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Guy Sella

Title
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Spence JP, Mostafavi H, Ota M, Milind N, Gjorgjieva T, Smith CJ, Simons YB, Sella G, Pritchard JK, Spence JP, Mostafavi H, Ota M, Milind N, Gjorgjieva T, Smith CJ, Simons YB, Sella G, Pritchard JK. Specificity, length, and luck: How genes are prioritized by rare and common variant association studies. bioRxiv. 2024 Dec 16. PMID: 39935885; PMCID: PMC11812597.
      Citations:    
    2. Aguirre M, Spence JP, Sella G, Pritchard JK, Aguirre M, Spence JP, Sella G, Pritchard JK. Gene regulatory network structure informs the distribution of perturbation effects. bioRxiv. 2024 Oct 22. PMID: 39005431; PMCID: PMC11245109.
      Citations:    
    3. Spisak N, de Manuel M, Milligan W, Sella G, Przeworski M. The clock-like accumulation of germline and somatic mutations can arise from the interplay of DNA damage and repair. PLoS Biol. 2024 Jun; 22(6):e3002678. PMID: 38885262; PMCID: PMC11213356.
      Citations: 2     Fields:    
    4. Baker Z, Przeworski M, Sella G. Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence. Elife. 2023 Oct 13; 12. PMID: 37830496; PMCID: PMC10703446.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    5. Spisak N, de Manuel M, Milligan W, Sella G, Przeworski M. Disentangling sources of clock-like mutations in germline and soma. bioRxiv. 2023 Sep 12. PMID: 37745549; PMCID: PMC10515775.
      Citations:    
    6. Elyashiv E, Amster G, Sella G, Murphy DA. Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements. Elife. 2023 Jun 23; 12. PMID: 36196994; PMCID: PMC10299832.
      Citations: 20     Fields:    Translation:Humans
    7. Hayward LK, Sella G. Polygenic adaptation after a sudden change in environment. Elife. 2022 09 26; 11. PMID: 36155653; PMCID: PMC9683794.
      Citations: 37     Fields:    
    8. Milligan WR, Amster G, Sella G. The impact of genetic modifiers on variation in germline mutation rates within and among human populations. Genetics. 2022 07 30; 221(4). PMID: 35666194; PMCID: PMC9339295.
      Citations: 5     Fields:    Translation:Humans
    9. Milligan WR, Fuller ZL, Agarwal I, Eisen MB, Przeworski M, Sella G. Impact of essential workers in the context of social distancing for epidemic control. PLoS One. 2021; 16(8):e0255680. PMID: 34347855; PMCID: PMC8336873.
      Citations: 8     Fields:    Translation:HumansPHPublic Health
    10. Amster G, Murphy DA, Milligan WR, Sella G. Changes in life history and population size can explain the relative neutral diversity levels on X and autosomes in extant human populations. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):20063-20069. PMID: 32747577; PMCID: PMC7443924.
      Citations: 4     Fields:    Translation:HumansCells
    11. Amster G, Sella G. Life History Effects on Neutral Diversity Levels of Autosomes and Sex Chromosomes. Genetics. 2020 08; 215(4):1133-1142. PMID: 32554702; PMCID: PMC7404230.
      Citations: 5     Fields:    Translation:HumansCells
    12. Sella G, Barton NH. Thinking About the Evolution of Complex Traits in the Era of Genome-Wide Association Studies. Annu Rev Genomics Hum Genet. 2019 08 31; 20:461-493. PMID: 31283361.
      Citations: 93     Fields:    Translation:Humans
    13. Fuller ZL, Berg JJ, Mostafavi H, Sella G, Przeworski M. Measuring intolerance to mutation in human genetics. Nat Genet. 2019 05; 51(5):772-776. PMID: 30962618; PMCID: PMC6615471.
      Citations: 64     Fields:    Translation:HumansAnimals
    14. Sheftel H, Szekely P, Mayo A, Sella G, Alon U. Evolutionary trade-offs and the structure of polymorphisms. Philos Trans R Soc Lond B Biol Sci. 2018 05 26; 373(1747). PMID: 29632259; PMCID: PMC5904293.
      Citations: 7     Fields:    
    15. Simons YB, Bullaughey K, Hudson RR, Sella G. A population genetic interpretation of GWAS findings for human quantitative traits. PLoS Biol. 2018 03; 16(3):e2002985. PMID: 29547617; PMCID: PMC5871013.
      Citations: 73     Fields:    Translation:Humans
    16. Simons YB, Sella G. The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives. Curr Opin Genet Dev. 2016 Dec; 41:150-158. PMID: 27744216; PMCID: PMC5161708.
      Citations: 50     Fields:    Translation:HumansAnimals
    17. Elyashiv E, Sattath S, Hu TT, Strutsovsky A, McVicker G, Andolfatto P, Coop G, Sella G. A Genomic Map of the Effects of Linked Selection in Drosophila. PLoS Genet. 2016 08; 12(8):e1006130. PMID: 27536991; PMCID: PMC4990265.
      Citations: 79     Fields:    Translation:Animals
    18. Amster G, Sella G. Life history effects on the molecular clock of autosomes and sex chromosomes. Proc Natl Acad Sci U S A. 2016 Feb 09; 113(6):1588-93. PMID: 26811451; PMCID: PMC4760823.
      Citations: 45     Fields:    Translation:AnimalsCells
    19. Gao Z, Wyman MJ, Sella G, Przeworski M. Interpreting the Dependence of Mutation Rates on Age and Time. PLoS Biol. 2016 Jan; 14(1):e1002355. PMID: 26761240; PMCID: PMC4711947.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    20. Gao Z, Przeworski M, Sella G. Footprints of ancient-balanced polymorphisms in genetic variation data from closely related species. Evolution. 2015 Feb; 69(2):431-46. PMID: 25403856; PMCID: PMC4335603.
      Citations: 36     Fields:    Translation:HumansAnimals
    21. Harpak A, Sella G. Neutral null models for diversity in serial transfer evolution experiments. Evolution. 2014 Sep; 68(9):2727-36. PMID: 24889376.
      Citations: 1     Fields:    
    22. Simons YB, Turchin MC, Pritchard JK, Sella G. The deleterious mutation load is insensitive to recent population history. Nat Genet. 2014 Mar; 46(3):220-4. PMID: 24509481; PMCID: PMC3953611.
      Citations: 153     Fields:    Translation:Humans
    23. Leffler EM, Gao Z, Pfeifer S, Auton A, Venn O, Bowden R, Bontrop R, Wall JD, Sella G, Donnelly P, McVean G, Przeworski M, Ségurel L. Multiple instances of ancient balancing selection shared between humans and chimpanzees. Science. 2013 Mar 29; 339(6127):1578-82. PMID: 23413192; PMCID: PMC3612375.
      Citations: 158     Fields:    Translation:HumansAnimalsCells
    24. Benger E, Sella G. Modeling the effect of changing selective pressures on polymorphism and divergence. Theor Popul Biol. 2013 May; 85:73-85. PMID: 23178187; PMCID: PMC4296563.
      Citations: 3     Fields:    Translation:Animals
    25. Thompson EE, Lovstad J, Venkat A, Margulis SW, Moyse J, Ross S, Gamble K, Sella G, Ober C, Przeworski M, Ségurel L, Flutre T. The ABO blood group is a trans-species polymorphism in primates. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18493-8. PMID: 23091028; PMCID: PMC3494955.
      Citations: 70     Fields:    Translation:Animals
    26. Hernandez RD, Kelley JL, Elyashiv E, Melton SC, Auton A, McVean G, 1000 Genomes Project, Sella G, Przeworski M. Classic selective sweeps were rare in recent human evolution. Science. 2011 Feb 18; 331(6019):920-4. PMID: 21330547; PMCID: PMC3669691.
      Citations: 234     Fields:    Translation:HumansCells
    27. Sattath S, Elyashiv E, Kolodny O, Rinott Y, Sella G. Pervasive adaptive protein evolution apparent in diversity patterns around amino acid substitutions in Drosophila simulans. PLoS Genet. 2011 Feb 10; 7(2):e1001302. PMID: 21347283; PMCID: PMC3037414.
      Citations: 59     Fields:    Translation:AnimalsCells
    28. Elyashiv E, Bullaughey K, Sattath S, Rinott Y, Przeworski M, Sella G. Shifts in the intensity of purifying selection: an analysis of genome-wide polymorphism data from two closely related yeast species. Genome Res. 2010 Nov; 20(11):1558-73. PMID: 20817943; PMCID: PMC2963819.
      Citations: 46     Fields:    Translation:Animals
    29. Sella G, Petrov DA, Przeworski M, Andolfatto P. Pervasive natural selection in the Drosophila genome? PLoS Genet. 2009 Jun; 5(6):e1000495. PMID: 19503600; PMCID: PMC2684638.
      Citations: 200     Fields:    Translation:Animals
    30. Cai JJ, Macpherson JM, Sella G, Petrov DA. Pervasive hitchhiking at coding and regulatory sites in humans. PLoS Genet. 2009 Jan; 5(1):e1000336. PMID: 19148272; PMCID: PMC2613029.
      Citations: 84     Fields:    Translation:HumansCells
    31. Sella G. An exact steady state solution of Fisher's geometric model and other models. Theor Popul Biol. 2009 Feb; 75(1):30-4. PMID: 18996138.
      Citations: 6     Fields:    Translation:Animals
    32. Macpherson JM, Sella G, Davis JC, Petrov DA. Genomewide spatial correspondence between nonsynonymous divergence and neutral polymorphism reveals extensive adaptation in Drosophila. Genetics. 2007 Dec; 177(4):2083-99. PMID: 18073425; PMCID: PMC2219485.
      Citations: 80     Fields:    Translation:Animals
    33. Sella G, Ardell DH. The coevolution of genes and genetic codes: Crick's frozen accident revisited. J Mol Evol. 2006 Sep; 63(3):297-313. PMID: 16838217.
      Citations: 26     Fields:    Translation:HumansAnimals
    34. Sella G, Hirsh AE. The application of statistical physics to evolutionary biology. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9541-6. PMID: 15980155; PMCID: PMC1172247.
      Citations: 157     Fields:    
    35. Ardell DH, Sella G. No accident: genetic codes freeze in error-correcting patterns of the standard genetic code. Philos Trans R Soc Lond B Biol Sci. 2002 Nov 29; 357(1427):1625-42. PMID: 12495519; PMCID: PMC1693064.
      Citations: 17     Fields:    Translation:AnimalsCells
    36. Sella G, Ardell DH. The impact of message mutation on the fitness of a genetic code. J Mol Evol. 2002 May; 54(5):638-51. PMID: 11965436.
      Citations: 18     Fields:    
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