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Stephanie Groman

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentAnesthesia and Critical Care
AddressChicago IL 60637
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    Dr. Groman is an Assistant Professor in the Department of Anesthesia and Critical Care at the University of Chicago. Her research program is investigating the neurobiological mechanisms of decision-making in normal and pathological states, with a particular interest in addiction. Her lab integrates behavioral paradigms with computational analyses, neuroimaging approaches, systems-level manipulations, and molecular analyses in rodents to generate mechanistic links between genes, signaling mechanisms, and behavior that can help us understand the pathology of addiction.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Moin Afshar N, Cinotti F, Martin D, Khamassi M, Calu DJ, Taylor JR, Groman SM. Reward-Mediated, Model-Free Reinforcement-Learning Mechanisms in Pavlovian and Instrumental Tasks Are Related. J Neurosci. 2023 01 18; 43(3):458-471. PMID: 36216504; PMCID: PMC9864557.
      Citations:    Fields:    Translation:Animals
    2. Asch RH, Pothula S, Toyonaga T, Fowles K, Groman SM, Garcia-Milian R, DiLeone RJ, Taylor JR, Esterlis I. Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats. Neuropsychopharmacology. 2023 02; 48(3):489-497. PMID: 36100654; PMCID: PMC9852230.
      Citations:    Fields:    Translation:Animals
    3. Villiamma P, Casby J, Groman SM. Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats. Psychopharmacology (Berl). 2022 Sep; 239(9):2885-2901. PMID: 35705734; PMCID: PMC10332493.
      Citations:    Fields:    Translation:Animals
    4. Rossano S, Toyonaga T, Berg E, Lorence I, Fowles K, Nabulsi N, Ropchan J, Li S, Ye Y, Felchner Z, Kukis D, Huang Y, Benveniste H, Tarantal AF, Groman S, Carson RE. Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET). Eur J Nucl Med Mol Imaging. 2022 09; 49(11):3679-3691. PMID: 35633376; PMCID: PMC9826644.
      Citations: 1     Fields:    Translation:Animals
    5. Young JW, Barback CV, Stolz LA, Groman SM, Vera DR, Hoh C, Kotta KK, Minassian A, Powell SB, Brody AL. MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV. Psychiatry Res Neuroimaging. 2022 04; 321:111445. PMID: 35101828.
      Citations: 3     Fields:    Translation:HumansAnimals
    6. Groman SM, Thompson SL, Lee D, Taylor JR. Reinforcement learning detuned in addiction: integrative and translational approaches. Trends Neurosci. 2022 02; 45(2):96-105. PMID: 34920884; PMCID: PMC8770604.
      Citations: 4     Fields:    Translation:HumansAnimals
    7. Suthaharan P, Reed EJ, Leptourgos P, Kenney JG, Uddenberg S, Mathys CD, Litman L, Robinson J, Moss AJ, Taylor JR, Groman SM, Corlett PR. Paranoia and belief updating during the COVID-19 crisis. Nat Hum Behav. 2021 09; 5(9):1190-1202. PMID: 34316049; PMCID: PMC8458246.
      Citations: 23     Fields:    Translation:HumansPHPublic Health
    8. Groman SM, Lee D, Taylor JR. Unlocking the reinforcement-learning circuits of the orbitofrontal cortex. Behav Neurosci. 2021 Apr; 135(2):120-128. PMID: 34060870; PMCID: PMC8201418.
      Citations: 4     Fields:    Translation:Animals
    9. Gianessi CA, Groman SM, Taylor JR. The effects of fatty acid amide hydrolase inhibition and monoacylglycerol lipase inhibition on habit formation in mice. Eur J Neurosci. 2022 02; 55(4):922-938. PMID: 33506530; PMCID: PMC10370500.
      Citations: 3     Fields:    Translation:Animals
    10. Suthaharan P, Reed EJ, Leptourgos P, Kenney J, Uddenberg S, Mathys CD, Litman L, Robinson J, Moss AJ, Taylor JR, Groman SM, Corlett PR. Paranoia and belief updating during a crisis. Res Sq. 2021 Jan 18. PMID: 33469574; PMCID: PMC7814833.
    11. Groman SM. Astrocytic Activation to Restore Goal-Directed Behaviors. Biol Psychiatry. 2020 11 15; 88(10):744-745. PMID: 33092692.
      Citations: 1     Fields:    Translation:Cells
    12. Groman SM, Ikemoto S, Rushworth M, Taylor JR, Whelan R. Introducing the PLOS ONE Collection on the neuroscience of reward and decision making. PLoS One. 2020; 15(10):e0240505. PMID: 33031482; PMCID: PMC7544023.
      Citations:    Fields:    Translation:Humans
    13. Moin Afshar N, Keip AJ, Taylor JR, Lee D, Groman SM. Reinforcement Learning during Adolescence in Rats. J Neurosci. 2020 07 22; 40(30):5857-5870. PMID: 32601244; PMCID: PMC7380962.
      Citations: 7     Fields:    Translation:HumansAnimals
    14. Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D3, Receptor Availability Following Cocaine Self-administration in Rats. Biol Psychiatry. 2020 11 15; 88(10):777-787. PMID: 32826065; PMCID: PMC8935943.
      Citations: 7     Fields:    Translation:Animals
    15. Reed EJ, Uddenberg S, Suthaharan P, Mathys CD, Taylor JR, Groman SM, Corlett PR. Paranoia as a deficit in non-social belief updating. Elife. 2020 05 26; 9. PMID: 32452769; PMCID: PMC7326495.
      Citations: 31     Fields:    Translation:HumansAnimals
    16. Bond CW, Trinko R, Foscue E, Furman K, Groman SM, Taylor JR, DiLeone RJ. Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption. J Neurosci. 2020 06 10; 40(24):4727-4738. PMID: 32354856; PMCID: PMC7294796.
      Citations: 10     Fields:    Translation:Animals
    17. Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Midbrain D3 Receptor Availability Predicts Escalation in Cocaine Self-administration. Biol Psychiatry. 2020 11 15; 88(10):767-776. PMID: 32312578; PMCID: PMC8954711.
      Citations: 9     Fields:    Translation:Animals
    18. Groman SM. The Neurobiology of Impulsive Decision-Making and Reinforcement Learning in Nonhuman Animals. Curr Top Behav Neurosci. 2020; 47:23-52. PMID: 32157666.
      Citations: 5     Fields:    Translation:HumansAnimals
    19. Groman SM, Keistler C, Keip AJ, Hammarlund E, DiLeone RJ, Pittenger C, Lee D, Taylor JR. Orbitofrontal Circuits Control Multiple Reinforcement-Learning Processes. Neuron. 2019 08 21; 103(4):734-746.e3. PMID: 31253468; PMCID: PMC6893860.
      Citations: 55     Fields:    Translation:AnimalsCells
    20. Groman SM. Investigating the computational underpinnings of addiction. Neuropsychopharmacology. 2019 12; 44(13):2149-2150. PMID: 31076651; PMCID: PMC6897857.
      Citations: 1     Fields:    
    21. Gianessi CA, Groman SM, Thompson SL, Jiang M, van der Stelt M, Taylor JR. Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment. Addict Biol. 2020 05; 25(3):e12768. PMID: 31056846; PMCID: PMC7790504.
      Citations: 13     Fields:    Translation:Animals
    22. Gianessi CA, Groman SM, Taylor JR. Bi-directional modulation of food habit expression by the endocannabinoid system. Eur J Neurosci. 2019 06; 49(12):1610-1622. PMID: 30589475; PMCID: PMC7790508.
      Citations: 8     Fields:    Translation:Animals
    23. Groman SM, Massi B, Mathias SR, Lee D, Taylor JR. Model-Free and Model-Based Influences in Addiction-Related Behaviors. Biol Psychiatry. 2019 06 01; 85(11):936-945. PMID: 30737015; PMCID: PMC6534429.
      Citations: 25     Fields:    Translation:Animals
    24. Groman SM, Massi B, Mathias SR, Curry DW, Lee D, Taylor JR. Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage Task. J Neurosci. 2019 01 09; 39(2):295-306. PMID: 30413646; PMCID: PMC6325257.
      Citations: 14     Fields:    Translation:Animals
    25. Groman SM, Rich KM, Smith NJ, Lee D, Taylor JR. Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in Rats. Neuropsychopharmacology. 2018 03; 43(4):770-780. PMID: 28741627; PMCID: PMC5809784.
      Citations: 22     Fields:    Translation:Animals
    26. Voon V, Reiter A, Sebold M, Groman S. Model-Based Control in Dimensional Psychiatry. Biol Psychiatry. 2017 09 15; 82(6):391-400. PMID: 28599832.
      Citations: 39     Fields:    Translation:HumansAnimals
    27. Feeney EJ, Groman SM, Taylor JR, Corlett PR. Explaining Delusions: Reducing Uncertainty Through Basic and Computational Neuroscience. Schizophr Bull. 2017 03 01; 43(2):263-272. PMID: 28177090; PMCID: PMC5605246.
      Citations: 17     Fields:    Translation:HumansAnimals
    28. Rapanelli M, Frick LR, Xu M, Groman SM, Jindachomthong K, Tamamaki N, Tanahira C, Taylor JR, Pittenger C. Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice. Biol Psychiatry. 2017 08 01; 82(3):194-203. PMID: 28347488; PMCID: PMC5374721.
      Citations: 38     Fields:    Translation:AnimalsCells
    29. Groman SM, Smith NJ, Petrullli JR, Massi B, Chen L, Ropchan J, Huang Y, Lee D, Morris ED, Taylor JR. Dopamine D3 Receptor Availability Is Associated with Inflexible Decision Making. J Neurosci. 2016 06 22; 36(25):6732-41. PMID: 27335404; PMCID: PMC4916249.
      Citations: 19     Fields:    Translation:AnimalsCells
    30. Kaneko G, Sanganahalli BG, Groman SM, Wang H, Coman D, Rao J, Herman P, Jiang L, Rich K, de Graaf RA, Taylor JR, Hyder F. Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model. Biol Psychiatry. 2017 03 15; 81(6):503-513. PMID: 27450031; PMCID: PMC5130616.
      Citations: 15     Fields:    Translation:Animals
    31. Elsworth JD, Jentsch JD, Groman SM, Roth RH, Redmond ED, Leranth C. Low circulating levels of bisphenol-A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys. J Comp Neurol. 2015 Jun 01; 523(8):1248-57. PMID: 25557059; PMCID: PMC4390445.
      Citations: 16     Fields:    Translation:AnimalsCellsPHPublic Health
    32. Elsworth JD, Groman SM, Jentsch JD, Leranth C, Redmond DE, Kim JD, Diano S, Roth RH. Primate phencyclidine model of schizophrenia: sex-specific effects on cognition, brain derived neurotrophic factor, spine synapses, and dopamine turnover in prefrontal cortex. Int J Neuropsychopharmacol. 2014 Oct 31; 18(6). PMID: 25522392; PMCID: PMC4438537.
      Citations: 9     Fields:    Translation:AnimalsCells
    33. Groman SM, James AS, Seu E, Tran S, Clark TA, Harpster SN, Crawford M, Burtner JL, Feiler K, Roth RH, Elsworth JD, London ED, Jentsch JD. In the blink of an eye: relating positive-feedback sensitivity to striatal dopamine D2-like receptors through blink rate. J Neurosci. 2014 Oct 22; 34(43):14443-54. PMID: 25339755; PMCID: PMC4205561.
      Citations: 47     Fields:    Translation:Animals
    34. Seu E, Groman SM, Arnold AP, Jentsch JD. Sex chromosome complement influences operant responding for a palatable food in mice. Genes Brain Behav. 2014 Jul; 13(6):527-534. PMID: 24861924; PMCID: PMC4079740.
      Citations: 13     Fields:    Translation:AnimalsCells
    35. Jentsch JD, Ashenhurst JR, Cervantes MC, Groman SM, James AS, Pennington ZT. Dissecting impulsivity and its relationships to drug addictions. Ann N Y Acad Sci. 2014 Oct; 1327:1-26. PMID: 24654857; PMCID: PMC4360991.
      Citations: 121     Fields:    Translation:HumansAnimalsCells
    36. Groman SM, Morales AM, Lee B, London ED, Jentsch JD. Methamphetamine-induced increases in putamen gray matter associate with inhibitory control. Psychopharmacology (Berl). 2013 Oct; 229(3):527-38. PMID: 23748383; PMCID: PMC3770792.
      Citations: 26     Fields:    Translation:Animals
    37. Groman SM, Jentsch JD. Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates. Curr Opin Neurobiol. 2013 Aug; 23(4):625-31. PMID: 23528268; PMCID: PMC3731407.
      Citations: 8     Fields:    Translation:HumansAnimals
    38. Jarcho JM, Feier NA, Bert A, Labus JA, Lee M, Stains J, Ebrat B, Groman SM, Tillisch K, Brody AL, London ED, Mandelkern MA, Mayer EA. Diminished neurokinin-1 receptor availability in patients with two forms of chronic visceral pain. Pain. 2013 Jul; 154(7):987-96. PMID: 23582152; PMCID: PMC4294187.
      Citations: 13     Fields:    Translation:HumansCells
    39. Groman SM, James AS, Seu E, Crawford MA, Harpster SN, Jentsch JD. Monoamine levels within the orbitofrontal cortex and putamen interact to predict reversal learning performance. Biol Psychiatry. 2013 Apr 15; 73(8):756-62. PMID: 23332512; PMCID: PMC3615106.
      Citations: 35     Fields:    Translation:Animals
    40. Dean AC, Groman SM, Morales AM, London ED. An evaluation of the evidence that methamphetamine abuse causes cognitive decline in humans. Neuropsychopharmacology. 2013 Jan; 38(2):259-74. PMID: 22948978; PMCID: PMC3527116.
      Citations: 91     Fields:    Translation:HumansAnimals
    41. Groman SM, Lee B, Seu E, James AS, Feiler K, Mandelkern MA, London ED, Jentsch JD. Dysregulation of D2-mediated dopamine transmission in monkeys after chronic escalating methamphetamine exposure. J Neurosci. 2012 Apr 25; 32(17):5843-52. PMID: 22539846; PMCID: PMC3353813.
      Citations: 59     Fields:    Translation:AnimalsCells
    42. Groman SM, Jentsch JD. Cognitive control and the dopamine D2-like receptor: a dimensional understanding of addiction. Depress Anxiety. 2012 Apr; 29(4):295-306. PMID: 22147558.
      Citations: 23     Fields:    Translation:Humans
    43. Elsworth JD, Groman SM, Jentsch JD, Valles R, Shahid M, Wong E, Marston H, Roth RH. Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration. Neuropharmacology. 2012 Mar; 62(3):1442-52. PMID: 21875607; PMCID: PMC3711239.
      Citations: 10     Fields:    Translation:Animals
    44. Groman SM, Lee B, London ED, Mandelkern MA, James AS, Feiler K, Rivera R, Dahlbom M, Sossi V, Vandervoort E, Jentsch JD. Dorsal striatal D2-like receptor availability covaries with sensitivity to positive reinforcement during discrimination learning. J Neurosci. 2011 May 18; 31(20):7291-9. PMID: 21593313; PMCID: PMC3114883.
      Citations: 61     Fields:    Translation:Animals
    45. Jentsch JD, Woods JA, Groman SM, Seu E. Behavioral characteristics and neural mechanisms mediating performance in a rodent version of the Balloon Analog Risk Task. Neuropsychopharmacology. 2010 Jul; 35(8):1797-806. PMID: 20375994; PMCID: PMC3055471.
      Citations: 42     Fields:    Translation:Animals
    46. Groman SM, James AS, Jentsch JD. Poor response inhibition: at the nexus between substance abuse and attention deficit/hyperactivity disorder. Neurosci Biobehav Rev. 2009 May; 33(5):690-8. PMID: 18789354; PMCID: PMC2728075.
      Citations: 71     Fields:    Translation:HumansAnimals
    47. James AS, Groman SM, Seu E, Jorgensen M, Fairbanks LA, Jentsch JD. Dimensions of impulsivity are associated with poor spatial working memory performance in monkeys. J Neurosci. 2007 Dec 26; 27(52):14358-64. PMID: 18160643; PMCID: PMC6673444.
      Citations: 25     Fields:    Translation:Animals
    48. Lee B, Groman S, London ED, Jentsch JD. Dopamine D2/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys. Neuropsychopharmacology. 2007 Oct; 32(10):2125-34. PMID: 17299511.
      Citations: 82     Fields:    Translation:Animals
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