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Kumaran Shanmugarajah

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentSurgery-Transplant
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cazzaniga B, Ali K, Kusakabe J, Liu Q, Tuul M, Miyazaki Y, Calderon E, Shanmugarajah K, Wakam G, Wehrle CJ, Zhang M, Pita A, Fujiki M, Kim J, Schlegel A, Eghtesad B, Kwon CHD, Aucejo F, Khalil M, Diago-Uso T, Tong MZ, Unai S, McCurry KR, Fares M, Modaresi-Esfeh J, Cywinski J, Quintini C, Miller C, Hashimoto K. Transforming Transplant Oversight: Enhancing Combined Cardiothoracic Surgery and Liver Transplantation With Normothermic Machine Perfusion. Transplant Direct. 2025 Jun; 11(6):e1810. PMID: 40406184; PMCID: PMC12097771.
      Citations:    
    2. Wehrle CJ, Gross A, Satish S, Shanmugarajah K, Nakayama T, Fleischer CM, Sheetz K, Aucejo F, Sasaki K, Kwon DC, Fujiki M, Pinna AD, Miller C, Hashimoto K, Schlegel A, Wakam GK. Out of Sequence Allocation in Liver Transplantation: A Poorly Used Tool to Improve Organ Utilization. Ann Surg. 2025 Apr 21. PMID: 40255174.
      Citations:    Fields:    
    3. Villani V, Nguyen HT, Shanmugarajah K. Evaluating Quality and Readability of AI-generated Information on Living Kidney Donation. Transplant Direct. 2025 Jan; 11(1):e1740. PMID: 39668891; PMCID: PMC11634323.
      Citations: 2     
    4. Villani V, Shanmugarajah K. Evaluating Readability and Reliability of Online Information Provided by Pancreas Transplant Centers in the United States. Clin Transplant. 2024 Dec; 38(12):e70055. PMID: 39670913.
      Citations:    Fields:    Translation:Humans
    5. Villani V, Kulkarni RD, Fair JH, Shanmugarajah K. Kidney Transplantation From Donors With Malignant Renal Masses: A Systematic Review. Clin Transplant. 2024 Nov; 38(11):e70020. PMID: 39512121.
      Citations:    Fields:    Translation:Humans
    6. Ali K, Cazzaniga B, Liu Q, Miyazaki Y, Tuul M, Raj R, Hussein A, Wehrle C, Zhang M, Calderon E, Kusakabe J, Shanmugarajah K, Wakam G, Khalil M, Pita A, Aucejo F, Md CDK, Kim J, Fujiki M, Miller C, Quintini C, Schlegel A, Hashimoto K. Machine Perfusion or Straight to Transplant? Predictive Value of Flavin Mononucleotide Levels in Flush Solution of Human Liver Allograft. Ann Surg. 2024 Oct 25. PMID: 39450507.
      Citations:    Fields:    
    7. Patwardhan S, Gunes ME, Manell E, Hong J, Jordache P, Chauhan I, Almesallmy A, Mulder H, Ekanayake-Alper D, Hajosi D, Ko HM, Shanmugarajah K, Cetrulo CL, Nowak G, Sachs DH, Sykes M, Weiner J. Durable mixed chimerism may permit subsequent immunosuppression-free intestinal transplantation-A proof-of-principle study. Am J Transplant. 2025 Apr; 25(4):825-835. PMID: 39442670.
      Citations: 1     Fields:    Translation:Animals
    8. Wehrle CJ, Gross A, Fares S, Kusakabe J, Calderon E, Shanmugarajah K, Uysal M, Fleischer CM, Allkushi E, Schold JD, Khalil M, Pita A, Fujiki M, Schlegel A, Miller C, Hashimoto K, Wakam GK. Changing Landscape of Open Offers in Liver Transplantation in the Machine Perfusion Era: Exposure, Equity, and Economics. Clin Transplant. 2024 Oct; 38(10):e70012. PMID: 39460610.
      Citations:    Fields:    Translation:Humans
    9. Proctor DW, Goodall R, Borsky K, Salciccioli JD, Marshall DC, Shanmugarajah K, Shalhoub J. Temporal Analysis of the Incidence, Mortality and Disability-Adjusted Life Years of Benign Gallbladder and Biliary Diseases in High-Income Nations, 1990-2019. Ann Surg Open. 2024 Jun; 5(2):e453. PMID: 38911626; PMCID: PMC11191896.
      Citations:    
    10. Otunla AA, Shanmugarajah K, Davies AH, Shalhoub J. Lipotoxicity and immunometabolism in ischemic acute kidney injury: current perspectives and future directions. Front Pharmacol. 2024; 15:1355674. PMID: 38464721; PMCID: PMC10924325.
      Citations: 2     
    11. Nabulsi S, Otunla AA, Salciccioli J, Marshall DC, Villani V, Shanmugarajah K, Shalhoub J. HLA matching between donors and recipients improves clinical liver transplant graft survival. Liver Int. 2024 Feb; 44(2):411-421. PMID: 38010995.
      Citations: 2     Fields:    Translation:Humans
    12. Proctor DW, Goodall R, Borsky K, Salciccioli JD, Marshall DC, Mohamed A, Shanmugarajah K, Shalhoub J. Trends in the mortality, incidence, and disability-adjusted life-years of intestinal obstruction and paralytic ileus: observational study of the Global Burden of Disease database. Br J Surg. 2023 11 09; 110(12):1650-1654. PMID: 37531553.
      Citations: 4     Fields:    Translation:Humans
    13. Proctor DW, Goodall R, Borsky K, Salciccioli JD, Marshall DC, Shanmugarajah K, Mohamed A, Shalhoub J. Trends in the mortality, incidence and disability-adjusted life-years of appendicitis in EU15+ countries: an observational study of the Global Burden of Disease Database, 1990-2019. Int J Surg. 2023 Sep 01; 109(9):2608-2613. PMID: 37232122; PMCID: PMC10498886.
      Citations: 3     Fields:    Translation:Humans
    14. Otunla AA, Shanmugarajah K, Salciccioli JD, Marshall DC, Davies AH, Madariaga ML, Shalhoub J. Symptomatic atherosclerotic vascular disease and graft survival in primary kidney transplant recipients - Observational analysis of the united network of organ sharing database. Transpl Immunol. 2022 12; 75:101734. PMID: 36328248.
      Citations:    Fields:    Translation:Humans
    15. Jamil OK, Shanmugarajah K, Azzam RK, Slidell MB. Improved Kasai Hepatoportoenterostomy Outcomes After Implementation of a Dedicated Biliary Atresia Team. Am Surg. 2023 Dec; 89(12):6270-6272. PMID: 36268550.
      Citations:    Fields:    Translation:Humans
    16. Milek D, Reed LT, Echternacht SR, Shanmugarajah K, Cetrulo CL, Lellouch AG, Langstein HN, Leckenby JI. A Systematic Review of the Reported Complications Related to Facial and Upper Extremity Vascularized Composite Allotransplantation. J Surg Res. 2023 01; 281:164-175. PMID: 36162189.
      Citations: 23     Fields:    Translation:Humans
    17. Reed LT, Echternacht SR, Shanmugarajah K, Hernandez R, Langstein HN, Leckenby JI. Twenty Years of Abdominal Wall Allotransplantation: A Systematic Review of the Short- and Long-Term Outcomes. Plast Reconstr Surg. 2022 11 01; 150(5):1062e-1070e. PMID: 36067486.
      Citations: 4     Fields:    Translation:Humans
    18. Lee ACH, Edobor A, Lysandrou M, Mirle V, Sadek A, Johnston L, Piech R, Rose R, Hart J, Amundsen B, Jendrisak M, Millis JM, Donington J, Madariaga ML, Barth RN, di Sabato D, Shanmugarajah K, Fung J. The Effect of Normothermic Machine Perfusion on the Immune Profile of Donor Liver. Front Immunol. 2022; 13:788935. PMID: 35720395; PMCID: PMC9201055.
      Citations: 8     Fields:    Translation:Humans
    19. Lee ACH, Edobor A, Wigakumar T, Lysandrou M, Johnston LK, McMullen P, Mirle V, Diaz A, Piech R, Rose R, Jendrisak M, di Sabato D, Shanmugarajah K, Fung J, Donington J, Madariaga ML. Donor leukocyte trafficking during human ex vivo lung perfusion. Clin Transplant. 2022 07; 36(7):e14670. PMID: 35396887; PMCID: PMC9540615.
      Citations: 3     Fields:    Translation:HumansCells
    20. Otunla AA, Shanmugarajah K, Davies AH, Lucia Madariaga M, Shalhoub J. The Biological Parallels Between Atherosclerosis and Cardiac Allograft Vasculopathy: Implications for Solid Organ Chronic Rejection. Cardiol Rev. 2024 Jan-Feb 01; 32(1):2-11. PMID: 38051983.
      Citations:    Fields:    Translation:Humans
    21. Otunla AA, Shanmugarajah K, Madariaga ML, Davies AH, Shalhoub J. Chronic Rejection and Atherosclerosis in Post-Transplant Cardiovascular Mortality: Two Sides of the Same Coin. Heart Lung Circ. 2022 Feb; 31(2):162-166. PMID: 34848149.
      Citations: 3     Fields:    Translation:Humans
    22. Li L, Dugan HL, Stamper CT, Lan LY, Asby NW, Knight M, Stovicek O, Zheng NY, Madariaga ML, Shanmugarajah K, Jansen MO, Changrob S, Utset HA, Henry C, Nelson C, Jedrzejczak RP, Fremont DH, Joachimiak A, Krammer F, Huang J, Khan AA, Wilson PC. Improved integration of single-cell transcriptome and surface protein expression by LinQ-View. Cell Rep Methods. 2021 08 23; 1(4):100056. PMID: 35475142; PMCID: PMC9017149.
      Citations: 7     Fields:    Translation:HumansCells
    23. Dugan HL, Stamper CT, Li L, Changrob S, Asby NW, Halfmann PJ, Zheng NY, Huang M, Shaw DG, Cobb MS, Erickson SA, Guthmiller JJ, Stovicek O, Wang J, Winkler ES, Madariaga ML, Shanmugarajah K, Jansen MO, Amanat F, Stewart I, Utset HA, Huang J, Nelson CA, Dai YN, Hall PD, Jedrzejczak RP, Joachimiak A, Krammer F, Diamond MS, Fremont DH, Kawaoka Y, Wilson PC. Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets. Immunity. 2021 06 08; 54(6):1290-1303.e7. PMID: 34022127; PMCID: PMC8101792.
      Citations: 85     Fields:    Translation:HumansCells
    24. Chen M, Rosenberg J, Cai X, Lee ACH, Shi J, Nguyen M, Wignakumar T, Mirle V, Edobor AJ, Fung J, Donington JS, Shanmugarajah K, Lin Y, Chang E, Randall G, Penaloza-MacMaster P, Tian B, Madariaga ML, Huang J. Nanotraps for the containment and clearance of SARS-CoV-2. Matter. 2021 Jun 02; 4(6):2059-2082. PMID: 33907732; PMCID: PMC8062026.
      Citations: 25     
    25. Guthmiller JJ, Stovicek O, Wang J, Changrob S, Li L, Halfmann P, Zheng NY, Utset H, Stamper CT, Dugan HL, Miller WD, Huang M, Dai YN, Nelson CA, Hall PD, Jansen M, Shanmugarajah K, Donington JS, Krammer F, Fremont DH, Joachimiak A, Kawaoka Y, Tesic V, Madariaga ML, Wilson PC. SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike. mBio. 2021 01 19; 12(1). PMID: 33468695; PMCID: PMC7845638.
      Citations: 72     Fields:    Translation:HumansCells
    26. Gama AR, Ng ZY, Shanmugarajah K, Mastroianni M, Randolph MA, Lellouch AG, Kohn J, Cetrulo CL. Local Immunosuppression for Vascularized Composite Allografts: Application of Topical FK506-TyroSpheres in a Nonhuman Primate Model. J Burn Care Res. 2020 11 30; 41(6):1172-1178. PMID: 32352521.
      Citations: 4     Fields:    Translation:Animals
    27. Stamper CT, Dugan HL, Li L, Asby NW, Halfmann PJ, Guthmiller JJ, Zheng NY, Huang M, Stovicek O, Wang J, Madariaga ML, Shanmugarajah K, Jansen MO, Amanat F, Stewart I, Changrob S, Utset HA, Huang J, Nelson CA, Dai YN, Hall PD, Jedrzejczak RP, Joachimiak A, Krammer F, Fremont DH, Kawaoka Y, Wilson PC. Distinct B cell subsets give rise to antigen-specific antibody responses against SARS-CoV-2. Res Sq. 2020 Sep 25. PMID: 32995763; PMCID: PMC7523131.
      Citations: 1     
    28. Guthmiller JJ, Stovicek O, Wang J, Changrob S, Li L, Halfmann P, Zheng NY, Utset H, Stamper CT, Dugan HL, Miller WD, Huang M, Dai YN, Nelson CA, Hall PD, Jansen M, Shanmugarajah K, Donington JS, Krammer F, Fremont DH, Joachimiak A, Kawaoka Y, Tesic V, Madariaga ML, Wilson PC. SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike. bioRxiv. 2020 Sep 13. PMID: 32935099; PMCID: PMC7491512.
      Citations: 1     
    29. Leonard DA, Powell HR, Defazio MW, Shanmugarajah K, Mastroianni M, Rosales IA, Farkash EA, Colvin RB, Randolph MA, Sachs DH, Kurtz JM, Cetrulo CL. Cutaneous leukocyte lineages in tolerant large animal and immunosuppressed clinical vascularized composite allograft recipients. Am J Transplant. 2021 02; 21(2):582-592. PMID: 32741100; PMCID: PMC7854956.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    30. Mastroianni M, Ng ZY, Goyal R, Mallard C, Farkash EA, Leonard DA, Albritton A, Shanmugarajah K, Kurtz JM, Sachs DH, Macri LK, Kohn J, Cetrulo CL. Topical Delivery of Immunosuppression to Prolong Xenogeneic and Allogeneic Split-Thickness Skin Graft Survival. J Burn Care Res. 2018 04 20; 39(3):363-373. PMID: 28639977; PMCID: PMC5720930.
      Citations: 6     Fields:    Translation:Animals
    31. Horton C, Shanmugarajah K, Fairchild PJ. Harnessing the properties of dendritic cells in the pursuit of immunological tolerance. Biomed J. 2017 Apr; 40(2):80-93. PMID: 28521905; PMCID: PMC6138597.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    32. Holzer PW, Leonard DA, Shanmugarajah K, Moulton KN, Ng ZY, Cetrulo CL, Sachs DH. A Comparative Examination of the Clinical Outcome and Histological Appearance of Cryopreserved and Fresh Split-Thickness Skin Grafts. J Burn Care Res. 2017 Jan/Feb; 38(1):e55-e61. PMID: 27606556; PMCID: PMC5179303.
      Citations: 8     Fields:    Translation:Animals
    33. Fairchild PJ, Horton C, Lahiri P, Shanmugarajah K, Davies TJ. Beneath the sword of Damocles: regenerative medicine and the shadow of immunogenicity. Regen Med. 2016 12; 11(8):817-829. PMID: 27905261.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    34. Madariaga ML, Spencer PJ, Shanmugarajah K, Crisalli KA, Chang DC, Markmann JF, Elias N, Cosimi AB, Sachs DH, Kawai T. Effect of tolerance versus chronic immunosuppression protocols on the quality of life of kidney transplant recipients. JCI Insight. 2016 Jun 02; 1(8). PMID: 27336062; PMCID: PMC4913782.
      Citations: 14     Fields:    
    35. Welman T, Shanmugarajah K, Sabah S, Bryan J, Hachach-Haram N, Segaren N, Collier J. Assessment of Emergency Department Eye Examinations in Patients Presenting with Mid-Face Injury. J Emerg Med. 2016 Mar; 50(3):422-6. PMID: 26443644.
      Citations: 2     Fields:    Translation:Humans
    36. Welman T, Michel S, Segaren N, Shanmugarajah K. Bioengineering for Organ Transplantation: Progress and Challenges. Bioengineered. 2015; 6(5):257-61. PMID: 26259720; PMCID: PMC4825836.
      Citations: 8     Fields:    Translation:HumansAnimals
    37. Madariaga MLL, Shanmugarajah K, Michel SG, Villani V, Muraglia GM, Torabi R, Leonard DA, Randolph MA, Colvin RB, Yamada K, Madsen JC, Cetrulo CL, Sachs DH. Immunomodulatory Strategies Directed Toward Tolerance of Vascularized Composite Allografts. Transplantation. 2015 Aug; 99(8):1590-1597. PMID: 25757218; PMCID: PMC4551576.
      Citations: 4     Fields:    Translation:AnimalsCells
    38. Madariaga MLL, Villani V, Shanmugarajah K, Michel SG. Current progress in xenotransplantation and organ bioengineering. Int J Surg. 2015 Jan; 13:239-244. PMID: 25496853.
      Citations: 7     Fields:    Translation:Humans
    39. Shanmugarajah K, Villani V, Madariaga ML, Shalhoub J, Michel SG. Current progress in public health models addressing the critical organ shortage. Int J Surg. 2014 Dec; 12(12):1363-8. PMID: 25463765.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    40. Ologunde R, Maruthappu M, Shanmugarajah K, Shalhoub J. Surgical care in low and middle-income countries: burden and barriers. Int J Surg. 2014; 12(8):858-63. PMID: 25019229.
      Citations: 73     Fields:    Translation:HumansPHPublic Health
    41. Shanmugarajah K, Mallard C, Leonard DA, Albritton A, Powell H, Harrington E, Randolph MA, Sachs DH, Kurtz JM, Cetrulo CL. Abstract 104: MHC class I sharing influences the fate of the epidermal component of vascularized composite allografts in mixed chimerism based tolerance protocols in miniature Swine. Plast Reconstr Surg. 2014 Mar; 133(3 Suppl):119. PMID: 25942215.
      Citations:    Fields:    
    42. Vivekanantham S, Ravindran RP, Shanmugarajah K, Maruthappu M, Shalhoub J. Surgical safety checklists in developing countries. Int J Surg. 2014; 12(5):2-6. PMID: 24239705.
      Citations: 20     Fields:    Translation:Humans
    43. Mastroianni M, Leto Barone AA, Shanmugarajah K, Leonard DA, Di Rosa L, Feingold RS, Israeli R, Cetrulo CL. Lower extremity soft tissue defect reconstruction with the serratus anterior flap. Microsurgery. 2014 Mar; 34(3):183-7. PMID: 24307318.
      Citations: 2     Fields:    Translation:Humans
    44. Shanmugarajah K, Madariaga ML, Michel S. Nighttime physician staffing in an intensive care unit. N Engl J Med. 2013 09 12; 369(11):1075. PMID: 24024850.
      Citations:    Fields:    Translation:Humans
    45. Hachach-Haram N, Benyon S, Shanmugarajah K, Kirkpatrick WN. Back to basics: a case series of angular dermoid cyst excision. J Plast Reconstr Aesthet Surg. 2013 Jan; 66(1):57-60. PMID: 22921308.
      Citations: 3     Fields:    Translation:Humans
    46. Shanmugarajah K, Hettiaratchy S, Butler PE. Facial transplantation. Curr Opin Otolaryngol Head Neck Surg. 2012 Aug; 20(4):291-7. PMID: 22894997.
      Citations: 8     Fields:    Translation:HumansCells
    47. Shanmugarajah K, Gaind S, Clarke A, Butler PE. The role of disgust emotions in the observer response to facial disfigurement. Body Image. 2012 Sep; 9(4):455-61. PMID: 22766453.
      Citations: 6     Fields:    Translation:Humans
    48. Shanmugarajah K, Hettiaratchy S, Clarke A, Butler PE. Clinical outcomes of facial transplantation: a review. Int J Surg. 2011; 9(8):600-7. PMID: 21982908.
      Citations: 15     Fields:    Translation:Humans
    49. Shanmugarajah K, Hui E, Vergis N, Schelvan C, Robinson S. Carcinoma of the uncinate process of the pancreas presenting with deep vein thrombosis: a case report. Cases J. 2009 Sep 16; 2:8780. PMID: 20184696; PMCID: PMC2827061.
      Citations: 2     
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