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Richard W. Mitchell

AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sharma P, Basu S, Mitchell RW, Stelmack GL, Anderson JE, Halayko AJ. Role of dystrophin in airway smooth muscle phenotype, contraction and lung function. PLoS One. 2014; 9(7):e102737. PMID: 25054970.
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    2. Sharma P, Ryu MH, Basu S, Maltby SA, Yeganeh B, Mutawe MM, Mitchell RW, Halayko AJ. Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase. Br J Pharmacol. 2012 Oct; 167(3):548-60. PMID: 22551156.
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    3. Dowell ML, Lavoie TL, Lakser OJ, Dulin NO, Fredberg JJ, Gerthoffer WT, Seow CY, Mitchell RW, Solway J. MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle. Eur Respir J. 2010 Sep; 36(3):630-7. PMID: 20110395.
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    4. Lavoie TL, Dowell ML, Lakser OJ, Gerthoffer WT, Fredberg JJ, Seow CY, Mitchell RW, Solway J. Disrupting actin-myosin-actin connectivity in airway smooth muscle as a treatment for asthma? Proc Am Thorac Soc. 2009 May 01; 6(3):295-300. PMID: 19387033.
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    5. Lakser OJ, Dowell ML, Hoyte FL, Chen B, Lavoie TL, Ferreira C, Pinto LH, Dulin NO, Kogut P, Churchill J, Mitchell RW, Solway J. Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma. Eur Respir J. 2008 Nov; 32(5):1224-30. PMID: 18768574.
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    6. Pinto LH, Eaton E, Chen B, Fleisher J, Shuster D, McCauley J, Kedainis D, Siepka SM, Shimomura K, Song EJ, Husain A, Lakser OJ, Mitchell RW, Dowell ML, Brown M, Camoretti-Mercado B, Naclerio R, Sperling AI, Levin SI, Turek FW, Solway J. Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness. Mamm Genome. 2008 Jan; 19(1):2-14. PMID: 18167028.
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    7. Mitchell RW, Dowell ML, Solway J, Lakser OJ. Force fluctuation-induced relengthening of acetylcholine-contracted airway smooth muscle. Proc Am Thorac Soc. 2008 Jan 01; 5(1):68-72. PMID: 18094087.
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    8. An SS, Bai TR, Bates JH, Black JL, Brown RH, Brusasco V, Chitano P, Deng L, Dowell M, Eidelman DH, Fabry B, Fairbank NJ, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gosens R, Gunst SJ, Halayko AJ, Ingram RH, Irvin CG, James AL, Janssen LJ, King GG, Knight DA, Lauzon AM, Lakser OJ, Ludwig MS, Lutchen KR, Maksym GN, Martin JG, Mauad T, McParland BE, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Paré PD, Pellegrino R, Sanderson MJ, Schellenberg RR, Seow CY, Silveira PS, Smith PG, Solway J, Stephens NL, Sterk PJ, Stewart AG, Tang DD, Tepper RS, Tran T, Wang L. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J. 2007 May; 29(5):834-60. PMID: 17470619.
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    9. Dupasquier CM, Weber AM, Ander BP, Rampersad PP, Steigerwald S, Wigle JT, Mitchell RW, Kroeger EA, Gilchrist JS, Moghadasian MM, Lukas A, Pierce GN. Effects of dietary flaxseed on vascular contractile function and atherosclerosis during prolonged hypercholesterolemia in rabbits. Am J Physiol Heart Circ Physiol. 2006 Dec; 291(6):H2987-96. PMID: 16844912.
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    10. Chen B, Liu G, Shardonofsky F, Dowell M, Lakser O, Mitchell RW, Fredberg JJ, Pinto LH, Solway J. Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice. J Appl Physiol (1985). 2006 Jul; 101(1):249-55. PMID: 16484363.
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    11. Bai TR, Bates JH, Brusasco V, Camoretti-Mercado B, Chitano P, Deng LH, Dowell M, Fabry B, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gunst SJ, Hai CM, Halayko AJ, Hirst SJ, James AL, Janssen LJ, Jones KA, King GG, Lakser OJ, Lambert RK, Lauzon AM, Lutchen KR, Maksym GN, Meiss RA, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Paré PD, Schellenberg RR, Seow CY, Sieck GC, Smith PG, Smolensky AV, Solway J, Stephens NL, Stewart AG, Tang DD, Wang L. On the terminology for describing the length-force relationship and its changes in airway smooth muscle. J Appl Physiol (1985). 2004 Dec; 97(6):2029-34. PMID: 15531570.
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    12. Dowell ML, Lakser OJ, Gerthoffer WT, Fredberg JJ, Stelmack GL, Halayko AJ, Solway J, Mitchell RW. Latrunculin B increases force fluctuation-induced relengthening of ACh-contracted, isotonically shortened canine tracheal smooth muscle. J Appl Physiol (1985). 2005 Feb; 98(2):489-97. PMID: 15465883.
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    13. Kotlikoff MI, Kannan MS, Solway J, Deng KY, Deshpande DA, Dowell M, Feldman M, Green KS, Ji G, Johnston R, Lakser O, Lee J, Lund FE, Milla C, Mitchell RW, Nakai J, Rishniw M, Walseth TF, White TA, Wilson J, Xin HB, Woodruff PG. Methodologic advancements in the study of airway smooth muscle. J Allergy Clin Immunol. 2004 Aug; 114(2 Suppl):S18-31. PMID: 15309016.
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    14. Burdyga T, Mitchell RW, Ragozzino J, Ford LE. Force and myosin light chain phosphorylation in dog airway smooth muscle activated in different ways. Respir Physiol Neurobiol. 2003 Sep 16; 137(2-3):141-9. PMID: 14516722.
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    15. Fernandes DJ, Mitchell RW, Lakser O, Dowell M, Stewart AG, Solway J. Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma? J Appl Physiol (1985). 2003 Aug; 95(2):844-53. PMID: 12851423.
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    16. Liu HW, Halayko AJ, Fernandes DJ, Harmon GS, McCauley JA, Kocieniewski P, McConville J, Fu Y, Forsythe SM, Kogut P, Bellam S, Dowell M, Churchill J, Lesso H, Kassiri K, Mitchell RW, Hershenson MB, Camoretti-Mercado B, Solway J. The RhoA/Rho kinase pathway regulates nuclear localization of serum response factor. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):39-47. PMID: 12600823.
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    17. Qi D, Mitchell RW, Burdyga T, Ford LE, Kuo KH, Seow CY. Myosin light chain phosphorylation facilitates in vivo myosin filament reassembly after mechanical perturbation. Am J Physiol Cell Physiol. 2002 Jun; 282(6):C1298-305. PMID: 11997244.
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    18. Mitchell RW, Seow CY, Burdyga T, Maass-Moreno R, Pratusevich VR, Ragozzino J, Ford LE. Relationship between myosin phosphorylation and contractile capability of canine airway smooth muscle. J Appl Physiol (1985). 2001 Jun; 90(6):2460-5. PMID: 11356814.
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    19. Maass-Moreno R, Burdyga T, Mitchell RW, Seow CY, Ragozzino J, Ford LE. Simple freezing apparatus for resolving rapid metabolic events associated with smooth muscle activation. J Appl Physiol (1985). 2001 Jun; 90(6):2453-9. PMID: 11356813.
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    20. Mitchell RW, Halayko AJ, Kahraman S, Solway J, Wylam ME. Selective restoration of calcium coupling to muscarinic M(3) receptors in contractile cultured airway myocytes. Am J Physiol Lung Cell Mol Physiol. 2000 May; 278(5):L1091-100. PMID: 10781442.
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    21. Halayko AJ, Camoretti-Mercado B, Forsythe SM, Vieira JE, Mitchell RW, Wylam ME, Hershenson MB, Solway J. Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes. Am J Physiol. 1999 01; 276(1):L197-206. PMID: 9887072.
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    22. Wylam ME, Gungor N, Mitchell RW, Umans JG. Eosinophils, major basic protein, and polycationic peptides augment bovine airway myocyte Ca2+ mobilization. Am J Physiol. 1998 06; 274(6):L997-L1005. PMID: 9609739.
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    23. Mitchell RW, Cozzi P, Ndukwu IM, Spaethe S, Leff AR, Padrid PA. Differential effects of cyclosporine A after acute antigen challenge in sensitized cats in vivo and ex vivo. Br J Pharmacol. 1998 Mar; 123(6):1198-204. PMID: 9559905.
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    24. Mitchell RW, Rabe KF, Magnussen H, Leff AR. Passive sensitization of human airways induces myogenic contractile responses in vitro. J Appl Physiol (1985). 1997 Oct; 83(4):1276-81. PMID: 9338437.
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    25. Ndukwu IM, White SR, Leff AR, Mitchell RW. EP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis. Am J Physiol. 1997 Sep; 273(3 Pt 1):L626-33. PMID: 9316498.
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    26. Mitchell RW, Ndukwu IM, Leff AR, Padrid PA. Muscarinic hyperresponsiveness of antigen-sensitized feline airway smooth muscle in vitro. Am J Vet Res. 1997 Jun; 58(6):672-6. PMID: 9185978.
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    27. Mitchell RW, Rühlmann E, Magnussen H, Muñoz NM, Leff AR, Rabe KF. Conservation of bronchiolar wall area during constriction and dilation of human airways. J Appl Physiol (1985). 1997 Mar; 82(3):954-8. PMID: 9074987.
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    28. Mitchell RW, Ndukwu IM, Herrnreiter A, Uzendoski K, Gitter B, Solway J, Leff AR. Differential tachykinin receptor subtype activation in capsaicin and KCl contractions of guinea pig trachealis. Am J Physiol. 1995 Dec; 269(6 Pt 1):L837-42. PMID: 8572245.
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    29. Padrid PA, Mitchell RW, Ndukwu IM, Spaethe S, Shiue P, Cozzi P, Leff AR, Shiou P [corrected to Shiue P]. Cyproheptadine-induced attenuation of type-I immediate-hypersensitivity reactions of airway smooth muscle from immune-sensitized cats. Am J Vet Res. 1995 Jan; 56(1):109-15. PMID: 7695137.
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    30. Mitchell RW, Rühlmann E, Magnussen H, Leff AR, Rabe KF. Passive sensitization of human bronchi augments smooth muscle shortening velocity and capacity. Am J Physiol. 1994 Aug; 267(2 Pt 1):L218-22. PMID: 8074246.
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    31. Ndukwu IM, Solway J, Arbetter K, Uzendoski K, Leff AR, Mitchell RW. Immune sensitization augments epithelium-dependent spontaneous tone in guinea pig trachealis. Am J Physiol. 1994 May; 266(5 Pt 1):L485-92. PMID: 8203543.
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    32. Hershenson MB, Wylam ME, Punjabi N, Umans JG, Schumacker PT, Mitchell RW, Solway J. Exposure of immature rats to hyperoxia increases tracheal smooth muscle stress generation in vitro. J Appl Physiol (1985). 1994 Feb; 76(2):743-9. PMID: 8175585.
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    33. Mitchell RW, Ndukwu IM, Arbetter K, Solway J, Leff AR. Effect of airway inflammation on smooth muscle shortening and contractility in guinea pig trachealis. Am J Physiol. 1993 Dec; 265(6 Pt 1):L549-54. PMID: 8279571.
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    34. Mitchell RW, Ndukuw IM, Ikeda K, Arbetter K, Leff AR. Effect of immune sensitization on stimulated ACh release from trachealis muscle in vitro. Am J Physiol. 1993 Jul; 265(1 Pt 1):L13-8. PMID: 8338177.
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    35. Strek ME, White SR, Ndukwu IM, Munoz NM, Williams FS, Vita AJ, Leff AR, Mitchell RW. Physiologic significance of epithelial removal on guinea pig tracheal smooth muscle response to acetylcholine and serotonin. Am Rev Respir Dis. 1993 Jun; 147(6 Pt 1):1477-82. PMID: 8503558.
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    36. Ferguson MK, Williams U, Leff AR, Mitchell RW. Length-tension characteristics of bovine tracheobronchial lymphatic smooth muscle. Lymphology. 1993 Mar; 26(1):19-24. PMID: 8464221.
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    37. Mitchell RW, Koenig SM, Popovich KJ, Kelly E, Tallet J, Leff AR. Pertussis toxin augments beta-adrenergic relaxation of muscarinic contraction in canine trachealis. Am Rev Respir Dis. 1993 Feb; 147(2):327-31. PMID: 8381630.
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    38. Mitchell RW, Murphy TM, Leff AR. Physiological mechanisms mediating enhanced force generation during development and immune sensitization. Can J Physiol Pharmacol. 1992 Apr; 70(4):615-23. PMID: 1498727.
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    39. Ikeda K, Mitchell RW, Guest KA, Seow CY, Kirchhoff CF, Murphy TM, Leff AR. Ontogeny of shortening velocity in porcine trachealis. Am J Physiol. 1992 Mar; 262(3 Pt 1):L280-5. PMID: 1550250.
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    40. Murphy TM, Mitchell RW, Phillips IJ, Leff AR. Ontogenic expression of acetylcholinesterase activity in trachealis of young swine. Am J Physiol. 1991 Oct; 261(4 Pt 1):L322-6. PMID: 1928367.
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    41. Mitchell RW, Murphy TM, Kelly E, Leff AR. Extracellular Ca2+ mobilization in potential-dependent contraction of trachealis of maturing swine. J Appl Physiol (1985). 1991 Oct; 71(4):1489-95. PMID: 1757374.
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    42. Mitchell RW, Kelly E, Leff AR. Reduced activity of acetylcholinesterase in canine tracheal smooth muscle homogenates after active immune-sensitization. Am J Respir Cell Mol Biol. 1991 Jul; 5(1):56-62. PMID: 1908687.
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    43. Murphy TM, Mitchell RW, Halayko A, Roach J, Roy L, Kelly EA, Munoz NM, Stephens NL, Leff AR. Effect of maturational changes in myosin content and morphometry on airway smooth muscle contraction. Am J Physiol. 1991 Jun; 260(6 Pt 1):L471-80. PMID: 2058690.
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    44. Mitchell RW, Kelly E, Leff AR. Effect of in vitro preconditioning on tracheal smooth muscle responsiveness. Am J Physiol. 1991 Feb; 260(2 Pt 1):L168-73. PMID: 1996660.
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    45. Murphy TM, Roy L, Phillips IJ, Mitchell RW, Kelly EA, Munoz NM, Leff AR. Effect of maturation on topographic distribution of bronchoconstrictor responses in large diameter airways of young swine. Am Rev Respir Dis. 1991 Jan; 143(1):126-31. PMID: 1670916.
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    46. Wylam ME, Samsel RW, Umans JG, Mitchell RW, Leff AR, Schumacker PT. Endotoxin in vivo impairs endothelium-dependent relaxation of canine arteries in vitro. Am Rev Respir Dis. 1990 Dec; 142(6 Pt 1):1263-7. PMID: 2252242.
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    47. Mitchell RW, Murphy TM, Kelly E, Leff AR. Maturation of acetylcholinesterase expression in tracheal smooth muscle contraction. Am J Physiol. 1990 Aug; 259(2 Pt 1):L130-5. PMID: 2382731.
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    48. Koenig SM, Mitchell RW, Kelly E, White SR, Leff AR, Popovich KJ. Beta-adrenergic relaxation of dog trachealis: contractile agonist-specific interaction. J Appl Physiol (1985). 1989 Jul; 67(1):181-5. PMID: 2474528.
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    49. Murphy TM, Mitchell RW, Blake JS, Mack MM, Kelly EA, Munoz NM, Leff AR. Expression of airway contractile properties and acetylcholinesterase activity in swine. J Appl Physiol (1985). 1989 Jul; 67(1):174-80. PMID: 2759942.
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    50. Mitchell RW, Koenig SM, Kelly E, Stephens NL, Leff AR. Ca2+-dependent facilitated shortening in isotonic contraction of trachealis muscle. J Appl Physiol (1985). 1989 Feb; 66(2):632-7. PMID: 2708194.
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    51. White SR, Popovich KJ, Mitchell RW, Koenig SM, Mack MM, Munoz NM, Leff AR. Antagonism of relaxation to isoproterenol caused by agonist interactions. J Appl Physiol (1985). 1988 Jun; 64(6):2501-7. PMID: 3403434.
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    52. Kroeger EA, Bergen JM, Mitchell RW. Effect of active sensitization on canine airway smooth muscle responsiveness to adrenergic and cholinergic mechanisms in vitro. Prog Clin Biol Res. 1988; 263:219-30. PMID: 2898152.
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    53. Mitchell RW, Kroeger EA, Kepron W, Stephens NL. Local parasympathetic mechanisms for ragweed-sensitized canine trachealis hyperresponsiveness. J Pharmacol Exp Ther. 1987 Dec; 243(3):907-14. PMID: 3694537.
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    54. Mitchell RW, Antonissen LA, Kepron W, Kroeger EA, Stephens NL. Effect of atropine on the hyperresponsiveness of ragweed-sensitized canine tracheal smooth muscle. J Pharmacol Exp Ther. 1986 Mar; 236(3):803-9. PMID: 3950872.
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    55. Stephens NL, Packer CS, Mitchell RW. Mechanical properties of airway smooth muscle. Bull Eur Physiopathol Respir. 1986; 22 Suppl 7:178-90. PMID: 2937474.
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    56. Mitchell RW, Stephens NL. Maximum shortening velocity of smooth muscle: zero load-clamp vs. afterloaded method. J Appl Physiol Respir Environ Exerc Physiol. 1983 Nov; 55(5):1630-3. PMID: 6643198.
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    57. Antonissen LA, Mitchell RW, Kroeger EA, Kepron W, Stephens NL, Bergen J. Histamine pharmacology in airway smooth muscle from a canine model of asthma. J Pharmacol Exp Ther. 1980 Apr; 213(1):150-5. PMID: 7359363.
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    58. Antonissen LA, Mitchell RW, Kroeger EA, Kepron W, Tse KS, Stephens NL. Mechanical alterations of airway smooth muscle in a canine asthmatic model. J Appl Physiol Respir Environ Exerc Physiol. 1979 Apr; 46(4):681-7. PMID: 457546.
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    59. Skoog C, Kromer U, Mitchell RW, Hoogstraten J, Stephens NL. Characterization of frog muscle mitochondria. Am J Physiol. 1978 Jan; 234(1):C1-6. PMID: 304678.
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    60. Stephens NL, Mitchell RW. Effect of respiratory acidosis and activity on airway smooth muscle intracellular pH. J Appl Physiol Respir Environ Exerc Physiol. 1977 Mar; 42(3):408-12. PMID: 14103.
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    61. Stephens NL, Mitchell RW. Mechanism of action of respiratory acidosis on tracheal smooth muscle. Am J Physiol. 1974 Sep; 227(3):647-51. PMID: 4414612.
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