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Robert Grossman

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Robert L. Grossman is the Frederick H. Rawson Distinguished Service Professor in Medicine and Computer Science and the Jim and Karen Frank Director of the Center for Translational Data Science at the University of Chicago. He has also served as the chief research informatics officer of the Biological Sciences Division since 2011. He is the Co-Chief in the Section of Computational Biomedicine and Biomedical Data Science in the Department of Medicine.

    Collapse Biography 
    Collapse awards and honors
    2016ACM Fellow
    2013AAAS Fellow
    2013Federal 100 Award Winner
    2011Pritzker Scholar, University of Chicago

    Collapse Research 
    Collapse research activities and funding
    OT2OD030208     (GROSSMAN, ROBERT L.)Sep 1, 2020 - Aug 31, 2025
    NIH
    Helping to End Addiction Long-term (HEAL) Data Platform
    Role: Principal Investigator
    U24HG010262     (LAWSON, JONATHAN)Sep 19, 2018 - Jun 30, 2028
    NIH
    Expanding the AnVIL Data Ecosystem
    Role: Co-Principal Investigator
    OT3HL142481     (PATEN, BENEDICT)Sep 30, 2017 - Mar 30, 2022
    NIH
    The Integration of Trans-omics for Precision Medicine (TOPMED) and Other Heart, Lung, Blood and Sleep (HLBS) Data Sets with the Data Commons
    Role: Co-Principal Investigator
    OT3OD025460     (PATEN, BENEDICT)Sep 30, 2017 - Nov 30, 2018
    NIH
    The Commons Alliance: A Partnership to Catalyze the Creation of an NIH Data Commons
    Role: Co-Principal Investigator
    U2CHD109731     (RESNICK, ADAM CAIN)Sep 26, 2017 - Aug 31, 2025
    NIH
    Gabriella Miller Kids First Pediatric Data Resource Center: Advancing Collaborative Platform-Enabled Data-Driven Discovery at the Intersection of Childhood Development and Cancer
    Role: Co-Principal Investigator
    U2CHL138346     (RESNICK, ADAM CAIN)Jun 25, 2017 - Aug 31, 2025
    NIH
    Administrative and Outreach Core
    Role: Co-Principal Investigator
    K12HL119995     (SOLWAY, JULIAN)Sep 1, 2013 - May 31, 2018
    NIH
    Training of Junior Faculty for Careers in Omics of Lung Diseases
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lockwood CM, Merker JD, Bain E, Compton C, Grossman RL, Johann D, Jones F, Jones G, Kreifels M, LeBlang S, Lee JSH, Lyle J, Martini JF, Saunders L, Scher H, Somiari S, Stewart M, Vinson J, Leiman LC. Towards Preanalytical Best Practices for Liquid Biopsy Studies: A BLOODPAC Landscape Analysis. Clin Pharmacol Ther. 2024 Aug 20. PMID: 39164947.
      Citations:    Fields:    
    2. Brady A, Charbonneau A, Grossman RL, Creasy HH, Renner R, Pihl T, Otridge J, Kim E, CRDC Program, Barnholtz-Sloan JS, Kerlavage AR. NCI Cancer Research Data Commons: Core Standards and Services. Cancer Res. 2024 May 02; 84(9):1384-1387. PMID: 38488505; PMCID: PMC11067691.
      Citations: 1     Fields:    Translation:Humans
    3. Wang Z, Davidsen TM, Kuffel GR, Addepalli K, Bell A, Casas-Silva E, Dingerdissen H, Farahani K, Fedorov A, Gaheen S, Grossman RL, Kikinis R, Kim E, Otridge J, Pihl T, Porter M, Rodriguez H, Staudt LM, Thangudu RR, Venkatachari S, Zenklusen JC, Zhang X, CRDC Program, Barnholtz-Sloan JS, Kerlavage AR. NCI Cancer Research Data Commons: Resources to Share Key Cancer Data. Cancer Res. 2024 May 02; 84(9):1388-1395. PMID: 38488507; PMCID: PMC11063687.
      Citations: 2     Fields:    Translation:HumansAnimals
    4. Trunnell M, Frankenberger C, Hota B, Hughes T, Martinov P, Ravichandran U, Shah NS, Grossman RL, Pandemic Response Commons Consortium . The Pandemic Response Commons. JAMIA Open. 2024 Jul; 7(2):ooae025. PMID: 38617994; PMCID: PMC11009464.
      Citations:    
    5. Grossman RL, Boyles RR, Davis-Dusenbery BN, Haddock A, Heath AP, O'Connor BD, Resnick AC, Taylor DM, Ahalt S. A Framework for the Interoperability of Cloud Platforms: Towards FAIR Data in SAFE Environments. Sci Data. 2024 Feb 26; 11(1):241. PMID: 38409183; PMCID: PMC10897146.
      Citations:    Fields:    
    6. Wyatt KD, Graglia L, Furner B, Kang B, Fitzsimons M, Grossman RL, Volchenboum SL. An open-source platform for pediatric cancer data exploration: a report from Data for the Common Good. JAMIA Open. 2024 Apr; 7(1):ooae004. PMID: 38304249; PMCID: PMC10833446.
      Citations:    
    7. Clark M, Meyer C, Ramos-Cejudo J, Elbers DC, Pierce-Murray K, Fricks R, Alterovitz G, Rao L, Brophy MT, Do NV, Grossman RL, Fillmore NR. Transfer Learning for Mortality Prediction in Non-Small Cell Lung Cancer with Low-Resolution Histopathology Slide Snapshots. Stud Health Technol Inform. 2024 Jan 25; 310:735-739. PMID: 38269906; PMCID: PMC11128309.
      Citations:    Fields:    Translation:Humans
    8. Hernandez KM, Venkat A, Elbers DC, Bihn JR, Brophy MT, Do NV, La J, Liu Q, Prokhorenkov A, Metoki-Shlubsky N, Sung FC, Paller CJ, Fillmore NR, Grossman RL. Prostate cancer patient stratification by molecular signatures in the Veterans Precision Oncology Data Commons. Cold Spring Harb Mol Case Stud. 2023 12; 9(4). PMID: 38050021; PMCID: PMC10815278.
      Citations:    Fields:    Translation:Humans
    9. Ahalt S, Avillach P, Boyles R, Bradford K, Cox S, Davis-Dusenbery B, Grossman RL, Krishnamurthy A, Manning A, Paten B, Philippakis A, Borecki I, Chen SH, Kaltman J, Ladwa S, Schwartz C, Thomson A, Davis S, Leaf A, Lyons J, Sheets E, Bis JC, Conomos M, Culotti A, Desain T, Digiovanna J, Domazet M, Gogarten S, Gutierrez-Sacristan A, Harris T, Heavner B, Jain D, O'Connor B, Osborn K, Pillion D, Pleiness J, Rice K, Rupp G, Serret-Larmande A, Smith A, Stedman JP, Stilp A, Barsanti T, Cheadle J, Erdmann C, Farlow B, Gartland-Gray A, Hayes J, Hiles H, Kerr P, Lenhardt C, Madden T, Mieczkowska JO, Miller A, Patton P, Rathbun M, Suber S, Asare J. Building a collaborative cloud platform to accelerate heart, lung, blood, and sleep research. J Am Med Inform Assoc. 2023 06 20; 30(7):1293-1300. PMID: 37192819; PMCID: PMC10280347.
      Citations: 3     Fields:    Translation:Humans
    10. Dolezal JM, Wolk R, Hieromnimon HM, Howard FM, Srisuwananukorn A, Karpeyev D, Ramesh S, Kochanny S, Kwon JW, Agni M, Simon RC, Desai C, Kherallah R, Nguyen TD, Schulte JJ, Cole K, Khramtsova G, Garassino MC, Husain AN, Li H, Grossman R, Cipriani NA, Pearson AT. Deep learning generates synthetic cancer histology for explainability and education. NPJ Precis Oncol. 2023 May 29; 7(1):49. PMID: 37248379; PMCID: PMC10227067.
      Citations: 8     
    11. Sweeney SM, Hamadeh HK, Abrams N, Adam SJ, Brenner S, Connors DE, Davis GJ, Fiore L, Gawel SH, Grossman RL, Hanlon SE, Hsu K, Kelloff GJ, Kirsch IR, Louv B, McGraw D, Meng F, Milgram D, Miller RS, Morgan E, Mukundan L, O'Brien T, Robbins P, Rubin EH, Rubinstein WS, Salmi L, Schaller T, Shi G, Sigman CC, Srivastava S. Challenges to Using Big Data in Cancer. Cancer Res. 2023 04 14; 83(8):1175-1182. PMID: 36625843; PMCID: PMC10102837.
      Citations: 8     Fields:    Translation:Humans
    12. Sweeney SM, Hamadeh HK, Abrams N, Adam SJ, Brenner S, Connors DE, Davis GJ, Fiore LD, Gawel SH, Grossman RL, Hanlon SE, Hsu K, Kelloff GJ, Kirsch IR, Louv B, McGraw D, Meng F, Milgram D, Miller RS, Morgan E, Mukundan L, O'Brien T, Robbins P, Rubin EH, Rubinstein WS, Salmi L, Schaller TH, Shi G, Sigman CC, Srivastava S. Case Studies for Overcoming Challenges in Using Big Data in Cancer. Cancer Res. 2023 04 14; 83(8):1183-1190. PMID: 36625851; PMCID: PMC10102839.
      Citations: 1     Fields:    Translation:Humans
    13. Lukowski M, Prokhorenkov A, Grossman RL. Towards self-describing and FAIR bulk formats for biomedical data. PLoS Comput Biol. 2023 03; 19(3):e1010944. PMID: 36913405; PMCID: PMC10035862.
      Citations:    Fields:    
    14. Grossman RL. Ten lessons for data sharing with a data commons. Sci Data. 2023 03 06; 10(1):120. PMID: 36878917; PMCID: PMC9988927.
      Citations: 7     Fields:    
    15. Hernandez KM, Bramlett KS, Agius P, Baden J, Cao R, Clement O, Corner AS, Craft J, Dean DA, Dry JR, Grigaityte K, Grossman RL, Hicks J, Higa N, Holzer TR, Jensen J, Johann DJ, Katz S, Kolatkar A, Keynton JL, Lee JSH, Maar D, Martini JF, Meyer CG, Roberts PC, Ryder M, Salvatore L, Schageman JJ, Somiari S, Stetson D, Stern M, Xu L, Leiman LC. Contrived Materials and a Data Set for the Evaluation of Liquid Biopsy Tests: A Blood Profiling Atlas in Cancer (BLOODPAC) Community Study. J Mol Diagn. 2023 03; 25(3):143-155. PMID: 36828596.
      Citations:    Fields:    Translation:Humans
    16. Clarke CA, Lang K, Putcha G, Beer JP, Champagne M, Ferris A, Godsey JH, Grossman RL, Hoyos JM, Johann DJ, Krunic N, Kuhn P, Lee JSH, Maddala T, Mata M, McDole J, Perez O, Scher H, Stewart MD, Bhan SS, Zhang Q, Leiman LC. BLOODPAC: Collaborating to chart a path towards blood-based screening for early cancer detection. Clin Transl Sci. 2023 01; 16(1):5-9. PMID: 36251491; PMCID: PMC9841293.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    17. Sheffield NC, Bonazzi VR, Bourne PE, Burdett T, Clark T, Grossman RL, Spjuth O, Yates AD. From biomedical cloud platforms to microservices: next steps in FAIR data and analysis. Sci Data. 2022 09 08; 9(1):553. PMID: 36075919; PMCID: PMC9458632.
      Citations: 7     Fields:    
    18. Schumm LP, Giurcanu MC, Locey KJ, Ortega JC, Zhang Z, Grossman RL. Racial and ethnic disparities in the observed COVID-19 case fatality rate among the U.S. population. Ann Epidemiol. 2022 10; 74:118-124. PMID: 35940395; PMCID: PMC9352645.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    19. Shi C, Babiker N, Urbanek JK, Grossman RL, Huisingh-Scheetz M, Rzhetsky A. Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts. NPJ Aging. 2022 Jun 06; 8(1):7. PMID: 35927250; PMCID: PMC9170733.
      Citations: 1     
    20. Barnes C, Bajracharya B, Cannalte M, Gowani Z, Haley W, Kass-Hout T, Hernandez K, Ingram M, Juvvala HP, Kuffel G, Martinov P, Maxwell JM, McCann J, Malhotra A, Metoki-Shlubsky N, Meyer C, Paredes A, Qureshi J, Ritter X, Schumm P, Shao M, Sheth U, Simmons T, VanTol A, Zhang Z, Grossman RL. The Biomedical Research Hub: a federated platform for patient research data. J Am Med Inform Assoc. 2022 03 15; 29(4):619-625. PMID: 35289369; PMCID: PMC8922179.
      Citations: 7     Fields:    Translation:Humans
    21. Kuang X, Wang F, Hernandez KM, Zhang Z, Grossman RL. Accurate and rapid prediction of tuberculosis drug resistance from genome sequence data using traditional machine learning algorithms and CNN. Sci Rep. 2022 02 14; 12(1):2427. PMID: 35165358; PMCID: PMC8844416.
      Citations: 14     Fields:    Translation:HumansCells
    22. Schatz MC, Philippakis AA, Afgan E, Banks E, Carey VJ, Carroll RJ, Culotti A, Ellrott K, Goecks J, Grossman RL, Hall IM, Hansen KD, Lawson J, Leek JT, Luria AO, Mosher S, Morgan M, Nekrutenko A, O'Connor BD, Osborn K, Paten B, Patterson C, Tan FJ, Taylor CO, Vessio J, Waldron L, Wang T, Wuichet K. Inverting the model of genomics data sharing with the NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space. Cell Genom. 2022 Jan 12; 2(1). PMID: 35199087; PMCID: PMC8863334.
      Citations: 66     Fields:    
    23. Rehm HL, Page AJH, Smith L, Adams JB, Alterovitz G, Babb LJ, Barkley MP, Baudis M, Beauvais MJS, Beck T, Beckmann JS, Beltran S, Bernick D, Bernier A, Bonfield JK, Boughtwood TF, Bourque G, Bowers SR, Brookes AJ, Brudno M, Brush MH, Bujold D, Burdett T, Buske OJ, Cabili MN, Cameron DL, Carroll RJ, Casas-Silva E, Chakravarty D, Chaudhari BP, Chen SH, Cherry JM, Chung J, Cline M, Clissold HL, Cook-Deegan RM, Courtot M, Cunningham F, Cupak M, Davies RM, Denisko D, Doerr MJ, Dolman LI, Dove ES, Dursi LJ, Dyke SOM, Eddy JA, Eilbeck K, Ellrott KP, Fairley S, Fakhro KA, Firth HV, Fitzsimons MS, Fiume M, Flicek P, Fore IM, Freeberg MA, Freimuth RR, Fromont LA, Fuerth J, Gaff CL, Gan W, Ghanaim EM, Glazer D, Green RC, Griffith M, Griffith OL, Grossman RL, Groza T, Auvil JMG, Guigó R, Gupta D, Haendel MA, Hamosh A, Hansen DP, Hart RK, Hartley DM, Haussler D, Hendricks-Sturrup RM, Ho CWL, Hobb AE, Hoffman MM, Hofmann OM, Holub P, Hsu JS, Hubaux JP, Hunt SE, Husami A, Jacobsen JO, Jamuar SS, Janes EL, Jeanson F, Jené A, Johns AL, Joly Y, Jones SJM, Kanitz A, Kato K, Keane TM, Kekesi-Lafrance K, Kelleher J, Kerry G, Khor SS, Knoppers BM, Konopko MA, Kosaki K, Kuba M, Lawson J, Leinonen R, Li S, Lin MF, Linden M, Liu X, Udara Liyanage I, Lopez J, Lucassen AM, Lukowski M, Mann AL, Marshall J, Mattioni M, Metke-Jimenez A, Middleton A, Milne RJ, Molnár-Gábor F, Mulder N, Munoz-Torres MC, Nag R, Nakagawa H, Nasir J, Navarro A, Nelson TH, Niewielska A, Nisselle A, Niu J, Nyrönen TH, O'Connor BD, Oesterle S, Ogishima S, Wang VO, Paglione LAD, Palumbo E, Parkinson HE, Philippakis AA, Pizarro AD, Prlic A, Rambla J, Rendon A, Rider RA, Robinson PN, Rodarmer KW, Rodriguez LL, Rubin AF, Rueda M, Rushton GA, Ryan RS, Saunders GI, Schuilenburg H, Schwede T, Scollen S, Senf A, Sheffield NC, Skantharajah N, Smith AV, Sofia HJ, Spalding D, Spurdle AB, Stark Z, Stein LD, Suematsu M, Tan P, Tedds JA, Thomson AA, Thorogood A, Tickle TL, Tokunaga K, Törnroos J, Torrents D, Upchurch S, Valencia A, Guimera RV, Vamathevan J, Varma S, Vears DF, Viner C, Voisin C, Wagner AH, Wallace SE, Walsh BP, Williams MS, Winkler EC, Wold BJ, Wood GM, Woolley JP, Yamasaki C, Yates AD, Yung CK, Zass LJ, Zaytseva K, Zhang J, Goodhand P, North K, Birney E. GA4GH: International policies and standards for data sharing across genomic research and healthcare. Cell Genom. 2021 Nov 10; 1(2). PMID: 35072136; PMCID: PMC8774288.
      Citations: 78     Fields:    
    24. Howard FM, Dolezal J, Kochanny S, Schulte J, Chen H, Heij L, Huo D, Nanda R, Olopade OI, Kather JN, Cipriani N, Grossman RL, Pearson AT. The impact of site-specific digital histology signatures on deep learning model accuracy and bias. Nat Commun. 2021 07 20; 12(1):4423. PMID: 34285218; PMCID: PMC8292530.
      Citations: 82     Fields:    Translation:Humans
    25. Heath AP, Ferretti V, Agrawal S, An M, Angelakos JC, Arya R, Bajari R, Baqar B, Barnowski JHB, Burt J, Catton A, Chan BF, Chu F, Cullion K, Davidsen T, Do PM, Dompierre C, Ferguson ML, Fitzsimons MS, Ford M, Fukuma M, Gaheen S, Ganji GL, Garcia TI, George SS, Gerhard DS, Gerthoffert F, Gomez F, Han K, Hernandez KM, Issac B, Jackson R, Jensen MA, Joshi S, Kadam A, Khurana A, Kim KMJ, Kraft VE, Li S, Lichtenberg TM, Lodato J, Lolla L, Martinov P, Mazzone JA, Miller DP, Miller I, Miller JS, Miyauchi K, Murphy MW, Nullet T, Ogwara RO, Pham PL, Popov MY, Porter JJ, Powell R, Rademacher K, Reid CP, Rich S, Rogel B, Sahni H, Savage JH, Schmitt KA, Simmons TJ, Sislow J, Spring J, Stein L, Sullivan S, Tang Y, Thiagarajan M, Troyer HD, Wang C, Wang Z, West BL, Wilmer A, Wilson S, Wu K, Wysocki WP, Xiang L, Yamada JT, Yang L, Yu C, Yung CK, Zenklusen JC, Zhang J, Zhang Z, Zhao Y, Zubair A, Staudt LM, Grossman RL, Ortuño FM, Pedrosa J. Author Correction: The NCI Genomic Data Commons. Nat Genet. 2021 Jun; 53(6):935. PMID: 34007079.
      Citations:    Fields:    
    26. Grossman RL, Dry JR, Hanlon SE, Johann DJ, Kolatkar A, Lee JSH, Meyer C, Salvatore L, Wells W, Leiman L. BloodPAC Data Commons for Liquid Biopsy Data. JCO Clin Cancer Inform. 2021 04; 5:479-486. PMID: 33929890; PMCID: PMC8140805.
      Citations: 4     Fields:    Translation:Humans
    27. Heath AP, Ferretti V, Agrawal S, An M, Angelakos JC, Arya R, Bajari R, Baqar B, Barnowski JHB, Burt J, Catton A, Chan BF, Chu F, Cullion K, Davidsen T, Do PM, Dompierre C, Ferguson ML, Fitzsimons MS, Ford M, Fukuma M, Gaheen S, Ganji GL, Garcia TI, George SS, Gerhard DS, Gerthoffert F, Gomez F, Han K, Hernandez KM, Issac B, Jackson R, Jensen MA, Joshi S, Kadam A, Khurana A, Kim KMJ, Kraft VE, Li S, Lichtenberg TM, Lodato J, Lolla L, Martinov P, Mazzone JA, Miller DP, Miller I, Miller JS, Miyauchi K, Murphy MW, Nullet T, Ogwara RO, Pham PL, Popov MY, Porter JJ, Powell R, Rademacher K, Reid CP, Rich S, Rogel B, Sahni H, Savage JH, Schmitt KA, Simmons TJ, Sislow J, Spring J, Stein L, Sullivan S, Tang Y, Thiagarajan M, Troyer HD, Wang C, Wang Z, West BL, Wilmer A, Wilson S, Wu K, Wysocki WP, Xiang L, Yamada JT, Yang L, Yu C, Yung CK, Zenklusen JC, Zhang J, Zhang Z, Zhao Y, Zubair A, Staudt LM, Grossman RL, Ortuño FM, Pedrosa J. The NCI Genomic Data Commons. Nat Genet. 2021 03; 53(3):257-262. PMID: 33619384.
      Citations: 39     Fields:    Translation:Humans
    28. Zhang Z, Hernandez K, Savage J, Li S, Miller D, Agrawal S, Ortuno F, Staudt LM, Heath A, Grossman RL. Uniform genomic data analysis in the NCI Genomic Data Commons. Nat Commun. 2021 02 22; 12(1):1226. PMID: 33619257; PMCID: PMC7900240.
      Citations: 49     Fields:    Translation:HumansCells
    29. Khomtchouk BB, Nelson CS, Vand KA, Palmisano S, Grossman RL. HeartBioPortal2.0: new developments and updates for genetic ancestry and cardiometabolic quantitative traits in diverse human populations. Database (Oxford). 2020 12 31; 2020. PMID: 33382884; PMCID: PMC7774463.
      Citations: 4     Fields:    Translation:Humans
    30. Elbers DC, Fillmore NR, Sung FC, Ganas SS, Prokhorenkov A, Meyer C, Hall RB, Ajjarapu SJ, Chen DC, Meng F, Grossman RL, Brophy MT, Do NV. The Veterans Affairs Precision Oncology Data Repository, a Clinical, Genomic, and Imaging Research Database. Patterns (N Y). 2020 Sep 11; 1(6):100083. PMID: 33205130; PMCID: PMC7660389.
      Citations: 6     
    31. Thomas S, Lichtenberg T, Dang K, Fitzsimons M, Grossman RL, Kundra R, Lavery JA, Lenoue-Newton ML, Panageas KS, Sawyers C, Schultz ND, Sirintrapun SJ, Topaloglu U, Welch A, Yu T, Zehir A, Gardos S. Linked Entity Attribute Pair (LEAP): A Harmonization Framework for Data Pooling. JCO Clin Cancer Inform. 2020 08; 4:691-699. PMID: 32755461; PMCID: PMC7469618.
      Citations: 1     Fields:    Translation:Humans
    32. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature. 2020 02; 578(7793):82-93. PMID: 32025007; PMCID: PMC7025898.
      Citations: 1077     Fields:    Translation:HumansCells
    33. Febbo PG, Martin AM, Scher HI, Barrett JC, Beaver JA, Beresford PJ, Blumenthal GM, Bramlett K, Compton C, Dittamore R, Eberhard DA, Edelstein D, Godsey J, Gruen A, Hanlon SE, Hicks J, Hovelson D, Hullings M, Johann D, Johnson J, Kolatkar A, Kuhn P, Levine R, Martini JF, Miller DP, Moore C, Moy B, Pathak A, Philip R, Reese D, Royalty W, Ryder M, Sakul H, Salvatore LM, Schade A, Silvestro A, Simmons JK, Simons J, Singh Bhan S, Smalley MD, Somiari SB, Talasaz A, Tewari M, Tseng HR, Vinson J, Wells W, Welsh A, Grossman RL, Lee JSH, Leiman LC. Minimum Technical Data Elements for Liquid Biopsy Data Submitted to Public Databases. Clin Pharmacol Ther. 2020 04; 107(4):730-734. PMID: 32017048; PMCID: PMC7158216.
      Citations: 8     Fields:    Translation:Humans
    34. Baron T, Grossman RI, Abramson SB, Pusic MV, Rivera R, Triola MM, Yanai I. Signatures of medical student applicants and academic success. PLoS One. 2020; 15(1):e0227108. PMID: 31940377; PMCID: PMC6961867.
      Citations: 4     Fields:    Translation:Humans
    35. Applebaum MA, Barr EK, Karpus J, West-Szymanski DC, Oliva M, Sokol EA, Zhang S, Zhang Z, Zhang W, Chlenski A, Salwen HR, Wilkinson E, Dobratic M, Grossman RL, Godley LA, Stranger BE, He C, Cohn SL. 5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma. Clin Cancer Res. 2020 03 15; 26(6):1309-1317. PMID: 31852832; PMCID: PMC7073281.
      Citations: 16     Fields:    Translation:HumansCells
    36. Do N, Grossman R, Feldman T, Fillmore N, Elbers D, Tuck D, Dhond R, Selva L, Meng F, Fitzsimons M, Ajjarapu S, Ayandeh S, Hall R, Do S, Brophy M. The Veterans Precision Oncology Data Commons: Transforming VA data into a national resource for research in precision oncology. Semin Oncol. 2019 Aug - Oct; 46(4-5):314-320. PMID: 31629530.
      Citations: 9     Fields:    Translation:Humans
    37. Do NV, Ramos JC, Fillmore NR, Grossman RL, Fitzsimons M, Elbers DC, Meng F, Johnson BR, Ajjarapu S, DeDomenico CL, Pierce-Murray KE, Hall RB, Do AF, Gaynor K, Elkin PL, Brophy MT. Machine Learning Methods to Predict Lung Cancer Survival Using the Veterans Affairs Research Precision Oncology Data Commons. Stud Health Technol Inform. 2019 Aug 21; 264:1453. PMID: 31438177.
      Citations:    Fields:    Translation:Humans
    38. Applebaum MA, Barr EK, Karpus J, Nie J, Zhang Z, Armstrong AE, Uppal S, Sukhanova M, Zhang W, Chlenski A, Salwen HR, Wilkinson E, Dobratic M, Grossman R, Godley LA, Stranger BE, He C, Cohn SL. 5-Hydroxymethylcytosine Profiles Are Prognostic of Outcome in Neuroblastoma and Reveal Transcriptional Networks That Correlate With Tumor Phenotype. JCO Precis Oncol. 2019; 3. PMID: 31179414; PMCID: PMC6553657.
      Citations: 14     Fields:    
    39. Friedman PN, Shaazuddin M, Gong L, Grossman RL, Harralson AF, Klein TE, Lee NH, Miller DC, Nutescu EA, O'Brien TJ, O'Donnell PH, O'Leary KJ, Tuck M, Meltzer DO, Perera MA. The ACCOuNT Consortium: A Model for the Discovery, Translation, and Implementation of Precision Medicine in African Americans. Clin Transl Sci. 2019 05; 12(3):209-217. PMID: 30592548; PMCID: PMC6510376.
      Citations: 23     Fields:    Translation:HumansCells
    40. Grossman RL. Data Lakes, Clouds, and Commons: A Review of Platforms for Analyzing and Sharing Genomic Data. Trends Genet. 2019 03; 35(3):223-234. PMID: 30691868; PMCID: PMC6474403.
      Citations: 28     Fields:    Translation:Humans
    41. Geeleher P, Nath A, Wang F, Zhang Z, Barbeira AN, Fessler J, Grossman RL, Seoighe C, Stephanie Huang R. Cancer expression quantitative trait loci (eQTLs) can be determined from heterogeneous tumor gene expression data by modeling variation in tumor purity. Genome Biol. 2018 09 11; 19(1):130. PMID: 30205839; PMCID: PMC6131897.
      Citations: 18     Fields:    Translation:HumansCells
    42. Lee JS, Kibbe WA, Grossman RL. Data Harmonization for a Molecularly Driven Health System. Cell. 2018 08 23; 174(5):1045-1048. PMID: 30142341.
      Citations: 7     Fields:    Translation:Humans
    43. Grossman RL. Progress Toward Cancer Data Ecosystems. Cancer J. 2018 May/Jun; 24(3):126-130. PMID: 29794537; PMCID: PMC5988431.
      Citations: 9     Fields:    Translation:Humans
    44. Peisert S, Dart E, Barnett W, Balas E, Cuff J, Grossman RL, Berman A, Shankar A, Tierney B. The medical science DMZ: a network design pattern for data-intensive medical science. J Am Med Inform Assoc. 2018 Mar 01; 25(3):267-274. PMID: 29040639; PMCID: PMC7651886.
      Citations: 1     Fields:    
    45. Jun G, Manning A, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Gaulton KJ, Dyer T, Blackwell TW, Chen H, Chines PS, Choi S, Churchhouse C, Fontanillas P, King R, Lee S, Lincoln SE, Trubetskoy V, DePristo M, Fingerlin T, Grossman R, Grundstad J, Heath A, Kim J, Kim YJ, Laramie J, Lee J, Li H, Liu X, Livne O, Locke AE, Maller J, Morris AP, Pollin TI, Ragona D, Reich D, Rivas MA, Scott LJ, Sim X, Tearle RG, Teo YY, Williams AL, Curran JE, Peralta J, Akolkar B, Bell GI, Cox NJ, Florez JC, Hanis CL, McKeon C, Mohlke KL, Seielstad M, Wilson JG, Atzmon G, Below JE, Nicolae DL, Lehman D, Park T, Won S, Altshuler D, McCarthy MI, Duggirala R, Boehnke M, Frayling TM, Blangero J, Cingolani P, Mazur A, Zöllner S, Burtt NP, Dupuis J, Sladek R, Abecasis GR. Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):379-384. PMID: 29279374; PMCID: PMC5777025.
      Citations: 23     Fields:    Translation:Humans
    46. Wilson S, Fitzsimons M, Ferguson M, Heath A, Jensen M, Miller J, Murphy MW, Porter J, Sahni H, Staudt L, Tang Y, Wang Z, Yu C, Zhang J, Ferretti V, Grossman RL, GDC Project. Developing Cancer Informatics Applications and Tools Using the NCI Genomic Data Commons API. Cancer Res. 2017 11 01; 77(21):e15-e18. PMID: 29092930; PMCID: PMC5683428.
      Citations: 18     Fields:    Translation:Humans
    47. Patterson MT, Grossman RL. Detecting Spatial Patterns of Disease in Large Collections of Electronic Medical Records Using Neighbor-Based Bootstrapping. Big Data. 2017 09; 5(3):213-224. PMID: 28933946; PMCID: PMC5647508.
      Citations: 1     Fields:    Translation:Humans
    48. Geeleher P, Zhang Z, Wang F, Gruener RF, Nath A, Morrison G, Bhutra S, Grossman RL, Huang RS. Discovering novel pharmacogenomic biomarkers by imputing drug response in cancer patients from large genomics studies. Genome Res. 2017 10; 27(10):1743-1751. PMID: 28847918; PMCID: PMC5630037.
      Citations: 65     Fields:    Translation:Humans
    49. Jensen MA, Ferretti V, Grossman RL, Staudt LM. The NCI Genomic Data Commons as an engine for precision medicine. Blood. 2017 07 27; 130(4):453-459. PMID: 28600341; PMCID: PMC5533202.
      Citations: 122     Fields:    Translation:Humans
    50. Stricker TP, Brown CD, Bandlamudi C, McNerney M, Kittler R, Montoya V, Peterson A, Grossman R, White KP. Robust stratification of breast cancer subtypes using differential patterns of transcript isoform expression. PLoS Genet. 2017 03; 13(3):e1006589. PMID: 28263985; PMCID: PMC5367891.
      Citations: 38     Fields:    Translation:HumansCells
    51. Volchenboum SL, Cox SM, Heath A, Resnick A, Cohn SL, Grossman R. Data Commons to Support Pediatric Cancer Research. Am Soc Clin Oncol Educ Book. 2017; 37:746-752. PMID: 28561664.
      Citations: 21     Fields:    Translation:Humans
    52. Grossman RL, Heath AP, Ferretti V, Varmus HE, Lowy DR, Kibbe WA, Staudt LM. Toward a Shared Vision for Cancer Genomic Data. N Engl J Med. 2016 Sep 22; 375(12):1109-12. PMID: 27653561; PMCID: PMC6309165.
      Citations: 771     Fields:    Translation:Humans
    53. Grossman RL, Heath A, Murphy M, Patterson M, Wells W. A Case for Data Commons: Toward Data Science as a Service. Comput Sci Eng. 2016 Sep-Oct; 18(5):10-20. PMID: 29033693; PMCID: PMC5636009.
      Citations: 26     
    54. Peisert S, Barnett W, Dart E, Cuff J, Grossman RL, Balas E, Berman A, Shankar A, Tierney B. The Medical Science DMZ. J Am Med Inform Assoc. 2016 11; 23(6):1199-1201. PMID: 27136944; PMCID: PMC5070525.
      Citations: 1     Fields:    
    55. Slattery M, Ma L, Spokony RF, Arthur RK, Kheradpour P, Kundaje A, Crofts A, Ptashkin R, Zieba J, Ostapenko A, Suchy S, Victorsen A, Jameel N, Grundstad AJ, Gao W, Moran JR, Rehm EJ, Grossman RL, Kellis M, White KP, Nègre N. Diverse patterns of genomic targeting by transcriptional regulators in Drosophila melanogaster. Genome Res. 2014 Jul; 24(7):1224-35. PMID: 24985916; PMCID: PMC4079976.
      Citations: 21     Fields:    Translation:AnimalsCells
    56. Heath AP, Greenway M, Powell R, Spring J, Suarez R, Hanley D, Bandlamudi C, McNerney ME, White KP, Grossman RL. Bionimbus: a cloud for managing, analyzing and sharing large genomics datasets. J Am Med Inform Assoc. 2014 Nov-Dec; 21(6):969-75. PMID: 24464852; PMCID: PMC4215034.
      Citations: 22     Fields:    Translation:Humans
    57. Kolker E, Martens L, Hancock W, Anderson G, Anderson N, Aynacioglu S, Baranova A, Campagna SR, Chen R, Choiniere J, Dearth SP, Feng WC, Ferguson L, Fox G, Frishman D, Grossman R, Heath A, Higdon R, Hutz MH, Janko I, Jiang L, Joshi S, Kel A, Kemnitz JW, Kohane IS, Kolker N, Lancet D, Lee E, Li W, Lisitsa A, Llerena A, Macnealy-Koch C, Marshall JC, Masuzzo P, May A, Mias G, Monroe M, Montague E, Mooney S, Nesvizhskii A, Noronha S, Omenn G, Rajasimha H, Ramamoorthy P, Sheehan J, Smarr L, Smith CV, Smith T, Snyder M, Rapole S, Srivastava S, Stanberry L, Stewart E, Toppo S, Uetz P, Verheggen K, Voy BH, Warnich L, Wilhelm SW, Yandl G, Özdemir V. Toward more transparent and reproducible omics studies through a common metadata checklist and data publications. OMICS. 2014 Jan; 18(1):10-4. PMID: 24456465; PMCID: PMC3903324.
      Citations: 20     Fields:    Translation:Humans
    58. Madzo J, Liu H, Rodriguez A, Vasanthakumar A, Sundaravel S, Caces DBD, Looney TJ, Zhang L, Lepore JB, Macrae T, Duszynski R, Shih AH, Song CX, Yu M, Yu Y, Grossman R, Raumann B, Verma A, He C, Levine RL, Lavelle D, Lahn BT, Wickrema A, Godley LA. Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis. Cell Rep. 2014 Jan 16; 6(1):231-244. PMID: 24373966; PMCID: PMC3976649.
      Citations: 65     Fields:    Translation:HumansCells
    59. Kolker E, Martens L, Hancock W, Anderson G, Anderson N, Aynacioglu S, Baranova A, Campagna SR, Chen R, Choiniere J, Dearth SP, Feng WC, Ferguson L, Fox G, Frishman D, Grossman R, Heath A, Higdon R, Hutz MH, Janko I, Jiang L, Joshi S, Kel A, Kemnitz JW, Kohane IS, Kolker N, Lancet D, Lee E, Li W, Lisitsa A, Llerena A, MacNealy-Koch C, Marshall JC, Masuzzo P, May A, Mias G, Monroe M, Montague E, Mooney S, Nesvizhskii A, Noronha S, Omenn G, Rajasimha H, Ramamoorthy P, Sheehan J, Smarr L, Smith CV, Smith T, Snyder M, Rapole S, Srivastava S, Stanberry L, Stewart E, Toppo S, Uetz P, Verheggen K, Voy BH, Warnich L, Wilhelm SW, Yandl G, Özdemir V. Toward More Transparent and Reproducible Omics Studies Through a Common Metadata Checklist and Data Publications. Big Data. 2013 Dec; 1(4):196-201. PMID: 27447251.
      Citations: 2     Fields:    
    60. Blair DR, Lyttle CS, Mortensen JM, Bearden CF, Jensen AB, Khiabanian H, Melamed R, Rabadan R, Bernstam EV, Jensen LJ, Nicolae D, Shah NH, Grossman RL, Cox NJ, White KP, Rzhetsky A, Brunak S. A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk. Cell. 2013 Sep 26; 155(1):70-80. PMID: 24074861; PMCID: PMC3844554.
      Citations: 124     Fields:    Translation:Humans
    61. Jiang ZF, Xia F, Johnson KW, Brown CD, Bartom E, Tuteja JH, Stevens R, Grossman RL, Brumin M, White KP, Ghanim M. Comparison of the genome sequences of "Candidatus Portiera aleyrodidarum" primary endosymbionts of the whitefly Bemisia tabaci B and Q biotypes. Appl Environ Microbiol. 2013 Mar; 79(5):1757-9. PMID: 23315735; PMCID: PMC3591977.
      Citations: 15     Fields:    Translation:AnimalsCells
    62. McNerney ME, Brown CD, Wang X, Bartom ET, Karmakar S, Bandlamudi C, Yu S, Ko J, Sandall BP, Stricker T, Anastasi J, Grossman RL, Cunningham JM, Le Beau MM, White KP. CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia. Blood. 2013 Feb 07; 121(6):975-83. PMID: 23212519; PMCID: PMC3567344.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    63. Jiang ZF, Xia F, Johnson KW, Bartom E, Tuteja JH, Stevens R, Grossman RL, Brumin M, White KP, Ghanim M. Genome sequences of the primary endosymbiont "Candidatus Portiera aleyrodidarum" in the whitefly Bemisia tabaci B and Q biotypes. J Bacteriol. 2012 Dec; 194(23):6678-9. PMID: 23144417; PMCID: PMC3497481.
      Citations: 16     Fields:    Translation:AnimalsCells
    64. Grossman RL, White KP. A vision for a biomedical cloud. J Intern Med. 2012 Feb; 271(2):122-30. PMID: 22142244; PMCID: PMC6338328.
      Citations: 13     Fields:    Translation:Humans
    65. Hricak H, Brody WR, Grossman RI, Zerhouni EA, Debatin JF. View from above. Radiology. 2012 Feb; 262(2):399-401. PMID: 22282180.
      Citations:    Fields:    Translation:Humans
    66. Feng X, Grossman R, Stein L. PeakRanger: a cloud-enabled peak caller for ChIP-seq data. BMC Bioinformatics. 2011 May 09; 12:139. PMID: 21554709; PMCID: PMC3103446.
      Citations: 71     Fields:    Translation:Cells
    67. ENCODE Project Consortium. A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol. 2011 Apr; 9(4):e1001046. PMID: 21526222; PMCID: PMC3079585.
      Citations: 905     Fields:    Translation:HumansCells
    68. Brown CD, Ma L, Bristow CA, Miller SW, Wagner U, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony RF, Chen J, Hwang L, Cheng C, Auburn RP, Davis MB, Domanus M, Shah PK, Morrison CA, Zieba J, Suchy S, Senderowicz L, Victorsen A, Bild NA, Grundstad AJ, Hanley D, MacAlpine DM, Mannervik M, Venken K, Bellen H, White R, Gerstein M, Russell S, Grossman RL, Ren B, Posakony JW, Kellis M, White KP, Nègre N. A cis-regulatory map of the Drosophila genome. Nature. 2011 Mar 24; 471(7339):527-31. PMID: 21430782; PMCID: PMC3179250.
      Citations: 316     Fields:    Translation:AnimalsCells
    69. modENCODE Consortium, Roy S, Ernst J, Kharchenko PV, Kheradpour P, Negre N, Eaton ML, Landolin JM, Bristow CA, Ma L, Lin MF, Washietl S, Arshinoff BI, Ay F, Meyer PE, Robine N, Washington NL, Di Stefano L, Berezikov E, Brown CD, Candeias R, Carlson JW, Carr A, Jungreis I, Marbach D, Sealfon R, Tolstorukov MY, Will S, Alekseyenko AA, Artieri C, Booth BW, Brooks AN, Dai Q, Davis CA, Duff MO, Feng X, Gorchakov AA, Gu T, Henikoff JG, Kapranov P, Li R, MacAlpine HK, Malone J, Minoda A, Nordman J, Okamura K, Perry M, Powell SK, Riddle NC, Sakai A, Samsonova A, Sandler JE, Schwartz YB, Sher N, Spokony R, Sturgill D, van Baren M, Wan KH, Yang L, Yu C, Feingold E, Good P, Guyer M, Lowdon R, Ahmad K, Andrews J, Berger B, Brenner SE, Brent MR, Cherbas L, Elgin SC, Gingeras TR, Grossman R, Hoskins RA, Kaufman TC, Kent W, Kuroda MI, Orr-Weaver T, Perrimon N, Pirrotta V, Posakony JW, Ren B, Russell S, Cherbas P, Graveley BR, Lewis S, Micklem G, Oliver B, Park PJ, Celniker SE, Henikoff S, Karpen GH, Lai EC, MacAlpine DM, Stein LD, White KP, Kellis M. Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science. 2010 Dec 24; 330(6012):1787-97. PMID: 21177974; PMCID: PMC3192495.
      Citations: 716     Fields:    Translation:AnimalsCells
    70. Tian F, Shah PK, Liu X, Negre N, Chen J, Karpenko O, White KP, Grossman RL. Flynet: a genomic resource for Drosophila melanogaster transcriptional regulatory networks. Bioinformatics. 2009 Nov 15; 25(22):3001-4. PMID: 19656951; PMCID: PMC2773252.
      Citations: 1     Fields:    Translation:Animals
    71. Gu Y, Grossman RL. Sector and Sphere: the design and implementation of a high-performance data cloud. Philos Trans A Math Phys Eng Sci. 2009 Jun 28; 367(1897):2429-45. PMID: 19451100; PMCID: PMC3391065.
      Citations: 1     Fields:    
    72. Tian F, Chen J, Bao S, Shi L, Liu X, Grossman R. A graph model based study on regulatory impacts of transcription factors of Drosophila melanogaster and comparison across species. Biochem Biophys Res Commun. 2009 Sep 04; 386(4):559-62. PMID: 19538943.
      Citations:    Fields:    Translation:AnimalsCells
    73. Wilkinson L, Anand A, Grossman R. High-dimensional visual analytics: interactive exploration guided by pairwise views of point distributions. IEEE Trans Vis Comput Graph. 2006 Nov-Dec; 12(6):1363-72. PMID: 17073361.
      Citations: 2     Fields:    
    74. Grossman R, Kasturi P, Hamelberg D, Liu B. An empirical study of the universal chemical key algorithm for assigning unique keys to chemical compounds. J Bioinform Comput Biol. 2004 Mar; 2(1):155-71. PMID: 15272437.
      Citations:    Fields:    
    75. Grossman R, Kasturi P, Hamelberg D, Liu B. Experimental studies of the Universal Chemical Key (UCK) algorithm on the NCI database of chemical compounds. Proc IEEE Comput Soc Bioinform Conf. 2003; 2:244-50. PMID: 16452799.
      Citations:    Fields:    
    76. Filippi M, Dousset V, McFarland HF, Miller DH, Grossman RI. Role of magnetic resonance imaging in the diagnosis and monitoring of multiple sclerosis: consensus report of the White Matter Study Group. J Magn Reson Imaging. 2002 May; 15(5):499-504. PMID: 11997889.
      Citations: 17     Fields:    Translation:Humans
    77. Fazekas F, Barkhof F, Filippi M, Grossman RI, Li DK, McDonald WI, McFarland HF, Paty DW, Simon JH, Wolinsky JS, Miller DH. The contribution of magnetic resonance imaging to the diagnosis of multiple sclerosis. Neurology. 1999 Aug 11; 53(3):448-56. PMID: 10449103.
      Citations: 61     Fields:    Translation:Humans
    78. Filippi M, Horsfield MA, Barkhof F, Bruzzi P, Evans A, Frank JA, Grossman RI, McFarland HF, Molyneux P, Paty DW, Simon J, Tofts PS, Wolinsky JS, Miller DH, Adèr HJ. Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis. Ann Neurol. 1998 Apr; 43(4):499-506. PMID: 9546332.
      Citations: 35     Fields:    Translation:Humans
    79. Miller DH, Grossman RI, Reingold SC, McFarland HF. The role of magnetic resonance techniques in understanding and managing multiple sclerosis. Brain. 1998 Jan; 121 ( Pt 1):3-24. PMID: 9549485.
      Citations: 106     Fields:    Translation:Humans
    80. Hirsch JA, Langlotz CP, Lee J, Tanio CP, Grossman RI, Schulman KA. Clinical assessment of MR of the brain in nonsurgical inpatients. AJNR Am J Neuroradiol. 1996 Aug; 17(7):1245-53. PMID: 8871707; PMCID: PMC8338541.
      Citations: 1     Fields:    Translation:Humans
    81. Zimmerman RA, Bilaniuk LT, Hackney DB, Goldberg HI, Grossman RI. Magnetic resonance imaging of the pediatric spinal cord and canal. Acta Radiol Suppl. 1986; 369:649-50. PMID: 2980584.
      Citations:    Fields:    Translation:Humans
    82. Levine RS, Grossman RI. Head and facial trauma. Emerg Med Clin North Am. 1985 Aug; 3(3):447-73. PMID: 3893976.
      Citations:    Fields:    Translation:Humans
    83. Zimmerman RA, Bilaniuk LT, Grossman RI, Levine RS, Lynch R, Goldberg HI, Samuel L, Edelstein W, Bottomley P, Redington RW. Resistive NMR of intracranial hematomas. Neuroradiology. 1985; 27(1):16-20. PMID: 3974860.
      Citations: 2     Fields:    Translation:Humans
    84. Teasdale G, Rowan JO, Turner J, Grossman R, Miller JD. Cerebral perfusion failure and cortical electrical activity. Acta Neurol Scand Suppl. 1977; 64:430-1. PMID: 409074.
      Citations:    Fields:    Translation:Animals
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