Loading...
The University of Chicago Header Logo
Keywords
Last Name
Institution

Piotr Witkowski

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentSurgery-Transplant
AddressChicago IL 60637
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    Pancreatic Islet Transplantation, Director
    ASTS Transplant Surgery Fellowship, Director
    Polish American Transplant Center, Director


    Collapse Biography 
    Collapse education and training
    Columbia Presbyterian Hospital , New York, NY06/2009Transplant Surgery Fellowship
    Columbia University , New York, NY06/2007Research Fellowship in Transplantation

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Research 
    Collapse research activities and funding
         (Piotr Witkowski)Nov 1, 2018
    Sernova/JDRF
    A Safety, Tolerability and Efficacy Study of Sernova Cell Pouch™ for Clinical Islet Transplantation. Phase 1/2 Clinical Study.
    Role Description: The goal is to assess safety and effectiveness of islet transplantation into prevascularized Sernova Cell Pouch in the abdominal muscles in patients with brittle type 1 diabetus mellitus.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Desai CS, Szempruch KR, Vonderau JS, Chetbourn M, Pattou F, Coates T, De Paep DL, Hawthorne W, Khan KM, de Koning EJP, Naziruddin B, Posselt A, Schrope BA, Wijkstrom M, Witkowski P, Shapiro AMJ. Anticoagulation Practices in Total Pancreatectomy with Autologous Islet Cell Transplant Patients: An International Survey of Clinical Programs. Transpl Int. 2021 Jan 16. PMID: 33452835.
      View in: PubMed
    2. Bachul PJ, Golab K, Basto L, Borek P, Perea L, Tibudan M, Pyda JS, Perez-Gutierrez A, Fung J, Matthews JB, Witkowski P. Long-term Stability of ß-Cell Graft Function After Total Pancreatectomy and Islet Autotransplantation. Pancreas. 2021 Jan 01; 50(1):e2-e4. PMID: 33370034.
      View in: PubMed
    3. Witkowski P, Philipson L, Kaufman DB, Ratner L, Abouljoud MS, Bellin M, Buse J, Kandeel F, Stock P, Mulligan D, Markmann JF, Kozlowski T, Andreoni K, Alejandro R, Baidal D, Hardy MA, Wickrema A, Mirmira RG, Fung J, Becker Y, Josephson MA, Bachul PJ, Pyda JS, Charlton M, Millis JM, Gaglia J, Stratta RJ, Fridell JA, Niederhaus S, Forbes RC, Jayant K, Robertson RP, Odorico J, Levy M, Harland R, Abrams PL, Olaitan OK, Kandaswamy R, Wellen J, Japour AJ, Desai CS, Naziruddin B, Balamurugan AN, Barth RN, Ricordi C. The Demise of Islet Allotransplantation in the US: A Call for an Urgent Regulatory Update The "ISLETS FOR US" Collaborative. Am J Transplant. 2020 Nov 29. PMID: 33251712.
      View in: PubMed
    4. Trikudanathan G, Elmunzer BJ, Yang Y, Abu-El-Haija M, Adams D, Ahmad S, Balamurugan AN, Beilman GJ, Chinnakotla S, Conwell DL, Freeman ML, Gardner TB, Hatipoglu B, Hodges JS, Kirchner V, Lara LF, Long-Simpson L, Mitchell R, Morgan K, Nathan JD, Naziruddin B, Posselt A, Pruett TL, Schwarzenberg SJ, Singh VK, Smith K, Wijkstrom M, Witkowski P, Bellin MD. Preoperative ERCP has no impact on islet yield following total pancreatectomy and islet autotransplantation (TPIAT): Results from the Prospective Observational Study of TPIAT (POST) cohort. Pancreatology. 2020 Nov 24. PMID: 33323311.
      View in: PubMed
    5. Generette GS, Bachul PJ, Golab K, Basto L, Pyda JS, Borek P, Tibudan M, Anteby R, Perea L, Charlton M, Perez-Gutierrez A, Jayant K, Lucander A, Matthews JB, Millis JM, Fung J, Witkowski P. En bloc liver and pancreas transplantation after total pancreatectomy with autologous islet transplantation. Eur J Transl Clin Med. 2020; 3(2):11-17. PMID: 33409500.
      View in: PubMed
    6. Generette GS, Bachul PJ, Boylan KE, Yassan LJ, Hart J, Pyda JS, Matthews JB, Fung J, Witkowski P. Neither amyloid depositions nor hepatic steatosis are associated with marginal islet mass early after autotransplantation. Am J Transplant. 2020 Nov 20. PMID: 33217154.
      View in: PubMed
    7. Bromberg J, Baan C, Chapman J, Anegon I, Brennan DC, Chakera A, Chong AS, Geissler EK, Guillonneau C, Heaton N, Hesselink DA, Jassem W, Jones CM, Josien R, Kaplan B, Kaufman CL, Lim W, Ma Y, Massey E, Ostrander DB, Slaughter MS, Tullius S, Witkowski P, Wong G. The Impact of COVID-19 on the State of Clinical and Laboratory Research Globally in Transplantation in May 2020. Transplantation. 2020 11; 104(11):2252-2257. PMID: 32541558.
      View in: PubMed
    8. Golab K, Krzystyniak A, Langa P, Pikula M, Kunovac S, Borek P, Trzonkowski P, Millis JM, Fung J, Witkowski P. Effect of serum on SmartFlare™ RNA Probes uptake and detection in cultured human cells. Biomed J Sci Tech Res. 2020; 28(4):21788-21793. PMID: 32851205.
      View in: PubMed
    9. Bachul PJ, Grybowski DJ, Anteby R, Basto L, Perea L, Golab K, Wang LJ, Tibudan M, Perez-Gutierrez A, Komorniczak M, Nagpal S, Lucander A, Fung J, Matthews JB, Witkowski P. Total pancreatectomy with islet autotransplantation in diabetic and pre-diabetic patients with intractable chronic pancreatitis. J Pancreatol. 2020 Jun; 3(2):86-92. PMID: 33005475.
      View in: PubMed
    10. Maffi P, Lundgren T, Tufveson G, Rafael E, Shaw JAM, Liew A, Saudek F, Witkowski P, Golab K, Bertuzzi F, Gustafsson B, Daffonchio L, Ruffini PA, Piemonti L. Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes. Diabetes Care. 2020 04; 43(4):710-718. PMID: 32019854.
      View in: PubMed
    11. Golebiewska JE, Golab K, Gorycki T, Sledzinski M, Gulczynski J, Zygowska I, Wolnik B, Hoffmann M, Witkowski P, Ricordi C, Szurowska E, Sledzinski Z, Debska-Slizien A. "Old School" Islet Purification Based on the Unit Gravity Sedimentation as a Rescue Technique for Intraportal Islet Transplantation-A Case Report. Cell Transplant. 2020 Jan-Dec; 29:963689720947098. PMID: 32749147.
      View in: PubMed
    12. Bachul PJ, Golebiewska JE, Basto L, Golab K, Anteby R, Wang LJ, Tibudan M, Thomas C, Fendler W, Lucander A, Grybowski DJ, Debska-Slizien A, Fung J, Witkowski P. BETA-2 score is an early predictor of graft decline and loss of insulin independence after pancreatic islet allotransplantation. Am J Transplant. 2020 03; 20(3):844-851. PMID: 31597009.
      View in: PubMed
    13. Lara LF, Bellin MD, Ugbarugba E, Nathan JD, Witkowski P, Wijkstrom M, Steel JL, Smith KD, Singh VK, Schwarzenberg SJ, Pruett TL, Naziruddin B, Long-Simpson L, Kirchner VA, Gardner TB, Freeman ML, Dunn TB, Chinnakotla S, Beilman GJ, Adams DB, Morgan KA, Abu-El-Haija MA, Ahmad S, Posselt AM, Hughes MG, Conwell DL. A Study on the Effect of Patient Characteristics, Geographical Utilization, and Patient Outcomes for Total Pancreatectomy Alone and Total Pancreatectomy With Islet Autotransplantation in Patients With Pancreatitis in the United States. Pancreas. 2019 10; 48(9):1204-1211. PMID: 31593020.
      View in: PubMed
    14. Savari O, Golab K, Solomina J, Konsur E, Cieply K, Ramachandran S, Tekin Z, Schenck L, Zhang SS, Tibudan M, Posner MC, Witkowski P. Total Pancreatectomy with Islet Autotransplantation for the Ampullary Cancer. A Case Report. J Gastrointest Cancer. 2019 09; 50(3):543-547. PMID: 29159772.
      View in: PubMed
    15. Golebiewska JE, Bachul PJ, Fillman N, Kijek MR, Basto L, Para M, Perea L, Golab K, Wang LJ, Tibudan M, Debska-Slizien A, Matthews JB, Fung J, Witkowski P. Early Infectious Complications After Total Pancreatectomy with Islet Autotransplantation: a Single Center Experience. J Gastrointest Surg. 2019 11; 23(11):2201-2210. PMID: 30719679.
      View in: PubMed
    16. Dybala MP, Olehnik SK, Fowler JL, Golab K, Millis JM, Golebiewska J, Bachul P, Witkowski P, Hara M. Pancreatic beta cell/islet mass and body mass index. Islets. 2019; 11(1):1-9. PMID: 30668226.
      View in: PubMed
    17. Golebiewska JE, Bachul PJ, Wang LJ, Matosz S, Basto L, Kijek MR, Fillman N, Golab K, Tibudan M, Debska-Slizien A, Millis JM, Fung J, Witkowski P. Validation of a New North American Islet Donor Score for Donor Pancreas Selection and Successful Islet Isolation in a Medium-Volume Islet Transplant Center. Cell Transplant. 2019 02; 28(2):185-194. PMID: 30520321.
      View in: PubMed
    18. Golebiewska JE, Bachul PJ, Fillman N, Basto L, Kijek MR, Golab K, Wang LJ, Tibudan M, Thomas C, Debska-Slizien A, Gelrud A, Matthews JB, Millis JM, Fung J, Witkowski P. Assessment of simple indices based on a single fasting blood sample as a tool to estimate beta-cell function after total pancreatectomy with islet autotransplantation - a prospective study. Transpl Int. 2019 03; 32(3):280-290. PMID: 30353611.
      View in: PubMed
    19. Bellin MD, Abu-El-Haija M, Morgan K, Adams D, Beilman GJ, Chinnakotla S, Conwell DL, Dunn TB, Freeman ML, Gardner T, Kirchner VA, Lara LF, Long-Simpson L, Nathan JD, Naziruddin B, Nyman JA, Pruett TL, Schwarzenberg SJ, Singh VK, Smith K, Steel JL, Wijkstrom M, Witkowski P, Hodges JS. A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT): POST (Prospective Observational Study of TPIAT). Pancreatology. 2018 Apr; 18(3):286-290. PMID: 29456124.
      View in: PubMed
    20. Golebiewska JE, Solomina J, Thomas C, Kijek MR, Bachul PJ, Basto L, Golab K, Wang LJ, Fillman N, Tibudan M, Cieply K, Philipson L, Debska-Slizien A, Millis JM, Fung J, Witkowski P. Comparative evaluation of simple indices using a single fasting blood sample to estimate beta cell function after islet transplantation. Am J Transplant. 2018 04; 18(4):990-997. PMID: 29218834.
      View in: PubMed
    21. Fuchs A, Gliwinski M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Golab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grzes D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Front Immunol. 2017; 8:1844. PMID: 29379498.
      View in: PubMed
    22. Xiao X, Guo P, Shiota C, Zhang T, Coudriet GM, Fischbach S, Prasadan K, Fusco J, Ramachandran S, Witkowski P, Piganelli JD, Gittes GK. Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes. Cell Stem Cell. 2018 01 04; 22(1):78-90.e4. PMID: 29304344.
      View in: PubMed
    23. Golab K, Grose R, Placencia V, Wickrema A, Solomina J, Tibudan M, Konsur E, Cieply K, Marek-Trzonkowska N, Trzonkowski P, Millis JM, Fung J, Witkowski P. Cell banking for regulatory T cell-based therapy: strategies to overcome the impact of cryopreservation on the Treg viability and phenotype. Oncotarget. 2018 Feb 09; 9(11):9728-9740. PMID: 29515766.
      View in: PubMed
    24. Solomina J, Golebiewska J, Kijek MR, Kotukhov A, Bachul PJ, Basto L, Golab K, Konsur E, Cieply K, Fillman N, Wang LJ, Thomas CC, Philipson LH, Tibudan M, Debska-Slizien A, Fung J, Gelrud A, Matthews JB, Witkowski P. Pain Control, Glucose Control, and Quality of Life in Patients With Chronic Pancreatitis After Total Pancreatectomy With Islet Autotransplantation: A Preliminary Report. Transplant Proc. 2017 Dec; 49(10):2333-2339. PMID: 29198673.
      View in: PubMed
    25. Golebiewska J, Solomina J, Kijek MR, Kotukhov A, Basto L, Golab K, Bachul PJ, Konsur E, Cieply K, Fillman N, Wang LJ, Thomas CC, Philipson LH, Tibudan M, Krenc A, Debska-Slizien A, Fung J, Witkowski P. External Validation of the Newly Developed BETA-2 Scoring System for Pancreatic Islet Graft Function Assessment. Transplant Proc. 2017 Dec; 49(10):2340-2346. PMID: 29198674.
      View in: PubMed
    26. Sondermeijer HP, Witkowski P, Seki T, van der Laarse A, Itescu S, Hardy MA. RGDfK-Peptide Modified Alginate Scaffold for Cell Transplantation and Cardiac Neovascularization. Tissue Eng Part A. 2018 05; 24(9-10):740-751. PMID: 28938862.
      View in: PubMed
    27. Marek-Trzonkowska N, Mysliwiec M, Iwaszkiewicz-Grzes D, Gliwinski M, Derkowska I, Zalinska M, Zielinski M, Grabowska M, Zielinska H, Piekarska K, Jazwinska-Curyllo A, Owczuk R, Szadkowska A, Wyka K, Witkowski P, Mlynarski W, Jarosz-Chobot P, Bossowski A, Siebert J, Trzonkowski P. Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes. J Transl Med. 2016 12 01; 14(1):332. PMID: 27903296.
      View in: PubMed
    28. Golab K, Grose R, Trzonkowski P, Wickrema A, Tibudan M, Marek-Trzonkowska N, Matosz S, Solomina J, Ostrega D, Michael Millis J, Witkowski P. Utilization of leukapheresis and CD4 positive selection in Treg isolation and the ex-vivo expansion for a clinical application in transplantation and autoimmune disorders. Oncotarget. 2016 Nov 29; 7(48):79474-79484. PMID: 27821811.
      View in: PubMed
    29. Tekin Z, Garfinkel MR, Chon WJ, Schenck L, Golab K, Savari O, Thistlethwaite JR, Philipson LH, Majewski C, Pannain S, Ramachandran S, Rezania K, Hariprasad SM, Millis JM, Witkowski P. Outcomes of Pancreatic Islet Allotransplantation Using the Edmonton Protocol at the University of Chicago. Transplant Direct. 2016 Oct; 2(10):e105. PMID: 27795987.
      View in: PubMed
    30. Sondermeijer HP, Witkowski P, Woodland D, Seki T, Aangenendt FJ, van der Laarse A, Itescu S, Hardy MA. Optimization of alginate purification using polyvinylidene difluoride membrane filtration: Effects on immunogenicity and biocompatibility of three-dimensional alginate scaffolds. J Biomater Appl. 2016 10; 31(4):510-520. PMID: 27114440.
      View in: PubMed
    31. Wang LJ, Kin T, O'Gorman D, Shapiro AMJ, Naziruddin B, Takita M, Levy MF, Posselt AM, Szot GL, Savari O, Barbaro B, McGarrigle J, Yeh CC, Oberholzer J, Lei J, Chen T, Lian M, Markmann JF, Alvarez A, Linetsky E, Ricordi C, Balamurugan AN, Loganathan G, Wilhelm JJ, Hering BJ, Bottino R, Trucco M, Liu C, Min Z, Li Y, Naji A, Fernandez LA, Ziemelis M, Danobeitia JS, Millis JM, Witkowski P. A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation. Cell Transplant. 2016; 25(8):1515-1523. PMID: 26922947.
      View in: PubMed
    32. Xiao X, Fischbach S, Song Z, Gaffar I, Zimmerman R, Wiersch J, Prasadan K, Shiota C, Guo P, Ramachandran S, Witkowski P, Gittes GK. Transient Suppression of TGFß Receptor Signaling Facilitates Human Islet Transplantation. Endocrinology. 2016 Apr; 157(4):1348-56. PMID: 26872091.
      View in: PubMed
    33. Savari O, Golab K, Wang LJ, Schenck L, Grose R, Tibudan M, Ramachandran S, Chon WJ, Posner MC, Millis JM, Matthews JB, Gelrud A, Witkowski P. Preservation of beta cell function after pancreatic islet autotransplantation: University of Chicago experience. Am Surg. 2015 Apr; 81(4):421-7. PMID: 25831191.
      View in: PubMed
    34. Chon WJ, Kadambi PV, Xu C, Becker YT, Witkowski P, Pursell K, Kane B, Josephson MA. Use of leflunomide in renal transplant recipients with ganciclovir-resistant/refractory cytomegalovirus infection: a case series from the University of Chicago. Case Rep Nephrol Dial. 2015 Jan-Apr; 5(1):96-105. PMID: 26000278.
      View in: PubMed
    35. Poudel A, Savari O, Striegel DA, Periwal V, Taxy J, Millis JM, Witkowski P, Atkinson MA, Hara M. Beta-cell destruction and preservation in childhood and adult onset type 1 diabetes. Endocrine. 2015 Aug; 49(3):693-702. PMID: 25605478.
      View in: PubMed
    36. Corritore E, Dugnani E, Pasquale V, Misawa R, Witkowski P, Lei J, Markmann J, Piemonti L, Sokal EM, Bonner-Weir S, Lysy PA. ß-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion. Cell Reprogram. 2014 Dec; 16(6):456-66. PMID: 25437872.
      View in: PubMed
    37. Krzystyniak A, Golab K, Witkowski P, Trzonkowski P. Islet cell transplant and the incorporation of Tregs. Curr Opin Organ Transplant. 2014 Dec; 19(6):610-5. PMID: 25304813.
      View in: PubMed
    38. Bailey KA, Savic D, Zielinski M, Park SY, Wang LJ, Witkowski P, Brady M, Hara M, Bell GI, Nobrega MA. Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice. Hum Mol Genet. 2015 Mar 15; 24(6):1646-54. PMID: 25398947.
      View in: PubMed
    39. Hoang DT, Matsunari H, Nagaya M, Nagashima H, Millis JM, Witkowski P, Periwal V, Hara M, Jo J. A conserved rule for pancreatic islet organization. PLoS One. 2014; 9(10):e110384. PMID: 25350558.
      View in: PubMed
    40. Wang LJ, Cochet O, Wang XJ, Krzystyniak A, Misawa R, Golab K, Tibudan M, Grose R, Savari O, Millis JM, Witkowski P. Donor height in combination with islet donor score improves pancreas donor selection for pancreatic islet isolation and transplantation. Transplant Proc. 2014 Jul-Aug; 46(6):1972-4. PMID: 25131085.
      View in: PubMed
    41. Golab K, Kizilel S, Bal T, Hara M, Zielinski M, Grose R, Savari O, Wang XJ, Wang LJ, Tibudan M, Krzystyniak A, Marek-Trzonkowska N, Millis JM, Trzonkowski P, Witkowski P. Improved coating of pancreatic islets with regulatory T cells to create local immunosuppression by using the biotin-polyethylene glycol-succinimidyl valeric acid ester molecule. Transplant Proc. 2014 Jul-Aug; 46(6):1967-71. PMID: 25131084.
      View in: PubMed
    42. Wang LJ, Kissler HJ, Wang X, Cochet O, Krzystyniak A, Misawa R, Golab K, Tibudan M, Grzanka J, Savari O, Kaufman DB, Millis M, Witkowski P. Application of Digital Image Analysis to Determine Pancreatic Islet Mass and Purity in Clinical Islet Isolation and Transplantation. Cell Transplant. 2015; 24(7):1195-204. PMID: 24806436.
      View in: PubMed
    43. Guo H, Xiong Y, Witkowski P, Cui J, Wang LJ, Sun J, Lara-Lemus R, Haataja L, Hutchison K, Shan SO, Arvan P, Liu M. Inefficient translocation of preproinsulin contributes to pancreatic ß cell failure and late-onset diabetes. J Biol Chem. 2014 Jun 06; 289(23):16290-302. PMID: 24770419.
      View in: PubMed
    44. Marek-Trzonkowska N, Mysliwiec M, Dobyszuk A, Grabowska M, Derkowska I, Juscinska J, Owczuk R, Szadkowska A, Witkowski P, Mlynarski W, Jarosz-Chobot P, Bossowski A, Siebert J, Trzonkowski P. Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up. Clin Immunol. 2014 Jul; 153(1):23-30. PMID: 24704576.
      View in: PubMed
    45. Witkowski P, Savari O, Matthews JB. Islet autotransplantation and total pancreatectomy. Adv Surg. 2014; 48:223-33. PMID: 25293618.
      View in: PubMed
    46. Wang LJ, Young S, Misawa R, Azzam R, Wang X, Golab K, Cochet O, Savari O, Tibudan M, Millis JM, Matthews JB, Witkowski P. Chronic pancreatitis and primary sclerosing cholangitis--first report of intrahepatic autologous islet transplantation. J Gastrointest Surg. 2014 Apr; 18(4):845-50. PMID: 24297649.
      View in: PubMed
    47. Savari O, Zielinski MC, Wang X, Misawa R, Millis JM, Witkowski P, Hara M. Distinct function of the head region of human pancreas in the pathogenesis of diabetes. Islets. 2013 Sep-Dec; 5(5):226-8. PMID: 24045229.
      View in: PubMed
    48. Wang X, Misawa R, Zielinski MC, Cowen P, Jo J, Periwal V, Ricordi C, Khan A, Szust J, Shen J, Millis JM, Witkowski P, Hara M. Regional differences in islet distribution in the human pancreas--preferential beta-cell loss in the head region in patients with type 2 diabetes. PLoS One. 2013; 8(6):e67454. PMID: 23826303.
      View in: PubMed
    49. Yin H, Park SY, Wang XJ, Misawa R, Grossman EJ, Tao J, Zhong R, Witkowski P, Bell GI, Chong AS. Enhancing pancreatic Beta-cell regeneration in vivo with pioglitazone and alogliptin. PLoS One. 2013; 8(6):e65777. PMID: 23762423.
      View in: PubMed
    50. Wang XJ, Leveson-Gower D, Golab K, Wang LJ, Marek-Trzonkowska N, Krzystyniak A, Wardowska A, Millis JM, Trzonkowski P, Witkowski P. Influence of pharmacological immunomodulatory agents on CD4(+)CD25(high)FoxP3(+) T regulatory cells in humans. Int Immunopharmacol. 2013 Jul; 16(3):364-70. PMID: 23499512.
      View in: PubMed
    51. Golab K, Krzystyniak A, Marek-Trzonkowska N, Misawa R, Wang LJ, Wang X, Cochet O, Tibudan M, Langa P, Millis JM, Trzonkowski P, Witkowski P. Impact of culture medium on CD4(+) CD25(high)CD127(lo/neg) Treg expansion for the purpose of clinical application. Int Immunopharmacol. 2013 Jul; 16(3):358-63. PMID: 23466550.
      View in: PubMed
    52. Grzanka J, Leveson-Gower D, Golab K, Wang XJ, Marek-Trzonkowska N, Krzystyniak A, Wardowska A, Mills JM, Trzonkowski P, Witkowski P. FoxP3, Helios, and SATB1: roles and relationships in regulatory T cells. Int Immunopharmacol. 2013 Jul; 16(3):343-7. PMID: 23428911.
      View in: PubMed
    53. Golab K, Leveson-Gower D, Wang XJ, Grzanka J, Marek-Trzonkowska N, Krzystyniak A, Millis JM, Trzonkowski P, Witkowski P. Challenges in cryopreservation of regulatory T cells (Tregs) for clinical therapeutic applications. Int Immunopharmacol. 2013 Jul; 16(3):371-5. PMID: 23428908.
      View in: PubMed
    54. Wang X, Zielinski MC, Misawa R, Wen P, Wang TY, Wang CZ, Witkowski P, Hara M. Quantitative analysis of pancreatic polypeptide cell distribution in the human pancreas. PLoS One. 2013; 8(1):e55501. PMID: 23383206.
      View in: PubMed
    55. Barton FB, Rickels MR, Alejandro R, Hering BJ, Wease S, Naziruddin B, Oberholzer J, Odorico JS, Garfinkel MR, Levy M, Pattou F, Berney T, Secchi A, Messinger S, Senior PA, Maffi P, Posselt A, Stock PG, Kaufman DB, Luo X, Kandeel F, Cagliero E, Turgeon NA, Witkowski P, Naji A, O'Connell PJ, Greenbaum C, Kudva YC, Brayman KL, Aull MJ, Larsen C, Kay TW, Fernandez LA, Vantyghem MC, Bellin M, Shapiro AM. Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care. 2012 Jul; 35(7):1436-45. PMID: 22723582.
      View in: PubMed
    56. Marek-Trzonkowska N, Mysliwiec M, Dobyszuk A, Grabowska M, Techmanska I, Juscinska J, Wujtewicz MA, Witkowski P, Mlynarski W, Balcerska A, Mysliwska J, Trzonkowski P. Administration of CD4+CD25highCD127- regulatory T cells preserves ß-cell function in type 1 diabetes in children. Diabetes Care. 2012 Sep; 35(9):1817-20. PMID: 22723342.
      View in: PubMed
    57. Kilimnik G, Zhao B, Jo J, Periwal V, Witkowski P, Misawa R, Hara M. Altered islet composition and disproportionate loss of large islets in patients with type 2 diabetes. PLoS One. 2011; 6(11):e27445. PMID: 22102895.
      View in: PubMed
    58. Marek N, Krzystyniak A, Ergenc I, Cochet O, Misawa R, Wang LJ, Golab K, Wang X, Kilimnik G, Hara M, Kizilel S, Trzonkowski P, Millis JM, Witkowski P. Coating human pancreatic islets with CD4(+)CD25(high)CD127(-) regulatory T cells as a novel approach for the local immunoprotection. Ann Surg. 2011 Sep; 254(3):512-8; discussion 518-9. PMID: 21865948.
      View in: PubMed
    59. Marek N, Bieniaszewska M, Krzystyniak A, Juscinska J, Mysliwska J, Witkowski P, Hellmann A, Trzonkowski P. The time is crucial for ex vivo expansion of T regulatory cells for therapy. Cell Transplant. 2011; 20(11-12):1747-58. PMID: 21457615.
      View in: PubMed
    60. Kim A, Kilimnik G, Guo C, Sung J, Jo J, Periwal V, Witkowski P, Dilorio P, Hara M. Computer-assisted large-scale visualization and quantification of pancreatic islet mass, size distribution and architecture. J Vis Exp. 2011 Mar 04; (49). PMID: 21403638.
      View in: PubMed
    61. Chang CC, Vlad G, D'Agati VD, Liu Z, Zhang QY, Witkowski P, Torkamani AA, Stokes MB, Ho EK, Cortesini R, Suciu-Foca N. BCL6 is required for differentiation of Ig-like transcript 3-Fc-induced CD8+ T suppressor cells. J Immunol. 2010 Nov 15; 185(10):5714-22. PMID: 20935202.
      View in: PubMed
    62. Kizilel S, Scavone A, Liu X, Nothias JM, Ostrega D, Witkowski P, Millis M. Encapsulation of pancreatic islets within nano-thin functional polyethylene glycol coatings for enhanced insulin secretion. Tissue Eng Part A. 2010 Jul; 16(7):2217-28. PMID: 20163204.
      View in: PubMed
    63. Hardy MA, Witkowski P, Sondermeijer H, Harris P. The long road to pancreatic islet transplantation. World J Surg. 2010 Apr; 34(4):625-7. PMID: 19830482.
      View in: PubMed
    64. Witkowski P, Sondermeijer H, Hardy MA, Woodland DC, Lee K, Bhagat G, Witkowski K, See F, Rana A, Maffei A, Itescu S, Harris PE. Islet grafting and imaging in a bioengineered intramuscular space. Transplantation. 2009 Nov 15; 88(9):1065-74. PMID: 19898201.
      View in: PubMed
    65. Halazun KJ, Hardy MA, Rana AA, Woodland DC, Luyten EJ, Mahadev S, Witkowski P, Siegel AB, Brown RS, Emond JC. Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma. Ann Surg. 2009 Jul; 250(1):141-51. PMID: 19561458.
      View in: PubMed
    66. Rana A, Robles S, Russo MJ, Halazun KJ, Woodland DC, Witkowski P, Ratner LE, Hardy MA. The combined organ effect: protection against rejection? Ann Surg. 2008 Nov; 248(5):871-9. PMID: 18948817.
      View in: PubMed
    67. Raffo A, Hancock K, Polito T, Xie Y, Andan G, Witkowski P, Hardy M, Barba P, Ferrara C, Maffei A, Freeby M, Goland R, Leibel RL, Sweet IR, Harris PE. Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine. J Endocrinol. 2008 Jul; 198(1):41-9. PMID: 18577569.
      View in: PubMed
    68. Witkowski P, Seki T, Xiang G, Martens T, Sondermeijer H, See F, Bhagat G, Schuster M, Hardy MA, Itescu S. A DNA enzyme against plasminogen activator inhibitor- type 1 (PAI-1) limits neointima formation after angioplasty in an obese diabetic rodent model. J Cardiovasc Pharmacol. 2007 Dec; 50(6):633-40. PMID: 18091579.
      View in: PubMed
    69. Witkowski P, Trabucco EE. Is there an increased risk of the vas deferens occlusion after mesh inguinal hernioplasty and what can we do about it? Ann Surg. 2007 Jan; 245(1):153-4. PMID: 17197981.
      View in: PubMed
    70. Witkowski P, Herold KC. Islet transplantation for type 1 diabetes--where should we go? Nat Clin Pract Endocrinol Metab. 2007 Jan; 3(1):2-3. PMID: 17179921.
      View in: PubMed
    71. Simpson NR, Souza F, Witkowski P, Maffei A, Raffo A, Herron A, Kilbourn M, Jurewicz A, Herold K, Liu E, Hardy MA, Van Heertum R, Harris PE. Visualizing pancreatic beta-cell mass with [11C]DTBZ. Nucl Med Biol. 2006 Oct; 33(7):855-64. PMID: 17045165.
      View in: PubMed
    72. Witkowski P, Zakai SB, Rana A, Sledzinski Z, Hardy MA. Pancreatic islet transplantation, what has been achieved since Edmonton break-through. Ann Transplant. 2006; 11(2):5-13; discussion 32-43. PMID: 17494283.
      View in: PubMed
    73. Liu J, Liu Z, Witkowski P, Vlad G, Manavalan JS, Scotto L, Kim-Schulze S, Cortesini R, Hardy MA, Suciu-Foca N. Rat CD8+ FOXP3+ T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection. Transpl Immunol. 2004 Dec; 13(4):239-47. PMID: 15589736.
      View in: PubMed
    74. Maffei A, Liu Z, Witkowski P, Moschella F, Del Pozzo G, Liu E, Herold K, Winchester RJ, Hardy MA, Harris PE. Identification of tissue-restricted transcripts in human islets. Endocrinology. 2004 Oct; 145(10):4513-21. PMID: 15231694.
      View in: PubMed
    75. Oluwole SF, Oluwole OO, DePaz HA, Adeyeri AO, Witkowski P, Hardy MA. CD4+CD25+ regulatory T cells mediate acquired transplant tolerance. Transpl Immunol. 2003 Jul-Sep; 11(3-4):287-93. PMID: 12967782.
      View in: PubMed
    76. DePaz HA, Oluwole OO, Adeyeri AO, Witkowski P, Jin MX, Hardy MA, Oluwole SF. Immature rat myeloid dendritic cells generated in low-dose granulocyte macrophage-colony stimulating factor prolong donor-specific rat cardiac allograft survival. Transplantation. 2003 Feb 27; 75(4):521-8. PMID: 12605121.
      View in: PubMed
    Witkowski's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _