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Alan Leff

TitleEmeritus/Emerita
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li J, Wang H, Zhong Q, Zhu X, Chen SJ, Qian Y, Costakis J, Bunney G, Beiser DG, Leff AR, Lewandowski ED, ÓDonnell JM, Vanden Hoek TL. A novel pharmacological strategy by PTEN inhibition for improving metabolic resuscitation and survival after mouse cardiac arrest. Am J Physiol Heart Circ Physiol. 2015 Jun 01; 308(11):H1414-22. PMID: 25795713.
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    2. Meng F, Mambetsariev I, Tian Y, Beckham Y, Meliton A, Leff A, Gardel ML, Allen MJ, Birukov KG, Birukova AA. Attenuation of lipopolysaccharide-induced lung vascular stiffening by lipoxin reduces lung inflammation. Am J Respir Cell Mol Biol. 2015 Feb; 52(2):152-61. PMID: 24992633.
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    3. Zhu X, Shao ZH, Li C, Li J, Zhong Q, Learoyd J, Meliton A, Meliton L, Leff AR, Vanden Hoek TL. TAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury. PLoS One. 2014; 9(4):e95622. PMID: 24752319.
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    4. Meliton AY, Muñoz NM, Meliton LN, Birukova AA, Leff AR, Birukov KG. Mechanical induction of group V phospholipase A(2) causes lung inflammation and acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2013 May 15; 304(10):L689-700. PMID: 23525785.
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    5. Kratzer E, Tian Y, Sarich N, Wu T, Meliton A, Leff A, Birukova AA. Oxidative stress contributes to lung injury and barrier dysfunction via microtubule destabilization. Am J Respir Cell Mol Biol. 2012 Nov; 47(5):688-97. PMID: 22842495.
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    6. Birukova AA, Wu T, Tian Y, Meliton A, Sarich N, Tian X, Leff A, Birukov KG. Iloprost improves endothelial barrier function in lipopolysaccharide-induced lung injury. Eur Respir J. 2013 Jan; 41(1):165-76. PMID: 22790920.
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    7. Muñoz NM, Desai A, Meliton LN, Meliton AY, Zhou T, Leff AR, Dudek SM. Group V phospholipase A(2) increases pulmonary endothelial permeability through direct hydrolysis of the cell membrane. Pulm Circ. 2012 Apr-Jun; 2(2):182-92. PMID: 22837859.
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    8. Birukova AA, Tian Y, Meliton A, Leff A, Wu T, Birukov KG. Stimulation of Rho signaling by pathologic mechanical stretch is a "second hit" to Rho-independent lung injury induced by IL-6. Am J Physiol Lung Cell Mol Physiol. 2012 May 01; 302(9):L965-75. PMID: 22345573.
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    9. Duan Y, Learoyd J, Meliton AY, Leff AR, Zhu X. Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury. Respir Res. 2012 Jan 18; 13:4. PMID: 22257498.
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    10. Li J, Beiser DG, Wang H, Das A, Berdyshev E, Li J, Leff AR, Stern SA, Vanden Hoek TL. Therapeutic hypothermia cardioprotection in murine hemorrhagic shock/resuscitation differentially affects p38a/p38?, Akt, and HspB1. J Trauma. 2011 Nov; 71(5):1262-70. PMID: 22071928.
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    11. Leff AR. The "other" airway. Proc Am Thorac Soc. 2011 Mar; 8(1):29. PMID: 21364217.
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    12. Wang L, Learoyd J, Duan Y, Leff AR, Zhu X. Hematopoietic Pyk2 regulates migration of differentiated HL-60 cells. J Inflamm (Lond). 2010 May 27; 7:26. PMID: 20507587.
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    13. Dudek SM, Muñoz NM, Desai A, Osan CM, Meliton AY, Leff AR. Group V phospholipase A2 mediates barrier disruption of human pulmonary endothelial cells caused by LPS in vitro. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):361-8. PMID: 20448053.
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    14. Meliton AY, Muñoz NM, Meliton LN, Binder DC, Osan CM, Zhu X, Dudek SM, Leff AR. Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro. J Inflamm (Lond). 2010 Mar 18; 7:14. PMID: 20298597.
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    15. Brusasco V, Dinh-Xuan AT, Leff AR, Adler KB, Glenny RW, Dempsey JA, Levy ML, Panettieri R, Reddel HK, Singh D, Virchow JC. Impact factor and its role in academic promotion. Eur Respir J. 2009 Dec; 34(6):1499-500. PMID: 19948921.
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    16. Meliton AY, Muñoz NM, Osan CM, Meliton LN, Leff AR. Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes. Eur Respir J. 2010 Feb; 35(2):402-9. PMID: 19679609.
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    17. Leff AR. Impact factor and its role in academic promotion. Proc Am Thorac Soc. 2009 Aug 01; 6(4):337. PMID: 19675343.
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    18. Duan Y, Learoyd J, Meliton AY, Clay BS, Leff AR, Zhu X. Inhibition of Pyk2 blocks airway inflammation and hyperresponsiveness in a mouse model of asthma. Am J Respir Cell Mol Biol. 2010 Apr; 42(4):491-7. PMID: 19520918.
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    19. Muñoz NM, Meliton AY, Meliton LN, Dudek SM, Leff AR. Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L879-87. PMID: 19286925.
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    20. Abraham E, Adler KB, Shapiro SD, Leff AR. The ATS journals' policy on image manipulation. Proc Am Thorac Soc. 2008 Dec 15; 5(9):869. PMID: 19056709.
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    21. Rennard SI, Higenbottam T, Leff AR. Foreword: "The Big Three". Proc Am Thorac Soc. 2008 Dec 01; 5(8):795. PMID: 19017731.
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    22. Abraham E, Adler KB, Shapiro SD, Leff AR. The ATS Journals' policy on image manipulation. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):499. PMID: 18927351.
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    23. Zhu X, Boetticher E, Wang L, Duan Y, Learoyd J, Leff AR. Proline-rich tyrosine kinase 2 regulates spreading and migration of eosinophils after beta2-integrin adhesion. Am J Respir Cell Mol Biol. 2008 Sep; 39(3):263-9. PMID: 18367725.
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    24. Leff AR, Muñoz NM. Future treatment to lessen exacerbations of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2007 Dec; 4(8):659-66. PMID: 18073398.
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    25. Meliton AY, Munoz NM, Zhu X, Leff AR. Attenuated translocation of group IVa phospholipase A2 and up-regulated annexin-1 synthesis by glucocorticoid blocks beta 2-integrin adhesion in neutrophils. J Leukoc Biol. 2008 Feb; 83(2):344-51. PMID: 17971499.
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    26. Muñoz NM, Meliton AY, Arm JP, Bonventre JV, Cho W, Leff AR. Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized mice. J Immunol. 2007 Oct 01; 179(7):4800-7. PMID: 17878379.
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    27. Meliton AY, Munoz NM, Leff AR. Blockade of avidity and focal clustering of beta 2-integrin by cysteinyl leukotriene antagonism attenuates eosinophil adhesion. J Allergy Clin Immunol. 2007 Dec; 120(6):1316-23. PMID: 17904626.
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    28. Leff AR. Racemic = R enantiomer: a dual citation. Am J Respir Crit Care Med. 2007 Mar 15; 175(6):628; author reply 628-9. PMID: 17341650.
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    29. Zhao Y, He D, Zhao J, Wang L, Leff AR, Spannhake EW, Georas S, Natarajan V. Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells. J Biol Chem. 2007 Apr 06; 282(14):10172-9. PMID: 17287216.
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    30. Zhu X, Learoyd J, Butt S, Zhu L, Usatyuk PV, Natarajan V, Munoz NM, Leff AR. Regulation of eosinophil adhesion by lysophosphatidylcholine via a non-store-operated Ca2+ channel. Am J Respir Cell Mol Biol. 2007 May; 36(5):585-93. PMID: 17218614.
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    31. Muñoz NM, Meliton AY, Lambertino A, Boetticher E, Learoyd J, Sultan F, Zhu X, Cho W, Leff AR. Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils. J Immunol. 2006 Jul 01; 177(1):574-82. PMID: 16785555.
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    32. Meliton AY, Muñoz NM, Lambertino A, Boetticher E, Learoyd J, Zhu X, Leff AR. Phosphodiesterase 4 inhibition of beta2-integrin adhesion caused by leukotriene B4 and TNF-alpha in human neutrophils. Eur Respir J. 2006 Nov; 28(5):920-8. PMID: 16807266.
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    33. Munoz NM, Leff AR. Highly purified selective isolation of eosinophils from human peripheral blood by negative immunomagnetic selection. Nat Protoc. 2006; 1(6):2613-20. PMID: 17406516.
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    34. Abraham E, Shapiro SD, Leff AR. The NIH Public Access Policy and ATS journals. Am J Respir Crit Care Med. 2005 Apr 01; 171(7):671-2. PMID: 15790862.
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    35. Sano M, Leff AR, Myou S, Boetticher E, Meliton AY, Learoyd J, Lambertino AT, Munoz NM, Zhu X. Regulation of interleukin-5-induced beta2-integrin adhesion of human eosinophils by phosphoinositide 3-kinase. Am J Respir Cell Mol Biol. 2005 Jul; 33(1):65-70. PMID: 15802551.
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    36. Liu J, Zhu X, Myo S, Lambertino AT, Xu C, Boetticher E, Muñoz NM, Sano M, Cordoba M, Learoyd J, Meliton A, Johnson M, Leff AR. Glucocorticoid-induced surface expression of annexin 1 blocks beta2-integrin adhesion of human eosinophils to intercellular adhesion molecule 1 surrogate protein. J Allergy Clin Immunol. 2005 Mar; 115(3):493-500. PMID: 15753895.
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    37. Abraham E, Shapiro SD, Leff AR. The NIH Public Access Policy and ATS journals. Proc Am Thorac Soc. 2005; 2(1):1-2. PMID: 16113460.
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    38. Leff AR, Shapiro SD, Abraham E. The unintended consequences of noble intentions to inform. Proc Am Thorac Soc. 2005; 2(1):2-3. PMID: 16113461.
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    39. Cox PG, Miller J, Mitzner W, Leff AR. Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: preliminary investigations. Eur Respir J. 2004 Oct; 24(4):659-63. PMID: 15459147.
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    40. Bates J, Irvin C, Brusasco V, Drazen J, Fredberg J, Loring S, Eidelman D, Ludwig M, Macklem P, Martin J, Milic-Emili J, Hantos Z, Hyatt R, Lai-Fook S, Leff A, Solway J, Lutchen K, Suki B, Mitzner W, Paré P, Pride N, Sly P. The use and misuse of Penh in animal models of lung disease. Am J Respir Cell Mol Biol. 2004 Sep; 31(3):373-4. PMID: 15317683.
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    41. Danek CJ, Lombard CM, Dungworth DL, Cox PG, Miller JD, Biggs MJ, Keast TM, Loomas BE, Wizeman WJ, Hogg JC, Leff AR. Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs. J Appl Physiol (1985). 2004 Nov; 97(5):1946-53. PMID: 15258133.
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    42. Myo S, Zhu X, Myou S, Meliton AY, Liu J, Boetticher E, Lambertino AT, Xu C, Muñoz NM, Leff AR. Additive blockade of beta 2-integrin adhesion of eosinophils by salmeterol and fluticasone propionate. Eur Respir J. 2004 Apr; 23(4):511-7. PMID: 15083746.
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    43. Liu J, Muñoz NM, Meliton AY, Zhu X, Lambertino AT, Xu C, Myo S, Myou S, Boetticher E, Johnson M, Leff AR. Beta2-integrin adhesion caused by eotaxin but not IL-5 is blocked by PDE-4 inhibition and beta2-adrenoceptor activation in human eosinophils. Pulm Pharmacol Ther. 2004; 17(2):73-9. PMID: 15123228.
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    44. Myou S, Leff AR, Myo S, Boetticher E, Tong J, Meliton AY, Liu J, Munoz NM, Zhu X. Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT. J Exp Med. 2003 Nov 17; 198(10):1573-82. PMID: 14623911.
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    45. Zhu X, Lambertino AT, Houghton TJ, McGilvra JD, Xu C, Rawal VH, Leff AR. Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. Life Sci. 2003 Oct 24; 73(23):3005-16. PMID: 14519449.
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    46. Myou S, Zhu X, Myo S, Boetticher E, Meliton AY, Liu J, Munoz NM, Leff AR. Blockade of airway inflammation and hyperresponsiveness by HIV-TAT-dominant negative Ras. J Immunol. 2003 Oct 15; 171(8):4379-84. PMID: 14530363.
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    47. Myou S, Leff AR, Myo S, Boetticher E, Meliton AY, Lambertino AT, Liu J, Xu C, Munoz NM, Zhu X. Activation of group IV cytosolic phospholipase A2 in human eosinophils by phosphoinositide 3-kinase through a mitogen-activated protein kinase-independent pathway. J Immunol. 2003 Oct 15; 171(8):4399-405. PMID: 14530366.
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    48. Meliton AY, Muñoz NM, Liu J, Lambertino AT, Boetticher E, Myo S, Myou S, Zhu X, Johnson M, Leff AR. Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. J Allergy Clin Immunol. 2003 Aug; 112(2):404-10. PMID: 12897749.
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    49. Muñoz NM, Kim YJ, Meliton AY, Kim KP, Han SK, Boetticher E, O'Leary E, Myou S, Zhu X, Bonventre JV, Leff AR, Cho W. Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. J Biol Chem. 2003 Oct 03; 278(40):38813-20. PMID: 12796497.
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    50. Noth I, Strek ME, Leff AR. Churg-Strauss syndrome. Lancet. 2003 Feb 15; 361(9357):587-94. PMID: 12598156.
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    51. Zhu X, Jacobs B, Boetticher E, Myou S, Meliton A, Sano H, Lambertino AT, Muñoz NM, Leff AR. IL-5-induced integrin adhesion of human eosinophils caused by ERK1/2-mediated activation of cPLA2. J Leukoc Biol. 2002 Nov; 72(5):1046-53. PMID: 12429728.
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    52. Myou S, Zhu X, Boetticher E, Myo S, Meliton A, Lambertino A, Munoz NM, Leff AR. Blockade of focal clustering and active conformation in beta 2-integrin-mediated adhesion of eosinophils to intercellular adhesion molecule-1 caused by transduction of HIV TAT-dominant negative Ras. J Immunol. 2002 Sep 01; 169(5):2670-6. PMID: 12193740.
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    53. Myou S, Zhu X, Boetticher E, Qin Y, Myo S, Meliton A, Lambertino A, Munoz NM, Hamann KJ, Leff AR. Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2. Immunology. 2002 Sep; 107(1):77-85. PMID: 12225365.
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    54. Kim YJ, Kim KP, Han SK, Munoz NM, Zhu X, Sano H, Leff AR, Cho W. Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group IVA phospholipase A2. J Biol Chem. 2002 Sep 27; 277(39):36479-88. PMID: 12124392.
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    55. Schmidt DT, Dent G, Rühlmann E, Muñoz NM, Leff AR, Rabe KF. Studying human airway pharmacology in microsections: application of videomicrometry. Eur Respir J. 2002 Jun; 19(6):991-6. PMID: 12108884.
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    56. Muñoz NM, Boetticher E, Sperling AI, Kim KP, Meliton AY, Zhu X, Lambertino A, Cho W, Leff AR. Quantitation of secretory group V phospholipase A(2) in human tissues by sandwich enzyme-linked immunosorbent assay. J Immunol Methods. 2002 Apr 01; 262(1-2):41-51. PMID: 11983218.
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    57. Sano A, Zhu X, Sano H, Muñoz NM, Boetticher E, Leff AR. Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2). Am J Physiol Lung Cell Mol Physiol. 2001 Oct; 281(4):L844-51. PMID: 11557588.
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    58. Zhu X, Sano H, Kim KP, Sano A, Boetticher E, Muñoz NM, Cho W, Leff AR. Role of mitogen-activated protein kinase-mediated cytosolic phospholipase A2 activation in arachidonic acid metabolism in human eosinophils. J Immunol. 2001 Jul 01; 167(1):461-8. PMID: 11418683.
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    59. Leff AR. The Antileukotriene Working Group consensus conference overview. Ann Allergy Asthma Immunol. 2001 Jun; 86(6 Suppl 1):1-3. PMID: 11426911.
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    60. Leff AR. Discovery of leukotrienes and development of antileukotriene agents. Ann Allergy Asthma Immunol. 2001 Jun; 86(6 Suppl 1):4-8. PMID: 11426915.
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    61. Sano H, Zhu X, Sano A, Boetticher EE, Shioya T, Jacobs B, Munoz NM, Leff AR. Extracellular signal-regulated kinase 1/2-mediated phosphorylation of cytosolic phospholipase A2 is essential for human eosinophil adhesion to fibronectin. J Immunol. 2001 Mar 01; 166(5):3515-21. PMID: 11207311.
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    62. Myou S, Sano H, Fujimura M, Zhu X, Kurashima K, Kita T, Nakao S, Nonomura A, Shioya T, Kim KP, Munoz NM, Cho W, Leff AR. Blockade of eosinophil migration and airway hyperresponsiveness by cPLA2-inhibition. Nat Immunol. 2001 Feb; 2(2):145-9. PMID: 11175812.
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    63. Leff AR. Regulation of leukotrienes in the management of asthma: biology and clinical therapy. Annu Rev Med. 2001; 52:1-14. PMID: 11160764.
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    64. Kim KP, Rafter JD, Bittova L, Han SK, Snitko Y, Munoz NM, Leff AR, Cho W. Mechanism of human group V phospholipase A2 (PLA2)-induced leukotriene biosynthesis in human neutrophils. A potential role of heparan sulfate binding in PLA2 internalization and degradation. J Biol Chem. 2001 Apr 06; 276(14):11126-34. PMID: 11118430.
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    65. Leff AR. Role of leukotrienes in bronchial hyperresponsiveness and cellular responses in airways. Thorax. 2000 Oct; 55 Suppl 2:S32-7. PMID: 10992554.
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    66. Zhu X, Subbaraman R, Sano H, Jacobs B, Sano A, Boetticher E, Muñoz NM, Leff AR. A surrogate method for assessment of beta(2)-integrin-dependent adhesion of human eosinophils to ICAM-1. J Immunol Methods. 2000 Jun 23; 240(1-2):157-64. PMID: 10854610.
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    67. Muñoz NM, van Seventer GA, Semnani RT, Leff AR. Augmentation of LTC(4) synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro. Am J Physiol Lung Cell Mol Physiol. 2000 Jun; 278(6):L1172-9. PMID: 10835322.
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    68. Dent G, Munoz NM, Zhu X, Rühlmann E, Magnussen H, Leff AR, Rabe KF. Involvement of protein tyrosine kinases in activation of human eosinophils by platelet-activating factor. Immunology. 2000 Jun; 100(2):231-7. PMID: 10886400.
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    69. Muñoz NM, Kim KP, Han SK, Boetticher E, Sperling AI, Sano H, Zhu X, Cho W, Leff AR. Characterization of monoclonal antibodies specific for 14-kDa human group V secretory phospholipase A2 (hVPLA2). Hybridoma. 2000 Apr; 19(2):171-6. PMID: 10868798.
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    70. Douglas IS, Leff AR, Sperling AI. CD4+ T cell and eosinophil adhesion is mediated by specific ICAM-3 ligation and results in eosinophil activation. J Immunol. 2000 Mar 15; 164(6):3385-91. PMID: 10706734.
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    71. Leff AR. Role of leukotrienes in bronchial hyperresponsiveness and cellular responses in airways. Am J Respir Crit Care Med. 2000 Feb; 161(2 Pt 2):S125-32. PMID: 10673241.
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    72. Ndukwu IM, Naureckas ET, Maxwell C, Waldman M, Leff AR. Relationship of cellular transmigration and airway response after allergen challenge. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 1):1516-24. PMID: 10556114.
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    73. Muñoz NM, Hamann KJ, Rabe KF, Sano H, Zhu X, Leff AR. Augmentation of eosinophil degranulation and LTC(4) secretion by integrin-mediated endothelial cell adhesion. Am J Physiol. 1999 10; 277(4):L802-10. PMID: 10516222.
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    74. Zhu X, Muñoz NM, Kim KP, Sano H, Cho W, Leff AR. Cytosolic phospholipase A2 activation is essential for beta 1 and beta 2 integrin-dependent adhesion of human eosinophils. J Immunol. 1999 Sep 15; 163(6):3423-9. PMID: 10477614.
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    75. Sano A, Muñoz NM, Sano H, Choi J, Zhu X, Jacobs B, Leff AR. Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. Am J Respir Crit Care Med. 1999 Jun; 159(6):1903-9. PMID: 10351938.
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    76. Carson SS, Bach PB, Brzozowski L, Leff A. Outcomes after long-term acute care. An analysis of 133 mechanically ventilated patients. Am J Respir Crit Care Med. 1999 May; 159(5 Pt 1):1568-73. PMID: 10228128.
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    77. Han SK, Kim KP, Koduri R, Bittova L, Munoz NM, Leff AR, Wilton DC, Gelb MH, Cho W. Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2. J Biol Chem. 1999 Apr 23; 274(17):11881-8. PMID: 10207008.
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    78. Sano H, Muñoz NM, Sano A, Zhu X, Herrnreiter A, Choi J, Leff AR. Upregulated surface expression of intracellularly sequestered Igepsilon receptors (FcepsilonRII/CD23) following activation in human peripheral blood eosinophils. Proc Assoc Am Physicians. 1999 Jan-Feb; 111(1):82-91. PMID: 9893160.
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    79. Bach PB, Carson SS, Leff A. Outcomes and resource utilization for patients with prolonged critical illness managed by university-based or community-based subspecialists. Am J Respir Crit Care Med. 1998 Nov; 158(5 Pt 1):1410-5. PMID: 9817687.
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    80. Leff AR. Biology of airway smooth muscle. Conference summary. Am J Respir Crit Care Med. 1998 Nov; 158(5 Pt 3):S78-9. PMID: 9817729.
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    81. Zhu X, Hamann KJ, Muñoz NM, Rubio N, Mayer D, Hernrreiter A, Leff AR. Intracellular expression of Fc gamma RIII (CD16) and its mobilization by chemoattractants in human eosinophils. J Immunol. 1998 Sep 01; 161(5):2574-9. PMID: 9725258.
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    82. Mitchell RW, Cozzi P, Ndukwu IM, Spaethe S, Leff AR, Padrid PA. Differential effects of cyclosporine A after acute antigen challenge in sensitized cats in vivo and ex vivo. Br J Pharmacol. 1998 Mar; 123(6):1198-204. PMID: 9559905.
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    83. Dent G, White SR, Tenor H, Bodtke K, Schudt C, Leff AR, Magnussen H, Rabe KF. Cyclic nucleotide phosphodiesterase in human bronchial epithelial cells: characterization of isoenzymes and functional effects of PDE inhibitors. Pulm Pharmacol Ther. 1998 Feb; 11(1):47-56. PMID: 9802963.
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    84. Leff AR. Pharmacologic management of asthma. J Allergy Clin Immunol. 1998 Feb; 101(2 Pt 2):S397-9. PMID: 9500737.
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    85. Dent G, Muñoz NM, Rühlmann E, Zhu X, Leff AR, Magnussen H, Rabe KF. Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. Am J Respir Cell Mol Biol. 1998 Jan; 18(1):136-44. PMID: 9448055.
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    86. Garland A, Necheles J, White SR, Neeley SP, Leff AR, Carson SS, Alger LE, McAllister K, Solway J. Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons. Am J Physiol. 1997 11; 273(5):L1096-102. PMID: 9374740.
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    87. Leff DR, Leff AR. Tuberculosis control policies in major metropolitan health departments in the United States. VI. Standard of practice in 1996. Am J Respir Crit Care Med. 1997 Nov; 156(5):1487-94. PMID: 9372665.
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    88. Leff A. Dose-response relationships in determining the safety:efficacy ratio. Respir Med. 1997 Nov; 91 Suppl A:34-7. PMID: 9474367.
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    89. Mitchell RW, Rabe KF, Magnussen H, Leff AR. Passive sensitization of human airways induces myogenic contractile responses in vitro. J Appl Physiol (1985). 1997 Oct; 83(4):1276-81. PMID: 9338437.
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    90. Heuertz RM, Hamann KJ, Hershenson MB, Leff AR. Adhesion of bovine airway smooth muscle cells activates extracellular signal-regulated kinases. Am J Respir Cell Mol Biol. 1997 Oct; 17(4):456-61. PMID: 9376120.
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    91. Palmer JS, Cromie WJ, Plzak LF, Leff AR. A platelet activating factor antagonist attenuates the effects of testicular ischemia. J Urol. 1997 Sep; 158(3 Pt 2):1186-90. PMID: 9258168.
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    92. Ndukwu IM, White SR, Leff AR, Mitchell RW. EP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis. Am J Physiol. 1997 Sep; 273(3 Pt 1):L626-33. PMID: 9316498.
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    93. Saito M, Sato R, Muñoz NM, Herrnreiter A, Oyaizu M, Kasugai H, Narahashi T, Leff AR. Association of granular exocytosis with Ca(2+)-activated K+ channels in human eosinophils. Am J Physiol. 1997 Jul; 273(1 Pt 1):L16-21. PMID: 9252535.
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    94. Mitchell RW, Ndukwu IM, Leff AR, Padrid PA. Muscarinic hyperresponsiveness of antigen-sensitized feline airway smooth muscle in vitro. Am J Vet Res. 1997 Jun; 58(6):672-6. PMID: 9185978.
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    95. Muñoz NM, Douglas I, Mayer D, Herrnreiter A, Zhu X, Leff AR. Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism. Am J Respir Crit Care Med. 1997 Apr; 155(4):1398-403. PMID: 9105085.
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    201. Tallet J, Munoz NM, Fried R, Leff AR. Endogenous modulation of alpha-adrenergic contraction in canine tracheal muscle. J Appl Physiol (1985). 1986 Aug; 61(2):464-71. PMID: 2875054.
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    202. Leff AR, Stimler NP, Munoz NM, Shioya T, Tallet J, Dame C. Augmentation of respiratory mast cell secretion of histamine caused by vagus nerve stimulation during antigen challenge. J Immunol. 1986 Feb 01; 136(3):1066-73. PMID: 2416826.
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    203. Leff AR, Leff DR. Tuberculosis: a reflection of political institutions and social concerns in the United States. Perspect Biol Med. 1986; 30(1):27-39. PMID: 3797211.
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    204. Leff AR, Tallet J, Munoz NM, Shoulberg N. Physiological antagonism caused by adrenergic stimulation of canine tracheal muscle. J Appl Physiol (1985). 1986 Jan; 60(1):216-24. PMID: 2867987.
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    205. Sands MF, Douglas FL, Green J, Banner AS, Robertson GL, Leff AR. Homeostatic regulation of bronchomotor tone by sympathetic activation during bronchoconstriction in normal and asthmatic humans. Am Rev Respir Dis. 1985 Nov; 132(5):993-8. PMID: 4062054.
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    206. Garrity ER, Stimler NP, Munoz NM, Tallet J, David AC, Leff AR. Sympathetic modulation of biochemical and physiological response to immune degranulation in canine bronchial airways in vivo. J Clin Invest. 1985 Jun; 75(6):2038-46. PMID: 2409114.
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    207. Leff AR, Munoz NM, Tallet J, Cavigelli M, David AC. Augmentation of parasympathetic contraction in tracheal and bronchial airways by PGF2 alpha in situ. J Appl Physiol (1985). 1985 May; 58(5):1558-64. PMID: 3858274.
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    208. Leff AR, Munoz NM, Tallet J, David AC, Cavigelli MA, Garrity ER. Autonomic response characteristics of porcine airway smooth muscle in vivo. J Appl Physiol (1985). 1985 Apr; 58(4):1176-88. PMID: 2859266.
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    209. Leff DR, Leff AR. Tuberculosis control practices in major metropolitan health departments in the United States. 3. Standard of practice in 1984. Chest. 1985 Feb; 87(2):206-11. PMID: 3967528.
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    210. Kearns TJ, Cole CH, Farer LS, Leff AR, Reza RJ, Sbarbaro JA, Stead WW. Public health issues in control of tuberculosis. Surveillance techniques and the role of health care providers. Chest. 1985 Feb; 87(2 Suppl):135S-138S. PMID: 3967549.
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    211. Leff DR, Leff AR. Current treatment modes for tuberculosis. Public policy and implementation. Chest. 1985 Feb; 87(2):139-40. PMID: 3967520.
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    212. Munoz NM, Cera LM, Leff AR. Distribution of innervation and circulation in porcine cervical trachea. Am J Vet Res. 1984 Oct; 45(10):1937-40. PMID: 6497090.
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    213. Leff AR, Garrity ER, Munoz NM, Tallet J, Cavigelli M, Deitchman D, Rajfer SI. Selectivity of the intrinsic sympathomimetic activity of the beta-adrenergic blocking drug bucindolol. J Cardiovasc Pharmacol. 1984 Sep-Oct; 6(5):859-66. PMID: 6209492.
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    214. Brown JK, Frey MJ, Reed BR, Leff AR, Shields R, Gold WM. Radioenzymatic assay for measurement of tissue concentrations of histamine: adaptation to correct for adherence of histamine to mechanical homogenizers. J Allergy Clin Immunol. 1984 Apr; 73(4):473-8. PMID: 6368647.
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    215. Garrity ER, Stimler NP, Munoz NM, Fried R, Leff AR. Response of bronchial smooth muscle to mast cell degranulation in situ. J Appl Physiol Respir Environ Exerc Physiol. 1983 Dec; 55(6):1803-10. PMID: 6662771.
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    216. Leff AR, Munoz NM, Hendrix SG. Parasympathetic and adrenergic contractile responses in canine trachea and bronchus. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jul; 55(1 Pt 1):113-20. PMID: 6885560.
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    217. Leff AR, Brown JK, Frey M, Reed B, Gold WM. Biochemical and physiological effects of compound 48/80 on canine trachea in vivo. J Appl Physiol Respir Environ Exerc Physiol. 1983 Mar; 54(3):720-9. PMID: 6188736.
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    218. Leff AR, Munoz NM, Hendrix SG. Comparative distribution of smooth muscle postsynaptic contractile responses in canine trachea and bronchus in vivo. J Pharmacol Exp Ther. 1983 Feb; 224(2):259-64. PMID: 6130142.
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    219. Hendrix SG, Munoz NM, Leff AR. Physiological and pharmacological response of canine bronchial smooth muscle in situ. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan; 54(1):215-24. PMID: 6826407.
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    220. Leff A, Rajfer SI, Addington WW. Subtype-specific pharmacology. The magic and the myth. Chest. 1982 Dec; 82(6):661. PMID: 7140389.
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    221. Brown JK, Leff AR, Frey MJ, Reed BR, Lazarus SC, Shields R, Gold WM. Characterization of tracheal mast cell reactions in vivo. Inhibition by a beta-adrenergic agonist. Am Rev Respir Dis. 1982 Nov; 126(5):842-8. PMID: 6183998.
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    222. Leff A. Patholphysiology of asthmatic bronchoconstriction. Chest. 1982 Jul; 82(1 Suppl):13S-21S. PMID: 6282546.
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    223. Leff AR, Munoz NM, Hendrix SG. Sympathetic inhibition of histamine-induced contraction of canine trachealis in vivo. J Appl Physiol Respir Environ Exerc Physiol. 1982 Jul; 53(1):21-9. PMID: 7118633.
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    224. Leff AR, Munoz NM, Alderman B. Measurement of airway response by isometric and nonisometric techniques in situ. J Appl Physiol Respir Environ Exerc Physiol. 1982 May; 52(5):1363-7. PMID: 7047473.
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    225. Leff A. Pathogenesis of asthma. Neurophysiology and pharmacology of bronchospasm. Chest. 1982 Feb; 81(2):224-9. PMID: 6276107.
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    226. Leff AR, Munoz NM. Interrelationship between alpha- and beta-adrenergic agonists and histamine in canine airways. J Allergy Clin Immunol. 1981 Oct; 68(4):300-9. PMID: 6116729.
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    227. Leff AR, Munoz NM. Cholinergic and alpha adrenergic augmentation of histamine-induced contraction of canine airway smooth muscle. J Pharmacol Exp Ther. 1981 Sep; 218(3):582-7. PMID: 6267247.
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    228. Leff AR, Munoz NM. Selective autonomic stimulation of canine trachealis with dimethylphenylpiperazinium. J Appl Physiol Respir Environ Exerc Physiol. 1981 Aug; 51(2):428-37. PMID: 6114944.
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    229. Leff AR, Munoz NM. Evidence for two subtypes of alpha adrenergic receptors in canine airway smooth muscle. J Pharmacol Exp Ther. 1981 May; 217(2):530-5. PMID: 6262489.
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    230. Leff AR, Leff DR, Brewin A. Tuberculosis chemotherapy practices in major metropolitan health departments in the United States. Am Rev Respir Dis. 1981 Feb; 123(2):176-80. PMID: 7235356.
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    231. Brown JK, Leff AR, Frey MJ, Reed BR, Gold WM. Physiological and pharmacological properties of canine trachealis muscle in vivo. J Appl Physiol Respir Environ Exerc Physiol. 1980 Jul; 49(1):84-94. PMID: 7399996.
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    232. Fein A, Leff A, Hopewell PC. Pathophysiology and management of the complications resulting from fire and the inhaled products of combustion: review of the literature. Crit Care Med. 1980 Feb; 8(2):94-8. PMID: 7353393.
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    233. Geppert EF, Leff A. The pathogenesis of pulmonary and miliary tuberculosis. Arch Intern Med. 1979 Dec; 139(12):1381-3. PMID: 518221.
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    234. Leff A, Herskowitz D, Gibert J, Brewin A. Tuberculosis chemoprophylaxis practices in metropolitan clinics. Am Rev Respir Dis. 1979 Jan; 119(1):161-70. PMID: 420430.
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    235. Leff A, Jacobs R, Gooding V, Hauch J, Conte J, Stulbarg M. Bacillus cereus pneumonia. Survival in a patient with cavitary disease treated with gentamicin. Am Rev Respir Dis. 1977 Jan; 115(1):151-4. PMID: 402096.
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    236. Whitnack E, Leff A, Mohammed S, Gaffney TE. The effect of L-dopa on chronotropic responses to cardioaccelerator nerve stimulation in dogs. J Pharmacol Exp Ther. 1971 May; 177(2):409-14. PMID: 5568797.
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    237. Josimovich JB, Wilson EL, Leff A. Vaginal mucification induced by pituitary prolactin and placental lactogen in mice. A luteotrophic test for protein hormone preparations. Gynecol Invest. 1970; 1(4):210-21. PMID: 5522107.
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