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Ghanashyam Ghadge

TitleSenior Research Associate
InstitutionUniversity of Chicago
DepartmentNeurology
AddressChicago IL 60637
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Masaki K, Sonobe Y, Ghadge G, Pytel P, Roos RP. TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection. PLoS Pathog. 2019 02; 15(2):e1007574. PMID: 30742696.
      View in: PubMed
    2. Ghadge GD, Kay BK, Drigotas C, Roos RP. Single chain variable fragment antibodies directed against SOD1 ameliorate disease in mutant SOD1 transgenic mice. Neurobiol Dis. 2019 01; 121:131-137. PMID: 30176351.
      View in: PubMed
    3. Sonobe Y, Ghadge G, Masaki K, Sendoel A, Fuchs E, Roos RP. Translation of dipeptide repeat proteins from the C9ORF72 expanded repeat is associated with cellular stress. Neurobiol Dis. 2018 08; 116:155-165. PMID: 29792928.
      View in: PubMed
    4. Riehm JJ, Wang L, Ghadge G, Teng M, Correa AM, Marks JD, Roos RP, Allen MJ. Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS. Neurobiol Dis. 2018 07; 115:115-126. PMID: 29627580.
      View in: PubMed
    5. Antinone SE, Ghadge GD, Ostrow LW, Roos RP, Green WN. S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects. Sci Rep. 2017 01 25; 7:41141. PMID: 28120938.
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    6. Antinone SE, Ghadge GD, Lam TT, Wang L, Roos RP, Green WN. Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants. J Biol Chem. 2013 Jul 26; 288(30):21606-17. PMID: 23760509.
      View in: PubMed
    7. Ghadge GD, Pavlovic JD, Koduvayur SP, Kay BK, Roos RP. Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1. Neurobiol Dis. 2013 Aug; 56:74-8. PMID: 23607939.
      View in: PubMed
    8. Allen MJ, Lacroix JJ, Ramachandran S, Capone R, Whitlock JL, Ghadge GD, Arnsdorf MF, Roos RP, Lal R. Mutant SOD1 forms ion channel: implications for ALS pathophysiology. Neurobiol Dis. 2012 Mar; 45(3):831-8. PMID: 21930207.
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    9. Ghadge GD, Wollmann R, Baida G, Traka M, Roos RP. The L-coding region of the DA strain of Theiler's murine encephalomyelitis virus causes dysfunction and death of myelin-synthesizing cells. J Virol. 2011 Sep; 85(18):9377-84. PMID: 21752920.
      View in: PubMed
    10. Stavrou S, Ghadge G, Roos RP. Apoptotic and antiapoptotic activity of L protein of Theiler's murine encephalomyelitis virus. J Virol. 2011 Jul; 85(14):7177-85. PMID: 21561911.
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    11. Stavrou S, Baida G, Viktorova E, Ghadge G, Agol VI, Roos RP. Theiler's murine encephalomyelitis virus L* amino acid position 93 is important for virus persistence and virus-induced demyelination. J Virol. 2010 Feb; 84(3):1348-54. PMID: 19923182.
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    12. Thomas AG, Bodner A, Ghadge G, Roos RP, Slusher BS. GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity. J Neurovirol. 2009 Sep; 15(5-6):449-57. PMID: 19995130.
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    13. Ghadge GD, Wang L, Sharma K, Monti AL, Bindokas V, Stevens FJ, Roos RP. Truncated wild-type SOD1 and FALS-linked mutant SOD1 cause neural cell death in the chick embryo spinal cord. Neurobiol Dis. 2006 Jan; 21(1):194-205. PMID: 16084730.
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    14. Mathiasen JR, McKenna BA, Saporito MS, Ghadge GD, Roos RP, Holskin BP, Wu ZL, Trusko SP, Connors TC, Maroney AC, Thomas BA, Thomas JC, Bozyczko-Coyne D. Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells. Brain Res. 2004 Apr 02; 1003(1-2):86-97. PMID: 15019567.
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    15. Ghadge GD, Slusher BS, Bodner A, Canto MD, Wozniak K, Thomas AG, Rojas C, Tsukamoto T, Majer P, Miller RJ, Monti AL, Roos RP. Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9554-9. PMID: 12876198.
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    16. Lee JP, Gerin C, Bindokas VP, Miller R, Ghadge G, Roos RP. No correlation between aggregates of Cu/Zn superoxide dismutase and cell death in familial amyotrophic lateral sclerosis. J Neurochem. 2002 Sep; 82(5):1229-38. PMID: 12358770.
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    17. Bodner A, Maroney AC, Finn JP, Ghadge G, Roos R, Miller RJ. Mixed lineage kinase 3 mediates gp120IIIB-induced neurotoxicity. J Neurochem. 2002 Sep; 82(6):1424-34. PMID: 12354290.
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    18. Lüders JC, Weihl CC, Lin G, Ghadge G, Stoodley M, Roos RP, Macdonald RL. Adenoviral gene transfer of nitric oxide synthase increases cerebral blood flow in rats. Neurosurgery. 2000 Nov; 47(5):1206-14; discussion 1214-5. PMID: 11063115.
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    19. Stoodley M, Weihl CC, Zhang ZD, Lin G, Johns LM, Kowalczuk A, Ghadge G, Roos RP, Macdonald RL. Effect of adenovirus-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage. Neurosurgery. 2000 May; 46(5):1193-202; discussion 1202-3. PMID: 10807252.
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    20. Weihl CC, Ghadge GD, Miller RJ, Roos RP. Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons. J Neurochem. 1999 Jul; 73(1):31-40. PMID: 10386952.
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    21. Weihl CC, Ghadge GD, Kennedy SG, Hay N, Miller RJ, Roos RP. Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB. J Neurosci. 1999 Jul 01; 19(13):5360-9. PMID: 10377346.
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    22. Lee JP, Palfrey HC, Bindokas VP, Ghadge GD, Ma L, Miller RJ, Roos RP. The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3251-6. PMID: 10077670.
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    23. Ghadge GD, Ma L, Sato S, Kim J, Roos RP. A protein critical for a Theiler's virus-induced immune system-mediated demyelinating disease has a cell type-specific antiapoptotic effect and a key role in virus persistence. J Virol. 1998 Nov; 72(11):8605-12. PMID: 9765399.
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    24. Ghadge GD, Lee JP, Bindokas VP, Jordan J, Ma L, Miller RJ, Roos RP. Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection. J Neurosci. 1997 Nov 15; 17(22):8756-66. PMID: 9348345.
      View in: PubMed
    25. Prehn JH, Jordán J, Ghadge GD, Preis E, Galindo MF, Roos RP, Krieglstein J, Miller RJ. Ca2+ and reactive oxygen species in staurosporine-induced neuronal apoptosis. J Neurochem. 1997 Apr; 68(4):1679-85. PMID: 9084441.
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    26. Jordán J, Galindo MF, Prehn JH, Weichselbaum RR, Beckett M, Ghadge GD, Roos RP, Leiden JM, Miller RJ. p53 expression induces apoptosis in hippocampal pyramidal neuron cultures. J Neurosci. 1997 Feb 15; 17(4):1397-405. PMID: 9006981.
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    27. Prehn JH, Bindokas VP, Jordán J, Galindo MF, Ghadge GD, Roos RP, Boise LH, Thompson CB, Krajewski S, Reed JC, Miller RJ. Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons. Mol Pharmacol. 1996 Feb; 49(2):319-28. PMID: 8632765.
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    28. Jordan J, Ghadge GD, Prehn JH, Toth PT, Roos RP, Miller RJ. Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth factor. Mol Pharmacol. 1995 Jun; 47(6):1095-1100. PMID: 7603446.
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    29. Chard PS, Jordán J, Marcuccilli CJ, Miller RJ, Leiden JM, Roos RP, Ghadge GD. Regulation of excitatory transmission at hippocampal synapses by calbindin D28k. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):5144-8. PMID: 7761464.
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    30. Ghadge GD, Roos RP, Kang UJ, Wollmann R, Fishman PS, Kalynych AM, Barr E, Leiden JM. CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses. Gene Ther. 1995 Mar; 2(2):132-7. PMID: 7536617.
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    31. Desai SY, Patel RC, Sen GC, Malhotra P, Ghadge GD, Thimmapaya B. Activation of interferon-inducible 2'-5' oligoadenylate synthetase by adenoviral VAI RNA. J Biol Chem. 1995 Feb 17; 270(7):3454-61. PMID: 7531709.
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    32. Ghadge GD, Malhotra P, Furtado MR, Dhar R, Thimmapaya B. In vitro analysis of virus-associated RNA I (VAI RNA): inhibition of the double-stranded RNA-activated protein kinase PKR by VAI RNA mutants correlates with the in vivo phenotype and the structural integrity of the central domain. J Virol. 1994 Jul; 68(7):4137-51. PMID: 7911532.
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    33. Kong WP, Ghadge GD, Roos RP. Involvement of cardiovirus leader in host cell-restricted virus expression. Proc Natl Acad Sci U S A. 1994 Mar 01; 91(5):1796-800. PMID: 8127884.
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    34. Radosevich JA, Ghadge GD, Haines GK, Malhotra P, Thimmappya B. Characterization of the mouse monoclonal antibody TJ4C4 directed at human p68 kinase. Tumour Biol. 1994; 15(5):255-62. PMID: 7527582.
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    35. Haines GK, Becker S, Ghadge G, Kies M, Pelzer H, Radosevich JA. Expression of the double-stranded RNA-dependent protein kinase (p68) in squamous cell carcinoma of the head and neck region. Arch Otolaryngol Head Neck Surg. 1993 Oct; 119(10):1142-7. PMID: 8104427.
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    36. Calenoff E, McMahan JT, Herzon GD, Kern RC, Ghadge GD, Hanson DG. Bacterial allergy in nasal polyposis. A new method for quantifying specific IgE. Arch Otolaryngol Head Neck Surg. 1993 Aug; 119(8):830-6. PMID: 8343243.
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    37. Haines GK, Ghadge G, Radosevich JA. Expression of p68 protein kinase as recognized by the monoclonal antibody TJ4C4 during human fetal development. Tumour Biol. 1993; 14(2):95-104. PMID: 8101013.
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    38. Haines GK, Ghadge GD, Becker S, Kies M, Pelzer H, Thimmappaya B, Radosevich JA. Correlation of the expression of double-stranded RNA-dependent protein kinase (p68) with differentiation in head and neck squamous cell carcinoma. Virchows Arch B Cell Pathol Incl Mol Pathol. 1993; 63(5):289-95. PMID: 8100099.
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    39. Haines GK, Ghadge G, Thimmappaya B, Radosevich JA. Expression of the protein kinase p-68 recognized by the monoclonal antibody TJ4C4 in human lung neoplasms. Virchows Arch B Cell Pathol Incl Mol Pathol. 1992; 62(3):151-8. PMID: 1357815.
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    40. Haines GK, Ghadge GD, Combs SG, Leslie W, Thimmappaya B, Radosevich JA. Immunohistochemical detection of double-stranded-RNA-dependent protein kinase (p68) with a novel monoclonal antibody TJ4C4. A case report of an AIDS-associated Kaposi's sarcoma treated with alpha-interferon. Tumour Biol. 1992; 13(5-6):324-9. PMID: 1283928.
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    41. Ghadge GD, Swaminathan S, Katze MG, Thimmapaya B. Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7140-4. PMID: 1714589.
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    42. Short ML, Manohar CF, Furtado MR, Ghadge GD, Wolinsky SM, Thimmapaya B, Jungmann RA. Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells. Nucleic Acids Res. 1991 Aug 11; 19(15):4290. PMID: 1831258.
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    43. Ghadge GD, Bodhe AM, Modak SR, Vartak HG. A procedure for easy removal of acrylamide gel rods from the casting glass tubes. Anal Biochem. 1983 Feb 01; 128(2):468-70. PMID: 6846822.
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