"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
|
| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.084.500.722.388 D03.605.869.388
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 1 | 1 |
| 2000 | 2 | 0 | 2 |
| 2002 | 2 | 0 | 2 |
| 2003 | 1 | 0 | 1 |
| 2004 | 3 | 0 | 3 |
| 2005 | 2 | 1 | 3 |
| 2006 | 2 | 1 | 3 |
| 2007 | 4 | 2 | 6 |
| 2008 | 1 | 0 | 1 |
| 2010 | 4 | 1 | 5 |
| 2011 | 2 | 0 | 2 |
| 2012 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 2 | 0 | 2 |
| 2019 | 2 | 0 | 2 |
| 2020 | 2 | 0 | 2 |
| 2021 | 6 | 0 | 6 |
| 2022 | 4 | 0 | 4 |
| 2023 | 1 | 0 | 1 |
| 2024 | 3 | 0 | 3 |
| 2025 | 1 | 1 | 2 |
| 2026 | 2 | 0 | 2 |
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Below are the most recent publications written about "Cocaine" by people in Profiles.
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Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats. Nat Commun. 2026 06 11; 17(1).
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Impact of a brief fentanyl educational intervention on demand for cocaine mixed with fentanyl. Drug Alcohol Depend. 2026 02 01; 279:113042.
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Anti-saccade error rates are associated with somatic depressive symptoms in cocaine use disorder. J Psychopharmacol. 2026 Feb; 40(2):296-304.
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Probability of fentanyl adulteration in cocaine selectively decreases cocaine demand. Exp Clin Psychopharmacol. 2026 Apr; 34(2):207-215.
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Undervaluing nondrug rewards or overvaluing cocaine? Cocaine demand relates to cocaine use severity more strongly than anhedonia in individuals with cocaine use disorder. Exp Clin Psychopharmacol. 2025 Feb; 33(1):91-99.
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Transcriptomic effects of paternal cocaine-seeking on the reward circuitry of male offspring. Transl Psychiatry. 2024 02 26; 14(1):120.
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Paternal cocaine-seeking motivation defines offspring's vulnerability to addiction by down-regulating GABAergic GABRG3 in the ventral tegmental area. Transl Psychiatry. 2024 02 22; 14(1):107.
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Deficits in consummatory reward relate to severity of cocaine use. Drug Alcohol Depend. 2023 08 01; 249:109950.
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Assessing cocaine motivational value: Comparison of brain reactivity bias toward cocaine cues and cocaine demand. Exp Clin Psychopharmacol. 2023 Aug; 31(4):861-867.
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Glutamate inputs from the laterodorsal tegmental nucleus to the ventral tegmental area are essential for the induction of cocaine sensitization in male mice. Psychopharmacology (Berl). 2022 Oct; 239(10):3263-3276.