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Dorothy Hanck

TitleEmeritus/Emerita, Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Cardiology
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sheets MF, Fozzard HA, Hanck DA. Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels. Biophys J. 2015 Dec 01; 109(11):2277-86. PMID: 26636939.
      View in: PubMed
    2. Sheets MF, Chen T, Hanck DA. Outward stabilization of the voltage sensor in domain II but not domain I speeds inactivation of voltage-gated sodium channels. . 2013 Oct 15; 305(8):H1213-21. PMID: 23893162.
      View in: PubMed
    3. Fozzard HA, Sheets MF, Hanck DA. The sodium channel as a target for local anesthetic drugs. Front Pharmacol. 2011; 2:68. PMID: 22053156.
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    4. Lipkind GM, Fozzard HA, Hanck DA. A molecular model of the inner pore of the Ca channel in its open state. Channels (Austin). 2011 Nov-Dec; 5(6):482-8. PMID: 22020562.
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    5. Li D, Herrera S, Bubula N, Nikitina E, Palmer AA, Hanck DA, Loweth JA, Vezina P. Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation. J Neurochem. 2011 Jul; 118(2):237-47. PMID: 21564097.
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    6. Bergson P, Lipkind G, Lee SP, Duban ME, Hanck DA. Verapamil block of T-type calcium channels. Mol Pharmacol. 2011 Mar; 79(3):411-9. PMID: 21149638.
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    7. Sheets MF, Chen T, Hanck DA. Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel. Pflugers Arch. 2011 Jan; 461(1):91-7. PMID: 20981437.
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    8. Fozzard H, Hanck D. In memoriam. Morton Arnsdorf: 1940-2010. Circ Res. 2010 Aug 20; 107(4):446-7. PMID: 20839390.
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    9. Fozzard H, Hanck D. Heart Rhythm. 2010 Jul 03. PMID: 20599523.
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    10. Edgerton GB, Blumenthal KM, Hanck DA. Inhibition of the activation pathway of the T-type calcium channel Ca(V)3.1 by ProTxII. Toxicon. 2010 Sep 15; 56(4):624-36. PMID: 20600227.
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    11. Sheets MF, Fozzard HA, Lipkind GM, Hanck DA. Sodium channel molecular conformations and antiarrhythmic drug affinity. Trends Cardiovasc Med. 2010 Jan; 20(1):16-21. PMID: 20685573.
      View in: PubMed
    12. Hanck DA, Nikitina E, McNulty MM, Fozzard HA, Lipkind GM, Sheets MF. Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity. Circ Res. 2009 Aug 28; 105(5):492-9. PMID: 19661462.
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    13. Kyle JW, Berthoud VM, Kurutz J, Minogue PJ, Greenspan M, Hanck DA, Beyer EC. The N terminus of connexin37 contains an alpha-helix that is required for channel function. J Biol Chem. 2009 Jul 24; 284(30):20418-27. PMID: 19478091.
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    14. Kyle JW, Minogue PJ, Thomas BC, Domowicz DA, Berthoud VM, Hanck DA, Beyer EC. An intact connexin N-terminus is required for function but not gap junction formation. J Cell Sci. 2008 Aug 15; 121(Pt 16):2744-50. PMID: 18664489.
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    15. Edgerton GB, Blumenthal KM, Hanck DA. Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5. Toxicon. 2008 Sep 01; 52(3):489-500. PMID: 18657562.
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    16. Bittner KC, Hanck DA. The relationship between single-channel and whole-cell conductance in the T-type Ca2+ channel CaV3.1. Biophys J. 2008 Jul; 95(2):931-41. PMID: 18375519.
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    17. Sheets MF, Hanck DA. Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels. J Physiol. 2007 Jul 01; 582(Pt 1):317-34. PMID: 17510181.
      View in: PubMed
    18. McNulty MM, Edgerton GB, Shah RD, Hanck DA, Fozzard HA, Lipkind GM. Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels. J Physiol. 2007 Jun 01; 581(Pt 2):741-55. PMID: 17363383.
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    19. Hanck DA, Sheets MF. Site-3 toxins and cardiac sodium channels. Toxicon. 2007 Feb; 49(2):181-93. PMID: 17092528.
      View in: PubMed
    20. McNulty MM, Kyle JW, Lipkind GM, Hanck DA. An inner pore residue (Asn406) in the Nav1.5 channel controls slow inactivation and enhances mibefradil block to T-type Ca2+ channel levels. Mol Pharmacol. 2006 Nov; 70(5):1514-23. PMID: 16885209.
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    21. Emerick MC, Stein R, Kunze R, McNulty MM, Regan MR, Hanck DA, Agnew WS. Profiling the array of Ca(v)3.1 variants from the human T-type calcium channel gene CACNA1G: alternative structures, developmental expression, and biophysical variations. Proteins. 2006 Aug 01; 64(2):320-42. PMID: 16671074.
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    22. Khan A, Kyle JW, Hanck DA, Lipkind GM, Fozzard HA. Isoform-dependent interaction of voltage-gated sodium channels with protons. J Physiol. 2006 Oct 15; 576(Pt 2):493-501. PMID: 16873405.
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    23. Freeze BS, McNulty MM, Hanck DA. State-dependent verapamil block of the cloned human Ca(v)3.1 T-type Ca(2+) channel. Mol Pharmacol. 2006 Aug; 70(2):718-26. PMID: 16699084.
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    24. Zhong X, Liu JR, Kyle JW, Hanck DA, Agnew WS. A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies. Hum Mol Genet. 2006 May 01; 15(9):1497-512. PMID: 16565161.
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    25. Lam AD, Chikina MD, McNulty MM, Glaaser IW, Hanck DA. Role of Domain IV/S4 outermost arginines in gating of T-type calcium channels. Pflugers Arch. 2005 Nov; 451(2):349-61. PMID: 16133267.
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    26. Sheets MF, Hanck DA. Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation. J Physiol. 2005 Feb 15; 563(Pt 1):83-93. PMID: 15576449.
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    27. McNulty MM, Hanck DA. State-dependent mibefradil block of Na+ channels. Mol Pharmacol. 2004 Dec; 66(6):1652-61. PMID: 15562257.
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    28. Puljung MC, Berthoud VM, Beyer EC, Hanck DA. Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels. J Gen Physiol. 2004 Nov; 124(5):587-603. PMID: 15504903.
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    29. Sunami A, Tracey A, Glaaser IW, Lipkind GM, Hanck DA, Fozzard HA. Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents. J Physiol. 2004 Dec 01; 561(Pt 2):403-13. PMID: 15579536.
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    30. Seibert AL, Liu J, Hanck DA, Blumenthal KM. Role of Asn-16 and Ser-19 in anthopleurin B binding. Implications for the electrostatic nature of Na(V) site 3. Biochemistry. 2004 Jun 08; 43(22):7082-9. PMID: 15170345.
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    31. Seibert AL, Liu J, Hanck DA, Blumenthal KM. Arg-14 loop of site 3 anemone toxins: effects of glycine replacement on toxin affinity. Biochemistry. 2003 Dec 16; 42(49):14515-21. PMID: 14661964.
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    32. Sheets MF, Hanck DA. Molecular action of lidocaine on the voltage sensors of sodium channels. J Gen Physiol. 2003 Feb; 121(2):163-75. PMID: 12566542.
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    33. Sheets MF, Hanck DA. The outermost lysine in the S4 of domain III contributes little to the gating charge in sodium channels. Biophys J. 2002 Jun; 82(6):3048-55. PMID: 12023227.
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    34. Martin RL, Pittendrigh B, Liu J, Reenan R, ffrench-Constant R, Hanck DA. Point mutations in domain III of a Drosophila neuronal Na channel confer resistance to allethrin. Insect Biochem Mol Biol. 2000 Nov; 30(11):1051-9. PMID: 10989292.
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    35. Martin RL, Lee JH, Cribbs LL, Perez-Reyes E, Hanck DA. Mibefradil block of cloned T-type calcium channels. J Pharmacol Exp Ther. 2000 Oct; 295(1):302-8. PMID: 10991994.
      View in: PubMed
    36. Sheets MF, Kyle JW, Hanck DA. The role of the putative inactivation lid in sodium channel gating current immobilization. J Gen Physiol. 2000 May; 115(5):609-20. PMID: 10779318.
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    37. Hanck DA, Makielski JC, Sheets MF. Lidocaine alters activation gating of cardiac Na channels. Pflugers Arch. 2000 Apr; 439(6):814-21. PMID: 10784357.
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    38. Sheets MF, Kyle JW, Kallen RG, Hanck DA. The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4. Biophys J. 1999 Aug; 77(2):747-57. PMID: 10423423.
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    39. Richard Benzinger G, Tonkovich GS, Hanck DA. Augmentation of recovery from inactivation by site-3 Na channel toxins. A single-channel and whole-cell study of persistent currents. J Gen Physiol. 1999 Feb; 113(2):333-46. PMID: 9925828.
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    40. Sheets MF, Hanck DA. Gating of skeletal and cardiac muscle sodium channels in mammalian cells. J Physiol. 1999 Jan 15; 514 ( Pt 2):425-36. PMID: 9852324.
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    41. Hanck D. Heartthrobs. Science. 1998 Feb 13; 279(5353):1004. PMID: 9490476.
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    42. Benzinger GR, Kyle JW, Blumenthal KM, Hanck DA. A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B. J Biol Chem. 1998 Jan 02; 273(1):80-4. PMID: 9417050.
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    43. Millonas MM, Hanck DA. Nonequilibrium response spectroscopy of voltage-sensitive ion channel gating. Biophys J. 1998 Jan; 74(1):210-29. PMID: 9449324.
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    44. Benzinger GR, Drum CL, Chen LQ, Kallen RG, Hanck DA, Hanck D. Differences in the binding sites of two site-3 sodium channel toxins. Pflugers Arch. 1997 Nov; 434(6):742-9. PMID: 9306007.
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    45. Kelso GJ, Drum CL, Hanck DA, Blumenthal KM. Role for Pro-13 in directing high-affinity binding of anthopleurin B to the voltage-sensitive sodium channel. Biochemistry. 1996 Nov 12; 35(45):14157-64. PMID: 8916901.
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    46. Dias-Kadambi BL, Combs KA, Drum CL, Hanck DA, Blumenthal KM. The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B. J Biol Chem. 1996 Sep 27; 271(39):23828-35. PMID: 8798612.
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    47. Sheets MF, Kyle JW, Krueger S, Hanck DA. Optimization of a mammalian expression system for the measurement of sodium channel gating currents. Am J Physiol. 1996 Sep; 271(3 Pt 1):C1001-6. PMID: 8843731.
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    48. Fozzard HA, Hanck DA. Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms. Physiol Rev. 1996 Jul; 76(3):887-926. PMID: 8757791.
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    49. Zeng D, Kyle JW, Martin RL, Ambler KS, Hanck DA. Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8. Am J Physiol. 1996 May; 270(5 Pt 1):C1522-31. PMID: 8967455.
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    50. Dias-Kadambi BL, Drum CL, Hanck DA, Blumenthal KM. Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel. J Biol Chem. 1996 Apr 19; 271(16):9422-8. PMID: 8621610.
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    51. Hanck DA, Sheets MF. Modification of inactivation in cardiac sodium channels: ionic current studies with Anthopleurin-A toxin. J Gen Physiol. 1995 Oct; 106(4):601-16. PMID: 8576699.
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    52. Sheets MF, Hanck DA. Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxin. J Gen Physiol. 1995 Oct; 106(4):617-40. PMID: 8576700.
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    53. Lipkind GM, Hanck DA, Fozzard HA. A structural motif for the voltage-gated potassium channel pore. Proc Natl Acad Sci U S A. 1995 Sep 26; 92(20):9215-9. PMID: 7568104.
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    54. Khera PK, Benzinger GR, Lipkind G, Drum CL, Hanck DA, Blumenthal KM. Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discrimination. Biochemistry. 1995 Jul 11; 34(27):8533-41. PMID: 7612595.
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    55. Ono K, Fozzard HA, Hanck DA. A direct effect of forskolin on sodium channel bursting. Pflugers Arch. 1995 Feb; 429(4):561-9. PMID: 7617447.
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    56. Page E, Goings GE, Upshaw-Earley J, Hanck DA. Endocytosis and uptake of lucifer yellow by cultured atrial myocytes and isolated intact atria from adult rats. Regulation and subcellular localization. Circ Res. 1994 Aug; 75(2):335-46. PMID: 8033344.
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    57. Hanck DA, Makielski JC, Sheets MF. Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study. J Gen Physiol. 1994 Jan; 103(1):19-43. PMID: 8169596.
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    58. Sheets MF, Hanck DA. Modification of sodium channel inactivation by alpha-chymotrypsin in canine cardiac Purkinje cells. J Cardiovasc Electrophysiol. 1993 Dec; 4(6):686-94. PMID: 8305988.
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    59. Page E, Upshaw-Earley J, Goings GE, Hanck DA. Fluid-phase endocytosis by in situ cardiac myocytes of rat atria. Am J Physiol. 1993 Oct; 265(4 Pt 1):C986-96. PMID: 8238324.
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    60. Ono K, Fozzard HA, Hanck DA. Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics. Circ Res. 1993 Apr; 72(4):807-15. PMID: 8383015.
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    61. Hanck DA, Sheets MF. Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells. J Physiol. 1992 Aug; 454:267-98. PMID: 1335501.
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    62. Sheets MF, Hanck DA. Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells. J Physiol. 1992 Aug; 454:299-320. PMID: 1335503.
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    63. Hanck DA, Sheets MF. Time-dependent changes in kinetics of Na+ current in single canine cardiac Purkinje cells. Am J Physiol. 1992 Apr; 262(4 Pt 2):H1197-207. PMID: 1314510.
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    64. el-Sherif N, Fozzard HA, Hanck DA. Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATXII. Circ Res. 1992 Feb; 70(2):285-301. PMID: 1346508.
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    65. Page E, Upshaw-Earley J, Goings GE, Hanck DA. Inhibition of atrial peptide secretion at different stages of the secretory process: Ca2+ dependence. Am J Physiol. 1991 Dec; 261(6 Pt 1):C1162-72. PMID: 1837420.
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    66. Sheets MF, Hanck DA. Atrionatriuretic peptide and calcium-conducting sodium channels. Science. 1991 Apr 19; 252(5004):449-52. PMID: 1850170.
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    67. Page E, Upshaw-Earley J, Goings GE, Hanck DA. Effect of external Ca2+ concentration on stretch-augmented natriuretic peptide secretion by rat atria. Am J Physiol. 1991 Apr; 260(4 Pt 1):C756-62. PMID: 1826817.
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    68. Makielski JC, Alpert LA, Hanck DA. Two components of use-dependent block of sodium current by lidocaine in voltage clamped cardiac Purkinje cells. J Mol Cell Cardiol. 1991 Feb; 23 Suppl 1:95-102. PMID: 1645416.
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    69. Scanley BE, Hanck DA, Chay T, Fozzard HA. Kinetic analysis of single sodium channels from canine cardiac Purkinje cells. J Gen Physiol. 1990 Mar; 95(3):411-37. PMID: 2157791.
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    70. Hanck DA, Sheets MF, Fozzard HA. Gating currents associated with Na channels in canine cardiac Purkinje cells. J Gen Physiol. 1990 Mar; 95(3):439-57. PMID: 2157792.
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    71. Alpert LA, Fozzard HA, Hanck DA, Makielski JC. Is there a second external lidocaine binding site on mammalian cardiac cells? Am J Physiol. 1989 Jul; 257(1 Pt 2):H79-84. PMID: 2546451.
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    72. Sheets MF, Hanck DA, Fozzard HA. Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells. Circ Res. 1988 Aug; 63(2):386-98. PMID: 2456164.
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    73. Nichols CG, Hanck DA, Jewell BR. The Anrep effect: an intrinsic myocardial mechanism. Can J Physiol Pharmacol. 1988 Jul; 66(7):924-9. PMID: 3214805.
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    74. Makielski JC, Undrovinas AI, Hanck DA, Sheets MF, Nesterenko VV, Alpert LA, Rosenshtraukh LV, Fozzard HA. Use-dependent block of sodium current by ethmozin in voltage-clamped internally perfused canine cardiac Purkinje cells. J Mol Cell Cardiol. 1988 Mar; 20(3):255-65. PMID: 2456399.
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    75. Fozzard HA, Hanck DA, Makielski JC, Scanley BE, Sheets MF. Sodium channels in cardiac Purkinje cells. Experientia. 1987 Dec 01; 43(11-12):1162-8. PMID: 2446909.
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    76. Jewell BR, Hanck DA. Effects of inotropic interventions on end systolic length-force curve of cat ventricular muscle. Cardiovasc Res. 1987 Aug; 21(8):559-64. PMID: 3454659.
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    77. Makielski JC, Sheets MF, Hanck DA, January CT, Fozzard HA. Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells. Biophys J. 1987 Jul; 52(1):1-11. PMID: 3607218.
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    78. Sheets MF, Scanley BE, Hanck DA, Makielski JC, Fozzard HA. Open sodium channel properties of single canine cardiac Purkinje cells. Biophys J. 1987 Jul; 52(1):13-22. PMID: 2440490.
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    79. Fozzard HA, Friedlander IR, Hanck DA, January CT, Makielski JC, Sheets MF. Sodium currents in single cardiac Purkinje cells. J Am Coll Cardiol. 1986 Jul; 8(1 Suppl A):79A-85A. PMID: 2423574.
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    80. Hanck DA, Jewell BR. Effects of physiological beating on the contractility of cat ventricular muscle. Am J Physiol. 1985 Jun; 248(6 Pt 2):H894-900. PMID: 4003566.
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