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Esra Tasali

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Pulmonary and Critical Care
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Associate Professor of Medicine
    Section of Pulmonary and Critical Care Medicine
    Department of Medicine
    The University of Chicago

    My research program focuses on the role of insufficient sleep in the development of metabolic diseases including type 2 diabetes and obesity. I have extensive experience investigating the relationships between sleep loss and metabolic disruptions utilizing experimental laboratory models in healthy humans, clinical studies in patients with obstructive sleep apnea, and field studies on energy metabolism in individuals at risk for diabetes and obesity.

    My NIH COMMONS name is etasali.

    Collapse Biography 
    Collapse awards and honors
    2001Alan Rechtshaffen Award, The University of Chicago
    2005Young Investigator Award of the American Academy of Sleep Medicine, American Academy of Sleep Medicine
    2006Best Clinical Research, The University of Chicago
    2006American Academy of Sleep Medicine/Pfizer Scholar in Sleep Medicine , American Academy of Sleep Medicine
    2008Young Investigator Award of the Sleep Research Society, Sleep Research Society

    Collapse Research 
    Collapse research activities and funding
    R01DK136214     (TASALI, ESRA)Sep 15, 2023 - Aug 31, 2028
    NIH
    Sleep Extension: A Novel Intervention for Weight Loss in Young Adults
    Role: Principal Investigator
    R01DK120312     (TASALI, ESRA)Aug 1, 2019 - Jul 31, 2024
    NIH
    Technology-Supported Treatment of Sleep Apnea in Prediabetes
    Role: Principal Investigator
    R01HL146127     (TASALI, ESRA)Jul 15, 2019 - Jun 30, 2024
    NIH
    Mechanisms of Prediabetic States in Obstructive Sleep Apnea
    Role: Principal Investigator
    R01DK100426     (TASALI, ESRA)Aug 15, 2014 - Jul 31, 2020
    NIH
    Sleep Extension To Reduce Diabetes and Obesity Risk
    Role: Principal Investigator
    RC1HL100046     (TASALI, ESRA)Sep 30, 2009 - Aug 31, 2012
    NIH
    Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Role: Principal Investigator
    R01HL086459     (TASALI, ESRA)Sep 15, 2006 - Jun 30, 2011
    NIH
    Pathways Linking Reduced Sleep Duration and Quality to Obesity Risk
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pamidi S, Benedetti A, Tasali E. One hour post-load glucose levels among patients with obstructive sleep apnea and normal glucose tolerance. J Diabetes Complications. 2023 08; 37(8):108551. PMID: 37478674.
      Citations:    Fields:    Translation:Humans
    2. Arosemena M, Salguero MV, Naylor RN, Wroblewski K, Tasali E, Philipson LH. Objective and Subjective Sleep Patterns in Adults With Maturity-Onset Diabetes of the Young (MODY). Diabetes Care. 2023 03 01; 46(3):608-612. PMID: 36637968; PMCID: PMC10090264.
      Citations:    Fields:    Translation:Humans
    3. Pfammatter AF, Hughes BO, Tucker B, Whitmore H, Spring B, Tasali E. The Development of a Novel mHealth Tool for Obstructive Sleep Apnea: Tracking Continuous Positive Airway Pressure Adherence as a Percentage of Time in Bed. J Med Internet Res. 2022 12 05; 24(12):e39489. PMID: 36469406; PMCID: PMC9764150.
      Citations:    Fields:    Translation:Humans
    4. Tasali E, Wroblewski K, Kahn E, Kilkus J, Schoeller DA. Effect of Sleep Extension on Objectively Assessed Energy Intake Among Adults With Overweight in Real-life Settings: A Randomized Clinical Trial. JAMA Intern Med. 2022 04 01; 182(4):365-374. PMID: 35129580; PMCID: PMC8822469.
      Citations: 29     Fields:    Translation:Humans
    5. Wilson K, St-Onge MP, Tasali E. Diet Composition and Objectively Assessed Sleep Quality: A Narrative Review. J Acad Nutr Diet. 2022 06; 122(6):1182-1195. PMID: 35063665; PMCID: PMC9124688.
      Citations: 14     Fields:    Translation:HumansAnimals
    6. Brandt R, Park M, Wroblewski K, Quinn L, Tasali E, Cinar A. Sleep quality and glycaemic variability in a real-life setting in adults with type 1 diabetes. Diabetologia. 2021 10; 64(10):2159-2169. PMID: 34136937; PMCID: PMC9254230.
      Citations: 8     Fields:    Translation:Humans
    7. Sam S, Tasali E. Role of obstructive sleep apnea in metabolic risk in PCOS. Curr Opin Endocr Metab Res. 2021 Apr; 17:46-51. PMID: 34368492; PMCID: PMC8341449.
      Citations: 2     
    8. St-Onge MP, Tasali E. Weight Loss Is Integral to Obstructive Sleep Apnea Management. Ten-Year Follow-up in Sleep AHEAD. Am J Respir Crit Care Med. 2021 01 15; 203(2):161-162. PMID: 32795248; PMCID: PMC7874406.
      Citations: 3     Fields:    Translation:Humans
    9. Pamidi S, Chapotot F, Wroblewski K, Whitmore H, Polonsky T, Tasali E. Optimal Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea Reduces Daytime Resting Heart Rate in Prediabetes: A Randomized Controlled Study. J Am Heart Assoc. 2020 10 20; 9(19):e016871. PMID: 32998624; PMCID: PMC7792375.
      Citations: 1     Fields:    Translation:Humans
    10. Morselli LL, Gamazon ER, Tasali E, Cox NJ, Van Cauter E, Davis LK. Shared Genetic Control of Brain Activity During Sleep and Insulin Secretion: A Laboratory-Based Family Study. Diabetes. 2018 01; 67(1):155-164. PMID: 29084784; PMCID: PMC5741150.
      Citations: 1     Fields:    Translation:Humans
    11. Bhutani S, Kahn E, Tasali E, Schoeller DA. Composition of two-week change in body weight under unrestricted free-living conditions. Physiol Rep. 2017 Jul; 5(13). PMID: 28676555; PMCID: PMC5506524.
      Citations: 19     Fields:    Translation:Humans
    12. Guyon A, Morselli LL, Balbo ML, Tasali E, Leproult R, Van Cauter E, Spiegel K, L'Hermite-Balériaux M. Effects of Insufficient Sleep on Pituitary-Adrenocortical Response to CRH Stimulation in Healthy Men. Sleep. 2017 06 01; 40(6). PMID: 28444400; PMCID: PMC6075556.
      Citations: 15     Fields:    Translation:HumansAnimalsCTClinical Trials
    13. Pamidi S, Tasali E. Continuous Positive Airway Pressure for Improving Glycemic Control in Type 2 Diabetes: Where Do We Stand? Am J Respir Crit Care Med. 2016 08 15; 194(4):397-400. PMID: 27525459.
      Citations: 3     Fields:    Translation:Humans
    14. Jacome-Sosa M, Parks EJ, Bruno RS, Tasali E, Lewis GF, Schneeman BO, Rains TM. Postprandial Metabolism of Macronutrients and Cardiometabolic Risk: Recent Developments, Emerging Concepts, and Future Directions. Adv Nutr. 2016 Mar; 7(2):364-74. PMID: 26980820; PMCID: PMC4785471.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    15. Hanlon EC, Tasali E, Stuhr KL, Doncheck E, de Wit H, Hillard CJ, Van Cauter E, Leproult R. Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol. Sleep. 2016 Mar 01; 39(3):653-64. PMID: 26612385; PMCID: PMC4763355.
      Citations: 48     Fields:    Translation:Humans
    16. Broussard JL, Wroblewski K, Kilkus JM, Tasali E. Two Nights of Recovery Sleep Reverses the Effects of Short-term Sleep Restriction on Diabetes Risk. Diabetes Care. 2016 Mar; 39(3):e40-1. PMID: 26786578; PMCID: PMC4764036.
      Citations: 21     Fields:    
    17. Broussard JL, Kilkus JM, Delebecque F, Abraham V, Day A, Whitmore HR, Tasali E. Elevated ghrelin predicts food intake during experimental sleep restriction. Obesity (Silver Spring). 2016 Jan; 24(1):132-8. PMID: 26467988; PMCID: PMC4688118.
      Citations: 60     Fields:    Translation:Humans
    18. Consensus Conference Panel, Watson NF, Badr MS, Belenky G, Bliwise DL, Buxton OM, Buysse D, Dinges DF, Gangwisch J, Grandner MA, Kushida C, Malhotra RK, Martin JL, Patel SR, Quan SF, Tasali E. Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion. J Clin Sleep Med. 2015 Aug 15; 11(8):931-52. PMID: 26235159; PMCID: PMC4513271.
      Citations: 149     Fields:    Translation:Humans
    19. Consensus Conference Panel, Watson NF, Badr MS, Belenky G, Bliwise DL, Buxton OM, Buysse D, Dinges DF, Gangwisch J, Grandner MA, Kushida C, Malhotra RK, Martin JL, Patel SR, Quan SF, Tasali E. Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion. Sleep. 2015 Aug 01; 38(8):1161-83. PMID: 26194576; PMCID: PMC4507722.
      Citations: 259     Fields:    Translation:Humans
    20. Pamidi S, Wroblewski K, Stepien M, Sharif-Sidi K, Kilkus J, Whitmore H, Tasali E. Eight Hours of Nightly Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea Improves Glucose Metabolism in Patients with Prediabetes. A Randomized Controlled Trial. Am J Respir Crit Care Med. 2015 Jul 01; 192(1):96-105. PMID: 25897569; PMCID: PMC4511421.
      Citations: 73     Fields:    Translation:Humans
    21. Consensus Conference Panel, Watson NF, Badr MS, Belenky G, Bliwise DL, Buxton OM, Buysse D, Dinges DF, Gangwisch J, Grandner MA, Kushida C, Malhotra RK, Martin JL, Patel SR, Quan SF, Tasali E, Non-Participating Observers, Twery M, Croft JB, Maher E, American Academy of Sleep Medicine Staff, Barrett JA, Thomas SM, Heald JL. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. J Clin Sleep Med. 2015 Jun 15; 11(6):591-2. PMID: 25979105; PMCID: PMC4442216.
      Citations: 184     Fields:    Translation:Humans
    22. Watson NF, Badr MS, Belenky G, Bliwise DL, Buxton OM, Buysse D, Dinges DF, Gangwisch J, Grandner MA, Kushida C, Malhotra RK, Martin JL, Patel SR, Quan SF, Tasali E. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. Sleep. 2015 Jun 01; 38(6):843-4. PMID: 26039963; PMCID: PMC4434546.
      Citations: 480     Fields:    Translation:Humans
    23. Broussard JL, Chapotot F, Abraham V, Day A, Delebecque F, Whitmore HR, Tasali E. Sleep restriction increases free fatty acids in healthy men. Diabetologia. 2015 Apr; 58(4):791-8. PMID: 25702040; PMCID: PMC4358810.
      Citations: 64     Fields:    Translation:HumansCells
    24. Tasali E, Leproult R, Stuhr KL, Doncheck E, de Wit H, Hillard CJ, Van Cauter E, Hanlon EC. Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol. J Clin Endocrinol Metab. 2015 Jan; 100(1):220-6. PMID: 25368979; PMCID: PMC5399498.
      Citations: 35     Fields:    Translation:Humans
    25. Ayas NT, Hirsch AA, Bradley TD, Malhotra A, Tasali E, Laher I, Polotsky VY. New frontiers in obstructive sleep apnoea. Clin Sci (Lond). 2014 Aug; 127(4):209-16. PMID: 24780001; PMCID: PMC4348094.
      Citations: 21     Fields:    Translation:HumansAnimals
    26. Tasali E, Chapotot F, Wroblewski K, Schoeller D. The effects of extended bedtimes on sleep duration and food desire in overweight young adults: a home-based intervention. Appetite. 2014 Sep; 80:220-4. PMID: 24858836; PMCID: PMC4112413.
      Citations: 46     Fields:    Translation:HumansAnimals
    27. Balbo M, Morselli LL, Tasali E, Leproult R, Van Cauter E, Spiegel K, Guyon A, L'Hermite-Balériaux M. Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men. J Clin Endocrinol Metab. 2014 Aug; 99(8):2861-8. PMID: 24823456; PMCID: PMC4121029.
      Citations: 41     Fields:    Translation:Humans
    28. Broussard JL, Ehrmann DA, Van Cauter E, Tasali E, Brady MJ. Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study. Ann Intern Med. 2012 Oct 16; 157(8):549-57. PMID: 23070488; PMCID: PMC4435718.
      Citations: 157     Fields:    Translation:HumansCells
    29. Pamidi S, Wroblewski K, Broussard J, Day A, Hanlon EC, Abraham V, Tasali E. Obstructive sleep apnea in young lean men: impact on insulin sensitivity and secretion. Diabetes Care. 2012 Nov; 35(11):2384-9. PMID: 22912423; PMCID: PMC3476882.
      Citations: 47     Fields:    Translation:Humans
    30. Pamidi S, Tasali E. Obstructive sleep apnea and type 2 diabetes: is there a link? Front Neurol. 2012; 3:126. PMID: 23015803; PMCID: PMC3449487.
      Citations: 88     
    31. Tasali E, Chapotot F, Leproult R, Whitmore H, Ehrmann DA. Treatment of obstructive sleep apnea improves cardiometabolic function in young obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2011 Feb; 96(2):365-74. PMID: 21123449; PMCID: PMC3048326.
      Citations: 37     Fields:    Translation:Humans
    32. Tasali E, Leproult R, Scherberg N, Van Cauter E, Spiegel K. Twenty-four-hour profiles of acylated and total ghrelin: relationship with glucose levels and impact of time of day and sleep. J Clin Endocrinol Metab. 2011 Feb; 96(2):486-93. PMID: 21106712; PMCID: PMC3206394.
      Citations: 49     Fields:    Translation:HumansCells
    33. Pamidi S, Aronsohn RS, Tasali E. Obstructive sleep apnea: role in the risk and severity of diabetes. Best Pract Res Clin Endocrinol Metab. 2010 Oct; 24(5):703-15. PMID: 21112020; PMCID: PMC2994098.
      Citations: 49     Fields:    Translation:HumansAnimals
    34. Aronsohn RS, Whitmore H, Van Cauter E, Tasali E. Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes. Am J Respir Crit Care Med. 2010 Mar 01; 181(5):507-13. PMID: 20019340; PMCID: PMC2830401.
      Citations: 156     Fields:    Translation:Humans
    35. Tasali E, Leproult R, Van Cauter E, Spiegel K. Effects of poor and short sleep on glucose metabolism and obesity risk. Nat Rev Endocrinol. 2009 May; 5(5):253-61. PMID: 19444258; PMCID: PMC4457292.
      Citations: 318     Fields:    Translation:Humans
    36. Tasali E, Leproult R, Spiegel K. Reduced sleep duration or quality: relationships with insulin resistance and type 2 diabetes. Prog Cardiovasc Dis. 2009 Mar-Apr; 51(5):381-91. PMID: 19249444.
      Citations: 59     Fields:    Translation:Humans
    37. Van Cauter E, Spiegel K, Tasali E, Leproult R. Metabolic consequences of sleep and sleep loss. Sleep Med. 2008 Sep; 9 Suppl 1:S23-8. PMID: 18929315; PMCID: PMC4444051.
      Citations: 247     Fields:    Translation:HumansCells
    38. Tasali E, Van Cauter E, Hoffman L, Ehrmann DA. Impact of obstructive sleep apnea on insulin resistance and glucose tolerance in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2008 Oct; 93(10):3878-84. PMID: 18647805; PMCID: PMC2579653.
      Citations: 29     Fields:    Translation:Humans
    39. Tasali E, Van Cauter E, Ehrmann DA. Polycystic Ovary Syndrome and Obstructive Sleep Apnea. Sleep Med Clin. 2008 Mar; 3(1):37-46. PMID: 19255602; PMCID: PMC2390828.
      Citations: 27     Fields:    
    40. Tasali E, Ip MS. Obstructive sleep apnea and metabolic syndrome: alterations in glucose metabolism and inflammation. Proc Am Thorac Soc. 2008 Feb 15; 5(2):207-17. PMID: 18250214.
      Citations: 136     Fields:    Translation:Humans
    41. Tasali E, Mokhlesi B, Van Cauter E. Obstructive sleep apnea and type 2 diabetes: interacting epidemics. Chest. 2008 Feb; 133(2):496-506. PMID: 18252916.
      Citations: 165     Fields:    Translation:Humans
    42. Tasali E, Leproult R, Ehrmann DA, Van Cauter E. Slow-wave sleep and the risk of type 2 diabetes in humans. Proc Natl Acad Sci U S A. 2008 Jan 22; 105(3):1044-9. PMID: 18172212; PMCID: PMC2242689.
      Citations: 364     Fields:    Translation:Humans
    43. Van Cauter E, Holmback U, Knutson K, Leproult R, Miller A, Nedeltcheva A, Pannain S, Penev P, Tasali E, Spiegel K. Impact of sleep and sleep loss on neuroendocrine and metabolic function. Horm Res. 2007; 67 Suppl 1:2-9. PMID: 17308390.
      Citations: 100     Fields:    Translation:Humans
    44. Latta F, Leproult R, Tasali E, Hofmann E, Van Cauter E. Sex differences in delta and alpha EEG activities in healthy older adults. Sleep. 2005 Dec; 28(12):1525-34. PMID: 16408411.
      Citations: 23     Fields:    Translation:Humans
    45. Latta F, Leproult R, Tasali E, Hofmann E, Copinschi G, Van Cauter E, L'Hermite-Balériaux M. Sex differences in nocturnal growth hormone and prolactin secretion in healthy older adults: relationships with sleep EEG variables. Sleep. 2005 Dec; 28(12):1519-24. PMID: 16408410.
      Citations: 14     Fields:    Translation:Humans
    46. Knutson K, Leproult R, Tasali E, Van Cauter E, Spiegel K. Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes. J Appl Physiol (1985). 2005 Nov; 99(5):2008-19. PMID: 16227462.
      Citations: 412     Fields:    Translation:Humans
    47. Tasali E, Van Cauter E, Ehrmann DA. Relationships between sleep disordered breathing and glucose metabolism in polycystic ovary syndrome. J Clin Endocrinol Metab. 2006 Jan; 91(1):36-42. PMID: 16219719.
      Citations: 34     Fields:    Translation:HumansCTClinical Trials
    48. Spiegel K, Tasali E, Penev P, Van Cauter E. Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med. 2004 Dec 07; 141(11):846-50. PMID: 15583226.
      Citations: 837     Fields:    Translation:HumansCTClinical Trials
    49. Tasali E, Van Cauter E. Sleep-disordered breathing and the current epidemic of obesity: consequence or contributing factor? Am J Respir Crit Care Med. 2002 Mar 01; 165(5):562-3. PMID: 11874803.
      Citations: 13     Fields:    Translation:HumansPHPublic Health
    50. Erkan F, Tasali E, Gül A. Pulmonary manifestations of Behçet's disease. Thorax. 2001 Jul; 56(7):572-8. PMID: 11413359; PMCID: PMC1746103.
      Citations: 67     Fields:    Translation:Humans
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