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William Green

TitleProfessor
InstitutionUniversity of Chicago
DepartmentNeurobiology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    My research is focused on ionotropic neurotransmitter receptors, the receptors responsible for the rapid postsynaptic response in nerve and muscle. These receptors are large oligomeric membrane proteins with subunits surrounding an ion channel that opens when neurotransmitters bind to the receptor. There are two different families of ionotropic neurotransmitter receptors. One family includes nicotinic acetylcholine receptors (AChRs), GABA and glycine receptors, and the other family are glutamate receptors, both NMDA- and AMPA-type glutamate receptors. The overall goal of my research is to understand how nerve and muscle build these receptors and traffic them specifically to and from synapses. These events regulate the number, density and function of the receptors at synapses, which helps define synaptic strength. The same events underlie learning and memory formation, and when they fail, can contribute to a number of diseases including Alzheimer’s disease, Huntington’s Disease, Myasthenia Gravis and Myasthenic Syndromes.

    There are several projects ongoing in my lab characterizing the basic cell biology of these receptors, which include receptor assembly, trafficking and clustering. Assembly refers to the processes that transform newly synthesized subunits into functional receptors usually in the endoplasmic reticulum. Trafficking refers to the processes that transport the receptors to and from different location in cells and targets them to these locations. Clustering is the process that packs and maintains the receptors in regions of high density such as synapses. Recently, we have developed new techniques for assaying the protein post-translation modification known as palmitoylation. This work has led to several collaborations in which we are helping to characterize the palmitoylation of a number of different proteins. I also am collaborating with Dr. Paul Selvin (University of Illinois) developing fluorescent single-molecule methods to characterize neurotransmitter receptor subunit composition, stoichiometry and the diffusion/trafficking of these receptors.

    Collapse Biography 
    Collapse education and training
    Yale University, New Haven, CTPostdoctoral Fellow12/1992Physiology & Neuroscience
    Cornell University Graduate School of Medical Sciences, New York, NYPh.D.06/1986Physiology & Biophysics
    University College, University of Toronto, Toronto, Canada B.Sc. 06/1978Physics & Zoology

    Collapse Research 
    Collapse research activities and funding
    R01NS100019     (CHUNG, HEE JUNG ;SELVIN, PAUL R)Jul 1, 2017 - Aug 31, 2026
    NIH
    Super-Resolution Microscopy of Neuronal Synapses with Advanced Imaging Tools
    Role: Co-Principal Investigator

    R01DA044760     (GREEN, WILLIAM)Jul 1, 2017 - Apr 30, 2022
    NIH
    PET imaging of a4b2 nicotinic receptor upregulation and smoking cessation
    Role: Principal Investigator

    R56NS090903     (SELVIN, PAUL R)Sep 30, 2014 - Sep 29, 2017
    NIH
    Organization and Dynamics of PSD-bound Glutamate Receptors at Super-resolution
    Role: Co-Principal Investigator

    R01DA035430     (GREEN, WILLIAM)Aug 1, 2013 - Apr 30, 2018
    NIH
    Different components of nicotine-induced upregulation of nicotinic receptors
    Role: Principal Investigator

    R21MH081251     (GREEN, WILLIAM NATHAN)Dec 4, 2009 - Nov 30, 2011
    NIH
    Proteomic Assays of Neuronal Protein Palmitoylation
    Role: Principal Investigator

    R13DK063646     (GREEN, WILLIAM N.)Sep 3, 2002 - Aug 31, 2003
    NIH
    Trafficking of Transporters
    Role: Principal Investigator

    R01NS043782     (GREEN, WILLIAM)Apr 1, 2002 - Jul 31, 2013
    NIH
    The Neuronal alpha-bungarotoxin Binding Site
    Role: Principal Investigator

    R56NS043782     (GREEN, WILLIAM N.)Apr 1, 2002 - Jul 31, 2009
    NIH
    The Neuronal alpha-bungarotoxin Binding Site
    Role: Principal Investigator

    R01DA013602     (GREEN, WILLIAM N.)Aug 1, 2001 - May 31, 2007
    NIH
    UPREGULATION OF NICOTINIC RECEPTORS
    Role: Principal Investigator

    R01NS032693     (GREEN, WILLIAM N.)Aug 1, 1997 - Mar 31, 2007
    NIH
    Quality Control of Nicotinic Receptor Assembly
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cao Y, Liu H, Lu SS, Jones KA, Govind AP, Jeyifous O, Simmons CQ, Tabatabaei N, Green WN, Holder JL, Tahmasebi S, George AL, Dickinson BC. RNA-based translation activators for targeted gene upregulation. Nat Commun. 2023 10 26; 14(1):6827. PMID: 37884512; PMCID: PMC10603104.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Zammit M, Kao CM, Zhang HJ, Tsai HM, Holderman N, Mitchell S, Tanios E, Bhuiyan M, Freifelder R, Kucharski A, Green WN, Mukherjee J, Chen CT. Evaluation of an Image-Derived Input Function for Kinetic Modeling of Nicotinic Acetylcholine Receptor-Binding PET Ligands in Mice. Int J Mol Sci. 2023 Oct 24; 24(21). PMID: 37958495; PMCID: PMC10650787.
      Citations:    Fields:    Translation:Animals
    3. Zhang HJ, Zammit M, Kao CM, Govind AP, Mitchell S, Holderman N, Bhuiyan M, Freifelder R, Kucharski A, Zhuang X, Mukherjee J, Chen CT, Green WN. Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by In Vitro Cellular Studies and In Vivo PET Imaging. J Neurosci. 2023 01 04; 43(1):2-13. PMID: 36028313; PMCID: PMC9838697.
      Citations: 2     Fields:    Translation:Animals
    4. Salerno M, Williams GR, Scheuermann RM, Kennedy C, Agarwal M, Green WR, Gu W, Zhang Z, Lin H, Carlson DJ, Dong L, Metz JM, Li T. Deploying a Single-Energy O-Ring Linac as the Sole Treatment Machine in a Community Setting: A Feasibility Study. Int J Radiat Oncol Biol Phys. 2021 Nov 01; 111(3S):e514. PMID: 34701634.
      Citations:    
    5. Govind AP, Jeyifous O, Russell TA, Yi Z, Weigel AV, Ramaprasad A, Newell L, Ramos W, Valbuena FM, Casler JC, Yan JZ, Glick BS, Swanson GT, Lippincott-Schwartz J, Green WN. Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome. Elife. 2021 09 21; 10. PMID: 34545811; PMCID: PMC8494481.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    6. Casler JC, Zajac AL, Valbuena FM, Sparvoli D, Jeyifous O, Turkewitz AP, Horne-Badovinac S, Green WN, Glick BS. ESCargo: a regulatable fluorescent secretory cargo for diverse model organisms. Mol Biol Cell. 2020 12 15; 31(26):2892-2903. PMID: 33112725; PMCID: PMC7927198.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    7. Yoshii A, Green WN. Editorial: Role of Protein Palmitoylation in Synaptic Plasticity and Neuronal Differentiation. Front Synaptic Neurosci. 2020; 12:27. PMID: 32754027; PMCID: PMC7381319.
      Citations: 1     
    8. Samra GK, Intskirveli I, Govind AP, Liang C, Lazar R, Green WN, Metherate R, Mukherjee J. Development of fluorescence imaging probes for nicotinic acetylcholine a4ß2* receptors. Bioorg Med Chem Lett. 2018 02 01; 28(3):371-377. PMID: 29277457; PMCID: PMC6004331.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Lee SH, Jin C, Cai E, Ge P, Ishitsuka Y, Teng KW, de Thomaz AA, Nall D, Baday M, Jeyifous O, Demonte D, Dundas CM, Park S, Delgado JY, Green WN, Selvin PR. Correction: Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes. Elife. 2017 11 08; 6. PMID: 29116041; PMCID: PMC5677364.
      Citations: 3     Fields:    
    10. Lee SH, Jin C, Cai E, Ge P, Ishitsuka Y, Teng KW, de Thomaz AA, Nall D, Baday M, Jeyifous O, Demonte D, Dundas CM, Park S, Delgado JY, Green WN, Selvin PR. Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes. Elife. 2017 07 27; 6. PMID: 28749340; PMCID: PMC5779237.
      Citations: 32     Fields:    Translation:AnimalsCells
    11. Govind AP, Vallejo YF, Stolz JR, Yan JZ, Swanson GT, Green WN. Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation. Elife. 2017 07 18; 6. PMID: 28718768; PMCID: PMC5546804.
      Citations: 13     Fields:    Translation:HumansCells
    12. Antinone SE, Ghadge GD, Ostrow LW, Roos RP, Green WN. S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects. Sci Rep. 2017 01 25; 7:41141. PMID: 28120938; PMCID: PMC5264640.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    13. Jeyifous O, Lin EI, Chen X, Antinone SE, Mastro R, Drisdel R, Reese TS, Green WN. Palmitoylation regulates glutamate receptor distributions in postsynaptic densities through control of PSD95 conformation and orientation. Proc Natl Acad Sci U S A. 2016 12 27; 113(52):E8482-E8491. PMID: 27956638; PMCID: PMC5206547.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    14. Zheng N, Jeyifous O, Munro C, Montgomery JM, Green WN. Synaptic activity regulates AMPA receptor trafficking through different recycling pathways. Elife. 2015 May 13; 4. PMID: 25970033; PMCID: PMC4451724.
      Citations: 29     Fields:    Translation:AnimalsCells
    15. Cai E, Rosenkranz T, Ge P, Teng KW, Lim SJ, Smith AM, Chung HJ, Sachs F, Green WN, Gottlieb P, Selvin PR, Wang Y. Small quantum dots conjugated to nanobodies as immunofluorescence probes for nanometric microscopy. Bioconjug Chem. 2014 Dec 17; 25(12):2205-11. PMID: 25397889; PMCID: PMC4275168.
      Citations: 16     Fields:    Translation:Cells
    16. Cai E, Ge P, Lee SH, Jeyifous O, Wang Y, Liu Y, Wilson KM, Lim SJ, Baird MA, Stone JE, Lee KY, Davidson MW, Chung HJ, Schulten K, Smith AM, Green WN, Selvin PR. Stable small quantum dots for synaptic receptor tracking on live neurons. Angew Chem Int Ed Engl. 2014 Nov 10; 53(46):12484-8. PMID: 25255882; PMCID: PMC4240739.
      Citations: 31     Fields:    Translation:AnimalsCells
    17. Cortes CJ, Qin K, Norstrom EM, Green WN, Bindokas VP, Mastrianni JA. Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy. Int J Cell Biol. 2013; 2013:560421. PMID: 24454378; PMCID: PMC3877647.
      Citations: 11     
    18. O'Connor MA, Green WR. Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis: lessons from a murine retrovirus-induced AIDS model. J Virol. 2014 Feb; 88(4):2349-53. PMID: 24335302; PMCID: PMC3911529.
      Citations: 4     Fields:    Translation:AnimalsCells
    19. Lin EI, Jeyifous O, Green WN. CASK regulates SAP97 conformation and its interactions with AMPA and NMDA receptors. J Neurosci. 2013 Jul 17; 33(29):12067-76. PMID: 23864692; PMCID: PMC3713737.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    20. Antinone SE, Ghadge GD, Lam TT, Wang L, Roos RP, Green WN. Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants. J Biol Chem. 2013 Jul 26; 288(30):21606-17. PMID: 23760509; PMCID: PMC3724620.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    21. Baker LK, Mao D, Chi H, Govind AP, Vallejo YF, Iacoviello M, Herrera S, Cortright JJ, Green WN, McGehee DS, Vezina P. Intermittent nicotine exposure upregulates nAChRs in VTA dopamine neurons and sensitises locomotor responding to the drug. Eur J Neurosci. 2013 Mar; 37(6):1004-11. PMID: 23331514; PMCID: PMC3604051.
      Citations: 21     Fields:    Translation:AnimalsCells
    22. Govind AP, Walsh H, Green WN. Nicotine-induced upregulation of native neuronal nicotinic receptors is caused by multiple mechanisms. J Neurosci. 2012 Feb 08; 32(6):2227-38. PMID: 22323734; PMCID: PMC3286518.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    23. Singaraja RR, Huang K, Sanders SS, Milnerwood AJ, Hines R, Lerch JP, Franciosi S, Drisdel RC, Vaid K, Young FB, Doty C, Wan J, Bissada N, Henkelman RM, Green WN, Davis NG, Raymond LA, Hayden MR. Altered palmitoylation and neuropathological deficits in mice lacking HIP14. Hum Mol Genet. 2011 Oct 15; 20(20):3899-909. PMID: 21775500; PMCID: PMC3177655.
      Citations: 59     Fields:    Translation:AnimalsCells
    24. Carlson TL, Green KA, Green WR. Alternative translational reading frames as a novel source of epitopes for an expanded CD8 T-cell repertoire: use of a retroviral system to assess the translational requirements for CTL recognition and lysis. Viral Immunol. 2010 Dec; 23(6):577-83. PMID: 21142443; PMCID: PMC2991181.
      Citations: 4     Fields:    Translation:AnimalsCells
    25. Simonson PD, Deberg HA, Ge P, Alexander JK, Jeyifous O, Green WN, Selvin PR. Counting bungarotoxin binding sites of nicotinic acetylcholine receptors in mammalian cells with high signal/noise ratios. Biophys J. 2010 Nov 17; 99(10):L81-3. PMID: 21081055; PMCID: PMC2980733.
      Citations: 28     Fields:    Translation:HumansCells
    26. Alexander JK, Sagher D, Krivoshein AV, Criado M, Jefford G, Green WN. Ric-3 promotes alpha7 nicotinic receptor assembly and trafficking through the ER subcompartment of dendrites. J Neurosci. 2010 Jul 28; 30(30):10112-26. PMID: 20668195; PMCID: PMC2945888.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    27. Alexander JK, Govind AP, Drisdel RC, Blanton MP, Vallejo Y, Lam TT, Green WN. Palmitoylation of nicotinic acetylcholine receptors. J Mol Neurosci. 2010 Jan; 40(1-2):12-20. PMID: 19693711; PMCID: PMC3523180.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    28. Jeyifous O, Waites CL, Specht CG, Fujisawa S, Schubert M, Lin EI, Marshall J, Aoki C, de Silva T, Montgomery JM, Garner CC, Green WN. SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway. Nat Neurosci. 2009 Aug; 12(8):1011-9. PMID: 19620977; PMCID: PMC2779056.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    29. Singaraja RR, Kang MH, Vaid K, Sanders SS, Vilas GL, Arstikaitis P, Coutinho J, Drisdel RC, El-Husseini Ael D, Green WN, Berthiaume L, Hayden MR. Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function. Circ Res. 2009 Jul 17; 105(2):138-47. PMID: 19556522.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    30. Govind AP, Vezina P, Green WN. Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction. Biochem Pharmacol. 2009 Oct 01; 78(7):756-65. PMID: 19540212; PMCID: PMC2728164.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    31. Waites CL, Specht CG, Leal-Ortiz S, Genoux D, Li D, Drisdel RC, Jeyifous O, Cheyne JE, Green WN, Montgomery JM, Garner CC, Härtel K. Synaptic SAP97 isoforms regulate AMPA receptor dynamics and access to presynaptic glutamate. J Neurosci. 2009 Apr 08; 29(14):4332-45. PMID: 19357261; PMCID: PMC3230533.
      Citations: 56     Fields:    Translation:AnimalsCells
    32. Kang R, Wan J, Arstikaitis P, Takahashi H, Huang K, Bailey AO, Thompson JX, Roth AF, Drisdel RC, Mastro R, Green WN, Yates JR, Davis NG, El-Husseini A. Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation. Nature. 2008 Dec 18; 456(7224):904-9. PMID: 19092927; PMCID: PMC2610860.
      Citations: 298     Fields:    Translation:AnimalsCells
    33. Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. J Biol Chem. 2009 Jan 16; 284(3):1373-84. PMID: 19028695; PMCID: PMC2615504.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    34. Liu Y, Padgett D, Takahashi M, Li H, Sayeed A, Teichert RW, Olivera BM, McArdle JJ, Green WN, Lin W. Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning. Development. 2008 Jun; 135(11):1957-67. PMID: 18434415; PMCID: PMC2650015.
      Citations: 31     Fields:    Translation:AnimalsCells
    35. Walsh H, Govind AP, Mastro R, Hoda JC, Bertrand D, Vallejo Y, Green WN. Up-regulation of nicotinic receptors by nicotine varies with receptor subtype. J Biol Chem. 2008 Mar 07; 283(10):6022-32. PMID: 18174175.
      Citations: 47     Fields:    Translation:AnimalsCells
    36. Vezina P, McGehee DS, Green WN. Exposure to nicotine and sensitization of nicotine-induced behaviors. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Nov 15; 31(8):1625-38. PMID: 17936462; PMCID: PMC2139894.
      Citations: 59     Fields:    Translation:HumansAnimals
    37. Wanamaker CP, Green WN. Endoplasmic reticulum chaperones stabilize nicotinic receptor subunits and regulate receptor assembly. J Biol Chem. 2007 Oct 26; 282(43):31113-23. PMID: 17728248; PMCID: PMC2365492.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    38. Drisdel RC, Sharp D, Henderson T, Hales TG, Green WN. High affinity binding of epibatidine to serotonin type 3 receptors. J Biol Chem. 2008 Apr 11; 283(15):9659-65. PMID: 17702741; PMCID: PMC2442297.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    39. Drisdel RC, Alexander JK, Sayeed A, Green WN. Assays of protein palmitoylation. Methods. 2006 Oct; 40(2):127-34. PMID: 17012024.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    40. Roth AF, Wan J, Green WN, Yates JR, Davis NG. Proteomic identification of palmitoylated proteins. Methods. 2006 Oct; 40(2):135-42. PMID: 17012025; PMCID: PMC2806795.
      Citations: 15     Fields:    Translation:AnimalsCells
    41. Roth AF, Wan J, Bailey AO, Sun B, Kuchar JA, Green WN, Phinney BS, Yates JR, Davis NG. Global analysis of protein palmitoylation in yeast. Cell. 2006 Jun 02; 125(5):1003-13. PMID: 16751107; PMCID: PMC2246083.
      Citations: 266     Fields:    Translation:AnimalsCells
    42. Yanai A, Huang K, Kang R, Singaraja RR, Arstikaitis P, Gan L, Orban PC, Mullard A, Cowan CM, Raymond LA, Drisdel RC, Green WN, Ravikumar B, Rubinsztein DC, El-Husseini A, Hayden MR. Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci. 2006 Jun; 9(6):824-31. PMID: 16699508; PMCID: PMC2279235.
      Citations: 137     Fields:    Translation:HumansAnimalsCells
    43. Wanamaker CP, Green WN. N-linked glycosylation is required for nicotinic receptor assembly but not for subunit associations with calnexin. J Biol Chem. 2005 Oct 07; 280(40):33800-10. PMID: 16091366; PMCID: PMC2373277.
      Citations: 19     Fields:    Translation:HumansCells
    44. Vallejo YF, Buisson B, Bertrand D, Green WN. Chronic nicotine exposure upregulates nicotinic receptors by a novel mechanism. J Neurosci. 2005 Jun 08; 25(23):5563-72. PMID: 15944384; PMCID: PMC2246082.
      Citations: 89     Fields:    Translation:HumansCells
    45. Drisdel RC, Manzana E, Green WN. The role of palmitoylation in functional expression of nicotinic alpha7 receptors. J Neurosci. 2004 Nov 17; 24(46):10502-10. PMID: 15548665; PMCID: PMC6730317.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    46. Christianson JC, Green WN. Regulation of nicotinic receptor expression by the ubiquitin-proteasome system. EMBO J. 2004 Oct 27; 23(21):4156-65. PMID: 15483627; PMCID: PMC524400.
      Citations: 47     Fields:    Translation:AnimalsCells
    47. Drisdel RC, Green WN. Labeling and quantifying sites of protein palmitoylation. Biotechniques. 2004 Feb; 36(2):276-85. PMID: 14989092.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    48. Wanamaker CP, Christianson JC, Green WN. Regulation of nicotinic acetylcholine receptor assembly. Ann N Y Acad Sci. 2003 Sep; 998:66-80. PMID: 14592864.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    49. Kopito RR, Green WN, Andersen O. The 56th Annual Meeting and Symposium of the Society of General Physiologists: trafficking of transporters. J Gen Physiol. 2003 Feb; 121(2):73-9. PMID: 12566536; PMCID: PMC2217324.
      Citations:    Fields:    Translation:HumansAnimals
    50. Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G, Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol Dis. 2002 Oct; 11(1):64-82. PMID: 12460547.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    51. Ghazi NG, Green WR. Pathology and pathogenesis of retinal detachment. Eye (Lond). 2002 Jul; 16(4):411-21. PMID: 12101448.
      Citations: 75     Fields:    Translation:Humans
    52. Mitra M, Wanamaker CP, Green WN. Rearrangement of nicotinic receptor alpha subunits during formation of the ligand binding sites. J Neurosci. 2001 May 01; 21(9):3000-8. PMID: 11312284; PMCID: PMC6762547.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    53. Buisson B, Vallejo YF, Green WN, Bertrand D. The unusual nature of epibatidine responses at the alpha4beta2 nicotinic acetylcholine receptor. Neuropharmacology. 2000 Oct; 39(13):2561-9. PMID: 11044727.
      Citations: 20     Fields:    Translation:AnimalsCells
    54. Hayashi N, Geraghty MT, Green WR. Ocular histopathologic study of a patient with the T 8993-G point mutation in Leigh's syndrome. Ophthalmology. 2000 Jul; 107(7):1397-402. PMID: 10889120.
      Citations: 3     Fields:    Translation:HumansCells
    55. Knox DL, Kerrison JB, Green WR. Histopathologic studies of ischemic optic neuropathy. Trans Am Ophthalmol Soc. 2000; 98:203-20; discussion 221-2. PMID: 11190024; PMCID: PMC1298227.
      Citations: 41     Fields:    Translation:HumansCells
    56. Drisdel RC, Green WN. Neuronal alpha-bungarotoxin receptors are alpha7 subunit homomers. J Neurosci. 2000 Jan 01; 20(1):133-9. PMID: 10627589; PMCID: PMC6774106.
      Citations: 78     Fields:    Translation:AnimalsCells
    57. Eertmoed AL, Green WN. Nicotinic receptor assembly requires multiple regions throughout the gamma subunit. J Neurosci. 1999 Aug 01; 19(15):6298-308. PMID: 10414959; PMCID: PMC6782796.
      Citations: 6     Fields:    Translation:AnimalsCells
    58. Rakhilin S, Drisdel RC, Sagher D, McGehee DS, Vallejo Y, Green WN. alpha-bungarotoxin receptors contain alpha7 subunits in two different disulfide-bonded conformations. J Cell Biol. 1999 Jul 12; 146(1):203-18. PMID: 10402471; PMCID: PMC2199736.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    59. Green WN. Ion channel assembly: creating structures that function. J Gen Physiol. 1999 Feb; 113(2):163-70. PMID: 9925815; PMCID: PMC2223360.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    60. Green WN, Wanamaker CP. Formation of the nicotinic acetylcholine receptor binding sites. J Neurosci. 1998 Aug 01; 18(15):5555-64. PMID: 9671647; PMCID: PMC6793068.
      Citations: 12     Fields:    Translation:AnimalsCells
    61. Green KA, Noelle RJ, Green WR. Evidence for a continued requirement for CD40/CD40 ligand (CD154) interactions in the progression of LP-BM5 retrovirus-induced murine AIDS. Virology. 1998 Feb 15; 241(2):260-8. PMID: 9499800.
      Citations: 16     Fields:    Translation:AnimalsCells
    62. Eertmoed AL, Vallejo YF, Green WN. Transient expression of heteromeric ion channels. Methods Enzymol. 1998; 293:564-85. PMID: 9711629.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    63. Mayrand SM, Schwarz DA, Green WR. An alternative translational reading frame encodes an immunodominant retroviral CTL determinant expressed by an immunodeficiency-causing retrovirus. J Immunol. 1998 Jan 01; 160(1):39-50. PMID: 9551954.
      Citations: 21     Fields:    Translation:AnimalsCells
    64. Rangwala F, Drisdel RC, Rakhilin S, Ko E, Atluri P, Harkins AB, Fox AP, Salman SS, Green WN. Neuronal alpha-bungarotoxin receptors differ structurally from other nicotinic acetylcholine receptors. J Neurosci. 1997 Nov 01; 17(21):8201-12. PMID: 9334396; PMCID: PMC6573741.
      Citations: 33     Fields:    Translation:AnimalsCells
    65. Green WN, Wanamaker CP. The role of the cystine loop in acetylcholine receptor assembly. J Biol Chem. 1997 Aug 15; 272(33):20945-53. PMID: 9252423.
      Citations: 31     Fields:    Translation:AnimalsCells
    66. Green WN, Millar NS. Ion-channel assembly. Trends Neurosci. 1995 Jun; 18(6):280-7. PMID: 7571003.
      Citations: 51     Fields:    Translation:Cells
    67. Jayawickreme SP, Green WN, Claudio T. Cyclic AMP-regulated AChR assembly is independent of AChR subunit phosphorylation by PKA. J Cell Sci. 1994 Jun; 107 ( Pt 6):1641-51. PMID: 7962204.
      Citations: 1     Fields:    Translation:AnimalsCells
    68. Green WN, Claudio T. Acetylcholine receptor assembly: subunit folding and oligomerization occur sequentially. Cell. 1993 Jul 16; 74(1):57-69. PMID: 8334706.
      Citations: 43     Fields:    Translation:AnimalsCells
    69. Green WN, Ross AF, Claudio T. Acetylcholine receptor assembly is stimulated by phosphorylation of its gamma subunit. Neuron. 1991 Oct; 7(4):659-66. PMID: 1931053.
      Citations: 12     Fields:    Translation:AnimalsCells
    70. Chabala LD, Urban BW, Weiss LB, Green WN, Andersen OS. Steady-state gating of batrachotoxin-modified sodium channels. Variability and electrolyte-dependent modulation. J Gen Physiol. 1991 Jul; 98(1):197-224. PMID: 1658190; PMCID: PMC2229043.
      Citations: 10     Fields:    Translation:Cells
    71. Paulson HL, Ross AF, Green WN, Claudio T. Analysis of early events in acetylcholine receptor assembly. J Cell Biol. 1991 Jun; 113(6):1371-84. PMID: 2045417; PMCID: PMC2289024.
      Citations: 20     Fields:    Translation:AnimalsCells
    72. Ross AF, Green WN, Hartman DS, Claudio T. Efficiency of acetylcholine receptor subunit assembly and its regulation by cAMP. J Cell Biol. 1991 May; 113(3):623-36. PMID: 1849906; PMCID: PMC2288962.
      Citations: 19     Fields:    Translation:AnimalsCells
    73. Green WN, Ross AF, Claudio T. cAMP stimulation of acetylcholine receptor expression is mediated through posttranslational mechanisms. Proc Natl Acad Sci U S A. 1991 Feb 01; 88(3):854-8. PMID: 1846964; PMCID: PMC50912.
      Citations: 10     Fields:    Translation:AnimalsCells
    74. Green WN, Andersen OS. Surface charges and ion channel function. Annu Rev Physiol. 1991; 53:341-59. PMID: 1710438.
      Citations: 111     Fields:    Translation:HumansAnimals
    75. Hartman DS, Poo MM, Green WN, Ross AF, Claudio T. Synaptic contact between embryonic neurons and acetylcholine receptor-fibroblast. J Physiol (Paris). 1990; 84(1):42-9. PMID: 2359035.
      Citations: 3     Fields:    Translation:AnimalsCells
    76. Claudio T, Paulson HL, Green WN, Ross AF, Hartman DS, Hayden D. Fibroblasts transfected with Torpedo acetylcholine receptor beta-, gamma-, and delta-subunit cDNAs express functional receptors when infected with a retroviral alpha recombinant. J Cell Biol. 1989 Jun; 108(6):2277-90. PMID: 2472403; PMCID: PMC2115590.
      Citations: 27     Fields:    Translation:AnimalsCells
    77. Claudio T, Green WN, Hartman DS, Hayden D, Paulson HL, Sigworth FJ, Sine SM, Swedlund A. Genetic reconstitution of functional acetylcholine receptor channels in mouse fibroblasts. Science. 1987 Dec 18; 238(4834):1688-94. PMID: 3686008.
      Citations: 22     Fields:    Translation:AnimalsCells
    78. Green WN, Weiss LB, Andersen OS. Batrachotoxin-modified sodium channels in planar lipid bilayers. Characterization of saxitoxin- and tetrodotoxin-induced channel closures. J Gen Physiol. 1987 Jun; 89(6):873-903. PMID: 2440978; PMCID: PMC2215969.
      Citations: 32     Fields:    Translation:AnimalsCells
    79. Green WN, Weiss LB, Andersen OS. Batrachotoxin-modified sodium channels in planar lipid bilayers. Ion permeation and block. J Gen Physiol. 1987 Jun; 89(6):841-72. PMID: 2440977; PMCID: PMC2215965.
      Citations: 71     Fields:    Translation:AnimalsCells
    80. Green WN, Andersen OS. Surface charges near the guanidinium neurotoxin binding site. Ann N Y Acad Sci. 1986; 479:306-12. PMID: 3468845.
      Citations: 6     Fields:    Translation:Animals
    81. Tam MR, Green WR, Nowinski RC. Cytotoxic activities of monoclonal antibodies against the envelope proteins of murine leukemia virus. Cancer Res. 1980 Oct; 40(10):3850-3. PMID: 6254643.
      Citations: 3     Fields:    Translation:AnimalsCells
    82. Wong VG, Green WR, Liu YP, Marsden ER. Experimental intraocular malignancy: the effect of intracameral perfusion. Trans Am Ophthalmol Soc. 1979; 77:63-79. PMID: 232585; PMCID: PMC1311694.
      Citations: 1     Fields:    Translation:Animals
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