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Dorothy A. Sipkins

TitleAssistant Professor
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    R01CA287772     (SIPKINS, DOROTHY A)Sep 19, 2023 - Aug 31, 2028
    Identifying and exploiting therapeutic vulnerabilities of tumor-host interactions that drive bone-to-meninges breast cancer metastasis
    Role: Principal Investigator

    R21CA263908     (SIPKINS, DOROTHY A)Aug 1, 2021 - Jul 31, 2023
    Novel use of PI3K inhibition to prevent recurrence of B-cell acute lymphoblastic leukemia
    Role: Principal Investigator

    R01CA234580     (SIPKINS, DOROTHY A)Jan 6, 2020 - Dec 31, 2024
    Defining and targeting a novel pathway for central nervous system leptomeningeal metastasis
    Role: Principal Investigator

    R01CA197848     (SIPKINS, DOROTHY A)Jan 9, 2017 - Sep 30, 2022
    Defining the Rules of Breast Cancer Cell Traffic Through Bone
    Role: Principal Investigator

    DP2OD002160     (SIPKINS, DOROTHY A)Sep 30, 2007 - Aug 31, 2012
    Stem cell, tumor and bone marrow microenvironment cross-talk in vivo
    Role: Principal Investigator

    K08CA112126     (SIPKINS, DOROTHY A)Aug 4, 2006 - Jul 31, 2011
    Imaging cell homing and engraftment in the bone marrow
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ridge SM, Whiteley AE, Yao H, Price TT, Brockman ML, Murray AS, Simon BG, Islam P, Sipkins DA. Pan-PI3Ki targets multiple B-ALL microenvironment interactions that fuel systemic and CNS relapse. Leuk Lymphoma. 2021 11; 62(11):2690-2702. PMID: 34355654; PMCID: PMC8722463.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Whiteley AE, Price TT, Cantelli G, Sipkins DA. Leukaemia: a model metastatic disease. Nat Rev Cancer. 2021 07; 21(7):461-475. PMID: 33953370; PMCID: PMC8722462.
      Citations: 38     Fields:    Translation:HumansAnimals
    3. Srinivasan ES, Tan AC, Anders CK, Pendergast AM, Sipkins DA, Ashley DM, Fecci PE, Khasraw M. Salting the Soil: Targeting the Microenvironment of Brain Metastases. Mol Cancer Ther. 2021 03; 20(3):455-466. PMID: 33402399; PMCID: PMC8041238.
      Citations: 10     Fields:    Translation:Humans
    4. Fan S, Price T, Huang W, Plue M, Warren J, Sundaramoorthy P, Paul B, Feinberg D, MacIver N, Chao N, Sipkins D, Kang Y. PINK1-Dependent Mitophagy Regulates the Migration and Homing of Multiple Myeloma Cells via the MOB1B-Mediated Hippo-YAP/TAZ Pathway. Adv Sci (Weinh). 2020 Mar; 7(5):1900860. PMID: 32154065; PMCID: PMC7055555.
      Citations: 21     Fields:    
    5. Yao H, Price TT, Cantelli G, Ngo B, Warner MJ, Olivere L, Ridge SM, Jablonski EM, Therrien J, Tannheimer S, McCall CM, Chenn A, Sipkins DA. Leukaemia hijacks a neural mechanism to invade the central nervous system. Nature. 2018 08; 560(7716):55-60. PMID: 30022166; PMCID: PMC10257142.
      Citations: 109     Fields:    Translation:Animals
    6. Rein LA, Wisler JW, Kim J, Theriot B, Huang L, Price T, Yang H, Chen M, Chen W, Sipkins D, Fedoriw Y, Walker JK, Premont RT, Lefkowitz RJ. ß-Arrestin2 mediates progression of murine primary myelofibrosis. JCI Insight. 2017 12 21; 2(24). PMID: 29263312; PMCID: PMC5752278.
      Citations: 4     Fields:    Translation:AnimalsCells
    7. Price TT, Sipkins DA. E-Selectin and SDF-1 regulate metastatic trafficking of breast cancer cells within the bone. Mol Cell Oncol. 2017; 4(4):e1214771. PMID: 28868340; PMCID: PMC5540205.
      Citations: 3     
    8. Price TT, Burness ML, Sivan A, Warner MJ, Cheng R, Lee CH, Olivere L, Comatas K, Magnani J, Kim Lyerly H, Cheng Q, McCall CM, Sipkins DA. Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone. Sci Transl Med. 2016 05 25; 8(340):340ra73. PMID: 27225183; PMCID: PMC8722465.
      Citations: 113     Fields:    Translation:HumansAnimalsCells
    9. Price T, Sipkins DA. Rewiring the niche: sympathetic neuropathy drives malignant niche transformation. Cell Stem Cell. 2014 Sep 04; 15(3):261-262. PMID: 25192459.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    10. Locke F, Agarwal R, Kunnavakkam R, van Besien K, Larson RA, Odenike O, Godley LA, Liu H, Le Beau MM, Gurbuxani S, Thirman MJ, Sipkins D, White C, Artz A, Stock W. A novel clofarabine bridge strategy facilitates allogeneic transplantation in patients with relapsed/refractory leukemia and high-risk myelodysplastic syndromes. Bone Marrow Transplant. 2013 Nov; 48(11):1437-43. PMID: 23771005; PMCID: PMC4279870.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    11. Boyerinas B, Zafrir M, Yesilkanal AE, Price TT, Hyjek EM, Sipkins DA. Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy. Blood. 2013 Jun 13; 121(24):4821-31. PMID: 23589674; PMCID: PMC3682335.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    12. Fox MF, Pontier A, Gurbuxani S, Sipkins DA. Stem cell factor expression in B cell malignancies is influenced by the niche. Leuk Lymphoma. 2013 Oct; 54(10):2274-80. PMID: 23418895.
      Citations: 5     Fields:    Translation:Humans
    13. Larson SM, Campbell NP, Huo D, Artz A, Zhang Y, Gajria D, Green M, Weiner H, Daugherty C, Odenike O, Godley LA, Hyjek E, Gurbuxani S, Thirman M, Sipkins D, Van Besien K, Larson RA, Stock W. High dose cytarabine and mitoxantrone: an effective induction regimen for high-risk acute myeloid leukemia (AML). Leuk Lymphoma. 2012 Mar; 53(3):445-50. PMID: 21913806.
      Citations: 6     Fields:    Translation:Humans
    14. Boyerinas B, Sipkins DA. HSPCs in the balance: The vascular niche. Cell Stem Cell. 2010 Dec 03; 7(6):645-6. PMID: 21112557.
      Citations: 3     Fields:    
    15. Burness ML, Sipkins DA. The stem cell niche in health and malignancy. Semin Cancer Biol. 2010 Apr; 20(2):107-15. PMID: 20510363.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    16. Sipkins DA. Rendering the leukemia cell susceptible to attack. N Engl J Med. 2009 Sep 24; 361(13):1307-9. PMID: 19776414.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    17. Colmone A, Amorim M, Pontier AL, Wang S, Jablonski E, Sipkins DA. Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science. 2008 Dec 19; 322(5909):1861-5. PMID: 19095944.
      Citations: 297     Fields:    Translation:HumansAnimalsCells
    18. Sipkins DA. Chemotherapy and the bone marrow stroma. Leuk Lymphoma. 2008 Jan; 49(1):17-8. PMID: 18203006.
      Citations: 1     Fields:    Translation:HumansCells
    19. Colmone A, Sipkins DA. Beyond angiogenesis: the role of endothelium in the bone marrow vascular niche. Transl Res. 2008 Jan; 151(1):1-9. PMID: 18061122.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    20. Wei X, Sipkins DA, Pitsillides CM, Novak J, Georgakoudi I, Lin CP. Real-time detection of circulating apoptotic cells by in vivo flow cytometry. Mol Imaging. 2005 Oct-Dec; 4(4):415-6. PMID: 16285902; PMCID: PMC2801924.
      Citations: 17     Fields:    Translation:HumansCells
    21. Sipkins DA, Wei X, Wu JW, Runnels JM, Means TK, Luster AD, Scadden DT, Lin CP, Côté D. In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature. 2005 Jun 16; 435(7044):969-73. PMID: 15959517; PMCID: PMC2570168.
      Citations: 376     Fields:    Translation:AnimalsCells
    22. Sipkins DA, Gijbels K, Tropper FD, Bednarski M, Li KC, Steinman L. ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging. J Neuroimmunol. 2000 Apr 03; 104(1):1-9. PMID: 10683508.
      Citations: 26     Fields:    Translation:Animals
    23. Sipkins DA, Cheresh DA, Kazemi MR, Nevin LM, Bednarski MD, Li KC. Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med. 1998 May; 4(5):623-6. PMID: 9585240.
      Citations: 214     Fields:    Translation:Animals
    24. Storrs RW, Tropper FD, Li HY, Song CK, Sipkins DA, Kuniyoshi JK, Bednarski MD, Strauss HW, Li KC. Paramagnetic polymerized liposomes as new recirculating MR contrast agents. J Magn Reson Imaging. 1995 Nov-Dec; 5(6):719-24. PMID: 8748492.
      Citations: 14     Fields:    Translation:Animals
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