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James Brorson

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentNeurology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Brorson is a neurologist specializing in vascular neurology, with over 25 years of patient care experience, as well as experience in basic and clinical research. His laboratory work focused on mechanisms of neuronal cell death pertinent to acute brain insults including ischemia, excitotoxicity, and metabolic derangements. His clinical interests focus on the treatment and prevention of stroke, and the management of diverse aspects of cerebrovascular disease, including carotid stenosis, intracranial arterial stenosis, intracranial aneurysms, hypercoagulable disorders, cerebral amyloid angiopathy, and stroke in the young. He has served as site PI for several clinical trials in secondary stroke prevention. Currently he is medical director of the University of Chicago Comprehensive Stroke Center, which cares for over 400 stroke patients annually.


    Collapse Biography 
    Collapse education and training
    University of Chicago, Chicago, ILPostdoctoral Fellowship03/1993Pharmacology & Physiology
    University of Pennsylvania, Philadelphia, PAResidency06/1989Neurology
    University of Chicago, Chicago, ILMD06/1985Medicine
    Princeton University, Princeton, NJAB06/1981Physics
    Collapse awards and honors
    2019Doroghazi Clinical Teaching Award, University of Chicago
    2018Department Teaching Award, University of Chicago
    2017Senior Faculty Scholar in the Bucksbaum Institute for Clinical Excellence, University of Chicago

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bourand N, Brorson JR. Predictors of very early stroke recurrence in the POINT trial population. BMC Neurol. 2022 May 14; 22(1):177. PMID: 35568804.
      View in: PubMed
    2. Bulwa ZB, Mendelson SJ, Brorson JR. Acute Secondary Prevention of Ischemic Stroke: Overlooked No Longer. Front Neurol. 2021; 12:701168. PMID: 34566845.
      View in: PubMed
    3. Brorson JR, Bulwa ZB. Two-State Kinetic Model of Rates of Stroke Recurrence in the POINT Study Population. Stroke. 2021 04; 52(4):1446-1449. PMID: 33596678.
      View in: PubMed
    4. Ortiz Garcia JG, Nathan S, Brorson JR. Neurologic complications of implantable devices. Handb Clin Neurol. 2021; 177:211-220. PMID: 33632440.
      View in: PubMed
    5. Loggini A, Del Brutto VJ, El Ammar F, Bulwa ZB, Saleh Velez F, McKoy C, Martinez RC, Brorson J, Goldenberg FD, Ardelt AA. Intracranial Hemorrhage in Hospitalized Patients: An Infrequently Studied Condition with High Mortality. Neurocrit Care. 2020 12; 33(3):725-731. PMID: 32212038.
      View in: PubMed
    6. Trifan G, Goldenberg FD, Caprio FZ, Biller J, Schneck M, Khaja A, Terna T, Brorson J, Lazaridis C, Bulwa Z, Alvarado Dyer R, Saleh Velez FG, Prabhakaran S, Liotta EM, Batra A, Reish NJ, Ruland S, Teitcher M, Taylor W, De la Pena P, Conners JJ, Grewal PK, Pinna P, Dafer RM, Osteraas ND, DaSilva I, Hall JP, John S, Shafi N, Miller K, Moustafa B, Vargas A, Gorelick PB, Testai FD. Characteristics of a Diverse Cohort of Stroke Patients with SARS-CoV-2 and Outcome by Sex. J Stroke Cerebrovasc Dis. 2020 Nov; 29(11):105314. PMID: 32951959.
      View in: PubMed
    7. Bulwa Z, Saleh Velez FG, Brorson JR, Pinto CB. Ipsilateral Nonstenotic Carotid Disease in Minor Ischemic Stroke: an Exploratory Analysis of The POINT Randomized Clinical Trial. J Stroke Cerebrovasc Dis. 2020 Nov; 29(11):105115. PMID: 33066893.
      View in: PubMed
    8. Marot JE, Rebeiz T, Kramer C, McKoy C, Brorson J, Goldenberg F, Liberman AL, Lee SK. WITHDRAWN: Neurological examination, rather than vascular risk factor assessment, serves to distinguish strokes from stroke mimics in a population with high prevalence of vascular risk factors. World Neurosurg. 2020 Jul 18. PMID: 32688035.
      View in: PubMed
    9. El Ammar F, Ardelt A, Del Brutto VJ, Loggini A, Bulwa Z, Martinez RC, McKoy CJ, Brorson J, Mansour A, Goldenberg FD. BE-FAST: A Sensitive Screening Tool to Identify In-Hospital Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2020 Jul; 29(7):104821. PMID: 32312632.
      View in: PubMed
    10. Bulwa Z, Del Brutto VJ, Loggini A, Ammar FE, Martinez RC, Christoforidis G, Brorson JR, Ardelt AA, Goldenberg FD. Mechanical Thrombectomy for Patients with In-Hospital Ischemic Stroke: A Case-Control Study. J Stroke Cerebrovasc Dis. 2020 May; 29(5):104692. PMID: 32085938.
      View in: PubMed
    11. Brorson JR, Cifu AS. Management of Patients With Acute Ischemic Stroke. JAMA. 2019 Aug 27; 322(8):777-778. PMID: 31318383.
      View in: PubMed
    12. Del Brutto VJ, Ardelt A, Loggini A, Bulwa Z, El-Ammar F, Martinez RC, Brorson J, Goldenberg F. Clinical Characteristics and Emergent Therapeutic Interventions in Patients Evaluated through the In-hospital Stroke Alert Protocol. J Stroke Cerebrovasc Dis. 2019 May; 28(5):1362-1370. PMID: 30846245.
      View in: PubMed
    13. Wang Y, Choi Y, Gallardo J, Nwaneri I, Brorson JR. Low Yield of Extensive Workup for Embolic Sources in Lacunar Stroke Patients. J Stroke Cerebrovasc Dis. 2018 Jun; 27(6):1575-1581. PMID: 29426678.
      View in: PubMed
    14. Del Brutto OH, Mera RM, Del Brutto VJ, Costa AF, Zambrano M, Brorson J. Basilar Artery Dolichoectasia: Prevalence and Correlates With Markers of Cerebral Small Vessel Disease in Community-Dwelling Older Adults. J Stroke Cerebrovasc Dis. 2017 Dec; 26(12):2909-2914. PMID: 28869136.
      View in: PubMed
    15. Lukas RV, Blood AD, Brorson JR, Albert DVF. Ambulatory training in neurology education. J Neurol Sci. 2017 Jan 15; 372:506-509. PMID: 27838003.
      View in: PubMed
    16. Albert DV, Blood AD, Park YS, Brorson JR, Lukas RV. Breadth versus volume: Neurology outpatient clinic cases in medical education. J Clin Neurosci. 2016 Jun; 28:20-3. PMID: 26896906.
      View in: PubMed
    17. Lukas RV, Brorson J, Albert DV. Author Response: Rimas V. Lukas, James Brorson, Chicago; Dara V. Albert, Columbus, OH. Neurology. 2016 Jan 26; 86(4):403. PMID: 27213202.
      View in: PubMed
    18. Sethi NK, Lukas RV, Brorson J, Albert DV. Structure of neuroscience clerkships in medical schools and matching in neuromedicine. Neurology. 2016 Jan 26; 86(4):403. PMID: 26810425.
      View in: PubMed
    19. Blood AD, Park YS, Lukas RV, Brorson JR. Neurology objective structured clinical examination reliability using generalizability theory. Neurology. 2015 Nov 03; 85(18):1623-9. PMID: 26432851.
      View in: PubMed
    20. Albert DV, Yin H, Amidei C, Dixit KS, Brorson JR, Lukas RV. Structure of neuroscience clerkships in medical schools and matching in neuromedicine. Neurology. 2015 Jul 14; 85(2):172-6. PMID: 26070342.
      View in: PubMed
    21. Lukas RV, Cooper B, Morgan I, Brorson JR, Dong H, Sherer R. Attitudes toward neurosciences in medical students in Wuhan, China: a survey study. World Neurosurg. 2014 Sep-Oct; 82(3-4):266-9. PMID: 24954255.
      View in: PubMed
    22. Tsien MZ, Brorson JR, Lukas RV, Dawson EC. A 16-year-old male with dizziness, parasthesias, and ataxia. Pediatr Ann. 2014 May; 43(5):e116-9. PMID: 24877493.
      View in: PubMed
    23. Albert DV, Brorson JR, Amidei C, Lukas RV. Education research: case logs in the assessment of medical students in the neurology outpatient clinic. Neurology. 2014 Apr 22; 82(16):e138-41. PMID: 24753516.
      View in: PubMed
    24. Lin W, Wadlington NL, Chen L, Zhuang X, Brorson JR, Kang UJ. Loss of PINK1 attenuates HIF-1a induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia. J Neurosci. 2014 Feb 19; 34(8):3079-89. PMID: 24553947.
      View in: PubMed
    25. Lukas RV, Blood A, Park YS, Brorson JR. Assessment of neurological clinical management reasoning in medical students. J Clin Neurosci. 2014 Jun; 21(6):919-22. PMID: 24308954.
      View in: PubMed
    26. Hodgson TS, Brorson JR, Ardelt AA, Lukas RV. Accrediting neurology fellowships accelerates subspecialization. Front Neurol. 2013; 4:94. PMID: 23888152.
      View in: PubMed
    27. Lukas RV, Adesoye T, Smith S, Blood A, Brorson JR. Student assessment by objective structured examination in a neurology clerkship. Neurology. 2012 Aug 14; 79(7):681-5. PMID: 22855865.
      View in: PubMed
    28. Leggett C, McGehee DS, Mastrianni J, Yang W, Bai T, Brorson JR. Tunicamycin produces TDP-43 cytoplasmic inclusions in cultured brain organotypic slices. J Neurol Sci. 2012 Jun 15; 317(1-2):66-73. PMID: 22459357.
      View in: PubMed
    29. Back A, Tupper KY, Bai T, Chiranand P, Goldenberg FD, Frank JI, Brorson JR. Ammonia-induced brain swelling and neurotoxicity in an organotypic slice model. Neurol Res. 2011 Dec; 33(10):1100-8. PMID: 22196764.
      View in: PubMed
    30. Li D, Bai T, Brorson JR. Adaptation to moderate hypoxia protects cortical neurons against ischemia-reperfusion injury and excitotoxicity independently of HIF-1a. Exp Neurol. 2011 Aug; 230(2):302-10. PMID: 21619879.
      View in: PubMed
    31. Jacob A, Brorson JR, Alexander JJ. Septic encephalopathy: inflammation in man and mouse. Neurochem Int. 2011 Mar; 58(4):472-6. PMID: 21219956.
      View in: PubMed
    32. Jacob A, Hack B, Bai T, Brorson JR, Quigg RJ, Alexander JJ. Inhibition of C5a receptor alleviates experimental CNS lupus. J Neuroimmunol. 2010 Apr 15; 221(1-2):46-52. PMID: 20207017.
      View in: PubMed
    33. Jacob A, Bao L, Brorson J, Quigg RJ, Alexander JJ. C3aR inhibition reduces neurodegeneration in experimental lupus. Lupus. 2010 Jan; 19(1):73-82. PMID: 19900981.
      View in: PubMed
    34. Jiao J, Nakajima A, Janssen WG, Bindokas VP, Xiong X, Morrison JH, Brorson JR, Tang YP. Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learning. PLoS One. 2008 Feb 27; 3(2):e1684. PMID: 18301761.
      View in: PubMed
    35. Li D, Shao Z, Vanden Hoek TL, Brorson JR. Reperfusion accelerates acute neuronal death induced by simulated ischemia. Exp Neurol. 2007 Aug; 206(2):280-7. PMID: 17599834.
      View in: PubMed
    36. Young KC, McGehee DS, Brorson JR. Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex. Neurobiol Dis. 2007 Apr; 26(1):78-85. PMID: 17240155.
      View in: PubMed
    37. Ruland S, Richardson D, Hung E, Brorson JR, Cruz-Flores S, Felton WL, Ford-Lynch G, Helgason C, Hsu C, Kramer J, Mitsias P, Gorelick PB. Predictors of recurrent stroke in African Americans. Neurology. 2006 Aug 22; 67(4):567-71. PMID: 16924005.
      View in: PubMed
    38. Li D, Marks JD, Schumacker PT, Young RM, Brorson JR. Physiological hypoxia promotes survival of cultured cortical neurons. Eur J Neurosci. 2005 Sep; 22(6):1319-26. PMID: 16190887.
      View in: PubMed
    39. Suzuki T, Abe Y, McGehee DS, Keath JR, Yajima H, Sharma K, Brorson JR. Long-lived retrograde fluorescent labeling of corticospinal neurons in the living animal. Brain Res Brain Res Protoc. 2004 Aug; 13(3):183-8. PMID: 15296856.
      View in: PubMed
    40. Brorson JR, Li D, Suzuki T. Selective expression of heteromeric AMPA receptors driven by flip-flop differences. J Neurosci. 2004 Apr 07; 24(14):3461-70. PMID: 15071093.
      View in: PubMed
    41. Hong TE, Thaler D, Brorson J, Heitschmidt M, Hijazi ZM. Transcatheter closure of patent foramen ovale associated with paradoxical embolism using the amplatzer PFO occluder: initial and intermediate-term results of the U.S. multicenter clinical trial. Catheter Cardiovasc Interv. 2003 Dec; 60(4):524-8. PMID: 14624434.
      View in: PubMed
    42. Du ZD, Cao QL, Joseph A, Koenig P, Heischmidt M, Waight DJ, Rhodes J, Brorson J, Hijazi ZM. Transcatheter closure of patent foramen ovale in patients with paradoxical embolism: intermediate-term risk of recurrent neurological events. Catheter Cardiovasc Interv. 2002 Feb; 55(2):189-94. PMID: 11835645.
      View in: PubMed
    43. Vandenberghe W, Brorson JR. Amyotrophic lateral sclerosis. N Engl J Med. 2001 Oct 11; 345(15):1131-2. PMID: 11596599.
      View in: PubMed
    44. Vandenberghe W, Bindokas VP, Miller RJ, Robberecht W, Brorson JR. Subcellular localization of calcium-permeable AMPA receptors in spinal motoneurons. Eur J Neurosci. 2001 Jul; 14(2):305-14. PMID: 11553281.
      View in: PubMed
    45. Vandenberghe W, Ihle EC, Patneau DK, Robberecht W, Brorson JR. AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability. J Neurosci. 2000 Oct 01; 20(19):7158-66. PMID: 11007871.
      View in: PubMed
    46. Maltepe E, Keith B, Arsham AM, Brorson JR, Simon MC. The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia. Biochem Biophys Res Commun. 2000 Jun 24; 273(1):231-8. PMID: 10873592.
      View in: PubMed
    47. Vandenberghe W, Robberecht W, Brorson JR. AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability. J Neurosci. 2000 Jan 01; 20(1):123-32. PMID: 10627588.
      View in: PubMed
    48. Brorson JR, Zhang Z, Vandenberghe W. Ca(2+) permeation of AMPA receptors in cerebellar neurons expressing glu receptor 2. J Neurosci. 1999 Nov 01; 19(21):9149-59. PMID: 10531418.
      View in: PubMed
    49. Brorson JR, Schumacker PT, Zhang H. Nitric oxide acutely inhibits neuronal energy production. The Committees on Neurobiology and Cell Physiology. J Neurosci. 1999 Jan 01; 19(1):147-58. PMID: 9870946.
      View in: PubMed
    50. Brorson JR, Zhang H. Disrupted [Ca2+]i homeostasis contributes to the toxicity of nitric oxide in cultured hippocampal neurons. J Neurochem. 1997 Nov; 69(5):1882-9. PMID: 9349531.
      View in: PubMed
    51. Brorson JR, Sulit RA, Zhang H. Nitric oxide disrupts Ca2+ homeostasis in hippocampal neurons. J Neurochem. 1997 Jan; 68(1):95-105. PMID: 8978714.
      View in: PubMed
    52. Zhang H, Weir B, Marton LS, Macdonald RL, Bindokas V, Miller RJ, Brorson JR. Mechanisms of hemolysate-induced [Ca2+]i elevation in cerebral smooth muscle cells. Am J Physiol. 1995 Dec; 269(6 Pt 2):H1874-90. PMID: 8594895.
      View in: PubMed
    53. Brorson JR, Marcuccilli CJ, Miller RJ. Delayed antagonism of calpain reduces excitotoxicity in cultured neurons. Stroke. 1995 Jul; 26(7):1259-66; discussion 1267. PMID: 7541574.
      View in: PubMed
    54. Brorson JR, Manzolillo PA, Gibbons SJ, Miller RJ. AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity. J Neurosci. 1995 Jun; 15(6):4515-24. PMID: 7540678.
      View in: PubMed
    55. Foucart S, Gibbons SJ, Brorson JR, Miller RJ. Increase in [Ca2+]i by CCh in adult rat sympathetic neurons are not dependent on intracellular Ca2+ pools. Am J Physiol. 1995 Apr; 268(4 Pt 1):C829-37. PMID: 7733231.
      View in: PubMed
    56. Brorson JR, Bindokas VP, Iwama T, Marcuccilli CJ, Chisholm JC, Miller RJ. The Ca2+ influx induced by beta-amyloid peptide 25-35 in cultured hippocampal neurons results from network excitation. J Neurobiol. 1995 Mar; 26(3):325-38. PMID: 7775966.
      View in: PubMed
    57. Holzwarth JA, Gibbons SJ, Brorson JR, Philipson LH, Miller RJ. Glutamate receptor agonists stimulate diverse calcium responses in different types of cultured rat cortical glial cells. J Neurosci. 1994 Apr; 14(4):1879-91. PMID: 8158245.
      View in: PubMed
    58. Brorson JR, Manzolillo PA, Miller RJ. Ca2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells. J Neurosci. 1994 Jan; 14(1):187-97. PMID: 7904304.
      View in: PubMed
    59. Bindokas VP, Brorson JR, Miller RJ. Characteristics of voltage sensitive calcium channels in dendrites of cultured rat cerebellar neurons. Neuropharmacology. 1993 Nov; 32(11):1213-20. PMID: 8107975.
      View in: PubMed
    60. Gibbons SJ, Brorson JR, Bleakman D, Chard PS, Miller RJ. Calcium influx and neurodegeneration. Ann N Y Acad Sci. 1993 May 28; 679:22-33. PMID: 8390144.
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    61. Brorson JR, Bleakman D, Chard PS, Miller RJ. Calcium directly permeates kainate/alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptors in cultured cerebellar Purkinje neurons. Mol Pharmacol. 1992 Apr; 41(4):603-8. PMID: 1373796.
      View in: PubMed
    62. Brorson JR, Bleakman D, Gibbons SJ, Miller RJ. The properties of intracellular calcium stores in cultured rat cerebellar neurons. J Neurosci. 1991 Dec; 11(12):4024-43. PMID: 1660539.
      View in: PubMed
    63. Brorson JR. Magnesium suppresses seizurelike discharges in cultured neurons. Arch Neurol. 1991 Jul; 48(7):677-8. PMID: 1830469.
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    64. Bleakman D, Brorson JR, Miller RJ. The effect of capsaicin on voltage-gated calcium currents and calcium signals in cultured dorsal root ganglion cells. Br J Pharmacol. 1990 Oct; 101(2):423-31. PMID: 1701680.
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    65. Brorson JR, Novak ES, Makinen MW. Solvent structure and enzyme activity. J Biomol Struct Dyn. 1985 Aug; 3(1):197-204. PMID: 3917015.
      View in: PubMed
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