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Last Name
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SARA SZUCHET

TitleProfessor
InstitutionUniversity of Chicago
DepartmentNeurology
AddressChicago IL 60637
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    Other Positions
    TitlePROFESSOR
    InstitutionUniversity of Chicago
    DepartmentBiological Sciences Collegiate Division


    Collapse Overview 
    Collapse overview
    Research Objectives
    The biology of oligodendrocytes and their myelinating and non-myelinating phenotypes
    The molecular mechanism of myelin sheath formation
    Oligodendrocyte-neuron signaling in patterning the myelinated axon
    The etiology and pathogenesis of multiple sclerosis


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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Szuchet S, Nielsen LL, Domowicz MS, Austin JR, Arvanitis DL. CNS myelin sheath is stochastically built by homotypic fusion of myelin membranes within the bounds of an oligodendrocyte process. J Struct Biol. 2015 Apr; 190(1):56-72. PMID: 25682762.
      View in: PubMed
    2. Szuchet S, Nielsen JA, Lovas G, Domowicz MS, de Velasco JM, Maric D, Hudson LD. The genetic signature of perineuronal oligodendrocytes reveals their unique phenotype. Eur J Neurosci. 2011 Dec; 34(12):1906-22. PMID: 22132705.
      View in: PubMed
    3. Szuchet S, Plachetzki DC, Seeger MA, Domowicz MS, Szele FG. NOVOcan: a molecular link among selected glial cells. Biophys Chem. 2004 Mar 01; 108(1-3):245-58. PMID: 15043933.
      View in: PubMed
    4. Szuchet S, Plachetzki DC, Karialukas R. Oligodendrocytes express an alpha/beta-interferon-susceptible Mx gene: molecular characterization of the encoded protein. Glia. 2002 Feb; 37(2):183-9. PMID: 11754216.
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    5. Szuchet S, Plachetzki DC, Eaton KS. Oligodendrocyte transmembrane protein: a novel member of the glutamate-binding protein subfamily. Biochem Biophys Res Commun. 2001 May 18; 283(4):900-7. PMID: 11350070.
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    6. Arvanitis DL, Stavridou AI, Mori de Moro G, Szuchet S. Reactive astrocytes upregulate one or more gene products that are recognized by monoclonal antibody H. Cell Tissue Res. 2001 Apr; 304(1):11-9. PMID: 11383877.
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    7. Szuchet S, Watanabe K, Yamaguchi Y. Differentiation/regeneration of oligodendrocytes entails the assembly of a cell-associated matrix. Int J Dev Neurosci. 2000 Nov; 18(7):705-20. PMID: 10978849.
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    8. Sanyal B, Polak PE, Szuchet S. Differential expression of the heavy-chain ferritin gene in non-adhered and adhered oligodendrocytes. J Neurosci Res. 1996 Oct 15; 46(2):187-97. PMID: 8915895.
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    9. Arvanitis D, Kouklis P, Demoro G, Goutas N, Kittas C, Szuchet S. Immunostaining of ductal breast carcinomas with the monoclonal-antibody-h. Oncol Rep. 1995 Nov; 2(6):991-5. PMID: 21597840.
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    10. LoPresti P, Szuchet S, Papasozomenos SC, Zinkowski RP, Binder LI. Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10369-73. PMID: 7479786.
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    11. Fierro-Renoy JF, Szuchet S, Falcone M, Macchia E, DeGroot L. Three different thyroid hormone receptor isoforms are detected in a pure culture of ovine oligodendrocytes. Glia. 1995 Aug; 14(4):322-8. PMID: 8530188.
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    12. Soliven B, Szuchet S. Signal transduction pathways in oligodendrocytes: role of tumor necrosis factor-alpha. Int J Dev Neurosci. 1995 Jun-Jul; 13(3-4):351-67. PMID: 7572287.
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    13. Schirmer EC, Farooqui J, Polak PE, Szuchet S. GRASP: a novel heparin-binding serum glycoprotein that mediates oligodendrocyte-substratum adhesion. J Neurosci Res. 1994 Nov 01; 39(4):457-73. PMID: 7533846.
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    14. Soliven B, Takeda M, Szuchet S. Depolarizing agents and tumor necrosis factor-alpha modulate protein phosphorylation in oligodendrocytes. J Neurosci Res. 1994 May 01; 38(1):91-100. PMID: 7520088.
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    15. Ludwin SK, Szuchet S. Myelination by mature ovine oligodendrocytes in vivo and in vitro: evidence that different steps in the myelination process are independently controlled. Glia. 1993 Aug; 8(4):219-31. PMID: 8406679.
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    16. Yim SH, Sherin JE, Szuchet S. Oligodendrocyte proteoglycans: modulation by cell-substratum adhesion. J Neurosci Res. 1993 Mar 01; 34(4):401-13. PMID: 8474142.
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    17. Vartanian T, Szuchet S, Dawson G. Oligodendrocyte-substratum adhesion activates the synthesis of specific lipid species involved in cell signaling. J Neurosci Res. 1992 May; 32(1):69-78. PMID: 1321254.
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    18. Arvanitis D, Dumas M, Szuchet S. Myelin palingenesis. 2. Immunocytochemical localization of myelin/oligodendrocyte glycolipids in multilamellar structures. Dev Neurosci. 1992; 14(5-6):328-35. PMID: 1306158.
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    19. Arvanitis D, Polak PE, Szuchet S. Myelin palingenesis. 1. Electron microscopical localization of myelin/oligodendrocyte proteins in multilamellar structures by the immunogold method. Dev Neurosci. 1992; 14(5-6):313-27. PMID: 1284852.
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    20. Soliven B, Szuchet S, Nelson DJ. Tumor necrosis factor inhibits K+ current expression in cultured oligodendrocytes. J Membr Biol. 1991 Nov; 124(2):127-37. PMID: 1662283.
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    21. Szuchet S, Yim SH. Adhesion-induced differentiation of oligodendrocytes signals the synthesis and polarization of heparan sulfate proteoglycans and sulfated glycoproteins. Ann N Y Acad Sci. 1991; 633:530-4. PMID: 1789575.
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    22. Hertz L, Soliven B, Hertz E, Szuchet S, Nelson DJ. Channel-mediated and carrier-mediated uptake of K+ into cultured ovine oligodendrocytes. Glia. 1990; 3(6):550-7. PMID: 2148557.
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    23. Vartanian T, Dawson G, Soliven B, Nelson DJ, Szuchet S. Phosphorylation of myelin basic protein in intact oligodendrocytes: inhibition by galactosylsphingosine and cyclic AMP. Glia. 1989; 2(5):370-9. PMID: 2478466.
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    24. Soliven B, Szuchet S, Arnason BG, Nelson DJ. Expression and modulation of K+ currents in oligodendrocytes: possible role in myelinogenesis. Dev Neurosci. 1989; 11(2):118-31. PMID: 2663420.
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    25. Soliven B, Szuchet S, Arnason BG, Nelson DJ. Forskolin and phorbol esters decrease the same K+ conductance in cultured oligodendrocytes. J Membr Biol. 1988 Oct; 105(2):177-86. PMID: 3216367.
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    26. Soliven B, Szuchet S, Arnason BG, Nelson DJ. Voltage-gated potassium currents in cultured ovine oligodendrocytes. J Neurosci. 1988 Jun; 8(6):2131-41. PMID: 2838593.
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    27. Vartanian T, Sprinkle TJ, Dawson G, Szuchet S. Oligodendrocyte substratum adhesion modulates expression of adenylate cyclase-linked receptors. Proc Natl Acad Sci U S A. 1988 Feb; 85(3):939-43. PMID: 2448785.
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    28. Szuchet S, Polak PE, Yim SH, Arvanitis D. Plasma membrane of cultured oligodendrocytes: III. Relatedness to myelin. Glia. 1988; 1(2):141-50. PMID: 2465269.
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    29. Vartanian T, Dawson G, Szuchet S. Intracellular messengers. Influence of oligodendrocyte substratum adhesion. Ann N Y Acad Sci. 1988; 540:433-6. PMID: 2462818.
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    30. Polak PE, Szuchet S. Plasma membrane of cultured oligodendrocytes: I. Isolation, purification, and initial characterization. Glia. 1988; 1(1):39-53. PMID: 2976738.
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    31. Mikol DD, Szuchet S, Stefansson K. A peanut agglutinin binding glycoprotein in CNS myelin and oligodendrocytes. Ann N Y Acad Sci. 1988; 540:409-12. PMID: 3207269.
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    32. Szuchet S, Polak PE, Yim SH, Lange Y. Plasma membrane of cultured oligodendrocytes: II. Possible structural and functional domains. Glia. 1988; 1(1):54-63. PMID: 2976739.
      View in: PubMed
    33. Vartanian T, Szuchet S, Dawson G, Campagnoni AT. Oligodendrocyte adhesion activates protein kinase C-mediated phosphorylation of myelin basic protein. Science. 1986 Dec 12; 234(4782):1395-8. PMID: 2431483.
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    34. Yim SH, Szuchet S, Polak PE. Cultured oligodendrocytes. A role for cell-substratum interaction in phenotypic expression. J Biol Chem. 1986 Sep 05; 261(25):11808-15. PMID: 3745167.
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    35. Yim SH, Monsma S, Hertz L, Szuchet S. Lipid and glycolipid metabolism of cultured astrocytes: a time course study. J Neurosci Res. 1986; 15(1):29-37. PMID: 3007768.
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    36. Szuchet S, Polak PE, Yim SH. Mature oligodendrocytes cultured in the absence of neurons recapitulate the ontogenic development of myelin membranes. Dev Neurosci. 1986; 8(4):208-21. PMID: 2435511.
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    37. Dumas M, Zurbriggen A, Vandevelde M, Yim SH, Arnason BG, Szuchet S, Meier C. A monoclonal antibody that binds to both astrocytes and myelin sheaths. J Neuroimmunol. 1985 Jul; 9(1-2):55-67. PMID: 4008637.
      View in: PubMed
    38. Stowring L, Haase AT, Petursson G, Georgsson G, Palsson P, Lutley R, Roos R, Szuchet S. Detection of visna virus antigens and RNA in glial cells in foci of demyelination. Virology. 1985 Mar; 141(2):311-8. PMID: 3002020.
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    39. Massa PT, Szuchet S, Mugnaini E. Cell-cell interactions of isolated and cultured oligodendrocytes: formation of linear occluding junctions and expression of peculiar intramembrane particles. J Neurosci. 1984 Dec; 4(12):3128-39. PMID: 6502227.
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    40. Szuchet S, Yim SH. Characterization of a subset of oligodendrocytes separated on the basis of selective adherence properties. J Neurosci Res. 1984; 11(2):131-44. PMID: 6200605.
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    41. Szuchet S, Yim SH, Monsma S. Lipid metabolism of isolated oligodendrocytes maintained in long-term culture mimics events associated with myelinogenesis. Proc Natl Acad Sci U S A. 1983 Nov; 80(22):7019-23. PMID: 6580624.
      View in: PubMed
    42. Szuchet S, Dumas M. An in-vitro approach to the study of oligodendrocytes and their involvement in multiple sclerosis. Neurol Clin. 1983 Aug; 1(3):729-55. PMID: 6680171.
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    43. Szuchet S, Polak PE. A simple cell disrupter designed for small cells with relatively large nuclei. Anal Biochem. 1983 Feb 01; 128(2):453-8. PMID: 6846820.
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    44. Oger J, Szuchet S, Antel J, Arnason BG. A monoclonal antibody against human T suppressor lymphocytes binds specifically to the surface of cultured oligodendrocytes. Nature. 1982 Jan 07; 295(5844):66-8. PMID: 6173754.
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    45. Mack SR, Szuchet S. Synthesis of myelin glycosphingolipids by isolated oligodendrocytes in tissue culture. Brain Res. 1981 Jun 09; 214(1):180-5. PMID: 7237158.
      View in: PubMed
    46. Mack SR, Szuchet S, Dawson G. Synthesis of gangliosides by cultured oligodendrocytes. J Neurosci Res. 1981; 6(3):361-7. PMID: 7299846.
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    47. Wollmann RL, Szuchet S, Barlow J, Jerkovic M. Ultrastructural changes accompanying the growth of isolated oligodendrocytes. J Neurosci Res. 1981; 6(6):757-69. PMID: 7334534.
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    48. Szuchet S, Stefansson K, Wollmann RL, Dawson G, Arnason BG. Maintenance of isolated oligodendrocytes in long-term culture. Brain Res. 1980 Oct 27; 200(1):151-64. PMID: 6251943.
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    49. Szuchet S, Arnason BG, Polak PE. Separation of ovine oligodendrocytes into two distinct bands on a linear sucrose gradient. J Neurosci Methods. 1980 Oct; 3(1):7-19. PMID: 7230879.
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    50. Szuchet S. Effect of purification procedures on the self-association of myosin at high ionic strength. Arch Biochem Biophys. 1977 Apr 30; 180(2):493-503. PMID: 879796.
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    51. Szuchet S. Equilibrium centrifugation of proteins in acid solutions. Ovalbumin in aqueous acetic, propionic, and butyric acids. Arch Biochem Biophys. 1976 Dec; 177(2):437-60. PMID: 1015828.
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    52. Szuchet S, Yphantis DA. Equilibrium centrifugation of proteins in acidic solutions. Beta-lactoglobulin A in aqueous acetic, propionic, and butyric acids. Arch Biochem Biophys. 1976 Apr; 173(2):495-516. PMID: 1275504.
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    53. Weiner RE, Szuchet S. The molecular weight of bovine lactoferrin. Biochim Biophys Acta. 1975 May 30; 393(1):143-7. PMID: 237563.
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    54. Szuchet S, Zobel CR. The dissociation of myosin in acid. Biochemistry. 1974 Mar 26; 13(7):1482-91. PMID: 4819761.
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    55. Szuchet S, Yphantis DA. Equilibrium sedimentation of proteins in acid solutions. Dissociation of aldolase by aqueous acetic acid. Biochemistry. 1973 Dec 04; 12(25):5115-27. PMID: 4799941.
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    56. DERECHIN M, JOHNSON P, SZUCHET S. Further studies with human plasminogen. Biochem J. 1962 Aug; 84:336-9. PMID: 13885558.
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    57. DERECHIN M, SZUCHET S. Gelation phenomena in degraded fibrinogen and fibrin. Arch Biochem Biophys. 1960 Mar; 87:100-3. PMID: 13816017.
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    58. SZUCHET S, DERECHIN M. Relation between degree of fibrinogen proteolysis by plasmin and fibrinolytic paracoagulation. Proc Soc Exp Biol Med. 1957 Feb; 94(2):267-9. PMID: 13408230.
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