization of the complex of glutathione S-transferase pi and 1-cysteine peroxiredoxin. Arch Biochem Biophys. 2008 Jun 01; 474(1):109-18. PMID: 18358825; PMCID: PMC4939725.
      Citations: 24     Fields:    Translation:HumansCells
    8. Ralat LA, Colman RF. Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi. Biochemistry. 2006 Oct 17; 45(41):12491-9. PMID: 17029404.
      Citations: 1     Fields:    Translation:HumansCells
    9. Ralat LA, Manevich Y, Fisher AB, Colman RF. Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase pi with activity changes in both enzymes. Biochemistry. 2006 Jan 17; 45(2):360-72. PMID: 16401067.
      Citations: 63     Fields:    Translation:HumansCells
    10. Ralat LA, Colman RF. Glutathione S-transferase Pi has at least three distinguishable xenobiotic substrate sites close to its glutathione-binding site. J Biol Chem. 2004 Nov 26; 279(48):50204-13. PMID: 15347687.
      Citations: 15     Fields:    Translation:HumansCells
    11. Ralat LA, Colman RF. Monobromobimane occupies a distinct xenobiotic substrate site in glutathione S-transferase pi. Protein Sci. 2003 Nov; 12(11):2575-87. PMID: 14573868; PMCID: PMC2366952.
      Citations: 3     Fields:    Translation:AnimalsCells
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