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Jeff A. Beeler

Title
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    R15DA052871     (BEELER, JEFF A.)Jul 15, 2021 - Jun 30, 2024
    NIH
    Visualizing obesity-induced changes in dopamine reinforcement
    Role: Principal Investigator
    R15DA046058     (BEELER, JEFF A.)Mar 1, 2018 - Feb 28, 2021
    NIH
    Dissecting contributions of different D2R populations to activity and appetite
    Role: Principal Investigator
    R21NS083578     (BEELER, JEFF A.)May 15, 2014 - Apr 30, 2017
    NIH
    Assessing aberrant motor learning in Parkinson's patients
    Role: Principal Investigator
    R01DA025875     (BEELER, JEFF A.)Sep 19, 2008 - May 31, 2013
    NIH
    Pharmacological Targets Facilitating Non-Drug Reward & Extinction of Drug-Seeking
    Role: Principal Investigator
    F32DA020427     (BEELER, JEFF A.)Nov 1, 2005 - Oct 31, 2007
    NIH
    Genetic Manipulation of Phasic Dopaminergic Activity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Meyers AM, Gnazzo FG, Barrera ED, Nabatian T, Chan L, Beeler JA. Dietary regulation of silent synapses in the dorsolateral striatum. Neuroscience. 2024 Dec 17; 563:43-50. PMID: 39510440; PMCID: PMC11616716.
      Citations:    Fields:    Translation:AnimalsCells
    2. Meyers AM, Gnazzo F, Barrera ED, Nabatian T, Chan L, Beeler J, Meyers AM, Gnazzo FG, Barrera ED, Nabatian T, Chan L, Beeler JA, Meyers AM, Gnazzo FG, Barrera ED, Nabatian T, Chan L, Beeler JA. DIETARY REGULATION OF SILENT SYNAPSES IN THE DORSOLATERAL STRIATUM. bioRxiv. 2024 Oct 01. PMID: 38585967; PMCID: PMC10996560.
      Citations:    
    3. Wen K, Shi Z, Yu P, Mo L, Sullere S, Yang V, Westneat N, Beeler JA, McGehee DS, Doiron B, Zhuang X. Opposing Motor Memories in the Direct and Indirect Pathways of the Basal Ganglia. bioRxiv. 2024 Feb 28. PMID: 38463990; PMCID: PMC10925233.
      Citations:    
    4. Beeler JA, Burghardt NS. The Rise and Fall of Dopamine: A Two-Stage Model of the Development and Entrenchment of Anorexia Nervosa. Front Psychiatry. 2021; 12:799548. PMID: 35087433; PMCID: PMC8787068.
      Citations: 4     
    5. Gnazzo FG, Mourra D, Guevara CA, Beeler JA. Chronic food restriction enhances dopamine-mediated intracranial self-stimulation. Neuroreport. 2021 09 08; 32(13):1128-1133. PMID: 34284450; PMCID: PMC8373704.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Beeler JA, Burghardt NS. Activity-based Anorexia for Modeling Vulnerability and Resilience in Mice. Bio Protoc. 2021 May 05; 11(9):e4009. PMID: 34124309; PMCID: PMC8161139.
      Citations: 7     
    7. Beeler JA, Burghardt NS. Commentary on Vulnerability and Resilience to Activity-Based Anorexia and the Role of Dopamine. J Exp Neurol. 2021 Mar; 2(1):21-28. PMID: 33768216; PMCID: PMC7990270.
      Citations: 4     
    8. Beeler JA, Mourra D, Zanca RM, Kalmbach A, Gellman C, Klein BY, Ravenelle R, Serrano P, Moore H, Rayport S, Mingote S, Burghardt NS. Vulnerable and Resilient Phenotypes in a Mouse Model of Anorexia Nervosa. Biol Psychiatry. 2021 12 15; 90(12):829-842. PMID: 32950210; PMCID: PMC7855473.
      Citations: 21     Fields:    Translation:Animals
    9. Mourra D, Gnazzo F, Cobos S, Beeler JA. Striatal Dopamine D2 Receptors Regulate Cost Sensitivity and Behavioral Thrift. Neuroscience. 2020 01 15; 425:134-145. PMID: 31809732; PMCID: PMC7228462.
      Citations: 4     Fields:    Translation:Animals
    10. Beeler JA, Kisbye Dreyer J. Synchronicity: The Role of Midbrain Dopamine in Whole-Brain Coordination. eNeuro. 2019 Mar/Apr; 6(2). PMID: 31053604; PMCID: PMC6500793.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    11. Beeler JA, Mourra D. To Do or Not to Do: Dopamine, Affordability and the Economics of Opportunity. Front Integr Neurosci. 2018; 12:6. PMID: 29487508; PMCID: PMC5816947.
      Citations: 10     
    12. Meyers AM, Mourra D, Beeler JA. High fructose corn syrup induces metabolic dysregulation and altered dopamine signaling in the absence of obesity. PLoS One. 2017; 12(12):e0190206. PMID: 29287121; PMCID: PMC5747444.
      Citations: 14     Fields:    Translation:AnimalsCells
    13. Xia J, Meyers AM, Beeler JA. Chronic Nicotine Alters Corticostriatal Plasticity in the Striatopallidal Pathway Mediated By NR2B-Containing Silent Synapses. Neuropsychopharmacology. 2017 Nov; 42(12):2314-2324. PMID: 28462940; PMCID: PMC5645753.
      Citations: 14     Fields:    Translation:AnimalsCells
    14. Jakowec MW, Wang Z, Holschneider D, Beeler J, Petzinger GM. Engaging cognitive circuits to promote motor recovery in degenerative disorders. exercise as a learning modality. J Hum Kinet. 2016 Sep 01; 52:35-51. PMID: 28149392; PMCID: PMC5260516.
      Citations: 4     
    15. Koranda JL, Krok AC, Xu J, Contractor A, McGehee DS, Beeler JA, Zhuang X. Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency. J Neurosci. 2016 05 11; 36(19):5228-40. PMID: 27170121; PMCID: PMC4863059.
      Citations: 5     Fields:    Translation:AnimalsCells
    16. Beeler JA, Faust RP, Turkson S, Ye H, Zhuang X. Low Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation. Biol Psychiatry. 2016 06 01; 79(11):887-97. PMID: 26281715; PMCID: PMC4728060.
      Citations: 33     Fields:    Translation:Animals
    17. Petzinger GM, Holschneider DP, Fisher BE, McEwen S, Kintz N, Halliday M, Toy W, Walsh JW, Beeler J, Jakowec MW. The Effects of Exercise on Dopamine Neurotransmission in Parkinson's Disease: Targeting Neuroplasticity to Modulate Basal Ganglia Circuitry. Brain Plast. 2015; 1(1):29-39. PMID: 26512345; PMCID: PMC4621077.
      Citations: 50     
    18. Augustin SM, Beeler JA, McGehee DS, Zhuang X. Cyclic AMP and afferent activity govern bidirectional synaptic plasticity in striatopallidal neurons. J Neurosci. 2014 May 07; 34(19):6692-9. PMID: 24806695; PMCID: PMC4012319.
      Citations: 19     Fields:    Translation:AnimalsCells
    19. Beeler JA, Cools R, Luciana M, Ostlund SB, Petzinger G. A kinder, gentler dopamine… highlighting dopamine's role in behavioral flexibility. Front Neurosci. 2014; 8:4. PMID: 24478624; PMCID: PMC3901300.
      Citations: 12     
    20. Koranda JL, Cone JJ, McGehee DS, Roitman MF, Beeler JA, Zhuang X. Nicotinic receptors regulate the dynamic range of dopamine release in vivo. J Neurophysiol. 2014 Jan; 111(1):103-11. PMID: 24089398; PMCID: PMC3921376.
      Citations: 26     Fields:    Translation:Animals
    21. Beeler JA, Petzinger G, Jakowec MW. The Enemy within: Propagation of Aberrant Corticostriatal Learning to Cortical Function in Parkinson's Disease. Front Neurol. 2013; 4:134. PMID: 24062721; PMCID: PMC3770942.
      Citations: 16     
    22. Petzinger GM, Fisher BE, McEwen S, Beeler JA, Walsh JP, Jakowec MW. Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease. Lancet Neurol. 2013 Jul; 12(7):716-26. PMID: 23769598; PMCID: PMC3690528.
      Citations: 269     Fields:    Translation:HumansAnimalsCells
    23. Beeler JA, Frank MJ, McDaid J, Alexander E, Turkson S, Bernardez Sarria MS, Bernandez MS, McGehee DS, Zhuang X. A role for dopamine-mediated learning in the pathophysiology and treatment of Parkinson's disease. Cell Rep. 2012 Dec 27; 2(6):1747-61. PMID: 23246005; PMCID: PMC3538862.
      Citations: 41     Fields:    Translation:AnimalsCells
    24. Beeler JA. Thorndike's Law 2.0: Dopamine and the Regulation of Thrift. Front Neurosci. 2012; 6:116. PMID: 22905023; PMCID: PMC3415691.
      Citations: 12     
    25. Beeler JA, Frazier CR, Zhuang X. Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources. Front Integr Neurosci. 2012; 6:49. PMID: 22833718; PMCID: PMC3400936.
      Citations: 57     
    26. Beeler JA, McCutcheon JE, Cao ZF, Murakami M, Alexander E, Roitman MF, Zhuang X. Taste uncoupled from nutrition fails to sustain the reinforcing properties of food. Eur J Neurosci. 2012 Aug; 36(4):2533-46. PMID: 22712685; PMCID: PMC3424366.
      Citations: 41     Translation:AnimalsPHPublic Health
    27. McCutcheon JE, Beeler JA, Roitman MF. Sucrose-predictive cues evoke greater phasic dopamine release than saccharin-predictive cues. Synapse. 2012 Apr; 66(4):346-51. PMID: 22170625; PMCID: PMC3269555.
      Citations: 43     Fields:    Translation:Animals
    28. Beeler JA, Frazier CR, Zhuang X. Dopaminergic enhancement of local food-seeking is under global homeostatic control. Eur J Neurosci. 2012 Jan; 35(1):146-59. PMID: 22118191; PMCID: PMC3251719.
      Citations: 14     Translation:HumansAnimals
    29. Beeler JA. Preservation of function in Parkinson's disease: what's learning got to do with it? Brain Res. 2011 Nov 14; 1423:96-113. PMID: 22000081; PMCID: PMC3205345.
      Citations: 16     Fields:    Translation:HumansAnimals
    30. Cortright JJ, Lorrain DS, Beeler JA, Tang WJ, Vezina P. Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine. J Pharmacol Exp Ther. 2011 Jun; 337(3):724-33. PMID: 21389094; PMCID: PMC3101004.
      Citations: 8     Fields:    Translation:Animals
    31. Beeler JA, Daw N, Frazier CR, Zhuang X. Tonic dopamine modulates exploitation of reward learning. Front Behav Neurosci. 2010; 4:170. PMID: 21120145; PMCID: PMC2991243.
      Citations: 79     
    32. Beeler JA, Cao ZF, Kheirbek MA, Ding Y, Koranda J, Murakami M, Kang UJ, Zhuang X. Dopamine-dependent motor learning: insight into levodopa's long-duration response. Ann Neurol. 2010 May; 67(5):639-47. PMID: 20437561; PMCID: PMC3129617.
      Citations: 47     Fields:    Translation:Animals
    33. Kheirbek MA, Beeler JA, Chi W, Ishikawa Y, Zhuang X. A molecular dissociation between cued and contextual appetitive learning. Learn Mem. 2010 Mar; 17(3):148-54. PMID: 20189959; PMCID: PMC2832921.
      Citations: 5     Fields:    Translation:Animals
    34. Kheirbek MA, Britt JP, Beeler JA, Ishikawa Y, McGehee DS, Zhuang X. Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning. J Neurosci. 2009 Sep 30; 29(39):12115-24. PMID: 19793969; PMCID: PMC2782774.
      Citations: 52     Fields:    Translation:Animals
    35. Kheirbek MA, Beeler JA, Ishikawa Y, Zhuang X. A cAMP pathway underlying reward prediction in associative learning. J Neurosci. 2008 Oct 29; 28(44):11401-8. PMID: 18971482; PMCID: PMC2610269.
      Citations: 18     Fields:    Translation:AnimalsCells
    36. Frazier CR, Mason P, Zhuang X, Beeler JA. Sucrose exposure in early life alters adult motivation and weight gain. PLoS One. 2008 Sep 17; 3(9):e3221. PMID: 18797507; PMCID: PMC2529404.
      Citations: 21     Fields:    Translation:Animals
    37. Beeler JA, Cao ZF, Kheirbek MA, Zhuang X. Loss of cocaine locomotor response in Pitx3-deficient mice lacking a nigrostriatal pathway. Neuropsychopharmacology. 2009 Apr; 34(5):1149-61. PMID: 18704092; PMCID: PMC2752723.
      Citations: 19     Fields:    Translation:AnimalsCells
    38. Beeler J. Should I stay or should I go? Neural substrates of being in the right place at the right time. Focus on "How prior reward experience biases exploratory movements: a probabilistic model". J Neurophysiol. 2007 Mar; 97(3):1878-9. PMID: 17215496.
      Citations:    Fields:    Translation:HumansAnimals
    39. Cagniard B, Beeler JA, Britt JP, McGehee DS, Marinelli M, Zhuang X. Dopamine scales performance in the absence of new learning. Neuron. 2006 Sep 07; 51(5):541-7. PMID: 16950153.
      Citations: 74     Fields:    Translation:AnimalsCells
    40. Beeler JA, Prendergast B, Zhuang X. Low amplitude entrainment of mice and the impact of circadian phase on behavior tests. Physiol Behav. 2006 May 30; 87(5):870-80. PMID: 16600314.
      Citations: 32     Fields:    Translation:Animals
    41. Hong J, Beeler J, Zhukovskaya NL, He W, Tang WJ, Rosner MR. Anthrax edema factor potency depends on mode of cell entry. Biochem Biophys Res Commun. 2005 Sep 30; 335(3):850-7. PMID: 16099427.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    42. Beeler JA, Yan SZ, Bykov S, Murza A, Asher S, Tang WJ. A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. Biochemistry. 2004 Dec 14; 43(49):15463-71. PMID: 15581358.
      Citations: 4     Fields:    Translation:HumansCells
    43. Beeler JA, Tang WJ. Expression and purification of soluble adenylyl cyclase from Escherichia coli. Methods Mol Biol. 2004; 237:39-53. PMID: 14501037.
      Citations: 1     Fields:    Translation:Cells
    44. Yan SZ, Beeler JA, Chen Y, Shelton RK, Tang WJ. The regulation of type 7 adenylyl cyclase by its C1b region and Escherichia coli peptidylprolyl isomerase, SlyD. J Biol Chem. 2001 Mar 16; 276(11):8500-6. PMID: 11113152.
      Citations: 16     Fields:    Translation:HumansCells
    45. Kim JH, Beeler JA, Vezina P. Group II, but not group I, metabotropic glutamate receptors in the rat nucleus accumbens contribute to amphetamine-induced locomotion. Neuropharmacology. 2000 Jul 24; 39(10):1692-9. PMID: 10884551.
      Citations: 5     Fields:    Translation:Animals
    46. Beeler J, DiProva V. Family adjustment following disclosure of homosexuality by a member: themes discerned in narrative accounts. J Marital Fam Ther. 1999 Oct; 25(4):443-59. PMID: 10553559.
      Citations: 10     Fields:    Translation:Humans
    47. Beeler J, Rosenthal A, Cohler B. Patterns of family caregiving and support provided to older psychiatric patients in long-term care. Psychiatr Serv. 1999 Sep; 50(9):1222-4. PMID: 10478912.
      Citations: 2     Fields:    Translation:Humans
    48. Mahadevan D, Thanki N, Aroca P, McPhie P, Yu JC, Beeler J, Santos E, Wlodawer A, Heidaran MA. A divalent metal ion binding site in the kinase insert domain of the alpha-platelet-derived growth factor receptor regulates its association with SH2 domains. Biochemistry. 1995 Feb 21; 34(7):2095-106. PMID: 7857921.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
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