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Manami Hara

TitleResearch Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Endocrinology
AddressChicago IL 60637
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    Collapse Research 
    Collapse research activities and funding
    R01DK117192     (HARA, MANAMI)Jan 15, 2019 - Dec 31, 2023
    NIH
    Heterogeneity of the human pancreas
    Role: Principal Investigator
    R03AG042151     (HARA, MANAMI)Sep 30, 2012 - Aug 31, 2014
    NIH
    Quantitative analysis of aging in the human pancreas
    Role: Principal Investigator
    R56DK081527     (HARA, MANAMI)Jul 1, 2008 - Jun 30, 2011
    NIH
    Role of the environmental cues for beta-cell differentiation from ES cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rupnik MS, Hara M, Slak Rupnik M, Hara M. Local Dialogues Between the Endocrine and Exocrine Cells in the Pancreas. Diabetes. 2024 04 01; 73(4):533-541. PMID: 38215069; PMCID: PMC10958587.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Aggarwal M, Striegel DA, Hara M, Periwal V. Geometric and topological characterization of the cytoarchitecture of islets of Langerhans. PLoS Comput Biol. 2023 Nov; 19(11):e1011617. PMID: 37943957; PMCID: PMC10662755.
      Citations:    Fields:    Translation:AnimalsCells
    3. Slak Rupnik M, Rizk AA, Dybala MP, Rodriguez KC, Hara M. Pancreatic regional blood flow links the endocrine and exocrine diseases. J Clin Invest. 2023 08 01; 133(15). PMID: 37338995; PMCID: PMC10378168.
      Citations: 3     Fields:    Translation:HumansAnimals
    4. Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, Ouaamari AE, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M, Olesen SS. Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433-448. Diabetes. 2023 Aug 01; 72(8):1173. PMID: 37116182; PMCID: PMC10382644.
      Citations:    Fields:    
    5. Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M, Olesen SS. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes. 2023 04 01; 72(4):433-448. PMID: 36940317; PMCID: PMC10033248.
      Citations: 1     Fields:    Translation:Humans
    6. Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Sander M, Pandol SJ, Olesen SS. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Pancreas. 2022 10 01; 51(9):1061-1073. PMID: 37078927; PMCID: PMC10328394.
      Citations: 3     Fields:    Translation:Humans
    7. Fan F, Wu Y, Hara M, Rizk A, Ji C, Nerad D, Tamarina N, Lou X. Dynamin deficiency causes insulin secretion failure and hyperglycemia. Proc Natl Acad Sci U S A. 2021 08 10; 118(32). PMID: 34362840; PMCID: PMC8364113.
      Citations: 5     Fields:    Translation:AnimalsCells
    8. Dybala MP, Hara M. In Vivo and In Situ Approach to Study Islet Microcirculation: A Mini-Review. Front Endocrinol (Lausanne). 2021; 12:602620. PMID: 34040578; PMCID: PMC8142941.
      Citations: 1     Fields:    Translation:HumansAnimals
    9. Dybala MP, Gebien LR, Reyna ME, Yu Y, Hara M. Implications of Integrated Pancreatic Microcirculation: Crosstalk between Endocrine and Exocrine Compartments. Diabetes. 2020 12; 69(12):2566-2574. PMID: 33148810; PMCID: PMC7679783.
      Citations: 6     Fields:    Translation:HumansAnimals
    10. Dybala MP, Butterfield JK, Hendren-Santiago BK, Hara M. Pancreatic Islets and Gestalt Principles. Diabetes. 2020 09; 69(9):1864-1874. PMID: 32669392; PMCID: PMC7458033.
      Citations: 7     Fields:    Translation:HumansAnimals
    11. Dybala MP, Kuznetsov A, Motobu M, Hendren-Santiago BK, Philipson LH, Chervonsky AV, Hara M. Integrated Pancreatic Blood Flow: Bidirectional Microcirculation Between Endocrine and Exocrine Pancreas. Diabetes. 2020 07; 69(7):1439-1450. PMID: 32198213; PMCID: PMC7306124.
      Citations: 40     Fields:    Translation:HumansAnimals
    12. Kaneko K, Hara M, Nishino T, Maruyama T. One-Step Biotinylation of Cellulose Paper by Polymer Coating to Prepare a Paper-Based Analytical Device. Anal Chem. 2020 01 21; 92(2):1978-1987. PMID: 31876140.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    13. Rodriguez-Diaz R, Tamayo A, Hara M, Caicedo A. The Local Paracrine Actions of the Pancreatic a-Cell. Diabetes. 2020 04; 69(4):550-558. PMID: 31882565; PMCID: PMC7085245.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    14. Dybala MP, Brady MJ, Hara M. Disparity in Adiposity among Adults with Normal Body Mass Index and Waist-to-Height Ratio. iScience. 2019 Nov 22; 21:612-623. PMID: 31731199; PMCID: PMC6889773.
      Citations: 5     
    15. Ruiz D, Regnier SM, Kirkley AG, Hara M, Haro F, Aldirawi H, Dybala MP, Sargis RM. Developmental exposure to the endocrine disruptor tolylfluanid induces sex-specific later-life metabolic dysfunction. Reprod Toxicol. 2019 10; 89:74-82. PMID: 31260803; PMCID: PMC6766412.
      Citations: 6     Fields:    Translation:AnimalsPHPublic Health
    16. Dybala MP, Hara M. Heterogeneity of the Human Pancreatic Islet. Diabetes. 2019 06; 68(6):1230-1239. PMID: 30936150; PMCID: PMC6610021.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    17. Dybala MP, Olehnik SK, Fowler JL, Golab K, Millis JM, Golebiewska J, Bachul P, Witkowski P, Hara M. Pancreatic beta cell/islet mass and body mass index. Islets. 2019; 11(1):1-9. PMID: 30668226; PMCID: PMC6389280.
      Citations: 10     Fields:    Translation:HumansCells
    18. Walker AV, Gelb LD, Barry GE, Subanajouy P, Poudel A, Hara M, Veryovkin IV, Bell GI, Hanley L. Femtosecond laser desorption ionization mass spectrometry imaging and multivariate analysis of lipids in pancreatic tissue. Biointerphases. 2018 04 02; 13(3):03B416. PMID: 29609468; PMCID: PMC5880676.
      Citations: 3     Fields:    Translation:Humans
    19. Fowler JL, Lee SS, Wesner ZC, Olehnik SK, Kron SJ, Hara M. Three-Dimensional Analysis of the Human Pancreas. Endocrinology. 2018 03 01; 159(3):1393-1400. PMID: 29390052; PMCID: PMC5839749.
      Citations: 23     Fields:    Translation:HumansAnimals
    20. Rotti PG, Xie W, Poudel A, Yi Y, Sun X, Tyler SR, Uc A, Norris AW, Hara M, Engelhardt JF, Gibson-Corley KN. Pancreatic and Islet Remodeling in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Ferrets. Am J Pathol. 2018 04; 188(4):876-890. PMID: 29366680; PMCID: PMC5963477.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    21. Lei CL, Kellard JA, Hara M, Johnson JD, Rodriguez B, Briant LJB. Beta-cell hubs maintain Ca2+ oscillations in human and mouse islet simulations. Islets. 2018; 10(4):151-167. PMID: 30142036; PMCID: PMC6113907.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    22. Olehnik SK, Fowler JL, Avramovich G, Hara M. Quantitative analysis of intra- and inter-individual variability of human beta-cell mass. Sci Rep. 2017 11 27; 7(1):16398. PMID: 29180621; PMCID: PMC5703964.
      Citations: 21     Fields:    Translation:HumansCells
    23. Kirkley AG, Carmean CM, Ruiz D, Ye H, Regnier SM, Poudel A, Hara M, Kamau W, Johnson DN, Roberts AA, Parsons PJ, Seino S, Sargis RM. Arsenic exposure induces glucose intolerance and alters global energy metabolism. Am J Physiol Regul Integr Comp Physiol. 2018 02 01; 314(2):R294-R303. PMID: 29118024; PMCID: PMC5867677.
      Citations: 24     Fields:    Translation:AnimalsCells
    24. Beamish CA, Mehta S, Strutt BJ, Chakrabarti S, Hara M, Hill DJ. Decrease in Ins+Glut2LO ß-cells with advancing age in mouse and human pancreas. J Endocrinol. 2017 06; 233(3):229-241. PMID: 28348115.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    25. Greeley SA, Zielinski MC, Poudel A, Ye H, Berry S, Taxy JB, Carmody D, Steiner DF, Philipson LH, Wood JR, Hara M. Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-Related Diabetes. J Clin Endocrinol Metab. 2017 01 01; 102(1):1-5. PMID: 27802092; PMCID: PMC5413092.
      Citations: 8     Fields:    Translation:HumansCells
    26. Poudel A, Fowler JL, Zielinski MC, Kilimnik G, Hara M. Stereological analyses of the whole human pancreas. Sci Rep. 2016 Sep 23; 6:34049. PMID: 27658965; PMCID: PMC5034323.
      Citations: 23     Fields:    
    27. Striegel DA, Hara M, Periwal V. Adaptation of pancreatic islet cyto-architecture during development. Phys Biol. 2016 Apr 11; 13(2):025004. PMID: 27063927; PMCID: PMC6309425.
      Citations: 5     Fields:    Translation:HumansCells
    28. Hoang DT, Hara M, Jo J. Design Principles of Pancreatic Islets: Glucose-Dependent Coordination of Hormone Pulses. PLoS One. 2016; 11(4):e0152446. PMID: 27035570; PMCID: PMC4818077.
      Citations: 14     Fields:    Translation:HumansAnimals
    29. Yi Y, Sun X, Gibson-Corley K, Xie W, Liang B, He N, Tyler SR, Uc A, Philipson LH, Wang K, Hara M, Ode KL, Norris AW, Engelhardt JF. A Transient Metabolic Recovery from Early Life Glucose Intolerance in Cystic Fibrosis Ferrets Occurs During Pancreatic Remodeling. Endocrinology. 2016 05; 157(5):1852-65. PMID: 26862997; PMCID: PMC4870869.
      Citations: 27     Fields:    Translation:Animals
    30. Hara M, Fowler JL, Bell GI, Philipson LH. Resting beta-cells - A functional reserve? Diabetes Metab. 2016 Jun; 42(3):157-61. PMID: 26827115.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    31. Striegel DA, Hara M, Periwal V. The Beta Cell in Its Cluster: Stochastic Graphs of Beta Cell Connectivity in the Islets of Langerhans. PLoS Comput Biol. 2015 Aug; 11(8):e1004423. PMID: 26266953; PMCID: PMC4534467.
      Citations: 12     Fields:    Translation:HumansCells
    32. Spaeth JM, Hunter CS, Bonatakis L, Guo M, French CA, Slack I, Hara M, Fisher SE, Ferrer J, Morrisey EE, Stanger BZ, Stein R. The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice. Diabetologia. 2015 Aug; 58(8):1836-44. PMID: 26021489; PMCID: PMC4785827.
      Citations: 28     Fields:    Translation:AnimalsCells
    33. Fahrmann J, Grapov D, Yang J, Hammock B, Fiehn O, Bell GI, Hara M. Systemic alterations in the metabolome of diabetic NOD mice delineate increased oxidative stress accompanied by reduced inflammation and hypertriglyceremia. Am J Physiol Endocrinol Metab. 2015 Jun 01; 308(11):E978-89. PMID: 25852003; PMCID: PMC4451288.
      Citations: 28     Fields:    Translation:AnimalsCells
    34. Izumi K, Mine K, Inoue Y, Teshima M, Ogawa S, Kai Y, Kurafuji T, Hirakawa K, Miyakawa D, Ikeda H, Inada A, Hara M, Yamada H, Akashi K, Niho Y, Ina K, Kobayashi T, Yoshikai Y, Anzai K, Yamashita T, Minagawa H, Fujimoto S, Kurisaki H, Shimoda K, Katsuta H, Nagafuchi S. Reduced Tyk2 gene expression in ß-cells due to natural mutation determines susceptibility to virus-induced diabetes. Nat Commun. 2015 Apr 07; 6:6748. PMID: 25849081; PMCID: PMC4396380.
      Citations: 29     Fields:    Translation:AnimalsCells
    35. Grapov D, Fahrmann J, Hwang J, Poudel A, Jo J, Periwal V, Fiehn O, Hara M. Diabetes Associated Metabolomic Perturbations in NOD Mice. Metabolomics. 2015 Apr; 11(2):425-437. PMID: 25755629; PMCID: PMC4351755.
      Citations: 20     Fields:    
    36. McKenna B, Guo M, Reynolds A, Hara M, Stein R. Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet ß cells. Cell Rep. 2015 Mar 31; 10(12):2032-42. PMID: 25801033; PMCID: PMC4651178.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    37. Poudel A, Savari O, Striegel DA, Periwal V, Taxy J, Millis JM, Witkowski P, Atkinson MA, Hara M. Beta-cell destruction and preservation in childhood and adult onset type 1 diabetes. Endocrine. 2015 Aug; 49(3):693-702. PMID: 25605478; PMCID: PMC4511725.
      Citations: 25     Fields:    Translation:HumansCells
    38. Bailey KA, Savic D, Zielinski M, Park SY, Wang LJ, Witkowski P, Brady M, Hara M, Bell GI, Nobrega MA. Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice. Hum Mol Genet. 2015 Mar 15; 24(6):1646-54. PMID: 25398947; PMCID: PMC4381752.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    39. Hoang DT, Matsunari H, Nagaya M, Nagashima H, Millis JM, Witkowski P, Periwal V, Hara M, Jo J. A conserved rule for pancreatic islet organization. PLoS One. 2014; 9(10):e110384. PMID: 25350558; PMCID: PMC4211668.
      Citations: 28     Fields:    Translation:HumansAnimals
    40. Golab K, Hara M, Zielinski M, Grose R, Savari O, Wang XJ, Wang LJ, Tibudan M, Krzystyniak A, Marek-Trzonkowska N, Millis JM, Trzonkowski P, Witkowski P, Kizilel S, Bal T. Improved coating of pancreatic islets with regulatory T cells to create local immunosuppression by using the biotin-polyethylene glycol-succinimidyl valeric acid ester molecule. Transplant Proc. 2014 Jul-Aug; 46(6):1967-71. PMID: 25131084; PMCID: PMC4435942.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    41. Miyatsuka T, Matsuoka TA, Sasaki S, Kubo F, Shimomura I, Watada H, German MS, Hara M. Chronological analysis with fluorescent timer reveals unique features of newly generated ß-cells. Diabetes. 2014 Oct; 63(10):3388-93. PMID: 24834978; PMCID: PMC4392905.
      Citations: 8     Fields:    Translation:AnimalsCells
    42. Matsunari H, Kobayashi T, Watanabe M, Umeyama K, Nakano K, Kanai T, Matsuda T, Nagaya M, Hara M, Nakauchi H, Nagashima H. Transgenic pigs with pancreas-specific expression of green fluorescent protein. J Reprod Dev. 2014; 60(3):230-7. PMID: 24748398; PMCID: PMC4085388.
      Citations: 8     Fields:    Translation:Animals
    43. Savari O, Zielinski MC, Wang X, Misawa R, Millis JM, Witkowski P, Hara M. Distinct function of the head region of human pancreas in the pathogenesis of diabetes. Islets. 2013 Sep-Dec; 5(5):226-8. PMID: 24045229; PMCID: PMC4010575.
      Citations: 4     Fields:    Translation:HumansCells
    44. Wang X, Misawa R, Zielinski MC, Cowen P, Jo J, Periwal V, Ricordi C, Khan A, Szust J, Shen J, Millis JM, Witkowski P, Hara M. Regional differences in islet distribution in the human pancreas--preferential beta-cell loss in the head region in patients with type 2 diabetes. PLoS One. 2013; 8(6):e67454. PMID: 23826303; PMCID: PMC3691162.
      Citations: 78     Fields:    Translation:HumansCells
    45. Jo J, Kilimnik G, Hara M, Ahlgren U, Periwal V, Hörnblad A. The fractal spatial distribution of pancreatic islets in three dimensions: a self-avoiding growth model. Phys Biol. 2013 Jun; 10(3):036009. PMID: 23629025; PMCID: PMC3767849.
      Citations: 6     Fields:    Translation:HumansAnimals
    46. Wang X, Zielinski MC, Misawa R, Wen P, Wang TY, Wang CZ, Witkowski P, Hara M. Quantitative analysis of pancreatic polypeptide cell distribution in the human pancreas. PLoS One. 2013; 8(1):e55501. PMID: 23383206; PMCID: PMC3561199.
      Citations: 37     Fields:    Translation:HumansCells
    47. Kilimnik G, Jo J, Periwal V, Zielinski MC, Hara M. Quantification of islet size and architecture. Islets. 2012 Mar-Apr; 4(2):167-72. PMID: 22653677; PMCID: PMC3396703.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    48. Jo J, Hara M, Sorenson R, Periwal V, Ahlgren U. Mathematical models of pancreatic islet size distributions. Islets. 2012 Jan-Feb; 4(1):10-9. PMID: 22504860; PMCID: PMC3365800.
      Citations: 14     Fields:    Translation:Humans
    49. Kilimnik G, Zhao B, Jo J, Periwal V, Witkowski P, Misawa R, Hara M. Altered islet composition and disproportionate loss of large islets in patients with type 2 diabetes. PLoS One. 2011; 6(11):e27445. PMID: 22102895; PMCID: PMC3216964.
      Citations: 74     Fields:    Translation:Humans
    50. Marek N, Krzystyniak A, Ergenc I, Cochet O, Misawa R, Wang LJ, Golab K, Wang X, Kilimnik G, Hara M, Kizilel S, Trzonkowski P, Millis JM, Witkowski P. Coating human pancreatic islets with CD4(+)CD25(high)CD127(-) regulatory T cells as a novel approach for the local immunoprotection. Ann Surg. 2011 Sep; 254(3):512-8; discussion 518-9. PMID: 21865948.
      Citations: 17     Fields:    Translation:HumansCells
    51. Jo J, Kilimnik G, Kim A, Guo C, Periwal V, Hara M. Formation of pancreatic islets involves coordinated expansion of small islets and fission of large interconnected islet-like structures. Biophys J. 2011 Aug 03; 101(3):565-74. PMID: 21806924; PMCID: PMC3145284.
      Citations: 17     Fields:    Translation:Animals
    52. Chen C, Chai J, Singh L, Kuo CY, Jin L, Feng T, Marzano S, Galeni S, Zhang N, Iacovino M, Qin L, Hara M, Stein R, Bromberg JS, Kyba M, Ku HT. Characterization of an in vitro differentiation assay for pancreatic-like cell development from murine embryonic stem cells: detailed gene expression analysis. Assay Drug Dev Technol. 2011 Aug; 9(4):403-19. PMID: 21395400; PMCID: PMC3148116.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    53. Kim A, Kilimnik G, Guo C, Sung J, Jo J, Periwal V, Witkowski P, Dilorio P, Hara M. Computer-assisted large-scale visualization and quantification of pancreatic islet mass, size distribution and architecture. J Vis Exp. 2011 Mar 04; (49). PMID: 21403638; PMCID: PMC3197293.
      Citations: 11     Fields:    Translation:HumansAnimals
    54. Stein J, Milewski WM, Hara M, Steiner DF, Dey A. GSK-3 inactivation or depletion promotes ß-cell replication via down regulation of the CDK inhibitor, p27 (Kip1). Islets. 2011 Jan-Feb; 3(1):21-34. PMID: 21278490; PMCID: PMC3060436.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    55. Minami K, Miyawaki K, Hara M, Yamada S, Seino S. Tracing phenotypic reversibility of pancreatic ß-cells in vitro. J Diabetes Investig. 2010 Dec 03; 1(6):242-51. PMID: 24843439; PMCID: PMC4014887.
      Citations: 3     Fields:    
    56. Higuchi Y, Shiraki N, Yamane K, Qin Z, Mochitate K, Araki K, Senokuchi T, Yamagata K, Hara M, Kume K, Kume S. Synthesized basement membranes direct the differentiation of mouse embryonic stem cells into pancreatic lineages. J Cell Sci. 2010 Aug 15; 123(Pt 16):2733-42. PMID: 20647375.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    57. Kim A, Kilimnik G, Hara M. In situ quantification of pancreatic beta-cell mass in mice. J Vis Exp. 2010 Jun 07; (40). PMID: 20548281; PMCID: PMC3153902.
      Citations: 5     Fields:    Translation:AnimalsCells
    58. Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M. Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic a-cells in mouse models of ß-cell regeneration. Islets. 2010 May-Jun; 2(3):149-55. PMID: 20657753; PMCID: PMC2908328.
      Citations: 62     Fields:    Translation:AnimalsCells
    59. Steiner DJ, Kim A, Miller K, Hara M. Pancreatic islet plasticity: interspecies comparison of islet architecture and composition. Islets. 2010 May-Jun; 2(3):135-45. PMID: 20657742; PMCID: PMC2908252.
      Citations: 194     Fields:    Translation:HumansAnimals
    60. Miller K, Kim A, Kilimnik G, Jo J, Moka U, Periwal V, Hara M. Islet formation during the neonatal development in mice. PLoS One. 2009 Nov 06; 4(11):e7739. PMID: 19893748; PMCID: PMC2770846.
      Citations: 46     Fields:    Translation:AnimalsCells
    61. Kilimnik G, Kim A, Jo J, Miller K, Hara M. Quantification of pancreatic islet distribution in situ in mice. Am J Physiol Endocrinol Metab. 2009 Dec; 297(6):E1331-8. PMID: 19808908; PMCID: PMC2793051.
      Citations: 19     Fields:    Translation:AnimalsCells
    62. Kim A, Miller K, Jo J, Kilimnik G, Wojcik P, Hara M. Islet architecture: A comparative study. Islets. 2009 Sep-Oct; 1(2):129-36. PMID: 20606719; PMCID: PMC2894473.
      Citations: 157     Fields:    Translation:HumansAnimalsCells
    63. Kharouta M, Miller K, Kim A, Wojcik P, Kilimnik G, Dey A, Steiner DF, Hara M. No mantle formation in rodent islets -- the prototype of islet revisited. Diabetes Res Clin Pract. 2009 Sep; 85(3):252-7. PMID: 19595468; PMCID: PMC2746740.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    64. Uchizono Y, Baldwin AC, Sakuma H, Pugh W, Polonsky KS, Hara M. Role of HNF-1alpha in regulating the expression of genes involved in cellular growth and proliferation in pancreatic beta-cells. Diabetes Res Clin Pract. 2009 Apr; 84(1):19-26. PMID: 19181415; PMCID: PMC2782714.
      Citations: 3     Fields:    Translation:AnimalsCells
    65. Milewski WM, Temple KA, Wesselschmidt RL, Hara M. Generation of embryonic stem cells from mouse insulin I promoter-green fluorescent protein transgenic mice and characterization in a teratoma model. In Vitro Cell Dev Biol Anim. 2009 Jan-Feb; 45(1-2):1-5. PMID: 18855079; PMCID: PMC2694942.
      Citations: 4     Fields:    Translation:AnimalsCells
    66. Mwangi S, Anitha M, Mallikarjun C, Ding X, Hara M, Parsadanian A, Larsen CP, Thule P, Sitaraman SV, Anania F, Srinivasan S. Glial cell line-derived neurotrophic factor increases beta-cell mass and improves glucose tolerance. Gastroenterology. 2008 Mar; 134(3):727-37. PMID: 18241861; PMCID: PMC3725148.
      Citations: 26     Fields:    Translation:AnimalsCells
    67. Hara M, Shen J, Pugh W, Polonsky KS, Le Beau MM, Bell GI. Sustained expression of hepatocyte nuclear factor-6 leads to loss of pancreatic beta-cells by apoptosis. Exp Clin Endocrinol Diabetes. 2007 Nov; 115(10):654-61. PMID: 18058600.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    68. Yin D, Tao J, Lee DD, Shen J, Hara M, Lopez J, Kuznetsov A, Philipson LH, Chong AS. Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen. Diabetes. 2006 Dec; 55(12):3256-63. PMID: 17130468.
      Citations: 40     Fields:    Translation:AnimalsCells
    69. Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH. Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration. Science. 2006 Mar 24; 311(5768):1774-5. PMID: 16556844.
      Citations: 38     Fields:    Translation:AnimalsCells
    70. Leung YM, Ahmed I, Sheu L, Gao X, Hara M, Tsushima RG, Diamant NE, Gaisano HY. Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition. Endocrinology. 2006 May; 147(5):2155-62. PMID: 16455778.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    71. Yin D, Ding JW, Shen J, Ma L, Hara M, Chong AS. Liver ischemia contributes to early islet failure following intraportal transplantation: benefits of liver ischemic-preconditioning. Am J Transplant. 2006 Jan; 6(1):60-8. PMID: 16433757.
      Citations: 36     Fields:    Translation:Animals
    72. Hara M, Dizon RF, Glick BS, Lee CS, Kaestner KH, Piston DW, Bindokas VP. Imaging pancreatic beta-cells in the intact pancreas. Am J Physiol Endocrinol Metab. 2006 May; 290(5):E1041-7. PMID: 16368785.
      Citations: 36     Fields:    Translation:AnimalsCells
    73. Hara M, Noiseux N, Bindokas VP. High resolution optical imaging of infarction in intact organs. Biotechniques. 2005 Sep; 39(3):373-6. PMID: 16206909; PMCID: PMC2907652.
      Citations: 1     Fields:    Translation:Animals
    74. Terashima T, Kojima H, Fujimiya M, Matsumura K, Oi J, Hara M, Kashiwagi A, Kimura H, Yasuda H, Chan L. The fusion of bone-marrow-derived proinsulin-expressing cells with nerve cells underlies diabetic neuropathy. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12525-30. PMID: 16116088; PMCID: PMC1194942.
      Citations: 29     Fields:    Translation:AnimalsCells
    75. Leung YM, Ahmed I, Sheu L, Tsushima RG, Diamant NE, Hara M, Gaisano HY. Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse. Endocrinology. 2005 Nov; 146(11):4766-75. PMID: 16109783.
      Citations: 31     Fields:    Translation:AnimalsCells
    76. Gunawardana SC, Hara M, Bell GI, Head WS, Magnuson MA, Piston DW. Imaging Beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic Beta cells. In Vitro Cell Dev Biol Anim. 2005 Jan-Feb; 41(1-2):7-11. PMID: 15926862.
      Citations: 2     Fields:    Translation:Animals
    77. Hara M, Yin D, Dizon RF, Shen J, Chong AS, Bindokas VP. A mouse model for studying intrahepatic islet transplantation. Transplantation. 2004 Aug 27; 78(4):615-8. PMID: 15446323; PMCID: PMC2907646.
      Citations: 12     Fields:    Translation:Animals
    78. Alcoser SY, Hara M, Bell GI, Ehrmann DA. Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome. J Clin Endocrinol Metab. 2004 Jun; 89(6):2973-6. PMID: 15181086.
      Citations: 1     Fields:    Translation:HumansCells
    79. Hara M, Bindokas V, Lopez JP, Kaihara K, Landa LR, Harbeck M, Roe MW. Imaging endoplasmic reticulum calcium with a fluorescent biosensor in transgenic mice. Am J Physiol Cell Physiol. 2004 Oct; 287(4):C932-8. PMID: 15163621.
      Citations: 20     Fields:    Translation:AnimalsCells
    80. Reutrakul S, Hathout EH, Janner D, Hara M, Donfack J, Bass J, Refetoff S. Familial juvenile autoimmune hypothyroidism, pituitary enlargement, obesity, and insulin resistance. Thyroid. 2004 Apr; 14(4):311-9. PMID: 15142366.
      Citations: 1     Fields:    Translation:Humans
    81. Kojima H, Fujimiya M, Matsumura K, Nakahara T, Hara M, Chan L. Extrapancreatic insulin-producing cells in multiple organs in diabetes. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2458-63. PMID: 14983031; PMCID: PMC356972.
      Citations: 72     Fields:    Translation:AnimalsCells
    82. Treutelaar MK, Skidmore JM, Dias-Leme CL, Hara M, Zhang L, Simeone D, Martin DM, Burant CF. Nestin-lineage cells contribute to the microvasculature but not endocrine cells of the islet. Diabetes. 2003 Oct; 52(10):2503-12. PMID: 14514633.
      Citations: 35     Fields:    Translation:AnimalsCells
    83. Hara M, Wang X, Kawamura T, Bindokas VP, Dizon RF, Alcoser SY, Magnuson MA, Bell GI, Hara M, Wang X, Kawamura T, Bindokas VP, Dizon RF, Alcoser SY, Magnuson MA, Bell GI. Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E177-83. PMID: 12388130.
      Citations: 177     Fields:    Translation:AnimalsCells
    84. Ehrmann DA, Schwarz PE, Hara M, Tang X, Horikawa Y, Imperial J, Bell GI, Cox NJ. Relationship of calpain-10 genotype to phenotypic features of polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Apr; 87(4):1669-73. PMID: 11932299.
      Citations: 20     Fields:    Translation:Humans
    85. Hara M, Alcoser SY, Qaadir A, Beiswenger KK, Cox NJ, Ehrmann DA, Hara M, Alcoser SY, Qaadir A, Beiswenger KK, Cox NJ, Ehrmann DA. Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene. J Clin Endocrinol Metab. 2002 Feb; 87(2):772-5. PMID: 11836319.
      Citations: 20     Fields:    Translation:HumansCells
    86. Hara M, Wang X, Paz VP, Iwasaki N, Honda M, Iwamoto Y, Bell GI. Identification of three missense mutations in the peroxisome proliferator-activated receptor alpha gene in Japanese subjects with maturity-onset diabetes of the young. J Hum Genet. 2001; 46(5):285-8. PMID: 11355020.
      Citations: 3     Fields:    Translation:Humans
    87. Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet. 2000 Oct; 26(2):163-75. PMID: 11017071.
      Citations: 323     Fields:    Translation:HumansCells
    88. Hara M, Wang X, Paz VP, Cox NJ, Iwasaki N, Ogata M, Iwamoto Y, Bell GI. No diabetes-associated mutations in the coding region of the hepatocyte nuclear factor-4gamma gene (HNF4G) in Japanese patients with MODY. Diabetologia. 2000 Aug; 43(8):1064-9. PMID: 10990086.
      Citations: 2     Fields:    Translation:HumansCells
    89. Chien EK, Zhang Y, Furuta H, Hara M. Expression of adenosine triphosphate-sensitive potassium channel subunits in female rat reproductive tissues: overlapping distribution of messenger ribonucleic acid for weak inwardly rectifying potassium channel subunit 6.1 and sulfonylurea-binding regulatory subunit 2. Am J Obstet Gynecol. 1999 May; 180(5):1121-6. PMID: 10329865.
      Citations: 3     Fields:    Translation:AnimalsCells
    90. Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI. Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese. Diabetes. 1998 Aug; 47(8):1356-8. PMID: 9703340.
      Citations: 7     Fields:    Translation:HumansCells
    91. Hara M, Lindner TH, Paz VP, Wang X, Iwasaki N, Ogata M, Iwamoto Y, Bell GI. Mutations in the coding region of the insulin promoter factor 1 gene are not a common cause of maturity-onset diabetes of the young in Japanese subjects. Diabetes. 1998 May; 47(5):845-6. PMID: 9588461.
      Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
    92. Chien EK, Hara M, Rouard M, Yano H, Phillippe M, Polonsky KS, Bell GI. Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats. Biochem Biophys Res Commun. 1997 Aug 18; 237(2):476-80. PMID: 9268737.
      Citations: 7     Fields:    Translation:Animals
    93. Glaum SR, Hara M, Bindokas VP, Lee CC, Polonsky KS, Bell GI, Miller RJ. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus. Mol Pharmacol. 1996 Aug; 50(2):230-5. PMID: 8700128.
      Citations: 23     Fields:    Translation:AnimalsCells
    94. Tokuyama Y, Hara M, Jones EM, Fan Z, Bell GI. Cloning of rat and mouse P2Y purinoceptors. Biochem Biophys Res Commun. 1995 Jun 06; 211(1):211-8. PMID: 7779087.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
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