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Paul Vezina

InstitutionUniversity of Chicago
DepartmentPsychiatry & Behav. Neurosci
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Research Interests
    Basal ganglia and the generation of appetitive behaviors
    Signaling pathways underlying drug-induced neuronal plasticity
    Neurobiology and neuropharmacology

    Collapse Biography 
    Collapse education and training
    Concordia University, Montreal, CanadaPh.D. 1988
    Collège de France, Paris, FrancePostdoctoral Research1990Neuropharmacologie

    Collapse Research 
    Collapse research activities and funding
    R21DA034184     (VEZINA, PAUL R)Jul 15, 2013 - Jun 30, 2016
    Uncertainty and stimulant self-administration
    Role: Principal Investigator

    P01DA019695     (VEZINA, PAUL R)May 1, 2007 - Mar 31, 2013
    Nicotine Exposure: Molecular to Behavioral Consequences
    Role: Principal Investigator

    R01DA010682     (VEZINA, PAUL R)Apr 1, 1998 - Feb 29, 2004
    Role: Principal Investigator

    R01DA009860     (VEZINA, PAUL R)Sep 30, 1997 - Jul 31, 2002
    Role: Principal Investigator

    R01DA009397     (VEZINA, PAUL R)Jul 1, 1995 - Feb 28, 2020
    Sensitization and Stimulant Self-Administration
    Role: Principal Investigator

    T32DA007255     (VEZINA, PAUL R)Sep 30, 1991 - Jun 30, 2014
    Neuropsychopharmacology Training for Drug Abuse Research
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Puranik A, Buie N, Arizanovska D, Vezina P, Steidl S. Glutamate inputs from the laterodorsal tegmental nucleus to the ventral tegmental area are essential for the induction of cocaine sensitization in male mice. Psychopharmacology (Berl). 2022 Oct; 239(10):3263-3276. PMID: 36006414.
      Citations: 1     Fields:    Translation:Animals
    2. Guillory AM, Herrera SH, Baker LK, Bubula N, Forneris J, You ZB, Vezina P, Singer BF. Conditioned inhibition of amphetamine sensitization. Neurobiol Learn Mem. 2022 07; 192:107636. PMID: 35597434.
      Citations:    Fields:    Translation:Animals
    3. Kozlova A, Butler RR, Zhang S, Ujas T, Zhang H, Steidl S, Sanders AR, Pang ZP, Vezina P, Duan J. Sex-specific nicotine sensitization and imprinting of self-administration in rats inform GWAS findings on human addiction phenotypes. Neuropsychopharmacology. 2021 09; 46(10):1746-1756. PMID: 34007041; PMCID: PMC8358005.
      Citations: 2     Fields:    Translation:HumansAnimals
    4. Singer BF, Anselme P, Robinson MJF, Vezina P. An overview of commonalities in the mechanisms underlying gambling and substance use disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2020 07 13; 101:109944. PMID: 32289336.
      Citations: 3     Fields:    Translation:Humans
    5. Mascia P, Wang Q, Brown J, Nesbitt KM, Kennedy RT, Vezina P. Maladaptive consequences of repeated intermittent exposure to uncertainty. Prog Neuropsychopharmacol Biol Psychiatry. 2020 04 20; 99:109864. PMID: 31952958; PMCID: PMC7107980.
      Citations: 2     Fields:    Translation:HumansAnimals
    6. Wang R, Hausknecht KA, Shen YL, Haj-Dahmane S, Vezina P, Shen RY. Environmental enrichment reverses increased addiction risk caused by prenatal ethanol exposure. Drug Alcohol Depend. 2018 10 01; 191:343-347. PMID: 30176547; PMCID: PMC6178821.
      Citations: 10     Fields:    Translation:Animals
    7. Wang R, Shen YL, Hausknecht KA, Chang L, Haj-Dahmane S, Vezina P, Shen RY. Prenatal ethanol exposure increases risk of psychostimulant addiction. Behav Brain Res. 2019 01 01; 356:51-61. PMID: 30076855; PMCID: PMC7395677.
      Citations: 17     Fields:    Translation:AnimalsCells
    8. Mascia P, Neugebauer NM, Brown J, Bubula N, Nesbitt KM, Kennedy RT, Vezina P. Exposure to conditions of uncertainty promotes the pursuit of amphetamine. Neuropsychopharmacology. 2019 01; 44(2):274-280. PMID: 29875447; PMCID: PMC6300556.
      Citations: 13     Fields:    Translation:Animals
    9. Lee JW, Kim WY, Cho BR, Vezina P, Kim JH. Leptin in the nucleus accumbens core disrupts acute cocaine effects: Implications for GSK3ß connections. Behav Brain Res. 2018 Jan 30; 337:46-52. PMID: 28964909.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Cho BR, Yoon HS, Kim WY, Vezina P, Kim JH. Cocaine inhibits leptin-induced increase of the cocaine- and amphetamine-regulated transcript peptide in the nucleus accumbens in rats. Neuroreport. 2017 Aug 02; 28(11):701-704. PMID: 28614180.
      Citations: 1     Fields:    Translation:Animals
    11. Steidl S, O'Sullivan S, Pilat D, Bubula N, Brown J, Vezina P. Operant responding for optogenetic excitation of LDTg inputs to the VTA requires D1 and D2 dopamine receptor activation in the NAcc. Behav Brain Res. 2017 08 30; 333:161-170. PMID: 28666837; PMCID: PMC5564287.
      Citations: 10     Fields:    Translation:Animals
    12. Wang Q, Li D, Bubula N, Campioni MR, McGehee DS, Vezina P. Sensitizing exposure to amphetamine increases AMPA receptor phosphorylation without increasing cell surface expression in the rat nucleus accumbens. Neuropharmacology. 2017 05 01; 117:328-337. PMID: 28223211; PMCID: PMC5396464.
      Citations: 7     Fields:    Translation:AnimalsCells
    13. Singer BF, Bubula N, Przybycien-Szymanska MM, Li D, Vezina P. Stimuli associated with the presence or absence of amphetamine regulate cytoskeletal signaling and behavior. Eur Neuropsychopharmacol. 2016 11; 26(11):1836-1842. PMID: 27720500; PMCID: PMC5159205.
      Citations:    Fields:    Translation:AnimalsCells
    14. Wang Q, Bubula N, Brown J, Wang Y, Kondev V, Vezina P. PKC phosphorylates residues in the N-terminal of the DA transporter to regulate amphetamine-induced DA efflux. Neurosci Lett. 2016 05 27; 622:78-82. PMID: 27113203; PMCID: PMC4870132.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    15. Singer BF, Bubula N, Li D, Przybycien-Szymanska MM, Bindokas VP, Vezina P. Drug-Paired Contextual Stimuli Increase Dendritic Spine Dynamics in Select Nucleus Accumbens Neurons. Neuropsychopharmacology. 2016 07; 41(8):2178-87. PMID: 26979294; PMCID: PMC4908651.
      Citations: 7     Fields:    Translation:AnimalsCells
    16. Hausknecht K, Haj-Dahmane S, Shen YL, Vezina P, Dlugos C, Shen RY. Excitatory synaptic function and plasticity is persistently altered in ventral tegmental area dopamine neurons after prenatal ethanol exposure. Neuropsychopharmacology. 2015 Mar; 40(4):893-905. PMID: 25284318; PMCID: PMC4330503.
      Citations: 20     Fields:    Translation:AnimalsCells
    17. Singer BF, Forneris J, Vezina P. Inhibiting cyclin-dependent kinase 5 in the nucleus accumbens enhances the expression of amphetamine-induced locomotor conditioning. Behav Brain Res. 2014 Dec 15; 275:96-100. PMID: 25196634; PMCID: PMC4253310.
      Citations: 5     Fields:    Translation:Animals
    18. Singer BF, Robinson MJ, Vezina P, Anselme P. Neuronal and psychological underpinnings of pathological gambling. Front Behav Neurosci. 2014; 8:230. PMID: 25071487; PMCID: PMC4076739.
      Citations: 3     
    19. Singer BF, Neugebauer NM, Forneris J, Rodvelt KR, Li D, Bubula N, Vezina P. Locomotor conditioning by amphetamine requires cyclin-dependent kinase 5 signaling in the nucleus accumbens. Neuropharmacology. 2014 Oct; 85:243-52. PMID: 24939858; PMCID: PMC4107072.
      Citations: 5     Fields:    Translation:AnimalsCells
    20. Leyton M, Vezina P. Dopamine ups and downs in vulnerability to addictions: a neurodevelopmental model. Trends Pharmacol Sci. 2014 Jun; 35(6):268-76. PMID: 24794705; PMCID: PMC4041845.
      Citations: 49     Fields:    Translation:Humans
    21. Neugebauer NM, Cortright JJ, Sampedro GR, Vezina P. Exposure to nicotine enhances its subsequent self-administration: contribution of nicotine-associated contextual stimuli. Behav Brain Res. 2014 Mar 01; 260:155-61. PMID: 24295728; PMCID: PMC3935320.
      Citations: 8     Fields:    Translation:Animals
    22. Coccaro EF, Lee R, Vezina P. Cerebrospinal fluid glutamate concentration correlates with impulsive aggression in human subjects. J Psychiatr Res. 2013 Sep; 47(9):1247-53. PMID: 23791397; PMCID: PMC3980459.
      Citations: 21     Fields:    Translation:Humans
    23. Loweth JA, Li D, Cortright JJ, Wilke G, Jeyifous O, Neve RL, Bayer KU, Vezina P. Persistent reversal of enhanced amphetamine intake by transient CaMKII inhibition. J Neurosci. 2013 Jan 23; 33(4):1411-6. PMID: 23345217; PMCID: PMC3710147.
      Citations: 22     Fields:    Translation:AnimalsCells
    24. Baker LK, Mao D, Chi H, Govind AP, Vallejo YF, Iacoviello M, Herrera S, Cortright JJ, Green WN, McGehee DS, Vezina P. Intermittent nicotine exposure upregulates nAChRs in VTA dopamine neurons and sensitises locomotor responding to the drug. Eur J Neurosci. 2013 Mar; 37(6):1004-11. PMID: 23331514; PMCID: PMC3604051.
      Citations: 21     Fields:    Translation:AnimalsCells
    25. Leyton M, Vezina P. Striatal ups and downs: their roles in vulnerability to addictions in humans. Neurosci Biobehav Rev. 2013 Nov; 37(9 Pt A):1999-2014. PMID: 23333263; PMCID: PMC3743927.
      Citations: 58     Fields:    Translation:HumansAnimals
    26. Schneck N, Vezina P. Enhanced dorsolateral striatal activity in drug use: the role of outcome in stimulus-response associations. Behav Brain Res. 2012 Dec 01; 235(2):136-42. PMID: 22884607; PMCID: PMC3448372.
      Citations: 7     Fields:    Translation:HumansAnimals
    27. Leyton M, Vezina P. On cue: striatal ups and downs in addictions. Biol Psychiatry. 2012 Nov 15; 72(10):e21-2. PMID: 22789688; PMCID: PMC3979432.
      Citations: 21     Fields:    Translation:Humans
    28. Cortright JJ, Sampedro GR, Neugebauer NM, Vezina P. Previous exposure to nicotine enhances the incentive motivational effects of amphetamine via nicotine-associated contextual stimuli. Neuropsychopharmacology. 2012 Sep; 37(10):2277-84. PMID: 22617358; PMCID: PMC3422492.
      Citations: 19     Fields:    Translation:Animals
    29. Mitrano DA, Schroeder JP, Smith Y, Cortright JJ, Bubula N, Vezina P, Weinshenker D. a-1 Adrenergic receptors are localized on presynaptic elements in the nucleus accumbens and regulate mesolimbic dopamine transmission. Neuropsychopharmacology. 2012 Aug; 37(9):2161-72. PMID: 22588352; PMCID: PMC3398716.
      Citations: 49     Fields:    Translation:AnimalsCells
    30. Singer BF, Scott-Railton J, Vezina P. Unpredictable saccharin reinforcement enhances locomotor responding to amphetamine. Behav Brain Res. 2012 Jan 01; 226(1):340-4. PMID: 21924296; PMCID: PMC3216637.
      Citations: 25     Fields:    Translation:Animals
    31. Li D, Herrera S, Bubula N, Nikitina E, Palmer AA, Hanck DA, Loweth JA, Vezina P. Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation. J Neurochem. 2011 Jul; 118(2):237-47. PMID: 21564097; PMCID: PMC3129449.
      Citations: 21     Fields:    Translation:AnimalsCells
    32. Chang B, Daniele CA, Gallagher K, Madonia M, Mitchum RD, Barrett L, Vezina P, McGehee DS. Nicotinic excitation of serotonergic projections from dorsal raphe to the nucleus accumbens. J Neurophysiol. 2011 Aug; 106(2):801-8. PMID: 21593391; PMCID: PMC3154831.
      Citations: 16     Fields:    Translation:AnimalsCells
    33. Cortright JJ, Lorrain DS, Beeler JA, Tang WJ, Vezina P. Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine. J Pharmacol Exp Ther. 2011 Jun; 337(3):724-33. PMID: 21389094; PMCID: PMC3101004.
      Citations: 8     Fields:    Translation:Animals
    34. Suto N, Wise RA, Vezina P. Dorsal as well as ventral striatal lesions affect levels of intravenous cocaine and morphine self-administration in rats. Neurosci Lett. 2011 Apr 08; 493(1-2):29-32. PMID: 21315801; PMCID: PMC3065204.
      Citations: 18     Fields:    Translation:Animals
    35. Singer BF, Loweth JA, Neve RL, Vezina P. Transient viral-mediated overexpression of alpha-calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell leads to long-lasting functional upregulation of alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors: dopamine type-1 receptor and protein kinase A dependence. Eur J Neurosci. 2010 Apr; 31(7):1243-51. PMID: 20345911; PMCID: PMC3534927.
      Citations: 9     Fields:    Translation:AnimalsCells
    36. Loweth JA, Singer BF, Baker LK, Wilke G, Inamine H, Bubula N, Alexander JK, Carlezon WA, Neve RL, Vezina P. Transient overexpression of alpha-Ca2+/calmodulin-dependent protein kinase II in the nucleus accumbens shell enhances behavioral responding to amphetamine. J Neurosci. 2010 Jan 20; 30(3):939-49. PMID: 20089902; PMCID: PMC2825054.
      Citations: 39     Fields:    Translation:Animals
    37. Govind AP, Vezina P, Green WN. Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction. Biochem Pharmacol. 2009 Oct 01; 78(7):756-65. PMID: 19540212; PMCID: PMC2728164.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    38. Loweth JA, Svoboda R, Austin JD, Guillory AM, Vezina P. The PKC inhibitor Ro31-8220 blocks acute amphetamine-induced dopamine overflow in the nucleus accumbens. Neurosci Lett. 2009 May 15; 455(2):88-92. PMID: 19368852; PMCID: PMC2688659.
      Citations: 13     Fields:    Translation:Animals
    39. Singer BF, Tanabe LM, Gorny G, Jake-Matthews C, Li Y, Kolb B, Vezina P. Amphetamine-induced changes in dendritic morphology in rat forebrain correspond to associative drug conditioning rather than nonassociative drug sensitization. Biol Psychiatry. 2009 May 15; 65(10):835-40. PMID: 19200535; PMCID: PMC2743186.
      Citations: 31     Fields:    Translation:AnimalsCells
    40. Bryant CD, Graham ME, Distler MG, Munoz MB, Li D, Vezina P, Sokoloff G, Palmer AA. A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine. Psychopharmacology (Berl). 2009 May; 203(4):703-11. PMID: 19050854; PMCID: PMC2729782.
      Citations: 29     Fields:    Translation:AnimalsCells
    41. Loweth JA, Baker LK, Guptaa T, Guillory AM, Vezina P. Inhibition of CaMKII in the nucleus accumbens shell decreases enhanced amphetamine intake in sensitized rats. Neurosci Lett. 2008 Oct 24; 444(2):157-60. PMID: 18694805; PMCID: PMC2703195.
      Citations: 22     Fields:    Translation:Animals
    42. Vezina P, Leyton M. Conditioned cues and the expression of stimulant sensitization in animals and humans. Neuropharmacology. 2009; 56 Suppl 1:160-8. PMID: 18657553; PMCID: PMC2635339.
      Citations: 74     Fields:    Translation:HumansAnimals
    43. Kim WY, Vezina P, Kim JH. Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment. Behav Brain Res. 2008 Aug 05; 191(1):62-6. PMID: 18433894.
      Citations: 4     Fields:    Translation:Animals
    44. Vezina P, McGehee DS, Green WN. Exposure to nicotine and sensitization of nicotine-induced behaviors. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Nov 15; 31(8):1625-38. PMID: 17936462; PMCID: PMC2139894.
      Citations: 59     Fields:    Translation:HumansAnimals
    45. Vezina P. Sensitization, drug addiction and psychopathology in animals and humans. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Nov 15; 31(8):1553-5. PMID: 17900776; PMCID: PMC2099252.
      Citations: 23     Fields:    Translation:HumansAnimals
    46. Fagen ZM, Mitchum R, Vezina P, McGehee DS. Enhanced nicotinic receptor function and drug abuse vulnerability. J Neurosci. 2007 Aug 15; 27(33):8771-8. PMID: 17699659; PMCID: PMC6672186.
      Citations: 20     Fields:    Translation:AnimalsCells
    47. Zernig G, Ahmed SH, Cardinal RN, Morgan D, Acquas E, Foltin RW, Vezina P, Negus SS, Crespo JA, Grubinger P, Madlung E, Haring C, Kurz M, Saria A, Stöckl P. Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests. Pharmacology. 2007; 80(2-3):65-119. PMID: 17570954.
      Citations: 77     Fields:    Translation:HumansAnimals
    48. Alexander JJ, Jacob A, Vezina P, Sekine H, Gilkeson GS, Quigg RJ. Absence of functional alternative complement pathway alleviates lupus cerebritis. Eur J Immunol. 2007 Jun; 37(6):1691-701. PMID: 17523212.
      Citations: 27     Fields:    Translation:AnimalsCells
    49. Scott-Railton J, Arnold G, Vezina P. Appetitive sensitization by amphetamine does not reduce its ability to produce conditioned taste aversion to saccharin. Behav Brain Res. 2006 Dec 15; 175(2):305-14. PMID: 17023060; PMCID: PMC2016791.
      Citations: 1     Fields:    Translation:Animals
    50. Chi H, Jang JK, Kim JH, Vezina P. Blockade of group II metabotropic glutamate receptors in the nucleus accumbens produces hyperlocomotion in rats previously exposed to amphetamine. Neuropharmacology. 2006 Oct; 51(5):986-92. PMID: 16901517.
      Citations: 4     Fields:    Translation:Animals
    51. Koeltzow TE, Vezina P. Locomotor activity and cocaine-seeking behavior during acquisition and reinstatement of operant self-administration behavior in rats. Behav Brain Res. 2005 May 28; 160(2):250-9. PMID: 15863221.
      Citations: 9     Fields:    Translation:Animals
    52. Kim JH, Austin JD, Tanabe L, Creekmore E, Vezina P. Activation of group II mGlu receptors blocks the enhanced drug taking induced by previous exposure to amphetamine. Eur J Neurosci. 2005 Jan; 21(1):295-300. PMID: 15654869.
      Citations: 40     Fields:    Translation:Animals
    53. Suto N, Tanabe LM, Austin JD, Creekmore E, Pham CT, Vezina P. Previous exposure to psychostimulants enhances the reinstatement of cocaine seeking by nucleus accumbens AMPA. Neuropsychopharmacology. 2004 Dec; 29(12):2149-59. PMID: 15266353.
      Citations: 68     Fields:    Translation:Animals
    54. Tanabe LM, Suto N, Creekmore E, Steinmiller CL, Vezina P. Blockade of D2 dopamine receptors in the VTA induces a long-lasting enhancement of the locomotor activating effects of amphetamine. Behav Pharmacol. 2004 Sep; 15(5-6):387-95. PMID: 15343065.
      Citations: 10     Fields:    Translation:Animals
    55. Vezina P. Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs. Neurosci Biobehav Rev. 2004 Jan; 27(8):827-39. PMID: 15019432.
      Citations: 217     Fields:    Translation:AnimalsCells
    56. Kim JH, Creekmore E, Vezina P. Microinjection of CART peptide 55-102 into the nucleus accumbens blocks amphetamine-induced locomotion. Neuropeptides. 2003 Dec; 37(6):369-73. PMID: 14698680.
      Citations: 28     Fields:    Translation:Animals
    57. Suto N, Tanabe LM, Austin JD, Creekmore E, Vezina P. Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in an NMDA, AMPA/kainate, and metabotropic glutamate receptor-dependent manner. Neuropsychopharmacology. 2003 Apr; 28(4):629-39. PMID: 12655307.
      Citations: 27     Fields:    Translation:Animals
    58. Koeltzow TE, Austin JD, Vezina P. Behavioral sensitization to quinpirole is not associated with increased nucleus accumbens dopamine overflow. Neuropharmacology. 2003 Jan; 44(1):102-10. PMID: 12559127.
      Citations: 11     Fields:    Translation:AnimalsCells
    59. Suto N, Austin JD, Tanabe LM, Kramer MK, Wright DA, Vezina P, Suto N, Austin JD, Tanabe LM, Kramer MK, Wright DA, Vezina P. Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in a D1 dopamine receptor dependent manner. Neuropsychopharmacology. 2002 Dec; 27(6):970-9. PMID: 12464454.
      Citations: 33     Fields:    Translation:Animals
    60. Kim JH, Vezina P. The mGlu2/3 receptor agonist LY379268 blocks the expression of locomotor sensitization by amphetamine. Pharmacol Biochem Behav. 2002 Sep; 73(2):333-7. PMID: 12117587.
      Citations: 22     Fields:    Translation:Animals
    61. Hu XT, Koeltzow TE, Cooper DC, Robertson GS, White FJ, Vezina P. Repeated ventral tegmental area amphetamine administration alters dopamine D1 receptor signaling in the nucleus accumbens. Synapse. 2002 Sep 01; 45(3):159-70. PMID: 12112395.
      Citations: 15     Fields:    Translation:AnimalsCells
    62. Vezina P, Lorrain DS, Arnold GM, Austin JD, Suto N. Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine. J Neurosci. 2002 Jun 01; 22(11):4654-62. PMID: 12040071; PMCID: PMC6758806.
      Citations: 86     Fields:    Translation:AnimalsCells
    63. Suto N, Austin JD, Vezina P. Locomotor response to novelty predicts a rat's propensity to self-administer nicotine. Psychopharmacology (Berl). 2001 Nov; 158(2):175-80. PMID: 11702091.
      Citations: 49     Fields:    Translation:Animals
    64. Kim JH, Perugini M, Austin JD, Vezina P. Previous exposure to amphetamine enhances the subsequent locomotor response to a D1 dopamine receptor agonist when glutamate reuptake is inhibited. J Neurosci. 2001 Mar 01; 21(5):RC133. PMID: 11222671; PMCID: PMC6762943.
      Citations: 5     Fields:    Translation:Animals
    65. Vezina P, Queen AL. Induction of locomotor sensitization by amphetamine requires the activation of NMDA receptors in the rat ventral tegmental area. Psychopharmacology (Berl). 2000 Aug; 151(2-3):184-91. PMID: 10972464.
      Citations: 38     Fields:    Translation:Animals
    66. Kim JH, Beeler JA, Vezina P. Group II, but not group I, metabotropic glutamate receptors in the rat nucleus accumbens contribute to amphetamine-induced locomotion. Neuropharmacology. 2000 Jul 24; 39(10):1692-9. PMID: 10884551.
      Citations: 5     Fields:    Translation:Animals
    67. Lorrain DS, Arnold GM, Vezina P. Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule. Behav Brain Res. 2000 Jan; 107(1-2):9-19. PMID: 10628726.
      Citations: 51     Fields:    Translation:Animals
    68. Vezina P, Pierre PJ, Lorrain DS. The effect of previous exposure to amphetamine on drug-induced locomotion and self-administration of a low dose of the drug. Psychopharmacology (Berl). 1999 Nov; 147(2):125-34. PMID: 10591879.
      Citations: 21     Fields:    Translation:Animals
    69. Lorrain DS, Arnold GM, Vezina P. Mesoaccumbens dopamine and the self-administration of amphetamine. Ann N Y Acad Sci. 1999 Jun 29; 877:820-2. PMID: 10415712.
      Citations: 2     Fields:    Translation:Animals
    70. Vezina P, Kim JH. Metabotropic glutamate receptors and the generation of locomotor activity: interactions with midbrain dopamine. Neurosci Biobehav Rev. 1999 Mar; 23(4):577-89. PMID: 10073895.
      Citations: 23     Fields:    Translation:HumansAnimals
    71. Kim JH, Vezina P. Blockade of glutamate reuptake in the rat nucleus accumbens increases locomotor activity. Brain Res. 1999 Feb 20; 819(1-2):165-9. PMID: 10082874.
      Citations: 2     Fields:    Translation:Animals
    72. Meeker D, Kim JH, Vezina P. Depletion of dopamine in the nucleus accumbens prevents the generation of locomotion by metabotropic glutamate receptor activation. Brain Res. 1998 Nov 23; 812(1-2):260-4. PMID: 9813358.
      Citations: 4     Fields:    Translation:Animals
    73. Pierre PJ, Vezina P. D1 dopamine receptor blockade prevents the facilitation of amphetamine self-administration induced by prior exposure to the drug. Psychopharmacology (Berl). 1998 Jul; 138(2):159-66. PMID: 9718285.
      Citations: 15     Fields:    Translation:Animals
    74. Kim JH, Vezina P. Metabotropic glutamate receptors are necessary for sensitization by amphetamine. Neuroreport. 1998 Feb 16; 9(3):403-6. PMID: 9512379.
      Citations: 8     Fields:    Translation:Animals
    75. Kim JH, Vezina P. Metabotropic glutamate receptors in the rat nucleus accumbens contribute to amphetamine-induced locomotion. J Pharmacol Exp Ther. 1998 Jan; 284(1):317-22. PMID: 9435194.
      Citations: 7     Fields:    Translation:Animals
    76. Kim JH, Vezina P. The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats. Neuropharmacology. 1998; 37(2):189-97. PMID: 9680243.
      Citations: 1     Fields:    Translation:Animals
    77. Kim JH, Vezina P. Activation of metabotropic glutamate receptors in the rat nucleus accumbens increases locomotor activity in a dopamine-dependent manner. J Pharmacol Exp Ther. 1997 Nov; 283(2):962-8. PMID: 9353420.
      Citations: 5     Fields:    Translation:Animals
    78. Balcells-Olivero M, Vezina P. Effects of naltrexone on amphetamine-induced locomotion and rearing: acute and repeated injections. Psychopharmacology (Berl). 1997 Jun; 131(3):230-8. PMID: 9203233.
      Citations: 9     Fields:    Translation:Animals
    79. Pierre PJ, Vezina P. Predisposition to self-administer amphetamine: the contribution of response to novelty and prior exposure to the drug. Psychopharmacology (Berl). 1997 Feb; 129(3):277-84. PMID: 9084067.
      Citations: 72     Fields:    Translation:Animals
    80. Jolly D, Vezina P. In vivo microdialysis in the rat: low cost and low labor construction of a small diameter, removable, concentric-style microdialysis probe system. J Neurosci Methods. 1996 Oct; 68(2):259-67. PMID: 8912199.
      Citations: 6     Fields:    Translation:Animals
    81. Vezina P. D1 dopamine receptor activation is necessary for the induction of sensitization by amphetamine in the ventral tegmental area. J Neurosci. 1996 Apr 01; 16(7):2411-20. PMID: 8601820; PMCID: PMC6578541.
      Citations: 73     Fields:    Translation:AnimalsCells
    82. Perugini M, Vezina P. Amphetamine administered to the ventral tegmental area sensitizes rats to the locomotor effects of nucleus accumbens amphetamine. J Pharmacol Exp Ther. 1994 Aug; 270(2):690-6. PMID: 8071860.
      Citations: 28     Fields:    Translation:Animals
    83. Blanc G, Trovero F, Vezina P, Godeheu AM, Glowinski J, Tassin JP, Hervé D. Blockade of prefronto-cortical alpha 1-adrenergic receptors prevents locomotor hyperactivity induced by subcortical D-amphetamine injection. Eur J Neurosci. 1994 Mar 01; 6(3):293-8. PMID: 7912614.
      Citations: 50     Fields:    Translation:Animals
    84. Glowinski J, Tassin JP, Vezina P, Hervé D. Injections of 6-hydroxydopamine into the ventral tegmental area destroy mesolimbic dopamine neurons but spare the locomotor activating effects of nicotine in the rat. Neurosci Lett. 1994 Feb 28; 168(1-2):111-4. PMID: 8028761.
      Citations: 1     Fields:    Translation:AnimalsCells
    85. Blanc G, Glowinski J, Tassin JP, Vezina P. Blockade of D-1 dopamine receptors in the medial prefrontal cortex produces delayed effects on pre- and postsynaptic indices of dopamine function in the nucleus accumbens. Synapse. 1994 Feb; 16(2):104-12. PMID: 8197574.
      Citations: 4     Fields:    Translation:AnimalsCells
    86. Vezina P. Amphetamine injected into the ventral tegmental area sensitizes the nucleus accumbens dopaminergic response to systemic amphetamine: an in vivo microdialysis study in the rat. Brain Res. 1993 Mar 12; 605(2):332-7. PMID: 8386970.
      Citations: 41     Fields:    Translation:AnimalsCells
    87. Tassin JP, Vezina P, Trovero F, Blanc G, Glowinski J, Hervé D. Cortico-subcortical interactions in behavioral sensitization: differential effects of daily nicotine and morphine. Ann N Y Acad Sci. 1992 Jun 28; 654:101-16. PMID: 1632576.
      Citations: 1     Fields:    Translation:AnimalsCells
    88. Blanc G, Glowinski J, Tassin JP, Vezina P. Nicotine and morphine differentially activate brain dopamine in prefrontocortical and subcortical terminal fields: effects of acute and repeated injections. J Pharmacol Exp Ther. 1992 May; 261(2):484-90. PMID: 1578364.
      Citations: 15     Fields:    Translation:Animals
    89. Vezina P, Mohr E, Grimes D. Deprenyl in Parkinson's disease: mechanisms, neuroprotective effect, indications and adverse effects. Can J Neurol Sci. 1992 Feb; 19(1 Suppl):142-6. PMID: 1571860.
      Citations: 10     Fields:    Translation:HumansCells
    90. Stewart J, Vezina P. Extinction procedures abolish conditioned stimulus control but spare sensitized responding to amphetamine. Behav Pharmacol. 1991 Feb; 2(1):65-71. PMID: 11224049.
      Citations: 38     Fields:    
    91. Blanc G, Glowinski J, Tassin JP, Vezina P. Opposed Behavioural Outputs of Increased Dopamine Transmission in Prefrontocortical and Subcortical Areas: A Role for the Cortical D-1 Dopamine Receptor. Eur J Neurosci. 1991; 3(10):1001-1007. PMID: 12106258.
      Citations: 29     Fields:    
    92. Trovero F, Blanc G, Vezina P, Glowinski J, Tassin JP, Hervé D. Involvement of dopamine neurons in the regulation of beta-adrenergic receptor sensitivity in rat prefrontal cortex. J Neurochem. 1990 Jun; 54(6):1864-9. PMID: 2159976.
      Citations:    Fields:    Translation:AnimalsCells
    93. Stewart J, Vezina P. Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditioned effects. Brain Res. 1990 May 14; 516(1):99-106. PMID: 2364286.
      Citations: 49     Fields:    Translation:Animals
    94. Vezina P, Stewart J. The effect of dopamine receptor blockade on the development of sensitization to the locomotor activating effects of amphetamine and morphine. Brain Res. 1989 Oct 09; 499(1):108-20. PMID: 2679971.
      Citations: 50     Fields:    Translation:Animals
    95. Stewart J, Vezina P. Microinjections of Sch-23390 into the ventral tegmental area and substantia nigra pars reticulata attenuate the development of sensitization to the locomotor activating effects of systemic amphetamine. Brain Res. 1989 Aug 28; 495(2):401-6. PMID: 2670065.
      Citations: 30     Fields:    Translation:Animals
    96. Vezina P, Giovino AA, Wise RA, Stewart J. Environment-specific cross-sensitization between the locomotor activating effects of morphine and amphetamine. Pharmacol Biochem Behav. 1989 Feb; 32(2):581-4. PMID: 2727020.
      Citations: 26     Fields:    Translation:Animals
    97. Stewart J, Vezina P. A comparison of the effects of intra-accumbens injections of amphetamine and morphine on reinstatement of heroin intravenous self-administration behavior. Brain Res. 1988 Aug 09; 457(2):287-94. PMID: 3219557.
      Citations: 27     Fields:    Translation:Animals
    98. Vezina P, Kalivas PW, Stewart J. Sensitization occurs to the locomotor effects of morphine and the specific mu opioid receptor agonist, DAGO, administered repeatedly to the ventral tegmental area but not to the nucleus accumbens. Brain Res. 1987 Aug 04; 417(1):51-8. PMID: 3040185.
      Citations: 25     Fields:    Translation:Animals
    99. Vezina P, Stewart J. Conditioned locomotion and place preference elicited by tactile cues paired exclusively with morphine in an open field. Psychopharmacology (Berl). 1987; 91(3):375-80. PMID: 3104962.
      Citations: 28     Fields:    Translation:Animals
    100. Vezina P, Stewart J. Morphine conditioned place preference and locomotion: the effect of confinement during training. Psychopharmacology (Berl). 1987; 93(2):257-60. PMID: 3122259.
      Citations: 24     Fields:    Translation:Animals
    101. Vezina P, Stewart J. Hyperthermia induced by morphine administration to the VTA of the rat brain: an effect dissociable from morphine-induced reward and hyperactivity. Life Sci. 1985 Mar 18; 36(11):1095-105. PMID: 2983167.
      Citations: 1     Fields:    Translation:Animals
    102. Vezina P, Stewart J. Conditioning and place-specific sensitization of increases in activity induced by morphine in the VTA. Pharmacol Biochem Behav. 1984 Jun; 20(6):925-34. PMID: 6463076.
      Citations: 39     Fields:    Translation:Animals
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