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Bin Zhou

InstitutionUniversity of Chicago
DepartmentPediatrics-Kennedy Center
AddressChicago IL 60637
ORCID ORCID Icon0000-0003-0832-4002 Additional info
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    Collapse Overview 
    Collapse overview
    The Zhou laboratory studies factors and mechanisms that control heart and coronary vessel development to understand the pathogenesis of congenital heart disease and to gain insights into potential repairing mechanisms to combat both congenital and acquired heart diseases. Our research uses mice, mouse and human stem cells as model systems. We apply an integrated approach of genetics, developmental, molecular and systems biology as well as advanced single cell technologies and CRISPR gene editing to address three major questions: (1) How individual cardiac cells and lineages are specified, maintained, or diversified during heart and coronary vessel development, disease, aging or regeneration (Wu et al. Circ Res 2011, Wu et al. Cell 2012, Lu et al. Nat Commun 2022, Lu et al. Dev Cell 2023)? (2) How cell-cell, or cell-environment communications are modulated to control cardiac functions under these conditions (Wang et al. Eur Heart J 2015, Wang et al. Nat Commun 2017, Lu et al. Nat Cell Biol 2021)? (3) How fetal cardiac gene program is controlled during development and reactivated in the diseased or failing heart (Wang et al. Cardiovasc Res 2017, Lu et al. Circ Res 2022)?

    Collapse Biography 
    Collapse education and training
    University of Pennsylvania , PhiladelphiaFellowship2002Heart Development
    University of Toronto, TorontoPhD1997Cardiovascular Pathobiology
    Nanjing Medical University, NanjingFellowship1991Cardiology
    Nanjing Medical University, NanjingResidency1989Medicine
    Nanjing Medical University, NanjingMD1986Medicine
    Collapse awards and honors
    2011Fellow of the American Heart Association, American Heart Association

    Collapse Research 
    Collapse research activities and funding
    R01HL163095     (SRINIVASAN, RAJANARAYANAN S)Dec 15, 2022 - Nov 30, 2026
    Novel lymphatic genes that regulate heart valve development and disease
    Role: Co-Investigator

    R01HL157347     (ZHOU, BIN)Jan 1, 2022 - Dec 31, 2025
    Molecular signaling in aortic valve development and congenital aortic valve defect
    Role: Principal Investigator

    R01HL159515     (ZHOU, BIN)Sep 1, 2021 - Aug 31, 2025
    Molecular and cellular mechanisms in cardiac outflow tract formation and defects
    Role: Principal Investigator

    R01HL148128     (ZHOU, BIN)Jul 15, 2020 - Apr 30, 2024
    Control of cardiomyocyte cell cycle by REST in heart failure and regeneration
    Role: Principal Investigator

    R21HD092944     (ZHENG, DEYOU)Sep 1, 2018 - Aug 31, 2020
    Single Cell RNA-seq to Identify Endocardial Ontogenic Factors for the Heart
    Role: Co-Principal Investigator

    R01HL143247     (BUTCHER, JONATHAN TALBOT)Aug 15, 2018 - Jul 31, 2023
    Endothelial-Interstitial Interactions in Aortic Valve Homeostasis and Disease
    Role: Co-Investigator

    R01HL132577     (MORROW, BERNICE E.)Jul 15, 2016 - Jun 30, 2021
    Molecular aspects of CRKL in heart development and human disease
    Role: Co-Principal Investigator

    R01HL133120     (ZHOU, BIN)Jun 1, 2016 - Dec 31, 2026
    Molecular and Cellular Mechanisms in Coronary Artery Development and Anomalies
    Role: Principal Investigator

    R01HL121197     (CHANG, CHING-PIN)Apr 1, 2014 - Jun 30, 2024
    LncRNA mechanism of heart failure
    Role: Co-Investigator

    R01HL116997     (ZHOU, BIN)Aug 1, 2013 - Jun 30, 2018
    Mechanisms of Coronary Ostium Formation and Coronary Artery Patterning
    Role: Principal Investigator

    R01HL111770     (ZHOU, BIN)Aug 3, 2012 - Jun 30, 2017
    Molecular and Cellular Mechanisms of Calcific Aortic Stenosis
    Role: Principal Investigator

    R21HL104444     (ZHOU, BIN)Jul 1, 2010 - Jun 30, 2013
    Mouse Model of Human Calcific Aortic Valve Stenosis
    Role: Principal Investigator

    R01HL078881     (ZHOU, BIN)Jul 1, 2006 - May 31, 2012
    Role: Principal Investigator

    P01HD070454     (MORROW, BERNICE E.)Jun 30, 2021
    Developmental mechanisms of human congenital heart disease
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu H, Zhou R, Li S, Dong J, Fang Y, Luo Y, Su H, Lai B, Liang L, Zhang D, Zhang Y, Shyy JY, Zhou B, Yuan Z, Wang Y. Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. iScience. 2024 Jan 19; 27(1):108722. PMID: 38226173; PMCID: PMC10788269.
    2. Lu P, Wu B, Wang Y, Zhang J, Zhou B. A sandwiched ventricular explant assay to model mouse coronary angiogenesis ex vivo. STAR Protoc. 2023 Dec 15; 4(4):102619. PMID: 37897735; PMCID: PMC10751554.
      Citations:    Fields:    Translation:AnimalsCells
    3. Wu B, Wu B, Benkaci S, Shi L, Lu P, Park T, Morrow BE, Wang Y, Zhou B. Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. J Am Heart Assoc. 2023 09 19; 12(18):e029683. PMID: 37702066; PMCID: PMC10547300.
      Citations: 1     Fields:    Translation:AnimalsCells
    4. Ho YC, Geng X, O'Donnell A, Ibarrola J, Fernandez-Celis A, Varshney R, Subramani K, Azartash-Namin ZJ, Kim J, Silasi R, Wylie-Sears J, Alvandi Z, Chen L, Cha B, Chen H, Xia L, Zhou B, Lupu F, Burkhart HM, Aikawa E, Olson LE, Ahamed J, López-Andrés N, Bischoff J, Yutzey KE, Srinivasan RS. PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves. Circ Res. 2023 09; 133(6):463-480. PMID: 37555328; PMCID: PMC10487359.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    5. Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y, Zhou B. ß-Catenin regulates endocardial cushion growth by suppressing p21. Life Sci Alliance. 2023 09; 6(9). PMID: 37385754; PMCID: PMC10310929.
      Citations:    Fields:    Translation:Animals
    6. Zhang H, Sun X, Li Z, Liu T, Zhang F, Meng X, Li K, Xu J, He W, Jing B, Wang T, Ni N, Sun B, Yao F, Wu Y, Wang Q, Du J, Chin EY, Zhou BP, Jiang P, Wang L, Deng J. Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression. Genes Dis. 2024 May; 11(3):100999. PMID: 38292172; PMCID: PMC10825233.
    7. Xiao F, Pan H, Yang D, Wang R, Wu B, Shao Y, Zhou B. Identification of TNFa-mediated inflammation as potential pathological marker and therapeutic target for calcification progress of congenital bicuspid aortic valve. Eur J Pharmacol. 2023 Jul 15; 951:175783. PMID: 37172927.
      Citations:    Fields:    Translation:Animals
    8. Lu P, Wu B, Wang Y, Russell M, Liu Y, Bernard DJ, Zheng D, Zhou B. Prerequisite endocardial-mesenchymal transition for murine cardiac trabecular angiogenesis. Dev Cell. 2023 05 08; 58(9):791-805.e4. PMID: 37023750; PMCID: PMC10656710.
      Citations:    Fields:    Translation:AnimalsCells
    9. Zhang F, Wang Y, Zhao Y, Wang M, Zhou B, Zhou B, Ge X. NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation. Elife. 2023 02 15; 12. PMID: 36790146; PMCID: PMC10076019.
      Citations: 3     Fields:    Translation:AnimalsCells
    10. Song H, Ye X, Liao Y, Zhang S, Xu D, Zhong S, Jing B, Wang T, Sun B, Xu J, Guo W, Li K, Hu M, Kuang Y, Ling J, Zhang T, Wu Y, Du J, Yao F, Chin YE, Wang Q, Zhou BP, Deng J. NF-?B represses retinoic acid receptor-mediated GPRC5A transactivation in lung epithelial cells to promote neoplasia. JCI Insight. 2023 01 10; 8(1). PMID: 36413416; PMCID: PMC9870083.
      Citations: 1     Fields:    Translation:HumansCells
    11. Syed S, Rajderkar S, Mann JM, Hawkins T, Wu B, Zhou B, Sugi Y, Mishina Y, Kaartinen V. Activation of AcvR1-Mediated Signaling Results in Semilunar Valve Defects. J Cardiovasc Dev Dis. 2022 Aug 16; 9(8). PMID: 36005436; PMCID: PMC9410128.
    12. Lu P, Wu B, Feng X, Cheng W, Kitsis RN, Zhou B. Cardiac Myosin Heavy Chain Reporter Mice to Study Heart Development and Disease. Circ Res. 2022 08 05; 131(4):364-366. PMID: 35862119; PMCID: PMC9357176.
      Citations:    Fields:    Translation:Animals
    13. Lu P, Wang P, Wu B, Wang Y, Liu Y, Cheng W, Feng X, Yuan X, Atteya MM, Ferro H, Sugi Y, Rydquist G, Esmaily M, Butcher JT, Chang CP, Lenz J, Zheng D, Zhou B. A SOX17-PDGFB signaling axis regulates aortic root development. Nat Commun. 2022 07 13; 13(1):4065. PMID: 35831318; PMCID: PMC9279414.
      Citations: 3     Fields:    Translation:Animals
    14. Shi L, Racedo SE, Diacou A, Park T, Zhou B, Morrow BE. Crk and Crkl have shared functions in neural crest cells for cardiac outflow tract septation and vascular smooth muscle differentiation. Hum Mol Genet. 2022 04 22; 31(8):1197-1215. PMID: 34686881; PMCID: PMC9029238.
      Citations: 3     Fields:    Translation:AnimalsCells
    15. Sun W, Zou H, Yong Y, Liu B, Zhang H, Lu J, Shen Y, Li P, Xu T, Chen X, Du A, Jiang M, Hua Y, Sheng Y, Zhou B, Lotan C, Kong X. The RAISE Trial: A Novel Device and First-in-Man Trial. Circ Heart Fail. 2022 04; 15(4):e008362. PMID: 35378984.
      Citations: 6     Fields:    Translation:HumansAnimalsCTClinical Trials
    16. Yin H, Jing B, Xu D, Guo W, Sun B, Zhang J, Liao Y, Song H, Wang T, Liu S, Kuang Y, Hu M, Li K, Zhang S, Zhang H, Xu J, Li X, Du J, Wu Y, Wu Y, Wang Q, Yao F, Chin YE, Zhou BP, Deng J. Identification of Active Bronchioalveolar Stem Cells as the Cell of Origin in Lung Adenocarcinoma. Cancer Res. 2022 03 15; 82(6):1025-1037. PMID: 35045987.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    17. Luo M, Sun W, Kong X. Emodin alleviates aortic valvular calcification by inhibiting the AKT/FOXO1 pathway. Ann Anat. 2022 Feb; 240:151885. PMID: 34958913.
      Citations: 2     Fields:    Translation:AnimalsCells
    18. McNeil M, Han Y, Sun P, Watanabe K, Jiang J, Chen N, Yu Z, Zhou B, Dai X. Nfatc1's Role in Mammary Epithelial Morphogenesis and Basal Stem/progenitor Cell Self-renewal. J Mammary Gland Biol Neoplasia. 2021 12; 26(4):357-365. PMID: 34932179; PMCID: PMC8858291.
      Citations:    Fields:    Translation:AnimalsCells
    19. Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis AK, Huang RYJ, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore GD, Mani SA, Massagué J, Mayor R, McClay D, Mostov KE, Newgreen DF, Nieto MA, Puisieux A, Runyan R, Savagner P, Stanger B, Stemmler MP, Takahashi Y, Takeichi M, Theveneau E, Thiery JP, Thompson EW, Weinberg RA, Williams ED, Xing J, Zhou BP, Sheng G, EMT International Association (TEMTIA). Author Correction: Guidelines and definitions for research on epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2021 Dec; 22(12):834. PMID: 34654908; PMCID: PMC8604719.
      Citations: 9     Fields:    
    20. Zhao K, Wu T, Yang C, Pan H, Xu T, Zhang J, Guo X, Tu J, Zhang D, Kong X, Zhou B, Sun W. Low-intensity pulsed ultrasound prevents angiotensin II-induced aortic smooth muscle cell phenotypic switch via hampering miR-17-5p and enhancing PPAR-?. Eur J Pharmacol. 2021 Nov 15; 911:174509. PMID: 34547245.
      Citations:    Fields:    
    21. Lu P, Wang Y, Liu Y, Wang Y, Wu B, Zheng D, Harvey RP, Zhou B. Perinatal angiogenesis from pre-existing coronary vessels via DLL4-NOTCH1 signalling. Nat Cell Biol. 2021 09; 23(9):967-977. PMID: 34497373.
      Citations: 9     Fields:    Translation:AnimalsCells
    22. Miao L, Lu Y, Nusrat A, Abdelnasser HY, Datta S, Zhou B, Schwartz RJ, Wu M. The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis. Cells. 2021 08 25; 10(9). PMID: 34571841; PMCID: PMC8471136.
      Citations: 6     Fields:    Translation:AnimalsCells
    23. Wang Y, Fang Y, Lu P, Wu B, Zhou B. NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease. Front Cardiovasc Med. 2021; 8:682298. PMID: 34239905; PMCID: PMC8259786.
      Citations: 11     
    24. Wang Y, Jiang T, Xu J, Gu Y, Zhou Y, Lin Y, Wu Y, Li W, Wang C, Shen B, Mo X, Wang X, Zhou B, Ding C, Hu Z. Mutations in RNA Methyltransferase Gene NSUN5 Confer High Risk of Outflow Tract Malformation. Front Cell Dev Biol. 2021; 9:623394. PMID: 33968922; PMCID: PMC8097101.
      Citations: 6     
    25. Erfani S, Hua H, Pan Y, Zhou BP, Yang XH. The Context-Dependent Impact of Integrin-Associated CD151 and Other Tetraspanins on Cancer Development and Progression: A Class of Versatile Mediators of Cellular Function and Signaling, Tumorigenesis and Metastasis. Cancers (Basel). 2021 Apr 21; 13(9). PMID: 33919420; PMCID: PMC8122392.
      Citations: 6     
    26. Liu Y, Wang T, Zhou B, Zheng D. Robust integration of multiple single-cell RNA sequencing datasets using a single reference space. Nat Biotechnol. 2021 07; 39(7):877-884. PMID: 33767393; PMCID: PMC8456427.
      Citations: 15     Fields:    Translation:HumansCells
    27. Cao J, Wang X, Dai T, Wu Y, Zhang M, Cao R, Zhang R, Wang G, Jiang R, Zhou BP, Shi J, Kang T. Erratum: Twist promotes tumor metastasis in basal-like breast cancer by transcriptionally upregulating ROR1: Erratum. Theranostics. 2021; 11(5):2077-2078. PMID: 33500710; PMCID: PMC7797675.
      Citations:    Fields:    
    28. Guo W, Li K, Sun B, Xu D, Tong L, Yin H, Liao Y, Song H, Wang T, Jing B, Hu M, Liu S, Kuang Y, Ling J, Li Q, Wu Y, Wang Q, Yao F, Zhou BP, Lin SH, Deng J. Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer. Cancer Res. 2021 02 01; 81(3):552-566. PMID: 33229341.
      Citations: 22     Fields:    Translation:AnimalsCells
    29. Zhang Y, Xu B, Shi J, Li J, Lu X, Xu L, Yang H, Hamad N, Wang C, Napier D, He S, Liu C, Liu Z, Qian H, Chen L, Wei X, Zheng X, Huang JA, Thibault O, Craven R, Wei D, Pan Y, Zhou BP, Wu Y, Yang XH. BRD4 modulates vulnerability of triple-negative breast cancer to targeting of integrin-dependent signaling pathways. Cell Oncol (Dordr). 2020 Dec; 43(6):1049-1066. PMID: 33006750; PMCID: PMC7716866.
      Citations: 6     Fields:    Translation:HumansCells
    30. Zou H, Yong Y, Zhang J, Zhou B, Zan L, Lu X, Kong X. A novel parametric method-based nomogram of left ventricular internal diameters in normal Chinese adults. Ann Transl Med. 2020 Sep; 8(17):1079. PMID: 33145298; PMCID: PMC7575974.
    31. Wang Y, Lu P, Jiang L, Wu B, Zhou B. Control of sinus venous valve and sinoatrial node development by endocardial NOTCH1. Cardiovasc Res. 2020 07 01; 116(8):1473-1486. PMID: 31591643; PMCID: PMC7314641.
      Citations: 5     Fields:    Translation:AnimalsCells
    32. Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis AK, Huang RYJ, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore GD, Mani SA, Massagué J, Mayor R, McClay D, Mostov KE, Newgreen DF, Nieto MA, Puisieux A, Runyan R, Savagner P, Stanger B, Stemmler MP, Takahashi Y, Takeichi M, Theveneau E, Thiery JP, Thompson EW, Weinberg RA, Williams ED, Xing J, Zhou BP, Sheng G, EMT International Association (TEMTIA). Guidelines and definitions for research on epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2020 06; 21(6):341-352. PMID: 32300252; PMCID: PMC7250738.
      Citations: 773     Fields:    Translation:HumansAnimals
    33. Han R, Hensley PJ, Li J, Zhang Y, Stark TW, Heller A, Qian H, Shi J, Liu Z, Huang JA, Jin T, Wei X, Zhou BP, Wu Y, Kyprianou N, Chen J, Yang XH. Integrin-associated CD151 is a suppressor of prostate cancer progression. Am J Transl Res. 2020; 12(4):1428-1442. PMID: 32355552; PMCID: PMC7191174.
      Citations: 2     
    34. Wang T, Jing B, Xu D, Liao Y, Song H, Sun B, Guo W, Xu J, Li K, Hu M, Liu S, Ling J, Kuang Y, Zhang T, Zhang S, Yao F, Zhou BP, Deng J. PTGES/PGE2 signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model. Oncogene. 2020 04; 39(15):3179-3194. PMID: 32060421; PMCID: PMC7142021.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    35. Xiong G, Chen J, Zhang G, Wang S, Kawasaki K, Zhu J, Zhang Y, Nagata K, Li Z, Zhou BP, Xu R. Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction. Proc Natl Acad Sci U S A. 2020 02 18; 117(7):3748-3758. PMID: 32015106; PMCID: PMC7035603.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    36. Gee T, Farrar E, Wang Y, Wu B, Hsu K, Zhou B, Butcher J. NF?B (Nuclear Factor ?-Light-Chain Enhancer of Activated B Cells) Activity Regulates Cell-Type-Specific and Context-Specific Susceptibility to Calcification in the Aortic Valve. Arterioscler Thromb Vasc Biol. 2020 03; 40(3):638-655. PMID: 31893948; PMCID: PMC7388286.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    37. Jing B, Wang T, Sun B, Xu J, Xu D, Liao Y, Song H, Guo W, Li K, Hu M, Zhang S, Ling J, Kuang Y, Zhang T, Zhou BP, Yao F, Deng J. IL6/STAT3 Signaling Orchestrates Premetastatic Niche Formation and Immunosuppressive Traits in Lung. Cancer Res. 2020 02 15; 80(4):784-797. PMID: 31848193.
      Citations: 43     Fields:    Translation:AnimalsCells
    38. Li H, Li J, Han R, Deng X, Shi J, Huang H, Hamad N, McCaughley A, Liu J, Wang C, Chen K, Wei D, Qiang J, Thatcher S, Wu Y, Liu C, Thibault O, Wei X, Chen S, Qian H, Zhou BP, Xu P, Yang XH. Deletion of tetraspanin CD151 alters the Wnt oncogene-induced mammary tumorigenesis: A cell type-linked function and signaling. Neoplasia. 2019 12; 21(12):1151-1163. PMID: 31783316; PMCID: PMC6888732.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    39. Chen D, Zhu X, Kofler N, Wang Y, Zhou B, Simons M. FRS2a-dependent cell fate transition during endocardial cushion morphogenesis. Dev Biol. 2020 02 01; 458(1):88-97. PMID: 31669335.
      Citations: 1     Fields:    Translation:AnimalsCells
    40. Guo W, Zhou BP. Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer. Genes Dis. 2019 Dec; 6(4):333-334. PMID: 31832512; PMCID: PMC6889240.
      Citations: 1     
    41. Wang Y, Dong C, Zhou BP. Metabolic reprogram associated with epithelial-mesenchymal transition in tumor progression and metastasis. Genes Dis. 2020 Jun; 7(2):172-184. PMID: 32215287; PMCID: PMC7083713.
      Citations: 16     
    42. Liu Y, Lu P, Wang Y, Morrow BE, Zhou B, Zheng D. Spatiotemporal Gene Coexpression and Regulation in Mouse Cardiomyocytes of Early Cardiac Morphogenesis. J Am Heart Assoc. 2019 08 06; 8(15):e012941. PMID: 31322043; PMCID: PMC6761639.
      Citations: 7     Fields:    Translation:AnimalsCells
    43. Gong J, Shen Y, Li P, Zhao K, Chen X, Li Y, Sheng Y, Zhou B, Kong X. Superoxide anions mediate the effects of angiotensin (1-7) analog, alamandine, on blood pressure and sympathetic activity in the paraventricular nucleus. Peptides. 2019 08; 118:170101. PMID: 31199949.
      Citations: 4     Fields:    Translation:Animals
    44. Wang T, Jing B, Sun B, Liao Y, Song H, Xu D, Guo W, Li K, Hu M, Liu S, Ling J, Kuang Y, Feng Y, Zhou BP, Deng J. Stabilization of PTGES by deubiquitinase USP9X promotes metastatic features of lung cancer via PGE2 signaling. Am J Cancer Res. 2019; 9(6):1145-1160. PMID: 31285948; PMCID: PMC6610053.
      Citations: 17     
    45. Lister R, Chamberlain A, Einstein F, Wu B, Zheng D, Zhou B. Intrauterine Programming of Diabetes Induced Cardiac Embryopathy. Diabetes Obes Int J. 2019; 4(3). PMID: 32537569; PMCID: PMC7293196.
      Citations: 2     
    46. Shigeta A, Huang V, Zuo J, Besada R, Nakashima Y, Lu Y, Ding Y, Pellegrini M, Kulkarni RP, Hsiai T, Deb A, Zhou B, Nakano H, Nakano A. Endocardially Derived Macrophages Are Essential for Valvular Remodeling. Dev Cell. 2019 03 11; 48(5):617-630.e3. PMID: 30799229; PMCID: PMC6440481.
      Citations: 32     Fields:    Translation:AnimalsCells
    47. Lister R, Garrison E, Hughes F, Baldwin S, Zhou B. Ovarian Stimulation Increases the Risk of Fetal Cardiac Defects of Pups Exposed to Severe Maternal Hyperglycemia. Gynecol Reprod Health. 2019 Feb; 3(1). PMID: 32705086; PMCID: PMC7377632.
    48. Cui B, Luo Y, Tian P, Peng F, Lu J, Yang Y, Su Q, Liu B, Yu J, Luo X, Yin L, Cheng W, An F, He B, Liang D, Wu S, Chu P, Song L, Liu X, Luo H, Xu J, Pan Y, Wang Y, Li D, Huang P, Yang Q, Zhang L, Zhou BP, Liu S, Xu G, Lam EW, Kelley KW, Liu Q. Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells. J Clin Invest. 2019 03 01; 129(3):1030-1046. PMID: 30688660; PMCID: PMC6391112.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    49. Chang L, Shen L, Zhou H, Gao J, Pan H, Zheng L, Armstrong B, Peng Y, Peng G, Zhou BP, Rosen ST, Shen B. ITCH nuclear translocation and H1.2 polyubiquitination negatively regulate the DNA damage response. Nucleic Acids Res. 2019 01 25; 47(2):824-842. PMID: 30517763; PMCID: PMC6344871.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    50. Liu J, Duan Z, Guo W, Zeng L, Wu Y, Chen Y, Tai F, Wang Y, Lin Y, Zhang Q, He Y, Deng J, Stewart RL, Wang C, Lin PC, Ghaffari S, Evers BM, Liu S, Zhou MM, Zhou BP, Shi J. Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer. Nat Commun. 2018 12 05; 9(1):5200. PMID: 30518851; PMCID: PMC6281582.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    51. Wang Y, Lu P, Wu B, Morrow BE, Zhou B. NOTCH maintains developmental cardiac gene network through WNT5A. J Mol Cell Cardiol. 2018 12; 125:98-105. PMID: 30347193; PMCID: PMC9531535.
      Citations: 3     Fields:    Translation:Animals
    52. Jiang L, Sun W, Zhang K, Zhou B, Kong X. Perioperative Sildenafil Therapy in Pediatric Congenital Cardiac Disease Patients. Int Heart J. 2018 Nov 28; 59(6):1333-1339. PMID: 30249921.
      Citations: 4     Fields:    Translation:Humans
    53. Wang Y, Lu P, Wu B, Riascos-Bernal DF, Sibinga NES, Valenta T, Basler K, Zhou B. Myocardial ß-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation. J Mol Cell Cardiol. 2018 10; 123:150-158. PMID: 30201295; PMCID: PMC10662972.
      Citations: 5     Fields:    Translation:AnimalsCells
    54. Boogerd CJ, Zhu X, Aneas I, Sakabe N, Zhang L, Sobreira DR, Montefiori L, Bogomolovas J, Joslin AC, Zhou B, Chen J, Nobrega MA, Evans SM. Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. Circ Res. 2018 08 03; 123(4):428-442. PMID: 29903739; PMCID: PMC6092109.
      Citations: 26     Fields:    Translation:AnimalsCells
    55. Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B, Harvey RP. Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature. 2018 05; 557(7705):439-445. PMID: 29743679.
      Citations: 86     Fields:    Translation:AnimalsCells
    56. Cao J, Wang X, Dai T, Wu Y, Zhang M, Cao R, Zhang R, Wang G, Jiang R, Zhou BP, Shi J, Kang T. Twist promotes tumor metastasis in basal-like breast cancer by transcriptionally upregulating ROR1. Theranostics. 2018; 8(10):2739-2751. PMID: 29774072; PMCID: PMC5957006.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    57. Miao L, Li J, Li J, Tian X, Lu Y, Hu S, Shieh D, Kanai R, Zhou BY, Zhou B, Liu J, Firulli AB, Martin JF, Singer H, Zhou B, Xin H, Wu M. Notch signaling regulates Hey2 expression in a spatiotemporal dependent manner during cardiac morphogenesis and trabecular specification. Sci Rep. 2018 02 08; 8(1):2678. PMID: 29422515; PMCID: PMC5805758.
      Citations: 14     Fields:    Translation:AnimalsCells
    58. Wang C, Zhou B, Kong X. [Identification and functional analysis of ?a novel HAND1 mutation associated with congenital ventricular septal defect]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Dec 28; 42(12):1383-1388. PMID: 29317578.
      Citations: 1     Fields:    Translation:HumansCells
    59. Wang J, Ye Q, Cao Y, Guo Y, Huang X, Mi W, Liu S, Wang C, Yang HS, Zhou BP, Evers BM, She QB. Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1. Nat Commun. 2017 12 20; 8(1):2207. PMID: 29263324; PMCID: PMC5738350.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    60. Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, Carroll TJ, Zhou B, Vermot J, Kahn ML. Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis. Dev Cell. 2017 11 06; 43(3):274-289.e5. PMID: 29056552; PMCID: PMC5760194.
      Citations: 66     Fields:    Translation:AnimalsCells
    61. Lin X, Chen W, Wei F, Zhou BP, Hung MC, Xie X. Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly. Theranostics. 2017; 7(19):4805-4824. PMID: 29187905; PMCID: PMC5706101.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    62. Wang Y, Wu B, Lu P, Zhang D, Wu B, Varshney S, Del Monte-Nieto G, Zhuang Z, Charafeddine R, Kramer AH, Sibinga NE, Frangogiannis NG, Kitsis RN, Adams RH, Alitalo K, Sharp DJ, Harvey RP, Stanley P, Zhou B. Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1. Nat Commun. 2017 09 18; 8(1):578. PMID: 28924218; PMCID: PMC5603578.
      Citations: 19     Fields:    Translation:AnimalsCells
    63. Lin Y, Wang Y, Shi Q, Yu Q, Liu C, Feng J, Deng J, Evers BM, Zhou BP, Wu Y. Stabilization of the transcription factors slug and twist by the deubiquitinase dub3 is a key requirement for tumor metastasis. Oncotarget. 2017 Sep 26; 8(43):75127-75140. PMID: 29088851; PMCID: PMC5650406.
      Citations: 27     Fields:    
    64. Saxon JG, Baer DR, Barton JA, Hawkins T, Wu B, Trusk TC, Harris SE, Zhou B, Mishina Y, Sugi Y. BMP2 expression in the endocardial lineage is required for AV endocardial cushion maturation and remodeling. Dev Biol. 2017 10 01; 430(1):113-128. PMID: 28790014; PMCID: PMC5948002.
      Citations: 15     Fields:    Translation:Animals
    65. Yu Q, Zhou BP, Wu Y. The regulation of snail: on the ubiquitin edge. Cancer Cell Microenviron. 2017; 4(2). PMID: 29147673; PMCID: PMC5685547.
      Citations: 7     
    66. Xiao F, Zheng R, Yang D, Cao K, Zhang S, Wu B, Shao Y, Zhou B. Sex-dependent aortic valve pathology in patients with rheumatic heart disease. PLoS One. 2017; 12(6):e0180230. PMID: 28662157; PMCID: PMC5491156.
      Citations: 7     Fields:    Translation:Humans
    67. Tai-Nagara I, Yoshikawa Y, Numata N, Ando T, Okabe K, Sugiura Y, Ieda M, Takakura N, Nakagawa O, Zhou B, Okabayashi K, Suematsu M, Kitagawa Y, Bastmeyer M, Sato K, Klein R, Navankasattusas S, Li DY, Yamagishi S, Kubota Y. Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling. Development. 2017 07 01; 144(13):2392-2401. PMID: 28576770.
      Citations: 17     Fields:    Translation:AnimalsCells
    68. Zhang D, Wu B, Wang P, Wang Y, Lu P, Nechiporuk T, Floss T, Greally JM, Zheng D, Zhou B. Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts. Nucleic Acids Res. 2017 04 07; 45(6):3102-3115. PMID: 27956497; PMCID: PMC5389556.
      Citations: 22     Fields:    Translation:AnimalsCells
    69. Lin X, Chen W, Wei F, Zhou BP, Hung MC, Xie X. POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells. Int J Cancer. 2017 06 01; 140(11):2517-2525. PMID: 28214331.
      Citations: 8     Fields:    Translation:HumansCells
    70. Guo W, Zhou BP. KDM1 links nuclear GSK3ß to epigenetic alterations. Transl Cancer Res. 2017 Mar; 6(Suppl 2):S366-S368. PMID: 30761265; PMCID: PMC6370299.
      Citations: 1     
    71. Wang Y, Wu B, Farrar E, Lui W, Lu P, Zhang D, Alfieri CM, Mao K, Chu M, Yang D, Xu D, Rauchman M, Taylor V, Conway SJ, Yutzey KE, Butcher JT, Zhou B. Notch-Tnf signalling is required for development and homeostasis of arterial valves. Eur Heart J. 2017 Mar 01; 38(9):675-686. PMID: 26491108; PMCID: PMC5837252.
      Citations: 32     Fields:    Translation:AnimalsCells
    72. Wu Y, Wang Y, Lin Y, Liu Y, Wang Y, Jia J, Singh P, Chi YI, Wang C, Dong C, Li W, Tao M, Napier D, Shi Q, Deng J, Evers BM, Zhou BP. Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation. Nat Commun. 2017 02 15; 8:14228. PMID: 28198361; PMCID: PMC5316870.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    73. Wu B, Wang Y, Xiao F, Butcher JT, Yutzey KE, Zhou B. Developmental Mechanisms of Aortic Valve Malformation and Disease. Annu Rev Physiol. 2017 02 10; 79:21-41. PMID: 27959615.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    74. Liu L, Zhi Q, Shen M, Gong FR, Zhou BP, Lian L, Shen B, Chen K, Duan W, Wu MY, Tao M, Li W. FH535, a ß-catenin pathway inhibitor, represses pancreatic cancer xenograft growth and angiogenesis. Oncotarget. 2016 Jul 26; 7(30):47145-47162. PMID: 27323403; PMCID: PMC5216931.
      Citations: 15     Fields:    Translation:HumansCells
    75. Boogerd CJ, Aneas I, Sakabe N, Dirschinger RJ, Cheng QJ, Zhou B, Chen J, Nobrega MA, Evans SM. Probing chromatin landscape reveals roles of endocardial TBX20 in septation. J Clin Invest. 2016 08 01; 126(8):3023-35. PMID: 27348591; PMCID: PMC4966318.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    76. Sung DC, Bowen CJ, Vaidya KA, Zhou J, Chapurin N, Recknagel A, Zhou B, Chen J, Kotlikoff M, Butcher JT. Cadherin-11 Overexpression Induces Extracellular Matrix Remodeling and Calcification in Mature Aortic Valves. Arterioscler Thromb Vasc Biol. 2016 08; 36(8):1627-37. PMID: 27312222; PMCID: PMC4965289.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    77. Yan J, Zhang L, Sultana N, Oh JG, Wu B, Hajjar RJ, Zhou B, Cai CL. A series of robust genetic indicators for definitive identification of cardiomyocytes. J Mol Cell Cardiol. 2016 08; 97:278-85. PMID: 27266388.
      Citations: 5     Fields:    Translation:AnimalsCells
    78. Chu M, Gao Y, Zhou B, Wu B, Wang J, Xu D. Circumferential Strain Can Be Used to Detect Lipopolysaccharide-Induced Myocardial Dysfunction and Predict the Mortality of Severe Sepsis in Mice. PLoS One. 2016; 11(5):e0155346. PMID: 27177150; PMCID: PMC4866772.
      Citations: 5     Fields:    Translation:Animals
    79. Liu S, Ye D, Xu D, Liao Y, Zhang L, Liu L, Yu W, Wang Y, He Y, Hu J, Guo W, Wang T, Sun B, Song H, Yin H, Liu J, Wu Y, Zhu H, Zhou BP, Deng J, Zhang Z. Autocrine epiregulin activates EGFR pathway for lung metastasis via EMT in salivary adenoid cystic carcinoma. Oncotarget. 2016 May 03; 7(18):25251-63. PMID: 26958807; PMCID: PMC5041901.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    80. Wang Y, Liu J, Ying X, Lin PC, Zhou BP. Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway. Sci Rep. 2016 Apr 20; 6:24606. PMID: 27094683; PMCID: PMC4837350.
      Citations: 67     Fields:    Translation:HumansCells
    81. MacGrogan D, D'Amato G, Travisano S, Martinez-Poveda B, Luxán G, Del Monte-Nieto G, Papoutsi T, Sbroggio M, Bou V, Gomez-Del Arco P, Gómez MJ, Zhou B, Redondo JM, Jiménez-Borreguero LJ, de la Pompa JL. Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis. Circ Res. 2016 05 13; 118(10):1480-97. PMID: 27056911.
      Citations: 50     Fields:    Translation:AnimalsCells
    82. Ge X, Tsang K, He L, Garcia RA, Ermann J, Mizoguchi F, Zhang M, Zhou B, Zhou B, Aliprantis AO. NFAT restricts osteochondroma formation from entheseal progenitors. JCI Insight. 2016 Apr; 1(4):e86254. PMID: 27158674; PMCID: PMC4855520.
      Citations: 10     Fields:    
    83. Li J, Miao L, Shieh D, Spiotto E, Li J, Zhou B, Paul A, Schwartz RJ, Firulli AB, Singer HA, Huang G, Wu M. Single-Cell Lineage Tracing Reveals that Oriented Cell Division Contributes to Trabecular Morphogenesis and Regional Specification. Cell Rep. 2016 Apr 05; 15(1):158-170. PMID: 27052172; PMCID: PMC4826812.
      Citations: 26     Fields:    Translation:AnimalsCells
    84. Yu W, Huang X, Tian X, Zhang H, He L, Wang Y, Nie Y, Hu S, Lin Z, Zhou B, Pu W, Lui KO, Zhou B. GATA4 regulates Fgf16 to promote heart repair after injury. Development. 2016 Mar 15; 143(6):936-49. PMID: 26893347.
      Citations: 59     Fields:    Translation:AnimalsCells
    85. Tao M, Liu L, Shen M, Zhi Q, Gong FR, Zhou BP, Wu Y, Liu H, Chen K, Shen B, Wu MY, Shou LM, Li W. Inflammatory stimuli promote growth and invasion of pancreatic cancer cells through NF-?B pathway dependent repression of PP2Ac. Cell Cycle. 2016; 15(3):381-93. PMID: 26761431; PMCID: PMC4943687.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    86. Xu M, Zhou BP, Tao M, Liu J, Li W. The Role of Stromal Components in Pancreatic Cancer Progression. Anticancer Agents Med Chem. 2016; 16(9):1117-24. PMID: 27039918.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    87. Zhu J, Zhi Q, Zhou BP, Tao M, Liu J, Li W. The Role of Tumor Associated Macrophages in the Tumor Microenvironment: Mechanism and Functions. Anticancer Agents Med Chem. 2016; 16(9):1133-41. PMID: 27198986.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    88. Liu J, Mi J, Zhou BP. Metabolic rewiring in cancer-associated fibroblasts provides a niche for oncogenesis and metastatic dissemination. Mol Cell Oncol. 2016 Jan-Feb; 3(1):e1056331. PMID: 27308568; PMCID: PMC4845206.
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    89. Zhou Y, Rucker EB, Zhou BP. Autophagy regulation in the development and treatment of breast cancer. Acta Biochim Biophys Sin (Shanghai). 2016 Jan; 48(1):60-74. PMID: 26637829; PMCID: PMC4689162.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    90. Chu M, Gao Y, Zhang Y, Zhou B, Wu B, Yao J, Xu D. The role of speckle tracking echocardiography in assessment of lipopolysaccharide-induced myocardial dysfunction in mice. J Thorac Dis. 2015 Dec; 7(12):2253-61. PMID: 26793347; PMCID: PMC4703658.
      Citations: 9     
    91. Wang X, Xu D, Liao Y, Zhong S, Song H, Sun B, Zhou BP, Deng J, Han B. Epithelial neoplasia coincides with exacerbated injury and fibrotic response in the lungs of Gprc5a-knockout mice following silica exposure. Oncotarget. 2015 Nov 24; 6(37):39578-93. PMID: 26447616; PMCID: PMC4741847.
      Citations: 7     Fields:    Translation:AnimalsCells
    92. Brownley RC, Agarwal S, Loder S, Eboda O, Li J, Peterson J, Hwang C, Breuler C, Kaartinen V, Zhou B, Mishina Y, Levi B. Characterization of Heterotopic Ossification Using Radiographic Imaging: Evidence for a Paradigm Shift. PLoS One. 2015; 10(11):e0141432. PMID: 26544555; PMCID: PMC4636348.
      Citations: 11     Fields:    Translation:Animals
    93. Sultana N, Zhang L, Yan J, Chen J, Cai W, Razzaque S, Jeong D, Sheng W, Bu L, Xu M, Huang GY, Hajjar RJ, Zhou B, Moon A, Cai CL. Resident c-kit(+) cells in the heart are not cardiac stem cells. Nat Commun. 2015 Oct 30; 6:8701. PMID: 26515110; PMCID: PMC4846318.
      Citations: 156     Fields:    Translation:HumansAnimalsCells
    94. Zhou P, Erfani S, Liu Z, Jia C, Chen Y, Xu B, Deng X, Alfáro JE, Chen L, Napier D, Lu M, Huang JA, Liu C, Thibault O, Segal R, Zhou BP, Kyprianou N, Horbinski C, Yang XH. CD151-a3ß1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion. Oncotarget. 2015 Oct 06; 6(30):29675-93. PMID: 26377974; PMCID: PMC4745755.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    95. Li P, Gong JX, Sun W, Zhou B, Kong XQ. Hexamethonium attenuates sympathetic activity and blood pressure in spontaneously hypertensive rats. Mol Med Rep. 2015 Nov; 12(5):7116-22. PMID: 26397056.
      Citations: 5     Fields:    Translation:Animals
    96. Leo L, Yu W, D'Rozario M, Waddell EA, Marenda DR, Baird MA, Davidson MW, Zhou B, Wu B, Baker L, Sharp DJ, Baas PW. Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules. Cell Rep. 2015 Sep 22; 12(11):1723-30. PMID: 26344772; PMCID: PMC4837332.
      Citations: 37     Fields:    Translation:AnimalsCells
    97. Xing Y, Zhao S, Zhou BP, Mi J. Metabolic reprogramming of the tumour microenvironment. FEBS J. 2015 Oct; 282(20):3892-8. PMID: 26255648.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    98. Gong FR, Wu MY, Shen M, Zhi Q, Xu ZK, Wang R, Wang WJ, Zong Y, Li ZL, Wu Y, Zhou BP, Chen K, Tao M, Li W. PP2A inhibitors arrest G2/M transition through JNK/Sp1- dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21. Oncotarget. 2015 Jul 30; 6(21):18469-83. PMID: 26053095; PMCID: PMC4621904.
      Citations: 17     Fields:    Translation:HumansCells
    99. Goodson WH, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondrácek J, Raju J, Roman J, Wise JP, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engström W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015 Jun; 36 Suppl 1:S254-96. PMID: 26106142; PMCID: PMC4480130.
      Citations: 88     Fields:    Translation:HumansAnimalsPHPublic Health
    100. Ochieng J, Nangami GN, Ogunkua O, Miousse IR, Koturbash I, Odero-Marah V, McCawley LJ, Nangia-Makker P, Ahmed N, Luqmani Y, Chen Z, Papagerakis S, Wolf GT, Dong C, Zhou BP, Brown DG, Colacci AM, Hamid RA, Mondello C, Raju J, Ryan EP, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Amedei A, Al-Temaimi R, Al-Mulla F, Bisson WH, Eltom SE. The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis. Carcinogenesis. 2015 Jun; 36 Suppl 1:S128-59. PMID: 26106135; PMCID: PMC4565611.
      Citations: 19     Fields:    Translation:HumansAnimalsPHPublic Health
    101. Hathaway CK, Grant R, Hagaman JR, Hiller S, Li F, Xu L, Chang AS, Madden VJ, Bagnell CR, Rojas M, Kim HS, Wu B, Zhou B, Smithies O, Kakoki M. Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):5141-6. PMID: 25848038; PMCID: PMC4413291.
      Citations: 27     Fields:    Translation:Animals
    102. Liu S, Ye D, Guo W, Yu W, He Y, Hu J, Wang Y, Zhang L, Liao Y, Song H, Zhong S, Xu D, Yin H, Sun B, Wang X, Liu J, Wu Y, Zhou BP, Zhang Z, Deng J. G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma. Oncotarget. 2015 Mar 30; 6(9):6887-901. PMID: 25749385; PMCID: PMC4466657.
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    103. Hill C, Jacobs B, Kennedy L, Rohde S, Zhou B, Baldwin S, Goudy S. Cranial neural crest deletion of VEGFa causes cleft palate with aberrant vascular and bone development. Cell Tissue Res. 2015 Sep; 361(3):711-22. PMID: 25759071.
      Citations: 16     Fields:    Translation:AnimalsCells
    104. Zhu J, Xiong G, Fu H, Evers BM, Zhou BP, Xu R. Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network. Cancer Res. 2015 Apr 15; 75(8):1580-91. PMID: 25744716; PMCID: PMC4401637.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    105. Zhong S, Yin H, Liao Y, Yao F, Li Q, Zhang J, Jiao H, Zhao Y, Xu D, Liu S, Song H, Gao Y, Liu J, Ma L, Pang Z, Yang R, Ding C, Sun B, Lin X, Ye X, Guo W, Han B, Zhou BP, Chin YE, Deng J. Lung Tumor Suppressor GPRC5A Binds EGFR and Restrains Its Effector Signaling. Cancer Res. 2015 May 01; 75(9):1801-14. PMID: 25744720.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    106. Zhang D, Wang Y, Shi Z, Liu J, Sun P, Hou X, Zhang J, Zhao S, Zhou BP, Mi J. Metabolic reprogramming of cancer-associated fibroblasts by IDH3a downregulation. Cell Rep. 2015 Mar 03; 10(8):1335-48. PMID: 25732824.
      Citations: 163     Fields:    Translation:HumansAnimalsCells
    107. Agarwal S, Loder SJ, Brownley C, Eboda O, Peterson JR, Hayano S, Wu B, Zhao B, Kaartinen V, Wong VC, Mishina Y, Levi B. BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints. Dev Biol. 2015 Apr 15; 400(2):202-9. PMID: 25722188; PMCID: PMC4397658.
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    108. Racedo SE, McDonald-McGinn DM, Chung JH, Goldmuntz E, Zackai E, Emanuel BS, Zhou B, Funke B, Morrow BE. Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation. Am J Hum Genet. 2015 Feb 05; 96(2):235-44. PMID: 25658046; PMCID: PMC4320261.
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    109. Zhou Z, Rawnsley DR, Goddard LM, Pan W, Cao XJ, Jakus Z, Zheng H, Yang J, Arthur JS, Whitehead KJ, Li D, Zhou B, Garcia BA, Zheng X, Kahn ML. The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression. Dev Cell. 2015 Jan 26; 32(2):168-80. PMID: 25625206; PMCID: PMC4589864.
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    110. Qu X, Zhou B, Scott Baldwin H. Tie1 is required for lymphatic valve and collecting vessel development. Dev Biol. 2015 Mar 01; 399(1):117-128. PMID: 25576926; PMCID: PMC4374493.
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    111. Liu J, Lin PC, Zhou BP. Inflammation fuels tumor progress and metastasis. Curr Pharm Des. 2015; 21(21):3032-40. PMID: 26004407; PMCID: PMC5644345.
      Citations: 47     Fields:    Translation:HumansAnimals
    112. Shi J, Cao J, Zhou BP. Twist-BRD4 complex: potential drug target for basal-like breast cancer. Curr Pharm Des. 2015; 21(10):1256-61. PMID: 25506891; PMCID: PMC5644350.
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    113. Wu Y, Zhou BP. Epigenetic regulation of LSD1 during mammary carcinogenesis. Mol Cell Oncol. 2014 Jul-Sep; 1(3):e963426. PMID: 27308339; PMCID: PMC4904887.
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    114. Baldwin LA, Hoff JT, Lefringhouse J, Zhang M, Jia C, Liu Z, Erfani S, Jin H, Xu M, She QB, van Nagell JR, Wang C, Chen L, Plattner R, Kaetzel DM, Luo J, Lu M, West D, Liu C, Ueland FR, Drapkin R, Zhou BP, Yang XH. CD151-a3ß1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling. Oncotarget. 2014 Dec 15; 5(23):12203-17. PMID: 25356755; PMCID: PMC4322965.
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    115. VanDusen NJ, Casanovas J, Vincentz JW, Firulli BA, Osterwalder M, Lopez-Rios J, Zeller R, Zhou B, Grego-Bessa J, De La Pompa JL, Shou W, Firulli AB. Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium. Cell Rep. 2014 Dec 24; 9(6):2071-83. PMID: 25497097; PMCID: PMC4277501.
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    116. Lin X, Zhong S, Ye X, Liao Y, Yao F, Yang X, Sun B, Zhang J, Li Q, Gao Y, Wang Y, Liu J, Han B, Chin YE, Zhou BP, Deng J. EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer. Mol Cancer. 2014 Oct 14; 13:233. PMID: 25311788; PMCID: PMC4200229.
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    117. Han P, Li W, Lin CH, Yang J, Shang C, Nuernberg ST, Jin KK, Xu W, Lin CY, Lin CJ, Xiong Y, Chien H, Zhou B, Ashley E, Bernstein D, Chen PS, Chen HV, Quertermous T, Chang CP. A long noncoding RNA protects the heart from pathological hypertrophy. Nature. 2014 Oct 02; 514(7520):102-106. PMID: 25119045; PMCID: PMC4184960.
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    118. Chamberlain AA, Lin M, Lister RL, Maslov AA, Wang Y, Suzuki M, Wu B, Greally JM, Zheng D, Zhou B. DNA methylation is developmentally regulated for genes essential for cardiogenesis. J Am Heart Assoc. 2014 Jun 19; 3(3):e000976. PMID: 24947998; PMCID: PMC4309105.
      Citations: 43     Fields:    Translation:AnimalsCells
    119. Moore-Morris T, Guimarães-Camboa N, Banerjee I, Zambon AC, Kisseleva T, Velayoudon A, Stallcup WB, Gu Y, Dalton ND, Cedenilla M, Gomez-Amaro R, Zhou B, Brenner DA, Peterson KL, Chen J, Evans SM. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest. 2014 Jul; 124(7):2921-34. PMID: 24937432; PMCID: PMC4071409.
      Citations: 318     Fields:    Translation:AnimalsCells
    120. Lin Y, Kang T, Zhou BP. Doxorubicin enhances Snail/LSD1-mediated PTEN suppression in a PARP1-dependent manner. Cell Cycle. 2014; 13(11):1708-16. PMID: 24675890; PMCID: PMC4111717.
      Citations: 24     Fields:    Translation:HumansCells
    121. Shi J, Wang Y, Zeng L, Wu Y, Deng J, Zhang Q, Lin Y, Li J, Kang T, Tao M, Rusinova E, Zhang G, Wang C, Zhu H, Yao J, Zeng YX, Evers BM, Zhou MM, Zhou BP. Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer. Cancer Cell. 2014 Feb 10; 25(2):210-25. PMID: 24525235; PMCID: PMC4004960.
      Citations: 255     Fields:    Translation:HumansAnimalsCells
    122. Yin Y, Deng X, Liu Z, Baldwin LA, Lefringhouse J, Zhang J, Hoff JT, Erfani SF, Rucker EB, O'Connor K, Liu C, Wu Y, Zhou BP, Yang XH. CD151 represses mammary gland development by maintaining the niches of progenitor cells. Cell Cycle. 2014; 13(17):2707-22. PMID: 25486358; PMCID: PMC4614859.
      Citations: 10     Fields:    Translation:AnimalsCells
    123. Lin Y, Dong C, Zhou BP. Epigenetic regulation of EMT: the Snail story. Curr Pharm Des. 2014; 20(11):1698-705. PMID: 23888971; PMCID: PMC4005722.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    124. Wang Y, Shi J, Chai K, Ying X, Zhou BP. The Role of Snail in EMT and Tumorigenesis. Curr Cancer Drug Targets. 2013 Nov; 13(9):963-972. PMID: 24168186; PMCID: PMC4004763.
      Citations: 434     Fields:    Translation:HumansCells
    125. Wu Y, Wang Y, Yang XH, Kang T, Zhao Y, Wang C, Evers BM, Zhou BP. The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells. Cell Rep. 2013 Oct 17; 5(1):224-36. PMID: 24075993; PMCID: PMC4004762.
      Citations: 78     Fields:    Translation:HumansCells
    126. Yang J, Zeini M, Lin CY, Lin CJ, Xiong Y, Shang C, Han P, Li W, Quertermous T, Zhou B, Chang CP. Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development. Cardiovasc Res. 2014 Jan 01; 101(1):120-9. PMID: 23946498; PMCID: PMC3868347.
      Citations: 5     Fields:    Translation:AnimalsCells
    127. Zhang Z, Zhou B. Accelerated coronary angiogenesis by vegfr1-knockout endocardial cells. PLoS One. 2013; 8(7):e70570. PMID: 23894673; PMCID: PMC3722158.
      Citations: 14     Fields:    Translation:Animals
    128. Cai X, Zhang W, Hu J, Zhang L, Sultana N, Wu B, Cai W, Zhou B, Cai CL. Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development. 2013 Aug; 140(15):3176-87. PMID: 23824573; PMCID: PMC3931733.
      Citations: 46     Fields:    Translation:AnimalsCells
    129. Wu B, Baldwin HS, Zhou B. Nfatc1 directs the endocardial progenitor cells to make heart valve primordium. Trends Cardiovasc Med. 2013 Nov; 23(8):294-300. PMID: 23669445; PMCID: PMC3766465.
      Citations: 20     Fields:    Translation:AnimalsCells
    130. Xiong Y, Li W, Shang C, Chen RM, Han P, Yang J, Stankunas K, Wu B, Pan M, Zhou B, Longaker MT, Chang CP. Brg1 governs a positive feedback circuit in the hair follicle for tissue regeneration and repair. Dev Cell. 2013 Apr 29; 25(2):169-81. PMID: 23602386.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    131. Wang Y, Wu B, Chamberlain AA, Lui W, Koirala P, Susztak K, Klein D, Taylor V, Zhou B. Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development. PLoS One. 2013; 8(4):e60244. PMID: 23560082; PMCID: PMC3613384.
      Citations: 46     Fields:    Translation:AnimalsCells
    132. Lin Y, Zhou BP. Histone mimics: digging down under. Front Biol (Beijing). 2013 Apr 01; 8(2):228-233. PMID: 24966873; PMCID: PMC4067130.
      Citations: 2     
    133. Wang Y, Zhou BP. Epithelial-mesenchymal Transition---A Hallmark of Breast Cancer Metastasis. Cancer Hallm. 2013 Mar; 1(1):38-49. PMID: 24611128; PMCID: PMC3944831.
      Citations: 81     
    134. Dong C, Yuan T, Wu Y, Wang Y, Fan TW, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell. 2013 Mar 18; 23(3):316-31. PMID: 23453623; PMCID: PMC3703516.
      Citations: 428     Fields:    Translation:HumansAnimalsCells
    135. Wu B, Zhang Z, Lui W, Chen X, Wang Y, Chamberlain AA, Moreno-Rodriguez RA, Markwald RR, O'Rourke BP, Sharp DJ, Zheng D, Lenz J, Baldwin HS, Chang CP, Zhou B. Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling. Cell. 2012 Nov 21; 151(5):1083-96. PMID: 23178125; PMCID: PMC3508471.
      Citations: 187     Fields:    Translation:AnimalsCells
    136. Wang Y, Zhou BP. FBW7-Aurora B-p53 feedback loop regulates mitosis and cell growth. Cell Cycle. 2012 Nov 15; 11(22):4113-4. PMID: 23099923; PMCID: PMC3524204.
      Citations: 6     Fields:    Translation:Humans
    137. Lin CJ, Lin CY, Chen CH, Zhou B, Chang CP. Partitioning the heart: mechanisms of cardiac septation and valve development. Development. 2012 Sep; 139(18):3277-99. PMID: 22912411; PMCID: PMC3424040.
      Citations: 101     Fields:    Translation:HumansAnimals
    138. Sauls K, de Vlaming A, Harris BS, Williams K, Wessels A, Levine RA, Slaugenhaupt SA, Goodwin RL, Pavone LM, Merot J, Schott JJ, Le Tourneau T, Dix T, Jesinkey S, Feng Y, Walsh C, Zhou B, Baldwin S, Markwald RR, Norris RA. Developmental basis for filamin-A-associated myxomatous mitral valve disease. Cardiovasc Res. 2012 Oct 01; 96(1):109-19. PMID: 22843703; PMCID: PMC3444235.
      Citations: 40     Fields:    Translation:AnimalsCells
    139. Zhang DW, Bian ZP, Xu JD, Wu HF, Gu CR, Zhou B, Chen XJ, Yang D. Astragaloside IV alleviates hypoxia/reoxygenation-induced neonatal rat cardiomyocyte injury via the protein kinase a pathway. Pharmacology. 2012; 90(1-2):95-101. PMID: 22797566.
      Citations: 6     Fields:    Translation:AnimalsCells
    140. Tang QL, Xie XB, Wang J, Chen Q, Han AJ, Zou CY, Yin JQ, Liu DW, Liang Y, Zhao ZQ, Yong BC, Zhang RH, Feng QS, Deng WG, Zhu XF, Zhou BP, Zeng YX, Shen JN, Kang T. Glycogen synthase kinase-3ß, NF-?B signaling, and tumorigenesis of human osteosarcoma. J Natl Cancer Inst. 2012 May 16; 104(10):749-63. PMID: 22534782; PMCID: PMC3352834.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    141. Dong C, Wu Y, Yao J, Wang Y, Yu Y, Rychahou PG, Evers BM, Zhou BP. G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest. 2012 Apr; 122(4):1469-86. PMID: 22406531; PMCID: PMC3314447.
      Citations: 266     Fields:    Translation:HumansAnimalsCells
    142. Xiong G, Wang C, Evers BM, Zhou BP, Xu R. RORa suppresses breast tumor invasion by inducing SEMA3F expression. Cancer Res. 2012 Apr 01; 72(7):1728-39. PMID: 22350413; PMCID: PMC3319846.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    143. Lin CY, Lin CJ, Chen CH, Chen RM, Zhou B, Chang CP. The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development. J Mol Cell Cardiol. 2012 May; 52(5):1096-102. PMID: 22300732; PMCID: PMC3327781.
      Citations: 11     Fields:    Translation:AnimalsCells
    144. Xiong Y, Zhou B, Chang CP. Analysis of the endocardial-to-mesenchymal transformation of heart valve development by collagen gel culture assay. Methods Mol Biol. 2012; 843:101-9. PMID: 22222525.
      Citations: 5     Fields:    Translation:Animals
    145. Lue HW, Yang X, Wang R, Qian W, Xu RZ, Lyles R, Osunkoya AO, Zhou BP, Vessella RL, Zayzafoon M, Liu ZR, Zhau HE, Chung LW. LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signaling. PLoS One. 2011; 6(11):e27720. PMID: 22110740; PMCID: PMC3218022.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    146. Wang Y, Zhou BP. Epithelial-mesenchymal transition in breast cancer progression and metastasis. Chin J Cancer. 2011 Sep; 30(9):603-11. PMID: 21880181; PMCID: PMC3702729.
      Citations: 103     Fields:    Translation:HumansCells
    147. Wu B, Wang Y, Lui W, Langworthy M, Tompkins KL, Hatzopoulos AK, Baldwin HS, Zhou B. Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Circ Res. 2011 Jul 08; 109(2):183-92. PMID: 21597012; PMCID: PMC3132827.
      Citations: 99     Fields:    Translation:AnimalsCells
    148. Li J, Zhou BP. Activation of ß-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters. BMC Cancer. 2011 Feb 01; 11:49. PMID: 21284870; PMCID: PMC3040162.
      Citations: 181     Fields:    Translation:HumansCells
    149. Song L, Zhao M, Wu B, Zhou B, Wang Q, Jiao K. Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos. Dev Dyn. 2011 Jan; 240(1):211-20. PMID: 21089072; PMCID: PMC3020975.
      Citations: 9     Fields:    Translation:Animals
    150. Hang CT, Yang J, Han P, Cheng HL, Shang C, Ashley E, Zhou B, Chang CP. Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature. 2010 Jul 01; 466(7302):62-7. PMID: 20596014; PMCID: PMC2898892.
      Citations: 259     Fields:    Translation:HumansAnimalsCells
    151. Jin H, Yu Y, Zhang T, Zhou X, Zhou J, Jia L, Wu Y, Zhou BP, Feng Y. Snail is critical for tumor growth and metastasis of ovarian carcinoma. Int J Cancer. 2010 May 01; 126(9):2102-11. PMID: 19795442.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    152. Wu Y, Zhou BP. Snail: More than EMT. Cell Adh Migr. 2010 Apr-Jun; 4(2):199-203. PMID: 20168078; PMCID: PMC2900613.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
    153. Lin Y, Wu Y, Li J, Dong C, Ye X, Chi YI, Evers BM, Zhou BP. The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J. 2010 Jun 02; 29(11):1803-16. PMID: 20389281; PMCID: PMC2885925.
      Citations: 215     Fields:    Translation:Animals
    154. Wu B, Zhou B, Wang Y, Cheng HL, Hang CT, Pu WT, Chang CP, Zhou B. Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse. Genesis. 2010 Jan; 48(1):63-72. PMID: 20014345; PMCID: PMC2806493.
      Citations: 23     Fields:    Translation:AnimalsCells
    155. Bowen KA, Doan HQ, Zhou BP, Wang Q, Zhou Y, Rychahou PG, Evers BM. PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells. Anticancer Res. 2009 Nov; 29(11):4439-49. PMID: 20032390; PMCID: PMC2932708.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    156. Wu Y, Zhou BP. Inflammation: a driving force speeds cancer metastasis. Cell Cycle. 2009 Oct 15; 8(20):3267-73. PMID: 19770594; PMCID: PMC3702728.
      Citations: 157     Fields:    Translation:Cells
    157. Zeini M, Hang CT, Lehrer-Graiwer J, Dao T, Zhou B, Chang CP. Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling. Development. 2009 Oct; 136(19):3335-45. PMID: 19710169; PMCID: PMC2739147.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    158. Torgerson TR, Genin A, Chen C, Zhang M, Zhou B, Añover-Sombke S, Frank MB, Dozmorov I, Ocheltree E, Kulmala P, Centola M, Ochs HD, Wells AD, Cron RQ. FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression. J Immunol. 2009 Jul 15; 183(2):907-15. PMID: 19564342; PMCID: PMC2778477.
      Citations: 22     Fields:    Translation:HumansCells
    159. Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest. 2009 Jun; 119(6):1462-76. PMID: 19411759; PMCID: PMC2689123.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    160. Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM, Zhou BP. Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell. 2009 May 05; 15(5):416-28. PMID: 19411070; PMCID: PMC2881229.
      Citations: 406     Fields:    Translation:HumansAnimalsCells
    161. Ying L, Lau A, Alvira CM, West R, Cann GM, Zhou B, Kinnear C, Jan E, Sarnow P, Van de Rijn M, Rabinovitch M. LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. J Cell Sci. 2009 May 01; 122(Pt 9):1441-51. PMID: 19366727; PMCID: PMC2672968.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    162. Langworthy M, Zhou B, de Caestecker M, Moeckel G, Baldwin HS. NFATc1 identifies a population of proximal tubule cell progenitors. J Am Soc Nephrol. 2009 Feb; 20(2):311-21. PMID: 19118153; PMCID: PMC2637056.
      Citations: 35     Fields:    Translation:AnimalsCells
    163. Wu Y, Evers BM, Zhou BP. Small C-terminal domain phosphatase enhances snail activity through dephosphorylation. J Biol Chem. 2009 Jan 02; 284(1):640-648. PMID: 19004823; PMCID: PMC2610500.
      Citations: 56     Fields:    Translation:HumansCells
    164. Wu Y, Zhou BP. New insights of epithelial-mesenchymal transition in cancer metastasis. Acta Biochim Biophys Sin (Shanghai). 2008 Jul; 40(7):643-50. PMID: 18604456; PMCID: PMC2740620.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    165. Zhau HE, Odero-Marah V, Lue HW, Nomura T, Wang R, Chu G, Liu ZR, Zhou BP, Huang WC, Chung LW. Epithelial to mesenchymal transition (EMT) in human prostate cancer: lessons learned from ARCaP model. Clin Exp Metastasis. 2008; 25(6):601-10. PMID: 18535913; PMCID: PMC3050737.
      Citations: 86     Fields:    Translation:HumansCells
    166. Cann GM, Guignabert C, Ying L, Deshpande N, Bekker JM, Wang L, Zhou B, Rabinovitch M. Developmental expression of LC3alpha and beta: absence of fibronectin or autophagy phenotype in LC3beta knockout mice. Dev Dyn. 2008 Jan; 237(1):187-95. PMID: 18069693.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    167. Wu Y, Zhou BP. Kinases meet at TSC. Cell Res. 2007 Dec; 17(12):971-3. PMID: 18075516.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    168. Wu H, Kao SC, Barrientos T, Baldwin SH, Olson EN, Crabtree GR, Zhou B, Chang CP. Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development. J Biol Chem. 2007 Oct 19; 282(42):30673-9. PMID: 17693409; PMCID: PMC2366997.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    169. Kim K, Lee J, Kim JH, Jin HM, Zhou B, Lee SY, Kim N. Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor. J Immunol. 2007 May 01; 178(9):5588-94. PMID: 17442941.
      Citations: 23     Fields:    Translation:AnimalsCells
    170. Chen JW, Zhou B, Yu QC, Shin SJ, Jiao K, Schneider MD, Baldwin HS, Bergelson JM. Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves. Circ Res. 2006 Apr 14; 98(7):923-30. PMID: 16543498.
      Citations: 46     Fields:    Translation:Animals
    171. Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science. 2005 Oct 14; 310(5746):306-10. PMID: 16224021.
      Citations: 302     Fields:    Translation:HumansAnimalsCells
    172. Zhou BP, Hung MC. Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis. Cell Cycle. 2005 Jun; 4(6):772-6. PMID: 15917668.
      Citations: 56     Fields:    Translation:HumansCells
    173. Li YM, Zhou BP, Deng J, Pan Y, Hay N, Hung MC. A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells. Cancer Res. 2005 Apr 15; 65(8):3257-63. PMID: 15833858.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    174. Zhou B, Wu B, Tompkins KL, Boyer KL, Grindley JC, Baldwin HS. Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart. Development. 2005 Mar; 132(5):1137-46. PMID: 15689382.
      Citations: 45     Fields:    Translation:AnimalsCells
    175. Li YM, Pan Y, Wei Y, Cheng X, Zhou BP, Tan M, Zhou X, Xia W, Hortobagyi GN, Yu D, Hung MC. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell. 2004 Nov; 6(5):459-69. PMID: 15542430.
      Citations: 227     Fields:    Translation:HumansAnimalsCells
    176. Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, Hung MC. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol. 2004 Oct; 6(10):931-40. PMID: 15448698.
      Citations: 788     Fields:    Translation:HumansCells
    177. Xia W, Chen JS, Zhou X, Sun PR, Lee DF, Liao Y, Zhou BP, Hung MC. Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients. Clin Cancer Res. 2004 Jun 01; 10(11):3815-24. PMID: 15173090.
      Citations: 66     Fields:    Translation:HumansCells
    178. Phoon CK, Ji RP, Aristizábal O, Worrad DM, Zhou B, Baldwin HS, Turnbull DH. Embryonic heart failure in NFATc1-/- mice: novel mechanistic insights from in utero ultrasound biomicroscopy. Circ Res. 2004 Jul 09; 95(1):92-9. PMID: 15166096.
      Citations: 37     Fields:    Translation:Animals
    179. Li YM, Wen Y, Zhou BP, Kuo HP, Ding Q, Hung MC. Enhancement of Bik antitumor effect by Bik mutants. Cancer Res. 2003 Nov 15; 63(22):7630-3. PMID: 14633680.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    180. Zhou BP, Hung MC. Dysregulation of cellular signaling by HER2/neu in breast cancer. Semin Oncol. 2003 Oct; 30(5 Suppl 16):38-48. PMID: 14613025.
      Citations: 33     Fields:    Translation:HumansCells
    181. Deng J, Miller SA, Wang HY, Xia W, Wen Y, Zhou BP, Li Y, Lin SY, Hung MC. beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell. 2002 Oct; 2(4):323-34. PMID: 12398896.
      Citations: 159     Fields:    Translation:HumansCells
    182. Zhou BP, Hung MC. Novel targets of Akt, p21(Cipl/WAF1), and MDM2. Semin Oncol. 2002 Jun; 29(3 Suppl 11):62-70. PMID: 12138399.
      Citations: 25     Fields:    Translation:HumansCells
    183. Zhou B, Cron RQ, Wu B, Genin A, Wang Z, Liu S, Robson P, Baldwin HS. Regulation of the murine Nfatc1 gene by NFATc2. J Biol Chem. 2002 Mar 22; 277(12):10704-11. PMID: 11786533.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    184. Zhou BP, Li Y, Hung MC. HER-2/Neu signaling and therapeutic approaches in breast cancer. Breast Dis. 2002; 15:13-24. PMID: 15687642.
      Citations: 4     Fields:    
    185. Cron RQ, Zhou B, Brunvand MW, Lewis DB. Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cells. Genes Immun. 2001 Dec; 2(8):464-8. PMID: 11781715.
      Citations: 6     Fields:    Translation:HumansCells
    186. Robson P, Stein P, Zhou B, Schultz RM, Baldwin HS. Inner cell mass-specific expression of a cell adhesion molecule (PECAM-1/CD31) in the mouse blastocyst. Dev Biol. 2001 Jun 15; 234(2):317-29. PMID: 11397002.
      Citations: 24     Fields:    Translation:AnimalsCells
    187. Jones PL, Jones FS, Zhou B, Rabinovitch M. Induction of vascular smooth muscle cell tenascin-C gene expression by denatured type I collagen is dependent upon a beta3 integrin-mediated mitogen-activated protein kinase pathway and a 122-base pair promoter element. J Cell Sci. 1999 Feb; 112 ( Pt 4):435-45. PMID: 9914156.
      Citations: 28     Fields:    Translation:AnimalsCells
    188. Mason CA, Bigras JL, O'Blenes SB, Zhou B, McIntyre B, Nakamura N, Kaneda Y, Rabinovitch M. Gene transfer in utero biologically engineers a patent ductus arteriosus in lambs by arresting fibronectin-dependent neointimal formation. Nat Med. 1999 Feb; 5(2):176-82. PMID: 9930865.
      Citations: 18     Fields:    Translation:AnimalsCells
    189. Zhou B, Coulber C, Rabinovitch M. Tissue-specific and developmental regulation of transforming growth factor-beta1 expression in fetal lamb ductus arteriosus endothelial cells. Pediatr Res. 1998 Dec; 44(6):865-72. PMID: 9853919.
      Citations: 3     Fields:    Translation:AnimalsCells
    190. Zhou B, Rabinovitch M. Microtubule involvement in translational regulation of fibronectin expression by light chain 3 of microtubule-associated protein 1 in vascular smooth muscle cells. Circ Res. 1998 Sep 07; 83(5):481-9. PMID: 9734470.
      Citations: 16     Fields:    Translation:AnimalsCells
    191. Zhou B, Boudreau N, Coulber C, Hammarback J, Rabinovitch M. Microtubule-associated protein 1 light chain 3 is a fibronectin mRNA-binding protein linked to mRNA translation in lamb vascular smooth muscle cells. J Clin Invest. 1997 Dec 15; 100(12):3070-82. PMID: 9399954; PMCID: PMC508520.
      Citations: 23     Fields:    Translation:AnimalsCells
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