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Jean Greenberg

InstitutionUniversity of Chicago
DepartmentMolecular Genetics and Cell Biology
AddressChicago IL 60637
ORCID ORCID Icon0000-0002-7213-7618 Additional info
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    Collapse Overview 
    Collapse overview
    My broad interest is in how organisms adapt to a changing environment. My lab studies this in the context of pathogen-host interactions using the gram negative pathogen Pseudomonas syringae and its interaction with several plants: the non-crop models Arabidopsis thaliana and Nicotiana benthamiana, and the crop plants tomato and snap beans. In response to infection, plants mount a complex local defense response involving cell suicide, changes at the plasma membrane, the crosslinking of cell wall components, production of antimicrobials and defense gene activation. Some leaf infections induce a primed state that allows plants to respond faster when a second infection occurs on distal leaves (systemic acquired resistance, SAR). Interactions of roots with beneficial microbes also induces a primed state in the aerial part of the plant (and induced systemic resistance, ISR). Although SAR and ISR were considered different immune programs, we have found that some of the same are proteins required for both systemic programs. These proteins are involved in mobilizing small molecule signals. The lab investigates plant defense and pathogen virulence mechanisms.

    We study how plants regulate their responses to pathogens by (1) using plant mutants that express one or more aspects of the defense response in the absence of pathogens or are compromised for local defense activation or SAR, (2) discovering and tracking the production and movement of novel defense signals and pathogen-derived molecules, and (3) exploiting secreted virulence effector proteins from the pathogen to discover immune components and discern how they are modified. This involves combining genetic analysis (including mosaic plants in which only some cells/tissues express specific defense components) with biochemistry and cell biology. We are very interested in how the defense response is coordinated and towards this end, we are investigating the sites of action at the tissue and subcellular levels of key SAR/ISR proteins. On the pathogen side, we are also characterizing how P. syringae uses its type III secretion apparatus and secreted effectors to modulate immunity and colonize plant tissue, including the surfaces of a leaf, a unique niche. We are using proteomic approaches to discern how pathogen effectors post-translationally modify both other pathogen effectors and host immune complexes to suppress signaling. We are interested in exploiting what we learn about P. syringae effectors to study orthologous effectors from diverse pathogens of both plants and animals.

    A recent additional interest is in peptide trafficking and signal output as it relates to development and microbial interactions.

    Our lab welcomes participants from all over the world and at many levels of education (high school, college, predoctoral, postdoctoral and teachers).

    Professional Activities and Service
    I have been a Senior Editor of The Plant Cell, a Reviewing Editor of eLIFE and Secretary to the Board of Directors of the International Society of Plant-Microbe Interactions.

    I am a member of the American Society of Plant Biology and the Society for Experimental Biology. I participated in developing and writing a recently published white paper concerning the promotion of plant heath: "Foundational and translational research opportunities to improve plant health." Currently I am a member of the Plant Biology Advisory Board for Landmarks.

    I am a strong advocate for diversity in science and serve on the University of Chicago Division of Biology's Diversity Committee and on the steering committee of the Molecular Genetics and Cell Biology Department's National Science Foundation-sponsored Research Education for Undergraduates program.

    Collapse Biography 
    Collapse education and training
    Barnard College, Columbia University, New York CityBA06/1983Biochemistry
    Harvard University, Cambridge, MAPhD06/1989Biophysics
    Massachusetts General Hospital, Boston, MApostdoc training12/1994Plant Biology
    Collapse awards and honors
    1983Magna Cum Laude, Barnard College, Columbia University
    1989 - 1992Postdoctoral Fellowship, National Science Foundation
    1996 - 1999Faculty Research Fellow, American Cancer Society
    1996 - 2001Biomedical Scholar, Pew Foundation
    2018Fellow, American Society for Plant Biology

    Collapse Research 
    Collapse research activities and funding
    Large scale EMSL 60746     (Jean Greenberg)Oct 1, 2023 - Sep 30, 2025
    EMSL (Department of Energy)
    Epidermal Plastid Reprogramming during Microbial Colonization
    Role Description: The goal of this project is to probe changes in root and leaf epidermal plastids during microbial colonization using analytical methods after affinity purification of plastids. This is a user facility award.
    Role: PI

    FWP: 39156     (Gyorgi Babnigg)Oct 1, 2022 - Sep 30, 2025
    Department of Energy
    Developing a high-throughput functional bioimaging capacity for rhizospere interactions using sensor cells, microfluidics, automation, and AI-guided analyses
    Role Description: The goal of this project is to develop biosensors of the root environment and create innovative automation and analysis tools for bioimaging roots.
    Role: Co-I

    CNMS2022-A-01182     (Jean Greenberg)Feb 1, 2022 - Jan 31, 2024
    Oak Ridge National Laboratory Center for Nanomaterials User Proposal (DOE)
    Nanotechnology Enabled Investigations of the Interactions of Bioactive Peptides and Gene Editing of Intact Plants
    Role Description: The goal of this work is to design and fabricate carbon nanofibers that can be used to deliver biomaterials to intact plants. This is a user facility award.
    Role: PI

    USDA-NIFA 2021-67013-34835     (Jean Greenberg)Jul 1, 2021 - Jun 30, 2024
    Nanotechnology-Enabled Gene Editing of Intact Plants
    Role Description: The goal of this project is to develop a nanotechnology that can enable editing in plants.
    Role: PI

    DE-SC0019104     (Jean Greenberg)Sep 1, 2018 - Aug 31, 2023
    Department of Energy
    Understanding Plant Signaling Via Innovations in Probe Delivery and Imaging
    Role Description: The goal of this project is to develop an iterative imaging platform for making non-destructive measurements and to develop nanomaterials to deliver probes to different plant organs.
    Role: PI

    NSF 1837824     (Jean Greenberg)Aug 1, 2018 - Jul 31, 2022
    National Science Foundation
    Rol:FELS EAGER: Emergent functions of secreted microbial effectors
    Role Description: The aim of this project is to study whether microbial effectors show emergent properties, like interactions with each other that can alter their interactions with host components.
    Role: PI

    IOS- 1456904     (Jean Greenberg)Aug 15, 2015 - Aug 14, 2020
    National Science Foundation
    Defense amplification and priming in Arabidopsis
    Role Description: The goal of this study is to understand how plants dynamically modulate their resistance to pathogens.
    Role: PI

    IOS 1238201     (Jean Greenberg and Stephen Kron)Dec 1, 2012 - Nov 30, 2017
    National Science Foundation
    Post-translational Modifications as Modulators of Crop Plant Defense Signaling: a Systems Approach
    Role: PI

    R03TW008059     (GREENBERG, JEAN T.)Apr 1, 2008 - Mar 31, 2012
    Exploiting pathogen-induced cell death to create disease resistant plants:R01GM05
    Role: Principal Investigator

    R01GM054292     (GREENBERG, JEAN T.)May 1, 1996 - Aug 31, 2011
    Molecular Basis of Pathogen-Induced Cell Death in Plants
    Role: Principal Investigator

    R29GM054292     (GREENBERG, JEAN T.)May 1, 1996 - Jun 30, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Roychoudhry S, Greenberg JT, Cecchini NM. Protocol for analyzing the movement and uptake of isotopically labeled signaling molecule azelaic acid in Arabidopsis. STAR Protoc. 2024 Mar 11; 5(2):102944. PMID: 38470913; PMCID: PMC10945267.
      Citations:    Fields:    
    2. Morgan JM, Jelenska J, Hensley DK, Li P, Srijanto BR, Retterer ST, Standaert RF, Morrell-Falvey JL, Greenberg JT. Using Vertically Aligned Carbon Nanofiber Arrays on Rigid or Flexible Substrates for Delivery of Biomolecules and Dyes to Plants. J Vis Exp. 2023 07 21; (197). PMID: 37677009.
      Citations:    Fields:    
    3. Hess RA, Erickson OA, Cole RB, Isaacs JM, Alvarez-Clare S, Arnold J, Augustus-Wallace A, Ayoob JC, Berkowitz A, Branchaw J, Burgio KR, Cannon CH, Ceballos RM, Cohen CS, Coller H, Disney J, Doze VA, Eggers MJ, Ferguson EL, Gray JJ, Greenberg JT, Hoffmann A, Jensen-Ryan D, Kao RM, Keene AC, Kowalko JE, Lopez SA, Mathis C, Minkara M, Murren CJ, Ondrechen MJ, Osano A, Padilla-Crespo E, Palchoudhury S, Qin H, Reithel J, Shaw CA, Smith A, Smith RJ, Tsien F, Dolan EL, Ordoñez P, Ramírez-Lugo J. Virtually the Same? Evaluating the Effectiveness of Remote Undergraduate Research Experiences. CBE Life Sci Educ. 2023 06; 22(2):ar25. PMID: 37058442; PMCID: PMC10228262.
      Citations:    Fields:    Translation:HumansPHPublic Health
    4. Yoo SJ, Choi HJ, Noh SW, Greenberg JT, Jung HW, Cecchini NM. Genetic requirements for infection-specific responses in conferring disease resistance in Arabidopsis. Front Plant Sci. 2022; 13:1068438. PMID: 36523630; PMCID: PMC9745044.
      Citations: 2     
    5. Morgan JM, Jelenska J, Hensley D, Retterer ST, Morrell-Falvey JL, Standaert RF, Greenberg JT. An efficient and broadly applicable method for transient transformation of plants using vertically aligned carbon nanofiber arrays. Front Plant Sci. 2022; 13:1051340. PMID: 36507425; PMCID: PMC9728956.
    6. Fonseca A, Jelenska J, Greenberg JT, Blanco-Herrera F, Urzúa T, Sbarbaro C, Seguel A, Duarte Y, Holuigue L, Herrera-Vásquez A. The TGA Transcription Factors from Clade II Negatively Regulate the Salicylic Acid Accumulation in Arabidopsis. Int J Mol Sci. 2022 Oct 01; 23(19). PMID: 36232932; PMCID: PMC9569720.
      Citations: 3     Fields:    Translation:AnimalsCells
    7. Banday ZZ, Speed DJ, Scott AT, Parent C, Hu CT, Filzen RC, Agbo E, Greenberg JT, Cecchini NM. Friend or foe: Hybrid proline-rich proteins determine how plants respond to beneficial and pathogenic microbes. Plant Physiol. 2022 08 29; 190(1):860-881. PMID: 35642916; PMCID: PMC9434206.
      Citations: 6     Fields:    Translation:AnimalsCells
    8. Erickson OA, Cole RB, Isaacs JM, Alvarez-Clare S, Arnold J, Augustus-Wallace A, Ayoob JC, Berkowitz A, Branchaw J, Burgio KR, Cannon CH, Ceballos RM, Cohen CS, Coller H, Disney J, Doze VA, Eggers MJ, Farina S, Ferguson EL, Gray JJ, Greenberg JT, Hoffmann A, Jensen-Ryan D, Kao RM, Keene AC, Kowalko JE, Lopez SA, Mathis C, Minkara M, Murren CJ, Ondrechen MJ, Osano A, Padilla-Crespo E, Palchoudhury S, Qin H, Reithel J, Shaw CA, Smith A, Smith R, Summers AP, Tsien F, Dolan EL, Ordoñez P, Ramírez-Lugo J. "How Do We Do This at a Distance?!" A Descriptive Study of Remote Undergraduate Research Programs during COVID-19. CBE Life Sci Educ. 2022 03; 21(1):ar1. PMID: 34978923; PMCID: PMC9250374.
      Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
    9. Jelenska J, Lee J, Manning AJ, Wolfgeher DJ, Ahn Y, Walters-Marrah G, Lopez IE, Garcia L, McClerklin SA, Michelmore RW, Kron SJ, Greenberg JT. Pseudomonas syringae effector HopZ3 suppresses the bacterial AvrPto1-tomato PTO immune complex via acetylation. PLoS Pathog. 2021 11; 17(11):e1010017. PMID: 34724007; PMCID: PMC8584673.
      Citations: 5     Fields:    Translation:AnimalsCells
    10. Jiang SC, Engle NL, Banday ZZ, Jung HW, Tschaplinski TJ, Greenberg JT, Cecchini NM. ALD1 accumulation in Arabidopsis epidermal plastids confers local and non-autonomous disease resistance. J Exp Bot. 2021 03 29; 72(7):2710-2726. PMID: 33463678; PMCID: PMC8006555.
      Citations: 11     Fields:    Translation:AnimalsCells
    11. Speed DJ, Roychoudhry S, Greenberg JT, Cecchini NM. Kinases and protein motifs required for AZI1 plastid localization and trafficking during plant defense induction. Plant J. 2021 03; 105(6):1615-1629. PMID: 33342031; PMCID: PMC8048937.
      Citations: 6     Fields:    Translation:Animals
    12. Song Y, Roychoudhry S, Greenberg JT, Haney CH, Cecchini NM. An Improved Bioassay to Study Arabidopsis Induced Systemic Resistance (ISR) Against Bacterial Pathogens and Insect Pests. Bio Protoc. 2019 May 20; 9(10):e3236. PMID: 33654765; PMCID: PMC7854143.
      Citations: 2     
    13. Roychoudhry S, Speed DJ, Steffes K, Tambe A, Zodrow K, Konstantinoff K, Jung HW, Engle NL, Tschaplinski TJ, Greenberg JT, Cecchini NM. Underground Azelaic Acid-Conferred Resistance to Pseudomonas syringae in Arabidopsis. Mol Plant Microbe Interact. 2019 01; 32(1):86-94. PMID: 30156481.
      Citations: 13     Fields:    Translation:AnimalsCells
    14. Jelenska J, Marr SK, Joyce MB, Gagesch KR, Shakoor N, Jiang SC, Wildermuth MC, Greenberg JT, Seguel A, Herrera-Vásquez A, Fonseca A, Holuigue L. PROHIBITIN3 Forms Complexes with ISOCHORISMATE SYNTHASE1 to Regulate Stress-Induced Salicylic Acid Biosynthesis in Arabidopsis. Plant Physiol. 2018 03; 176(3):2515-2531. PMID: 29438088; PMCID: PMC5841719.
      Citations: 21     Fields:    Translation:AnimalsCells
    15. Manning AJ, Lee J, Wolfgeher DJ, Kron SJ, Greenberg JT. Simple strategies to enhance discovery of acetylation post-translational modifications by quadrupole-orbitrap LC-MS/MS. Biochim Biophys Acta Proteins Proteom. 2018 Feb; 1866(2):224-229. PMID: 29050961.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    16. Michelmore R, Coaker G, Bart R, Beattie G, Bent A, Bruce T, Cameron D, Dangl J, Dinesh-Kumar S, Edwards R, Eves-van den Akker S, Gassmann W, Greenberg JT, Hanley-Bowdoin L, Harrison RJ, Harvey J, He P, Huffaker A, Hulbert S, Innes R, Jones JDG, Kaloshian I, Kamoun S, Katagiri F, Leach J, Ma W, McDowell J, Medford J, Meyers B, Nelson R, Oliver R, Qi Y, Saunders D, Shaw M, Smart C, Subudhi P, Torrance L, Tyler B, Valent B, Walsh J. Foundational and Translational Research Opportunities to Improve Plant Health. Mol Plant Microbe Interact. 2017 07; 30(7):515-516. PMID: 28398839; PMCID: PMC5810936.
      Citations: 8     Fields:    Translation:HumansAnimals
    17. Zhang Z, Tateda C, Jiang SC, Shrestha J, Jelenska J, Speed DJ, Greenberg JT. A Suite of Receptor-Like Kinases and a Putative Mechano-Sensitive Channel Are Involved in Autoimmunity and Plasma Membrane-Based Defenses in Arabidopsis. Mol Plant Microbe Interact. 2017 02; 30(2):150-160. PMID: 28051349.
      Citations: 6     Fields:    Translation:AnimalsCells
    18. Jelenska J, Davern SM, Standaert RF, Mirzadeh S, Greenberg JT. Flagellin peptide flg22 gains access to long-distance trafficking in Arabidopsis via its receptor, FLS2. J Exp Bot. 2017 03 01; 68(7):1769-1783. PMID: 28521013; PMCID: PMC5444442.
      Citations: 16     Fields:    Translation:Animals
    19. Davern SM, McKnight TE, Standaert RF, Morrell-Falvey JL, Shpak ED, Kalluri UC, Jelenska J, Greenberg JT, Mirzadeh S. Carbon Nanofiber Arrays: A Novel Tool for Microdelivery of Biomolecules to Plants. PLoS One. 2016; 11(4):e0153621. PMID: 27119338; PMCID: PMC4847769.
      Citations: 1     Fields:    Translation:Animals
    20. Lu H, Greenberg JT, Holuigue L. Editorial: Salicylic Acid Signaling Networks. Front Plant Sci. 2016; 7:238. PMID: 26941775; PMCID: PMC4764731.
      Citations: 17     
    21. Lee J, Manning AJ, Wolfgeher D, Jelenska J, Cavanaugh KA, Xu H, Fernandez SM, Michelmore RW, Kron SJ, Greenberg JT. Acetylation of an NB-LRR Plant Immune-Effector Complex Suppresses Immunity. Cell Rep. 2015 Nov 24; 13(8):1670-82. PMID: 26586425; PMCID: PMC4967551.
      Citations: 30     Fields:    Translation:Cells
    22. Tateda C, Zhang Z, Greenberg JT. Linking pattern recognition and salicylic acid responses in Arabidopsis through ACCELERATED CELL DEATH6 and receptors. Plant Signal Behav. 2015; 10(10):e1010912. PMID: 26442718; PMCID: PMC4883847.
      Citations: 6     Fields:    Translation:AnimalsCells
    23. Steffes K, Gifford AN, Greenberg JT, Cecchini NM, Schläppi MR. Arabidopsis AZI1 family proteins mediate signal mobilization for systemic defence priming. Nat Commun. 2015 Jul 23; 6:7658. PMID: 26203923.
      Citations: 46     Fields:    Translation:AnimalsCells
    24. Jung HW, Engle NL, Tschaplinski TJ, Greenberg JT, Cecchini NM. ALD1 Regulates Basal Immune Components and Early Inducible Defense Responses in Arabidopsis. Mol Plant Microbe Interact. 2015 Apr; 28(4):455-66. PMID: 25372120.
      Citations: 29     Fields:    Translation:AnimalsCells
    25. Tateda C, Zhang Z, Shrestha J, Jelenska J, Chinchilla D, Greenberg JT. Salicylic acid regulates Arabidopsis microbial pattern receptor kinase levels and signaling. Plant Cell. 2014 Oct; 26(10):4171-87. PMID: 25315322; PMCID: PMC4247590.
      Citations: 52     Fields:    Translation:AnimalsCells
    26. Bi FC, Liu Z, Wu JX, Liang H, Xi XL, Fang C, Sun TJ, Yin J, Dai GY, Rong C, Greenberg JT, Su WW, Yao N. Loss of ceramide kinase in Arabidopsis impairs defenses and promotes ceramide accumulation and mitochondrial H2O2 bursts. Plant Cell. 2014 Aug; 26(8):3449-67. PMID: 25149397; PMCID: PMC4176443.
      Citations: 41     Fields:    Translation:AnimalsCells
    27. Kang Y, Jelenska J, Cecchini NM, Li Y, Lee MW, Kovar DR, Greenberg JT. HopW1 from Pseudomonas syringae disrupts the actin cytoskeleton to promote virulence in Arabidopsis. PLoS Pathog. 2014 Jun; 10(6):e1004232. PMID: 24968323; PMCID: PMC4072799.
      Citations: 43     Fields:    Translation:AnimalsCells
    28. Zhang Z, Shrestha J, Tateda C, Greenberg JT. Salicylic acid signaling controls the maturation and localization of the arabidopsis defense protein ACCELERATED CELL DEATH6. Mol Plant. 2014 Aug; 7(8):1365-1383. PMID: 24923602; PMCID: PMC4168298.
      Citations: 20     Fields:    Translation:AnimalsCells
    29. Jelenska J, Kang Y, Greenberg JT. Plant pathogenic bacteria target the actin microfilament network involved in the trafficking of disease defense components. Bioarchitecture. 2014; 4(4-5):149-53. PMID: 25551177; PMCID: PMC4914032.
      Citations: 7     Fields:    Translation:Cells
    30. Lee J, Teitzel GM, Greenberg JT. SGT1b is required for HopZ3-mediated suppression of the epiphytic growth of Pseudomonas syringae on N. benthamiana. Plant Signal Behav. 2012 Sep 01; 7(9):1129-31. PMID: 22899059; PMCID: PMC3489644.
      Citations: 1     Fields:    Translation:AnimalsCells
    31. Lee J, Teitzel GM, Munkvold K, del Pozo O, Martin GB, Michelmore RW, Greenberg JT. Type III secretion and effectors shape the survival and growth pattern of Pseudomonas syringae on leaf surfaces. Plant Physiol. 2012 Apr; 158(4):1803-18. PMID: 22319072; PMCID: PMC3320187.
      Citations: 37     Fields:    Translation:AnimalsCells
    32. Pattanayak GK, Venkataramani S, Hortensteiner S, Kunz L, Christ B, Moulin M, Smith AG, Okamoto Y, Tamiaki H, Sugishima M, Greenberg JT. Accelerated cell death 2 suppresses mitochondrial oxidative bursts and modulates cell death in Arabidopsis. Plant J. 2012 Feb; 69(4):589-600. PMID: 21988537; PMCID: PMC3274588.
      Citations: 20     Fields:    Translation:AnimalsCells
    33. Bi FC, Zhang QF, Liu Z, Fang C, Li J, Su JB, Greenberg JT, Wang HB, Yao N. A conserved cysteine motif is critical for rice ceramide kinase activity and function. PLoS One. 2011 Mar 31; 6(3):e18079. PMID: 21483860; PMCID: PMC3069040.
      Citations: 7     Fields:    Translation:AnimalsCells
    34. Jelenska J, van Hal JA, Greenberg JT. Pseudomonas syringae hijacks plant stress chaperone machinery for virulence. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13177-82. PMID: 20615948; PMCID: PMC2919979.
      Citations: 79     Fields:    Translation:AnimalsCells
    35. Wroblewski T, Caldwell KS, Piskurewicz U, Cavanaugh KA, Xu H, Kozik A, Ochoa O, McHale LK, Lahre K, Jelenska J, Castillo JA, Blumenthal D, Vinatzer BA, Greenberg JT, Michelmore RW. Comparative large-scale analysis of interactions between several crop species and the effector repertoires from multiple pathovars of Pseudomonas and Ralstonia. Plant Physiol. 2009 Aug; 150(4):1733-49. PMID: 19571308; PMCID: PMC2719141.
      Citations: 38     Fields:    Translation:AnimalsCells
    36. Jung HW, Tschaplinski TJ, Wang L, Glazebrook J, Greenberg JT. Priming in systemic plant immunity. Science. 2009 Apr 03; 324(5923):89-91. PMID: 19342588.
      Citations: 302     Fields:    Translation:AnimalsCells
    37. Lu H, Salimian S, Gamelin E, Wang G, Fedorowski J, LaCourse W, Greenberg JT. Genetic analysis of acd6-1 reveals complex defense networks and leads to identification of novel defense genes in Arabidopsis. Plant J. 2009 May; 58(3):401-12. PMID: 19144005; PMCID: PMC2727925.
      Citations: 29     Fields:    Translation:AnimalsCells
    38. Genger RK, Jurkowski GI, McDowell JM, Lu H, Jung HW, Greenberg JT, Bent AF. Signaling pathways that regulate the enhanced disease resistance of Arabidopsis "defense, no death" mutants. Mol Plant Microbe Interact. 2008 Oct; 21(10):1285-96. PMID: 18785824; PMCID: PMC2923831.
      Citations: 39     Fields:    Translation:AnimalsCells
    39. Lee MW, Jelenska J, Greenberg JT. Arabidopsis proteins important for modulating defense responses to Pseudomonas syringae that secrete HopW1-1. Plant J. 2008 May; 54(3):452-65. PMID: 18266921.
      Citations: 48     Fields:    Translation:AnimalsCells
    40. Lee MW, Lu H, Jung HW, Greenberg JT. A key role for the Arabidopsis WIN3 protein in disease resistance triggered by Pseudomonas syringae that secrete AvrRpt2. Mol Plant Microbe Interact. 2007 Oct; 20(10):1192-200. PMID: 17918621.
      Citations: 28     Fields:    Translation:AnimalsCells
    41. Jelenska J, Yao N, Vinatzer BA, Wright CM, Brodsky JL, Greenberg JT. A J domain virulence effector of Pseudomonas syringae remodels host chloroplasts and suppresses defenses. Curr Biol. 2007 Mar 20; 17(6):499-508. PMID: 17350264; PMCID: PMC1857343.
      Citations: 110     Fields:    Translation:AnimalsCells
    42. Vinatzer BA, Greenberg JT. Whole-genome analysis to identify type III-secreted effectors. Methods Mol Biol. 2007; 354:19-34. PMID: 17172741.
      Citations: 4     Fields:    Translation:AnimalsCells
    43. Greenberg JT, Castillo JA. Evolutionary dynamics of Ralstonia solanacearum. Appl Environ Microbiol. 2007 Feb; 73(4):1225-38. PMID: 17189443; PMCID: PMC1828673.
      Citations: 33     Fields:    Translation:Cells
    44. Vinatzer BA, Teitzel GM, Lee MW, Jelenska J, Hotton S, Fairfax K, Jenrette J, Greenberg JT. The type III effector repertoire of Pseudomonas syringae pv. syringae B728a and its role in survival and disease on host and non-host plants. Mol Microbiol. 2006 Oct; 62(1):26-44. PMID: 16942603.
      Citations: 81     Fields:    Translation:AnimalsCells
    45. Gabriel DW, Allen C, Schell M, Denny TP, Greenberg JT, Duan YP, Flores-Cruz Z, Huang Q, Clifford JM, Presting G, Reddy J, Elphinstone J, Swanson J, Yao J, Mulholland V, Liu L, Farmerie W, Patnaikuni M, Balogh B, Norman D, Alvarez A, Castillo JA, Jones J, Saddler G, Walunas T, Zhukov A, Mikhailova N, González ET. Identification of open reading frames unique to a select agent: Ralstonia solanacearum race 3 biovar 2. Mol Plant Microbe Interact. 2006 Jan; 19(1):69-79. PMID: 16404955.
      Citations: 50     Fields:    Translation:Cells
    46. Yao N, Greenberg JT. Arabidopsis ACCELERATED CELL DEATH2 modulates programmed cell death. Plant Cell. 2006 Feb; 18(2):397-411. PMID: 16387834; PMCID: PMC1356547.
      Citations: 102     Fields:    Translation:AnimalsCells
    47. Lu H, Liu Y, Greenberg JT. Structure-function analysis of the plasma membrane- localized Arabidopsis defense component ACD6. Plant J. 2005 Dec; 44(5):798-809. PMID: 16297071.
      Citations: 26     Fields:    Translation:AnimalsCells
    48. Vinatzer BA, Jelenska J, Greenberg JT. Bioinformatics correctly identifies many type III secretion substrates in the plant pathogen Pseudomonas syringae and the biocontrol isolate P. fluorescens SBW25. Mol Plant Microbe Interact. 2005 Aug; 18(8):877-88. PMID: 16134900.
      Citations: 23     Fields:    Translation:AnimalsCellsPHPublic Health
    49. Greenberg JT. Degrade or die: a dual function for autophagy in the plant immune response. Dev Cell. 2005 Jun; 8(6):799-801. PMID: 15935769.
      Citations: 2     Fields:    Translation:AnimalsCells
    50. Lindeberg M, Stavrinides J, Chang JH, Alfano JR, Collmer A, Dangl JL, Greenberg JT, Mansfield JW, Guttman DS. Proposed guidelines for a unified nomenclature and phylogenetic analysis of type III Hop effector proteins in the plant pathogen Pseudomonas syringae. Mol Plant Microbe Interact. 2005 Apr; 18(4):275-82. PMID: 15828679.
      Citations: 64     Fields:    Translation:Cells
    51. Yao N, Eisfelder BJ, Marvin J, Greenberg JT. The mitochondrion--an organelle commonly involved in programmed cell death in Arabidopsis thaliana. Plant J. 2004 Nov; 40(4):596-610. PMID: 15500474.
      Citations: 77     Fields:    Translation:AnimalsCells
    52. Song JT, Lu H, McDowell JM, Greenberg JT. A key role for ALD1 in activation of local and systemic defenses in Arabidopsis. Plant J. 2004 Oct; 40(2):200-12. PMID: 15447647.
      Citations: 74     Fields:    Translation:AnimalsCells
    53. Greenberg JT, Yao N. The role and regulation of programmed cell death in plant-pathogen interactions. Cell Microbiol. 2004 Mar; 6(3):201-11. PMID: 14764104.
      Citations: 240     Fields:    Translation:AnimalsCells
    54. Song JT, Lu H, Greenberg JT. Divergent roles in Arabidopsis thaliana development and defense of two homologous genes, aberrant growth and death2 and AGD2-LIKE DEFENSE RESPONSE PROTEIN1, encoding novel aminotransferases. Plant Cell. 2004 Feb; 16(2):353-66. PMID: 14729919; PMCID: PMC341909.
      Citations: 59     Fields:    Translation:AnimalsCells
    55. Liang H, Yao N, Song JT, Luo S, Lu H, Greenberg JT. Ceramides modulate programmed cell death in plants. Genes Dev. 2003 Nov 01; 17(21):2636-41. PMID: 14563678; PMCID: PMC280613.
      Citations: 146     Fields:    Translation:Animals
    56. Lu H, Rate DN, Song JT, Greenberg JT. ACD6, a novel ankyrin protein, is a regulator and an effector of salicylic acid signaling in the Arabidopsis defense response. Plant Cell. 2003 Oct; 15(10):2408-20. PMID: 14507999; PMCID: PMC197305.
      Citations: 96     Fields:    Translation:Cells
    57. Greenberg JT, Vinatzer BA. Identifying type III effectors of plant pathogens and analyzing their interaction with plant cells. Curr Opin Microbiol. 2003 Feb; 6(1):20-8. PMID: 12615215.
      Citations: 57     Fields:    Translation:AnimalsCells
    58. Guttman DS, Vinatzer BA, Sarkar SF, Ranall MV, Kettler G, Greenberg JT. A functional screen for the type III (Hrp) secretome of the plant pathogen Pseudomonas syringae. Science. 2002 Mar 01; 295(5560):1722-6. PMID: 11872842.
      Citations: 130     Fields:    Translation:AnimalsCells
    59. Vanacker H, Lu H, Rate DN, Greenberg JT. A role for salicylic acid and NPR1 in regulating cell growth in Arabidopsis. Plant J. 2001 Oct; 28(2):209-16. PMID: 11722764.
      Citations: 44     Fields:    Translation:AnimalsCells
    60. Rate DN, Greenberg JT, Rate DN, Greenberg JT. The Arabidopsis aberrant growth and death2 mutant shows resistance to Pseudomonas syringae and reveals a role for NPR1 in suppressing hypersensitive cell death. Plant J. 2001 Aug; 27(3):203-11. PMID: 11532166.
      Citations: 54     Fields:    Translation:AnimalsCells
    61. Guttman DS, Greenberg JT, Guttman DS, Greenberg JT. Functional analysis of the type III effectors AvrRpt2 and AvrRpm1 of Pseudomonas syringae with the use of a single-copy genomic integration system. Mol Plant Microbe Interact. 2001 Feb; 14(2):145-55. PMID: 11204777.
      Citations: 62     Fields:    Translation:AnimalsCells
    62. Mach JM, Castillo AR, Hoogstraten R, Greenberg JT. The Arabidopsis-accelerated cell death gene ACD2 encodes red chlorophyll catabolite reductase and suppresses the spread of disease symptoms. Proc Natl Acad Sci U S A. 2001 Jan 16; 98(2):771-6. PMID: 11149948; PMCID: PMC14663.
      Citations: 98     Fields:    Translation:AnimalsCells
    63. Greenberg JT, Silverman FP, Liang H. Uncoupling salicylic acid-dependent cell death and defense-related responses from disease resistance in the Arabidopsis mutant acd5. Genetics. 2000 Sep; 156(1):341-50. PMID: 10978297; PMCID: PMC1461250.
      Citations: 74     Fields:    Translation:AnimalsCells
    64. Greenberg JT. Positive and negative regulation of salicylic acid-dependent cell death and pathogen resistance in Arabidopsis lsd6 and ssi1 mutants. Mol Plant Microbe Interact. 2000 Aug; 13(8):877-81. PMID: 10939259.
      Citations: 5     Fields:    Translation:AnimalsCells
    65. Rate DN, Cuenca JV, Bowman GR, Guttman DS, Greenberg JT. The gain-of-function Arabidopsis acd6 mutant reveals novel regulation and function of the salicylic acid signaling pathway in controlling cell death, defenses, and cell growth. Plant Cell. 1999 Sep; 11(9):1695-708. PMID: 10488236; PMCID: PMC144313.
      Citations: 120     Fields:    Translation:AnimalsCells
    66. Butt A, Mousley C, Morris K, Beynon J, Can C, Holub E, Greenberg JT, Buchanan-Wollaston V. Differential expression of a senescence-enhanced metallothionein gene in Arabidopsis in response to isolates of Peronospora parasitica and Pseudomonas syringae. Plant J. 1998 Oct; 16(2):209-21. PMID: 9839466.
      Citations: 40     Fields:    Translation:AnimalsCells
    67. Greenberg JT. PROGRAMMED CELL DEATH IN PLANT-PATHOGEN INTERACTIONS. Annu Rev Plant Physiol Plant Mol Biol. 1997 Jun; 48:525-545. PMID: 15012273.
      Citations: 118     
    68. Greenberg JT. Programmed cell death: a way of life for plants. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12094-7. PMID: 8901538; PMCID: PMC37948.
      Citations: 122     Fields:    Translation:AnimalsCells
    69. Greenberg JT, Guo A, Klessig DF, Ausubel FM. Programmed cell death in plants: a pathogen-triggered response activated coordinately with multiple defense functions. Cell. 1994 May 20; 77(4):551-63. PMID: 8187175.
      Citations: 156     Fields:    Translation:AnimalsCells
    70. Greenberg JT, Ausubel FM. Arabidopsis mutants compromised for the control of cellular damage during pathogenesis and aging. Plant J. 1993 Aug; 4(2):327-41. PMID: 8220484.
      Citations: 80     Fields:    Translation:AnimalsCells
    71. Chou JH, Greenberg JT, Demple B. Posttranscriptional repression of Escherichia coli OmpF protein in response to redox stress: positive control of the micF antisense RNA by the soxRS locus. J Bacteriol. 1993 Feb; 175(4):1026-31. PMID: 7679383; PMCID: PMC193015.
      Citations: 58     Fields:    Translation:Cells
    72. Greenberg JT, Chou JH, Monach PA, Demple B. Activation of oxidative stress genes by mutations at the soxQ/cfxB/marA locus of Escherichia coli. J Bacteriol. 1991 Jul; 173(14):4433-9. PMID: 1648558; PMCID: PMC208106.
      Citations: 62     Fields:    Translation:Cells
    73. Greenberg JT, Monach P, Chou JH, Josephy PD, Demple B. Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6181-5. PMID: 1696718; PMCID: PMC54496.
      Citations: 195     Fields:    Translation:Cells
    74. Greenberg JT, Demple B. A global response induced in Escherichia coli by redox-cycling agents overlaps with that induced by peroxide stress. J Bacteriol. 1989 Jul; 171(7):3933-9. PMID: 2472381; PMCID: PMC210145.
      Citations: 77     Fields:    Translation:Cells
    75. Greenberg JT, Demple B. Overproduction of peroxide-scavenging enzymes in Escherichia coli suppresses spontaneous mutagenesis and sensitivity to redox-cycling agents in oxyR-mutants. EMBO J. 1988 Aug; 7(8):2611-7. PMID: 2847922; PMCID: PMC457135.
      Citations: 51     Fields:    Translation:Cells
    76. Greenberg JT, Demple B. Glutathione in Escherichia coli is dispensable for resistance to H2O2 and gamma radiation. J Bacteriol. 1986 Nov; 168(2):1026-9. PMID: 3536846; PMCID: PMC213589.
      Citations: 48     Fields:    Translation:Cells
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