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James Liao

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
Phone+1 (773) 7028950
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    Collapse Overview 
    Collapse overview
    Dr. Liao is the Harold H. Hines Jr. Professor of Medicine and Chief of Cardiology Section at the University of Chicago. He is also the Director of the Physician Scientist Development Program and Principal Investigator of the NIH T32 Cardiovascular Sciences Training Grant. His laboratory has made many important discoveries, which has helped elucidate signaling mechanisms in the vascular wall. Specifically, his laboratory explored molecular pathways which revealed how HMG-CoA reductase inhibitors (or statins) could exert cholesterol-independent or "pleiotropic" effects. This translational work provided a mechanistic basis for the benefit of statin therapy in stroke patients for which he received and was awarded the Cardiovascular Research Prize from the American Heart Association. His laboratory also identified, cloned, and characterized a novel cytochrome P450 epoxygenase, CYP2J2, and its products, epoxyeicosatrienoic acids (EETs), as endothelium-derived hyporpolarizing factors with anti-inflammatory and anti-ischemic properties. In addition, his work also led to the discovery of a novel, rapid, nongenomic effect of steroid hormone receptors. For his research accomplishments, Dr. Liao received the Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award from the American Heart Association and the Outstanding Investigator Award from the American Federation for Medical Research. He has served on numerous NIH study sections, advisory committees, and special emphasis panels.

    Collapse Research 
    Collapse research activities and funding
    R56DK129644     (LIAO, JAMES KUANG-JAN)Aug 19, 2021 - Aug 18, 2022
    NIH
    Cellular Determinants of Adipocyte Phenotype and Function
    Role: Principal Investigator

    R01HL136962     (LIAO, JAMES KUANG-JAN)Dec 22, 2017 - Nov 30, 2021
    NIH
    Mechanisms Underlying Vascular Aging
    Role: Principal Investigator

    R01DK085006     (LIAO, JAMES KUANG-JAN)Mar 1, 2010 - Nov 30, 2016
    NIH
    ROCK and Obesity
    Role: Principal Investigator

    R01NS070001     (LIAO, JAMES KUANG-JAN)Feb 1, 2010 - Jan 31, 2017
    NIH
    Novel Signaling Pathways in Ischemic Stroke
    Role: Principal Investigator

    R01HL080187     (LIAO, JAMES KUANG-JAN)Feb 15, 2006 - Jan 31, 2011
    NIH
    Endothelial Akt in Vascular Injury
    Role: Principal Investigator

    R01DK062729     (LIAO, JAMES KUANG-JAN)Jun 1, 2003 - Apr 30, 2009
    NIH
    Role of PI3-Kinase in Estrogen-induced eNOS Activation
    Role: Principal Investigator

    R01HL070274     (LIAO, JAMES KUANG-JAN)May 16, 2002 - Mar 31, 2008
    NIH
    Activation of eNOS by Steroid Hormones
    Role: Principal Investigator

    R01HL052233     (LIAO, JAMES KUANG-JAN)Jul 1, 1995 - Jun 30, 2019
    NIH
    Lipoproteins Effect on G Protein Function
    Role: Principal Investigator

    K11HL002508     (LIAO, JAMES KUANG-JAN)Jul 1, 1990 - Jun 30, 1995
    NIH
    GTP-BINDING PROTEINS AND MEDIATING EDRF RELEASE
    Role: Principal Investigator

    T32HL007381     (GILAD, YOAV)Jul 1, 1978 - Jun 30, 2024
    NIH
    Cardiovascular Sciences Training Grant
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ayata C, Kim H, Morrison L, Liao JK, Gutierrez J, Lopez-Toledano M, Carrazana E, Rabinowicz AL, Awad IA. Role of Rho-Associated Kinase in the Pathophysiology of Cerebral Cavernous Malformations. Neurol Genet. 2024 Feb; 10(1):e200121. PMID: 38179414; PMCID: PMC10766084.
      Citations:    
    2. German CA, Liao JK. Understanding the molecular mechanisms of statin pleiotropic effects. Arch Toxicol. 2023 06; 97(6):1529-1545. PMID: 37084080; PMCID: PMC10119541.
      Citations: 6     Fields:    Translation:Humans
    3. Ullah K, Ai L, Li Y, Liu L, Zhang Q, Pan K, Humayun Z, Sitikov A, Su Q, Zhao Q, Sharp WW, Fang Y, Wu D, Liao JK, Wu R. A Novel HIF-2a/ARNT Signaling Pathway Protects Against Microvascular Dysfunction and heart failure After Myocardial Infarction. bioRxiv. 2023 Mar 13. PMID: 36993497; PMCID: PMC10054928.
      Citations:    
    4. Liu PY, Fukuma N, Hiroi Y, Kunita A, Tokiwa H, Ueda K, Kariya T, Numata G, Adachi Y, Tajima M, Toyoda M, Li Y, Noma K, Harada M, Toko H, Ushiku T, Kanai Y, Takimoto E, Liao JK, Komuro I. Tie2-Cre-Induced Inactivation of Non-Nuclear Estrogen Receptor-a Signaling Abrogates Estrogen Protection Against Vascular Injury. JACC Basic Transl Sci. 2023 Jan; 8(1):55-67. PMID: 36777173; PMCID: PMC9911321.
      Citations: 1     
    5. Yu B, Osman AEG, Sladojevic N, Prabhu N, Tai HC, Chen D, Perla G, Park L, Larson RA, Liao JK. Involvement of Rho-Associated Coiled-Coil Containing Kinase (ROCK) in BCR-ABL1 Tyrosine Kinase Inhibitor Cardiovascular Toxicity. JACC CardioOncol. 2022 Sep; 4(3):371-383. PMID: 36213346; PMCID: PMC9537085.
      Citations: 1     
    6. Yu D, Liao JK. Emerging views of statin pleiotropy and cholesterol lowering. Cardiovasc Res. 2022 01 29; 118(2):413-423. PMID: 33533892; PMCID: PMC8803071.
      Citations: 25     Fields:    Translation:HumansAnimals
    7. Li Y, Tai HC, Sladojevic N, Kim HH, Liao JK. Vascular Stiffening Mediated by Rho-Associated Coiled-Coil Containing Kinase Isoforms. J Am Heart Assoc. 2021 10 19; 10(20):e022568. PMID: 34612053; PMCID: PMC8751888.
      Citations: 4     Fields:    Translation:Animals
    8. Wei J, Liao JK, Bairey Merz CN. Challenging Statin Pleiotropy: Preeclampsia. Circulation. 2021 08 31; 144(9):680-683. PMID: 34460319; PMCID: PMC8437106.
      Citations: 3     Fields:    Translation:Humans
    9. Zhang Q, Zheng M, Betancourt CE, Liu L, Sitikov A, Sladojevic N, Zhao Q, Zhang JH, Liao JK, Wu R. Increase in Blood-Brain Barrier (BBB) Permeability Is Regulated by MMP3 via the ERK Signaling Pathway. Oxid Med Cell Longev. 2021; 2021:6655122. PMID: 33859779; PMCID: PMC8026308.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    10. Anyanwu EC, Chua RFM, Besser SA, Sun D, Liao JK, Tabit CE. SALAD-BAAR: A numerical risk score for hospital admission or emergency department presentation in ambulatory patients with cardiovascular disease. Clin Cardiol. 2021 Feb; 44(2):193-199. PMID: 33277922; PMCID: PMC7852175.
      Citations: 1     Fields:    Translation:Humans
    11. Sladojevic N, Yu B, Liao JK. Regulator of G-Protein Signaling 5 Maintains Brain Endothelial Cell Function in Focal Cerebral Ischemia. J Am Heart Assoc. 2020 09 15; 9(18):e017533. PMID: 32875943; PMCID: PMC7726987.
      Citations: 9     Fields:    Translation:Animals
    12. Vohra AS, Chua RFM, Besser SA, Alcain CF, Basnet S, Battle B, Coplan MJ, Liao JK, Tabit CE. Community Health Workers Reduce Rehospitalizations and Emergency Department Visits for Low-Socioeconomic Urban Patients With Heart Failure. Crit Pathw Cardiol. 2020 09; 19(3):139-145. PMID: 32209825; PMCID: PMC7679953.
      Citations: 2     Fields:    Translation:Humans
    13. Ricker E, Chinenov Y, Pannellini T, Flores-Castro D, Ye C, Gupta S, Manni M, Liao JK, Pernis AB. Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis. J Clin Invest. 2020 07 01; 130(7):3654-3670. PMID: 32229726; PMCID: PMC7324193.
      Citations: 12     Fields:    Translation:AnimalsCells
    14. Yu B, Sladojevic N, Blair JE, Liao JK. Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening. Expert Opin Ther Targets. 2020 01; 24(1):47-62. PMID: 31906742; PMCID: PMC7662835.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    15. Polster SP, Stadnik A, Akers AL, Cao Y, Christoforidis GA, Fam MD, Flemming KD, Girard R, Hobson N, Koenig JI, Lane K, Liao JK, Lee C, McBee N, Morrison L, Piedad K, Shenkar R, Sorrentino M, Thompson RE, Whitehead KJ, Zeineddine HA, Hanley DF, Awad IA, Koskimäki J, Lyne SB. Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial. Neurosurgery. 2019 12 01; 85(6):843-853. PMID: 30476251; PMCID: PMC7054711.
      Citations: 32     Fields:    Translation:HumansCTClinical Trials
    16. Tung EL, Chua RFM, Besser SA, Lindau ST, Kolak M, Anyanwu EC, Liao JK, Tabit CE. Association of Rising Violent Crime With Blood Pressure and Cardiovascular Risk: Longitudinal Evidence From Chicago, 2014-2016. Am J Hypertens. 2019 11 15; 32(12):1192-1198. PMID: 31414132; PMCID: PMC7962900.
      Citations: 12     Fields:    Translation:Humans
    17. McKerracher L, Shenkar R, Abbinanti M, Cao Y, Peiper A, Liao JK, Lightle R, Moore T, Hobson N, Gallione C, Ruschel J, Girard R, Rosen K, Marchuk DA, Awad IA, Koskimäki J. A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease. Transl Stroke Res. 2020 06; 11(3):365-376. PMID: 31446620; PMCID: PMC7036327.
      Citations: 13     Fields:    Translation:Animals
    18. Kishimoto S, Oki K, Maruhashi T, Kajikawa M, Matsui S, Hashimoto H, Takaeko Y, Kihara Y, Chayama K, Goto C, Aibara Y, Yusoff FM, Nakashima A, Noma K, Liao JK, Higashi Y. Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study. J Hypertens. 2019 05; 37(5):1083-1095. PMID: 30418321; PMCID: PMC6467648.
      Citations: 5     Fields:    Translation:Humans
    19. Shenkar R, Peiper A, Pardo H, Moore T, Lightle R, Girard R, Hobson N, Polster SP, Zhang D, Cao Y, Chaudagar K, Saadat L, Gallione C, Pytel P, Liao JK, Marchuk D, Awad IA, Koskimäki J, Lyne SB. Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease. Stroke. 2019 03; 50(3):738-744. PMID: 30744543; PMCID: PMC6389370.
      Citations: 19     Fields:    Translation:Animals
    20. Oesterle A, Liao JK. The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia. Curr Vasc Pharmacol. 2019; 17(3):222-232. PMID: 30124154; PMCID: PMC6378117.
      Citations: 27     Fields:    Translation:HumansAnimals
    21. Li S, Wang Y, Jiang Z, Huai Y, Liao JK, Lynch KA, Zafonte R, Wood LJ, Wang QM. Impaired Cognitive Performance in Endothelial Nitric Oxide Synthase Knockout Mice After Ischemic Stroke: A Pilot Study. Am J Phys Med Rehabil. 2018 07; 97(7):492-499. PMID: 29406402; PMCID: PMC6008172.
      Citations: 8     Fields:    Translation:Animals
    22. Knipe RS, Probst CK, Lagares D, Franklin A, Spinney JJ, Brazee PL, Grasberger P, Zhang L, Black KE, Sakai N, Shea BS, Liao JK, Medoff BD, Tager AM. The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 04; 58(4):471-481. PMID: 29211497; PMCID: PMC5894496.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    23. Hiroi Y, Noma K, Kim HH, Sladojevic N, Tabit CE, Li Y, Soydan G, Salomone S, Moskowitz MA, Liao JK. Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice. Circ J. 2018 03 23; 82(4):1195-1204. PMID: 29353861; PMCID: PMC6235674.
      Citations: 10     Fields:    Translation:AnimalsCells
    24. Sladojevic N, Yu B, Liao JK. ROCK as a therapeutic target for ischemic stroke. Expert Rev Neurother. 2017 Dec; 17(12):1167-1177. PMID: 29057688; PMCID: PMC6221831.
      Citations: 22     Fields:    Translation:Humans
    25. Sladojevic N, Oh GT, Kim HH, Beaulieu LM, Kaminski K, Freedman JE, Liao JK, Falet H. Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets. Cardiovasc Res. 2017 Sep 01; 113(11):1307-1317. PMID: 28430966; PMCID: PMC5852540.
      Citations: 12     Fields:    Translation:AnimalsCells
    26. Shimizu T, Narang N, Chen P, Yu B, Knapp M, Janardanan J, Blair J, Liao JK. Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. JCI Insight. 2017 Jul 06; 2(13). PMID: 28679962; PMCID: PMC5499369.
      Citations: 33     Fields:    
    27. Tabit CE, Coplan MJ, Chen P, Jeevanandam V, Uriel N, Liao JK. Tumor necrosis factor-a levels and non-surgical bleeding in continuous-flow left ventricular assist devices. J Heart Lung Transplant. 2018 01; 37(1):107-115. PMID: 28651907; PMCID: PMC5722712.
      Citations: 23     Fields:    Translation:Humans
    28. Tabit CE, Coplan MJ, Spencer KT, Alcain CF, Spiegel T, Vohra AS, Adelman D, Liao JK, Sanghani RM. Cardiology Consultation in the Emergency Department Reduces Re-hospitalizations for Low-Socioeconomic Patients with Acute Decompensated Heart Failure. Am J Med. 2017 09; 130(9):1112.e17-1112.e31. PMID: 28457798; PMCID: PMC5572103.
      Citations: 8     Fields:    Translation:Humans
    29. Kasahara DI, Mathews JA, Ninin FM, Wurmbrand AP, Liao JK, Shore SA. Role of ROCK2 in CD4+ cells in allergic airways responses in mice. Clin Exp Allergy. 2017 Feb; 47(2):224-235. PMID: 27886408; PMCID: PMC5280456.
      Citations: 3     Fields:    Translation:AnimalsCells
    30. Oesterle A, Laufs U, Liao JK. Pleiotropic Effects of Statins on the Cardiovascular System. Circ Res. 2017 Jan 06; 120(1):229-243. PMID: 28057795; PMCID: PMC5467317.
      Citations: 402     Fields:    Translation:HumansAnimals
    31. Shenkar R, Shi C, Austin C, Moore T, Lightle R, Cao Y, Zhang L, Wu M, Zeineddine HA, Girard R, McDonald DA, Rorrer A, Gallione C, Pytel P, Liao JK, Marchuk DA, Awad IA. RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations. Stroke. 2017 01; 48(1):187-194. PMID: 27879448; PMCID: PMC5183488.
      Citations: 49     Fields:    Translation:Animals
    32. Zhou Q, Einert M, Schmitt H, Wang Z, Pankratz F, Olivier CB, Bode C, Liao JK, Moser M. MnTBAP increases BMPR-II expression in endothelial cells and attenuates vascular inflammation. Vascul Pharmacol. 2016 09; 84:67-73. PMID: 27401963; PMCID: PMC5563469.
      Citations: 5     Fields:    Translation:AnimalsCells
    33. Tabit CE, Chen P, Kim GH, Fedson SE, Sayer G, Coplan MJ, Jeevanandam V, Uriel N, Liao JK. Elevated Angiopoietin-2 Level in Patients With Continuous-Flow Left Ventricular Assist Devices Leads to Altered Angiogenesis and Is Associated With Higher Nonsurgical Bleeding. Circulation. 2016 Jul 12; 134(2):141-52. PMID: 27354285; PMCID: PMC4942355.
      Citations: 44     Fields:    Translation:HumansCells
    34. Shimizu T, Liao JK. Rho Kinases and Cardiac Remodeling. Circ J. 2016 Jun 24; 80(7):1491-8. PMID: 27251065; PMCID: PMC5563468.
      Citations: 51     Fields:    Translation:HumansAnimals
    35. Lennon FE, Cianci GC, Kanteti R, Riehm JJ, Arif Q, Poroyko VA, Lupovitch E, Vigneswaran W, Husain A, Chen P, Liao JK, Sattler M, Kindler HL, Salgia R. Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesothelioma. Sci Rep. 2016 Apr 15; 6:24578. PMID: 27080907; PMCID: PMC4832330.
      Citations: 25     Fields:    Translation:HumansCells
    36. Hofmann Bowman MA, Liao JK. Relative Lack of Culprit and Obstructive Coronary Lesions in Patients With Acute Ischemic Stroke and Elevated Cardiac Troponin. Circulation. 2016 Mar 29; 133(13):1228-9. PMID: 26933084; PMCID: PMC4891305.
      Citations: 1     Fields:    Translation:Humans
    37. Girard R, Khanna O, Shenkar R, Zhang L, Wu M, Jesselson M, Zeineddine HA, Gangal A, Fam MD, Gibson CC, Whitehead KJ, Li DY, Liao JK, Shi C, Awad IA. Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease. Biomark Med. 2016; 10(3):255-64. PMID: 26861901; PMCID: PMC4926533.
      Citations: 16     Fields:    Translation:HumansCells
    38. Hsieh ML, Liu PY, Wu JM, Liao JK, Wang JN. Interventional Transcatheter Closure Ameliorates the Leukocyte Rho Kinase Activities among Patients with Patent Ductus Arteriosus. Acta Cardiol Sin. 2015 Nov; 31(6):494-9. PMID: 27122913; PMCID: PMC4804973.
      Citations:    
    39. Kajikawa M, Noma K, Nakashima A, Maruhashi T, Iwamoto Y, Matsumoto T, Iwamoto A, Oda N, Hidaka T, Kihara Y, Aibara Y, Chayama K, Sasaki S, Kato M, Dote K, Goto C, Liao JK, Higashi Y. Rho-associated kinase activity is an independent predictor of cardiovascular events in acute coronary syndrome. Hypertension. 2015 Oct; 66(4):892-9. PMID: 26283039; PMCID: PMC4989242.
      Citations: 3     Fields:    Translation:Humans
    40. Kasahara DI, Mathews JA, Park CY, Cho Y, Hunt G, Wurmbrand AP, Liao JK, Shore SA. ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 01; 309(7):L736-46. PMID: 26276827; PMCID: PMC4593838.
      Citations: 18     Fields:    Translation:HumansAnimals
    41. Zhou Q, Keller C, Schmitt H, Esser J, Moser M, Liao JK, Gensch C. MnTBAP stimulates angiogenic functions in endothelial cells through mitofusin-1. Vascul Pharmacol. 2015 Sep; 72:163-71. PMID: 26015376; PMCID: PMC4547864.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    42. Maruhashi T, Noma K, Fujimura N, Kajikawa M, Matsumoto T, Hidaka T, Nakashima A, Kihara Y, Liao JK, Higashi Y. Exogenous nitric oxide inhibits Rho-associated kinase activity in patients with angina pectoris: a randomized controlled trial. Hypertens Res. 2015 Jul; 38(7):485-90. PMID: 25740292; PMCID: PMC4889444.
      Citations: 3     Fields:    Translation:HumansCells
    43. Kasahara DI, Ninin FM, Wurmbrand AP, Liao JK, Shore SA. Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency. Clin Exp Allergy. 2015 Feb; 45(2):457-70. PMID: 25323425; PMCID: PMC4568824.
      Citations: 11     Fields:    Translation:AnimalsCells
    44. Matsumoto T, Oki K, Kajikawa M, Nakashima A, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Hidaka T, Kihara Y, Kohno N, Chayama K, Goto C, Aibara Y, Noma K, Liao JK, Higashi Y. Effect of aldosterone-producing adenoma on endothelial function and Rho-associated kinase activity in patients with primary aldosteronism. Hypertension. 2015 Apr; 65(4):841-8. PMID: 25624340; PMCID: PMC4917381.
      Citations: 19     Fields:    Translation:Humans
    45. Knipe RS, Tager AM, Liao JK. The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis. Pharmacol Rev. 2015; 67(1):103-17. PMID: 25395505; PMCID: PMC4279074.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    46. Liao YC, Liu PY, Lin HF, Lin WY, Liao JK, Juo SH. Two functional polymorphisms of ROCK2 enhance arterial stiffening through inhibiting its activity and expression. J Mol Cell Cardiol. 2015 Feb; 79:180-6. PMID: 25481646; PMCID: PMC4889447.
      Citations: 5     Fields:    Translation:HumansCells
    47. Maruhashi T, Noma K, Iwamoto Y, Iwamoto A, Oda N, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Nakashima A, Goto C, Liao JK, Higashi Y. Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells. PLoS One. 2014; 9(10):e109017. PMID: 25280018; PMCID: PMC4184841.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    48. Liu PY, Lee PT, Chang WT, Tai YL, Chao TH, Lee CH, Li YH, Chen JH, Tsai LM, Liao JK. Evidence of pleiotropy by statins: leukocyte Rho kinase (ROCK) activity and pretreated statin before percutaneous coronary interventions are clinical vascular outcome predictors. Int J Cardiol. 2014 Sep; 176(1):250-3. PMID: 25034804; PMCID: PMC6444050.
      Citations: 1     Fields:    Translation:HumansCells
    49. Zee RYL, Wang QM, Chasman DI, Ridker PM, Liao JK. Gene variations of ROCKs and risk of ischaemic stroke: the Women's Genome Health Study. Clin Sci (Lond). 2014 Jun; 126(12):829-835. PMID: 24351102; PMCID: PMC4059841.
      Citations: 4     Fields:    Translation:Humans
    50. Miao Y, Liao JK. Potential serum biomarkers in the pathophysiological processes of stroke. Expert Rev Neurother. 2014 Feb; 14(2):173-85. PMID: 24417214; PMCID: PMC3939679.
      Citations: 19     Fields:    Translation:HumansAnimals
    51. Kajikawa M, Noma K, Maruhashi T, Mikami S, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Nakashima A, Goto C, Liao JK, Higashi Y. Rho-associated kinase activity is a predictor of cardiovascular outcomes. Hypertension. 2014 Apr; 63(4):856-64. PMID: 24379190; PMCID: PMC4101172.
      Citations: 16     Fields:    Translation:Humans
    52. Sawada N, Liao JK. Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis. Antioxid Redox Signal. 2014 Mar 10; 20(8):1251-67. PMID: 23919640; PMCID: PMC3934442.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    53. Tanaka S, Fukumoto Y, Nochioka K, Minami T, Kudo S, Shiba N, Takai Y, Williams CL, Liao JK, Shimokawa H. Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation. Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1591-600. PMID: 23640485; PMCID: PMC3863549.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    54. Toque HA, Nunes KP, Yao L, Liao JK, Webb RC, Caldwell RB, Caldwell RW. Activated Rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: possible involvement of p38 MAPK activation. J Sex Med. 2013 Jun; 10(6):1502-15. PMID: 23566117; PMCID: PMC3807104.
      Citations: 22     Fields:    Translation:AnimalsCells
    55. Dong M, Jiang X, Liao JK, Yan BP. Elevated rho-kinase activity as a marker indicating atherosclerosis and inflammation burden in polyvascular disease patients with concomitant coronary and peripheral arterial disease. Clin Cardiol. 2013 Jun; 36(6):347-51. PMID: 23553913; PMCID: PMC3807086.
      Citations: 3     Fields:    Translation:HumansCells
    56. Liao JK. Linking endothelial dysfunction with endothelial cell activation. J Clin Invest. 2013 Feb; 123(2):540-1. PMID: 23485580; PMCID: PMC3561809.
      Citations: 198     Fields:    Translation:HumansAnimalsCells
    57. Montalvo J, Spencer C, Hackathorn A, Masterjohn K, Perkins A, Doty C, Arumugam A, Ongusaha PP, Lakshmanaswamy R, Liao JK, Mitchell DC, Bryan BA. ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression. Curr Mol Med. 2013 Jan; 13(1):205-19. PMID: 22934846; PMCID: PMC3580831.
      Citations: 25     Fields:    Translation:AnimalsCells
    58. Okamoto R, Li Y, Noma K, Hiroi Y, Liu PY, Taniguchi M, Ito M, Liao JK. FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2. FASEB J. 2013 Apr; 27(4):1439-49. PMID: 23271052; PMCID: PMC3606529.
      Citations: 55     Fields:    Translation:AnimalsCells
    59. Medvetz DA, Khabibullin D, Hariharan V, Ongusaha PP, Goncharova EA, Schlechter T, Darling TN, Hofmann I, Krymskaya VP, Liao JK, Huang H, Henske EP. Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion. PLoS One. 2012; 7(11):e47842. PMID: 23139756; PMCID: PMC3490959.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    60. Wang QM, Stalker TJ, Gong Y, Rikitake Y, Scalia R, Liao JK. Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury. Vasc Med. 2012 Dec; 17(6):379-85. PMID: 23015643; PMCID: PMC3807093.
      Citations: 11     Fields:    Translation:AnimalsCells
    61. Mei Y, Shoji T, Han X, Kaminski K, Oh GT, Ongusaha PP, Zhang K, Schmitt H, Moser M, Bode C, Liao JK, Zhou Q. Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis. Circulation. 2012 Oct 30; 126(18):2236-47. PMID: 23011471; PMCID: PMC3807088.
      Citations: 22     Fields:    Translation:AnimalsCells
    62. Wang QM, Liao JK. ROCKs as immunomodulators of stroke. Expert Opin Ther Targets. 2012 Oct; 16(10):1013-25. PMID: 22925075; PMCID: PMC3807092.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    63. Dong M, Liao JK, Yan B, Li R, Zhang M, Yu CM. A combination of increased Rho kinase activity and N-terminal pro-B-type natriuretic peptide predicts worse cardiovascular outcome in patients with acute coronary syndrome. Int J Cardiol. 2013 Sep 10; 167(6):2813-9. PMID: 22921817; PMCID: PMC3807084.
      Citations: 6     Fields:    Translation:HumansCells
    64. Dong M, Liao JK, Fang F, Lee AP, Yan BP, Liu M, Yu CM. Increased Rho kinase activity in congestive heart failure. Eur J Heart Fail. 2012 Sep; 14(9):965-73. PMID: 22588320; PMCID: PMC3707433.
      Citations: 18     Fields:    Translation:Humans
    65. Hung MJ, Cherng WJ, Hung MY, Kuo LT, Cheng CW, Wang CH, Yang NI, Liao JK. Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina. Atherosclerosis. 2012 Apr; 221(2):521-6. PMID: 22293227; PMCID: PMC3312984.
      Citations: 18     Fields:    Translation:HumansCells
    66. Wang CY, Liao JK. A mouse model of diet-induced obesity and insulin resistance. Methods Mol Biol. 2012; 821:421-33. PMID: 22125082; PMCID: PMC3807094.
      Citations: 216     Fields:    Translation:HumansAnimals
    67. Fujimura N, Noma K, Hata T, Soga J, Hidaka T, Idei N, Fujii Y, Mikami S, Maruhashi T, Iwamoto Y, Kihara Y, Chayama K, Kato H, Liao JK, Higashi Y, ROCK Study Group. Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits Rho-associated kinase activity in patients with hypertension. Clin Pharmacol Ther. 2012 Feb; 91(2):289-97. PMID: 22205191; PMCID: PMC6444052.
      Citations: 26     Fields:    Translation:HumansCells
    68. Liao JK. Mitohormesis: another pleiotropic effect of statins? Eur Heart J. 2012 Jun; 33(11):1299-301. PMID: 21979988; PMCID: PMC3365272.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    69. Soga J, Noma K, Hata T, Hidaka T, Fujii Y, Idei N, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Liao JK, Higashi Y, ROCK Study Group. Rho-associated kinase activity, endothelial function, and cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 2011 Oct; 31(10):2353-9. PMID: 21737782; PMCID: PMC3852695.
      Citations: 29     Fields:    Translation:HumansCells
    70. Huh YH, Zhou Q, Liao JK, Kitazawa T. ROCK inhibition prevents fetal serum-induced alteration in structure and function of organ-cultured mesenteric artery. J Muscle Res Cell Motil. 2011 Sep; 32(2):65-76. PMID: 21643972; PMCID: PMC3177025.
      Citations: 2     Fields:    Translation:AnimalsCells
    71. Zhu M, Liu PY, Kasahara DI, Williams AS, Verbout NG, Halayko AJ, Fedulov A, Shoji T, Williams ES, Noma K, Shore SA, Liao JK. Role of Rho kinase isoforms in murine allergic airway responses. Eur Respir J. 2011 Oct; 38(4):841-50. PMID: 21565918; PMCID: PMC3263528.
      Citations: 20     Fields:    Translation:AnimalsCells
    72. Liao JK. Squalene synthase inhibitor lapaquistat acetate: could anything be better than statins? Circulation. 2011 May 10; 123(18):1925-8. PMID: 21518979; PMCID: PMC3807098.
      Citations: 8     Fields:    Translation:Humans
    73. Reis SA, Thompson MN, Lee JM, Fossale E, Kim HH, Liao JK, Moskowitz MA, Shaw SY, Dong L, Haggarty SJ, MacDonald ME, Seong IS. Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis. Hum Mol Genet. 2011 Jun 15; 20(12):2344-55. PMID: 21447599; PMCID: PMC3098733.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    74. Li Y, Hiroi Y, Ngoy S, Okamoto R, Noma K, Wang CY, Wang HW, Zhou Q, Radtke F, Liao R, Liao JK. Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarction. Circulation. 2011 Mar 01; 123(8):866-76. PMID: 21321153; PMCID: PMC3488350.
      Citations: 36     Fields:    Translation:AnimalsCells
    75. Kikuchi R, Takeshita K, Uchida Y, Kondo M, Cheng XW, Nakayama T, Yamamoto K, Matsushita T, Liao JK, Murohara T. Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF. Lab Invest. 2011 May; 91(5):691-703. PMID: 21301413; PMCID: PMC3807100.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    76. Hata T, Soga J, Hidaka T, Idei N, Fujii Y, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Noma K, Liao JK, Higashi Y, ROCK Study Group. Calcium channel blocker and Rho-associated kinase activity in patients with hypertension. J Hypertens. 2011 Feb; 29(2):373-9. PMID: 21063203; PMCID: PMC3807090.
      Citations: 22     Fields:    Translation:HumansCells
    77. Zhou Q, Gensch C, Liao JK. Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease. Trends Pharmacol Sci. 2011 Mar; 32(3):167-73. PMID: 21242007; PMCID: PMC3080120.
      Citations: 65     Fields:    Translation:HumansAnimals
    78. Wei Y, Yemisci M, Kim HH, Yung LM, Shin HK, Hwang SK, Guo S, Qin T, Alsharif N, Brinkmann V, Liao JK, Lo EH, Waeber C. Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann Neurol. 2011 Jan; 69(1):119-29. PMID: 21280082; PMCID: PMC3200194.
      Citations: 144     Fields:    Translation:AnimalsCells
    79. Yan J, Liao JK, Wang D. Elevated homocysteine and C-reactive protein levels independently predict worsening prognosis after stroke in Chinese patients. J Huazhong Univ Sci Technolog Med Sci. 2010 Oct; 30(5):643-7. PMID: 21063849; PMCID: PMC3807101.
      Citations: 8     Fields:    Translation:Humans
    80. Hata T, Goto C, Soga J, Hidaka T, Fujii Y, Idei N, Fujimura N, Maruhashi T, Mikami S, Kihara Y, Chayama K, Noma K, Liao JK, Higashi Y. Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil. Atherosclerosis. 2011 Jan; 214(1):117-21. PMID: 21035804; PMCID: PMC3807089.
      Citations: 11     Fields:    Translation:HumansCells
    81. Harari OA, Liao JK. NF-?B and innate immunity in ischemic stroke. Ann N Y Acad Sci. 2010 Oct; 1207:32-40. PMID: 20955423; PMCID: PMC3807097.
      Citations: 145     Fields:    Translation:HumansAnimals
    82. Li Y, Hiroi Y, Liao JK. Notch signaling as an important mediator of cardiac repair and regeneration after myocardial infarction. Trends Cardiovasc Med. 2010 Oct; 20(7):228-31. PMID: 22293023; PMCID: PMC3307142.
      Citations: 38     Fields:    Translation:AnimalsCells
    83. Biswas PS, Gupta S, Chang E, Song L, Stirzaker RA, Liao JK, Bhagat G, Pernis AB. Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J Clin Invest. 2010 Sep; 120(9):3280-95. PMID: 20697158; PMCID: PMC2929726.
      Citations: 116     Fields:    Translation:AnimalsCells
    84. Dong M, Yan BP, Liao JK, Lam YY, Yip GW, Yu CM. Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases. Drug Discov Today. 2010 Aug; 15(15-16):622-9. PMID: 20601092; PMCID: PMC3807099.
      Citations: 60     Fields:    Translation:HumansAnimals
    85. Bryan BA, Dennstedt E, Mitchell DC, Walshe TE, Noma K, Loureiro R, Saint-Geniez M, Campaigniac JP, Liao JK, D'Amore PA. RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis. FASEB J. 2010 Sep; 24(9):3186-95. PMID: 20400538; PMCID: PMC2923346.
      Citations: 142     Fields:    Translation:HumansAnimalsCells
    86. Zhou Q, Liao JK. Pleiotropic effects of statins. - Basic research and clinical perspectives -. Circ J. 2010 May; 74(5):818-26. PMID: 20424337; PMCID: PMC3807085.
      Citations: 184     Fields:    Translation:HumansCells
    87. Ii M, Takeshita K, Ibusuki K, Luedemann C, Wecker A, Eaton E, Thorne T, Asahara T, Liao JK, Losordo DW. Notch signaling regulates endothelial progenitor cell activity during recovery from arterial injury in hypercholesterolemic mice. Circulation. 2010 Mar 09; 121(9):1104-12. PMID: 20176991; PMCID: PMC2838724.
      Citations: 24     Fields:    Translation:AnimalsCells
    88. Hidaka T, Hata T, Soga J, Fujii Y, Idei N, Fujimura N, Kihara Y, Noma K, Liao JK, Higashi Y. Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers. Hypertens Res. 2010 Apr; 33(4):354-9. PMID: 20139919; PMCID: PMC2929361.
      Citations: 19     Fields:    Translation:HumansCells
    89. Sawada N, Li Y, Liao JK. Novel aspects of the roles of Rac1 GTPase in the cardiovascular system. Curr Opin Pharmacol. 2010 Apr; 10(2):116-21. PMID: 20060361; PMCID: PMC2843793.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    90. Sawada N, Liao JK. Targeting eNOS and beyond: emerging heterogeneity of the role of endothelial Rho proteins in stroke protection. Expert Rev Neurother. 2009 Aug; 9(8):1171-86. PMID: 19673606; PMCID: PMC2929364.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    91. Liao JK. Genetically elevated C-reactive protein and ischemic vascular disease. Curr Atheroscler Rep. 2009 Jul; 11(4):245. PMID: 19500486.
      Citations: 3     Fields:    
    92. Liao JK. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. Curr Atheroscler Rep. 2009 Jul; 11(4):243-4. PMID: 19500485.
      Citations: 8     Fields:    
    93. Li Y, Takeshita K, Liu PY, Satoh M, Oyama N, Mukai Y, Chin MT, Krebs L, Kotlikoff MI, Radtke F, Gridley T, Liao JK. Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation. 2009 May 26; 119(20):2686-92. PMID: 19433762; PMCID: PMC2744039.
      Citations: 69     Fields:    Translation:AnimalsCells
    94. Aoyama T, Takeshita K, Kikuchi R, Yamamoto K, Cheng XW, Liao JK, Murohara T. gamma-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun. 2009 May 29; 383(2):216-21. PMID: 19345673; PMCID: PMC2929363.
      Citations: 37     Fields:    Translation:AnimalsCells
    95. Wang CY, Kim HH, Hiroi Y, Sawada N, Salomone S, Benjamin LE, Walsh K, Moskowitz MA, Liao JK. Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. Sci Signal. 2009 Mar 17; 2(62):ra11. PMID: 19293429; PMCID: PMC2667954.
      Citations: 79     Fields:    Translation:AnimalsCells
    96. Sawada N, Kim HH, Moskowitz MA, Liao JK. Rac1 is a critical mediator of endothelium-derived neurotrophic activity. Sci Signal. 2009 Mar 10; 2(61):ra10. PMID: 19278959; PMCID: PMC2668716.
      Citations: 14     Fields:    Translation:AnimalsCells
    97. Zhou Q, Liao JK. Rho kinase: an important mediator of atherosclerosis and vascular disease. Curr Pharm Des. 2009; 15(27):3108-15. PMID: 19754385; PMCID: PMC2896789.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    98. Zhou Q, Liao JK. Statins and cardiovascular diseases: from cholesterol lowering to pleiotropy. Curr Pharm Des. 2009; 15(5):467-78. PMID: 19199975; PMCID: PMC2896785.
      Citations: 93     Fields:    Translation:HumansAnimals
    99. Rawlings R, Nohria A, Liu PY, Donnelly J, Creager MA, Ganz P, Selwyn A, Liao JK. Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event. Am J Cardiol. 2009 Feb 15; 103(4):437-41. PMID: 19195498; PMCID: PMC2673911.
      Citations: 25     Fields:    Translation:Humans
    100. Feske SK, Sorond FA, Henderson GV, Seto M, Hitomi A, Kawasaki K, Sasaki Y, Asano T, Liao JK. Increased leukocyte ROCK activity in patients after acute ischemic stroke. Brain Res. 2009 Feb 27; 1257:89-93. PMID: 19133241; PMCID: PMC2646801.
      Citations: 19     Fields:    Translation:HumansCells
    101. Nohria A, Prsic A, Liu PY, Okamoto R, Creager MA, Selwyn A, Liao JK, Ganz P. Statins inhibit Rho kinase activity in patients with atherosclerosis. Atherosclerosis. 2009 Aug; 205(2):517-21. PMID: 19167712; PMCID: PMC2717178.
      Citations: 63     Fields:    Translation:HumansCells
    102. Liu PY, Liu YW, Lin LJ, Chen JH, Liao JK. Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation. Circulation. 2009 Jan 06; 119(1):131-8. PMID: 19075102; PMCID: PMC2745913.
      Citations: 81     Fields:    Translation:HumansCells
    103. Ongusaha PP, Qi HH, Raj L, Kim YB, Aaronson SA, Davis RJ, Shi Y, Liao JK, Lee SW. Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. Sci Signal. 2008 Nov 25; 1(47):ra14. PMID: 19036714; PMCID: PMC2649725.
      Citations: 29     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    104. Wang CY, Wen MS, Wang HW, Hsieh IC, Li Y, Liu PY, Lin FC, Liao JK. Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2. Circulation. 2008 Nov 18; 118(21):2166-73. PMID: 18981300; PMCID: PMC2656770.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    105. Osorio JC, Cheema FH, Martens TP, Mahmut N, Kinnear C, Gonzalez AM, Bonney W, Homma S, Liao JK, Mital S. Simvastatin reverses cardiac hypertrophy caused by disruption of the bradykinin 2 receptor. Can J Physiol Pharmacol. 2008 Sep; 86(9):633-42. PMID: 18758513; PMCID: PMC3034156.
      Citations: 5     Fields:    Translation:AnimalsCells
    106. Yan G, You B, Chen SP, Liao JK, Sun J. Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1. Circ Res. 2008 Sep 12; 103(6):591-7. PMID: 18688046; PMCID: PMC2753820.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    107. Liao JK. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. Curr Atheroscler Rep. 2008 Aug; 10(4):281. PMID: 18606093.
      Citations: 3     Fields:    
    108. Liao JK. Effect of torcetrapib in patients at high risk for coronary events. Curr Atheroscler Rep. 2008 Aug; 10(4):282. PMID: 18606094.
      Citations:    Fields:    
    109. Liao JK. Fine-tuning the angiogenic response to vascular endothelial growth factor. Circ Res. 2008 Aug 01; 103(3):229-30. PMID: 18669928; PMCID: PMC2662039.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    110. Sawada N, Salomone S, Kim HH, Kwiatkowski DJ, Liao JK. Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1. Circ Res. 2008 Aug 15; 103(4):360-8. PMID: 18599867; PMCID: PMC2615563.
      Citations: 44     Fields:    Translation:AnimalsCells
    111. Wang HW, Liu PY, Oyama N, Rikitake Y, Kitamoto S, Gitlin J, Liao JK, Boisvert WA. Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice. FASEB J. 2008 Oct; 22(10):3561-70. PMID: 18556458; PMCID: PMC2537434.
      Citations: 38     Fields:    Translation:AnimalsCells
    112. Noma K, Rikitake Y, Oyama N, Yan G, Alcaide P, Liu PY, Wang H, Ahl D, Sawada N, Okamoto R, Hiroi Y, Shimizu K, Luscinskas FW, Sun J, Liao JK. ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury. J Clin Invest. 2008 May; 118(5):1632-44. PMID: 18414683; PMCID: PMC2293333.
      Citations: 82     Fields:    Translation:AnimalsCells
    113. Kim HH, Sawada N, Soydan G, Lee HS, Zhou Z, Hwang SK, Waeber C, Moskowitz MA, Liao JK. Additive effects of statin and dipyridamole on cerebral blood flow and stroke protection. J Cereb Blood Flow Metab. 2008 Jul; 28(7):1285-93. PMID: 18382469; PMCID: PMC2662038.
      Citations: 25     Fields:    Translation:AnimalsCells
    114. Arboleda-Velasquez JF, Zhou Z, Shin HK, Louvi A, Kim HH, Savitz SI, Liao JK, Salomone S, Ayata C, Moskowitz MA, Artavanis-Tsakonas S. Linking Notch signaling to ischemic stroke. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4856-61. PMID: 18347334; PMCID: PMC2290794.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    115. Hiroi Y, Guo Z, Li Y, Beggs AH, Liao JK. Dynamic regulation of endothelial NOS mediated by competitive interaction with alpha-actinin-4 and calmodulin. FASEB J. 2008 May; 22(5):1450-7. PMID: 18180332; PMCID: PMC2515824.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    116. Kim HH, Liao JK. Translational therapeutics of dipyridamole. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):s39-42. PMID: 18174451; PMCID: PMC2615560.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    117. Liu PY, Liao JK. A method for measuring Rho kinase activity in tissues and cells. Methods Enzymol. 2008; 439:181-9. PMID: 18374165; PMCID: PMC2615566.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    118. Wang CY, Liu PY, Liao JK. Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. Trends Mol Med. 2008 Jan; 14(1):37-44. PMID: 18068482; PMCID: PMC2621332.
      Citations: 221     Fields:    Translation:Humans
    119. Liao JK. Is statin discontinuation an option in patients who have had a stroke? Nat Clin Pract Neurol. 2008 Jan; 4(1):18-9. PMID: 18059384; PMCID: PMC2615565.
      Citations:    Fields:    
    120. Liao JK. Does it matter whether or not a lipid-lowering agent inhibits Rho kinase? Curr Atheroscler Rep. 2007 Nov; 9(5):384-8. PMID: 18001621; PMCID: PMC2643375.
      Citations: 2     Fields:    Translation:HumansAnimals
    121. Blondeau N, Lai Y, Tyndall S, Popolo M, Topalkara K, Pru JK, Zhang L, Kim H, Liao JK, Ding K, Waeber C. Distribution of sphingosine kinase activity and mRNA in rodent brain. J Neurochem. 2007 Oct; 103(2):509-17. PMID: 17623044; PMCID: PMC2639651.
      Citations: 55     Fields:    Translation:AnimalsCells
    122. Liao JK, Seto M, Noma K. Rho kinase (ROCK) inhibitors. J Cardiovasc Pharmacol. 2007 Jul; 50(1):17-24. PMID: 17666911; PMCID: PMC2692906.
      Citations: 150     Fields:    Translation:HumansAnimals
    123. Satoh M, Matter CM, Ogita H, Takeshita K, Wang CY, Dorn GW, Liao JK. Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. Circulation. 2007 Jun 26; 115(25):3197-204. PMID: 17562954; PMCID: PMC2701741.
      Citations: 58     Fields:    Translation:AnimalsCells
    124. Liu PY, Chen JH, Lin LJ, Liao JK. Increased Rho kinase activity in a Taiwanese population with metabolic syndrome. J Am Coll Cardiol. 2007 Apr 17; 49(15):1619-1624. PMID: 17433952; PMCID: PMC2615567.
      Citations: 53     Fields:    Translation:Humans
    125. Liao JK. Secondary prevention of stroke and transient ischemic attack: is more platelet inhibition the answer? Circulation. 2007 Mar 27; 115(12):1615-21. PMID: 17389280; PMCID: PMC2667676.
      Citations: 17     Fields:    Translation:Humans
    126. Noma K, Goto C, Nishioka K, Jitsuiki D, Umemura T, Ueda K, Kimura M, Nakagawa K, Oshima T, Chayama K, Yoshizumi M, Liao JK, Higashi Y. Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness. J Am Coll Cardiol. 2007 Feb 13; 49(6):698-705. PMID: 17291936; PMCID: PMC2615568.
      Citations: 44     Fields:    Translation:Humans
    127. Mukai Y, Wang CY, Rikitake Y, Liao JK. Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells. Am J Physiol Heart Circ Physiol. 2007 Apr; 292(4):H1937-42. PMID: 17172275; PMCID: PMC2651639.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    128. Liao JK. Safety and efficacy of statins in Asians. Am J Cardiol. 2007 Feb 01; 99(3):410-4. PMID: 17261409; PMCID: PMC2651637.
      Citations: 95     Fields:    Translation:Humans
    129. Takeshita K, Satoh M, Ii M, Silver M, Limbourg FP, Mukai Y, Rikitake Y, Radtke F, Gridley T, Losordo DW, Liao JK. Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res. 2007 Jan 05; 100(1):70-8. PMID: 17158336; PMCID: PMC2615564.
      Citations: 112     Fields:    Translation:AnimalsCells
    130. Nohria A, Grunert ME, Rikitake Y, Noma K, Prsic A, Ganz P, Liao JK, Creager MA. Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease. Circ Res. 2006 Dec 08; 99(12):1426-32. PMID: 17095725; PMCID: PMC2666070.
      Citations: 85     Fields:    Translation:Humans
    131. Shin HK, Salomone S, Potts EM, Lee SW, Millican E, Noma K, Huang PL, Boas DA, Liao JK, Moskowitz MA, Ayata C. Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms. J Cereb Blood Flow Metab. 2007 May; 27(5):998-1009. PMID: 17033691; PMCID: PMC2614438.
      Citations: 59     Fields:    Translation:AnimalsCells
    132. Hiroi Y, Kim HH, Ying H, Furuya F, Huang Z, Simoncini T, Noma K, Ueki K, Nguyen NH, Scanlan TS, Moskowitz MA, Cheng SY, Liao JK. Rapid nongenomic actions of thyroid hormone. Proc Natl Acad Sci U S A. 2006 Sep 19; 103(38):14104-9. PMID: 16966610; PMCID: PMC1599919.
      Citations: 147     Fields:    Translation:HumansAnimalsCells
    133. Liao JK. Rho-kinase: a potential link between hypercholesterolemia and abnormal vascular smooth muscle contraction. Circ Res. 2006 Aug 04; 99(3):238-9. PMID: 16888249; PMCID: PMC2662040.
      Citations: 4     Fields:    Translation:HumansAnimals
    134. Sun J, Yan G, Ren A, You B, Liao JK. FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1. Circ Res. 2006 Sep 01; 99(5):468-76. PMID: 16888242; PMCID: PMC2614439.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    135. Sakoda K, Yamamoto M, Negishi Y, Liao JK, Node K, Izumi Y. Simvastatin decreases IL-6 and IL-8 production in epithelial cells. J Dent Res. 2006 Jun; 85(6):520-3. PMID: 16723648; PMCID: PMC3001137.
      Citations: 62     Fields:    Translation:HumansCells
    136. Xiang F, Sakata Y, Cui L, Youngblood JM, Nakagami H, Liao JK, Liao R, Chin MT. Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1997-2006. PMID: 16603706; PMCID: PMC2692281.
      Citations: 24     Fields:    Translation:AnimalsCells
    137. Satoh M, Ogita H, Takeshita K, Mukai Y, Kwiatkowski DJ, Liao JK. Requirement of Rac1 in the development of cardiac hypertrophy. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7432-7. PMID: 16651530; PMCID: PMC1455410.
      Citations: 118     Fields:    Translation:AnimalsCells
    138. Harari OA, Alcaide P, Ahl D, Luscinskas FW, Liao JK. Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway. Circ Res. 2006 May 12; 98(9):1134-40. PMID: 16574902; PMCID: PMC2701732.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    139. Noma K, Oyama N, Liao JK. Physiological role of ROCKs in the cardiovascular system. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C661-8. PMID: 16469861; PMCID: PMC2692274.
      Citations: 144     Fields:    Translation:HumansAnimals
    140. Mukai Y, Rikitake Y, Shiojima I, Wolfrum S, Satoh M, Takeshita K, Hiroi Y, Salomone S, Kim HH, Benjamin LE, Walsh K, Liao JK. Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt. J Clin Invest. 2006 Feb; 116(2):334-43. PMID: 16453020; PMCID: PMC1359051.
      Citations: 42     Fields:    Translation:AnimalsCells
    141. Liang KW, Ting CT, Yin SC, Chen YT, Lin SJ, Liao JK, Hsu SL. Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury. Biochem Pharmacol. 2006 Mar 14; 71(6):806-17. PMID: 16448624; PMCID: PMC2639653.
      Citations: 31     Fields:    Translation:AnimalsCells
    142. Rikitake Y, Liao JK. Rho GTPases, statins, and nitric oxide. Circ Res. 2005 Dec 09; 97(12):1232-5. PMID: 16339495; PMCID: PMC2633589.
      Citations: 166     Fields:    Translation:HumansAnimalsCells
    143. Liao JK. Clinical implications for statin pleiotropy. Curr Opin Lipidol. 2005 Dec; 16(6):624-9. PMID: 16276239.
      Citations: 40     Fields:    Translation:Humans
    144. Sacco RL, Liao JK. Drug Insight: statins and stroke. Nat Clin Pract Cardiovasc Med. 2005 Nov; 2(11):576-84. PMID: 16258569; PMCID: PMC2743272.
      Citations: 10     Fields:    Translation:Humans
    145. Rikitake Y, Oyama N, Wang CY, Noma K, Satoh M, Kim HH, Liao JK. Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice. Circulation. 2005 Nov 08; 112(19):2959-65. PMID: 16260635; PMCID: PMC2640100.
      Citations: 110     Fields:    Translation:Animals
    146. Miyamoto A, Wada R, Inoue A, Ishiguro S, Liao JK, Nishio A. Role of angiotensin II receptor subtypes in porcine basilar artery: functional, radioligand binding, and cell culture studies. Life Sci. 2006 Jan 25; 78(9):943-9. PMID: 16223512; PMCID: PMC2641039.
      Citations: 2     Fields:    Translation:AnimalsCells
    147. Liao JK. Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterol. Am J Cardiol. 2005 Sep 05; 96(5A):24F-33F. PMID: 16126020; PMCID: PMC2684977.
      Citations: 69     Fields:    Translation:HumansCells
    148. Rikitake Y, Kim HH, Huang Z, Seto M, Yano K, Asano T, Moskowitz MA, Liao JK. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct; 36(10):2251-7. PMID: 16141422; PMCID: PMC2633591.
      Citations: 151     Fields:    Translation:HumansAnimalsCells
    149. Rikitake Y, Liao JK. Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells. Circulation. 2005 Jun 21; 111(24):3261-8. PMID: 15956119; PMCID: PMC2633592.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    150. Asahi M, Huang Z, Thomas S, Yoshimura S, Sumii T, Mori T, Qiu J, Amin-Hanjani S, Huang PL, Liao JK, Lo EH, Moskowitz MA. Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia. J Cereb Blood Flow Metab. 2005 Jun; 25(6):722-9. PMID: 15716855; PMCID: PMC2742229.
      Citations: 53     Fields:    Translation:Animals
    151. Rikitake Y, Liao JK. ROCKs as therapeutic targets in cardiovascular diseases. Expert Rev Cardiovasc Ther. 2005 May; 3(3):441-51. PMID: 15889972; PMCID: PMC2643373.
      Citations: 26     Fields:    Translation:Humans
    152. Limbourg FP, Takeshita K, Radtke F, Bronson RT, Chin MT, Liao JK. Essential role of endothelial Notch1 in angiogenesis. Circulation. 2005 Apr 12; 111(14):1826-32. PMID: 15809373; PMCID: PMC2633594.
      Citations: 129     Fields:    Translation:AnimalsCells
    153. Liao JK, Laufs U. Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol. 2005; 45:89-118. PMID: 15822172; PMCID: PMC2694580.
      Citations: 559     Fields:    Translation:HumansAnimals
    154. Sun J, Liao JK. Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol. 2004 Dec; 24(12):2238-44. PMID: 15486309; PMCID: PMC2633590.
      Citations: 28     Fields:    Translation:HumansCells
    155. Spiecker M, Darius H, Hankeln T, Soufi M, Sattler AM, Node K, Lindpaintner K, Huesing A, Maisch B, Zeldin DC, Liao JK, Schaefer JR, Börgel J, Mügge A. Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. Circulation. 2004 Oct 12; 110(15):2132-6. PMID: 15466638; PMCID: PMC2633457.
      Citations: 91     Fields:    Translation:HumansCells
    156. Liao JK. Statins: potent vascular anti-inflammatory agents. Int J Clin Pract Suppl. 2004 Oct; (143):41-8. PMID: 16035395.
      Citations: 5     Fields:    Translation:Humans
    157. Wolfrum S, Dendorfer A, Rikitake Y, Stalker TJ, Gong Y, Scalia R, Dominiak P, Liao JK. Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1842-7. PMID: 15319269; PMCID: PMC2649731.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    158. Nakagami H, Liao JK. Statins and myocardial hypertrophy. Coron Artery Dis. 2004 Aug; 15(5):247-50. PMID: 15238820; PMCID: PMC2662036.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    159. Beckman JA, Liao JK, Hurley S, Garrett LA, Chui D, Mitra D, Creager MA. Atorvastatin restores endothelial function in normocholesterolemic smokers independent of changes in low-density lipoprotein. Circ Res. 2004 Jul 23; 95(2):217-23. PMID: 15178637; PMCID: PMC2633456.
      Citations: 31     Fields:    Translation:HumansCTClinical Trials
    160. Abbruzzese TA, Havens J, Belkin M, Donaldson MC, Whittemore AD, Liao JK, Conte MS. Statin therapy is associated with improved patency of autogenous infrainguinal bypass grafts. J Vasc Surg. 2004 Jun; 39(6):1178-85. PMID: 15192555; PMCID: PMC2643376.
      Citations: 24     Fields:    
    161. Liao JK. Statin therapy: having the good without the bad. Hypertension. 2004 Jun; 43(6):1171-2. PMID: 15166178; PMCID: PMC2640840.
      Citations: 2     Fields:    Translation:HumansAnimals
    162. Liao JK. Statin therapy for cardiac hypertrophy and heart failure. J Investig Med. 2004 May; 52(4):248-53. PMID: 15521546; PMCID: PMC2662037.
      Citations: 12     Fields:    Translation:Humans
    163. Laufs U, Liao JK, Moskowitz MA, Endres M. Targeting eNOS for stroke protection. Trends Neurosci. 2004 May; 27(5):283-9. PMID: 15111011.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    164. Abraham SS, Osorio JC, Homma S, Wang J, Thaker HM, Liao JK, Mital S. Simvastatin preserves cardiac function in genetically determined cardiomyopathy. J Cardiovasc Pharmacol. 2004 Mar; 43(3):454-61. PMID: 15076231; PMCID: PMC2643377.
      Citations: 9     Fields:    Translation:Animals
    165. Liao JK, Laufs U, Böhm M. Lipid management with statins. The lower the better? Z Kardiol. 2004 Jan; 93(1):4-9. PMID: 14740235.
      Citations: 3     Fields:    Translation:Humans
    166. Harari O, Liao JK. Inhibition of MHC II gene transcription by nitric oxide and antioxidants. Curr Pharm Des. 2004; 10(8):893-8. PMID: 15032692; PMCID: PMC2633593.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    167. Falck JR, Reddy LM, Reddy YK, Bondlela M, Krishna UM, Ji Y, Sun J, Liao JK. 11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression. Bioorg Med Chem Lett. 2003 Nov 17; 13(22):4011-4. PMID: 14592496.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    168. Trochu JN, Mital S, Zhang Xp, Xu X, Ochoa M, Liao JK, Recchia FA, Hintze TH. Preservation of NO production by statins in the treatment of heart failure. Cardiovasc Res. 2003 Nov 01; 60(2):250-8. PMID: 14613854; PMCID: PMC2653218.
      Citations: 20     Fields:    Translation:Animals
    169. Laufs U, Liao JK. Isoprenoid metabolism and the pleiotropic effects of statins. Curr Atheroscler Rep. 2003 Sep; 5(5):372-8. PMID: 12911847; PMCID: PMC2676316.
      Citations: 28     Fields:    Translation:Humans
    170. Young-Xu Y, Chan KA, Liao JK, Ravid S, Blatt CM. Long-term statin use and psychological well-being. J Am Coll Cardiol. 2003 Aug 20; 42(4):690-7. PMID: 12932603; PMCID: PMC2673913.
      Citations: 37     Fields:    Translation:Humans
    171. Kawasaki K, Smith RS, Hsieh CM, Sun J, Chao J, Liao JK. Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis. Mol Cell Biol. 2003 Aug; 23(16):5726-37. PMID: 12897144; PMCID: PMC166338.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    172. Node K, Fujita M, Kitakaze M, Hori M, Liao JK. Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy. Circulation. 2003 Aug 19; 108(7):839-43. PMID: 12885745; PMCID: PMC2665260.
      Citations: 87     Fields:    Translation:HumansCTClinical Trials
    173. Nakagami H, Takemoto M, Liao JK. NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy. J Mol Cell Cardiol. 2003 Jul; 35(7):851-9. PMID: 12818576.
      Citations: 82     Fields:    Translation:AnimalsCells
    174. Limbourg FP, Liao JK. Nontranscriptional actions of the glucocorticoid receptor. J Mol Med (Berl). 2003 Mar; 81(3):168-74. PMID: 12682725; PMCID: PMC2649714.
      Citations: 27     Fields:    Translation:HumansCells
    175. Grimm M, Heidbreder M, Dendorfer A, Katus HA, Liao JK, Richardt G, Wolfrum S. Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase. J Cardiovasc Pharmacol. 2003 Mar; 41(3):474-80. PMID: 12605027.
      Citations: 17     Fields:    Translation:AnimalsCells
    176. Liao JK. Role of statin pleiotropism in acute coronary syndromes and stroke. Int J Clin Pract Suppl. 2003 Mar; (134):51-7. PMID: 12793598.
      Citations: 6     Fields:    Translation:Humans
    177. Wolfrum S, Jensen KS, Liao JK. Endothelium-dependent effects of statins. Arterioscler Thromb Vasc Biol. 2003 May 01; 23(5):729-36. PMID: 12615672.
      Citations: 112     Fields:    Translation:HumansCells
    178. Laufs U, Liao JK. Rapid effects of statins: from prophylaxis to therapy for ischemic stroke. Arterioscler Thromb Vasc Biol. 2003 Feb 01; 23(2):156-7. PMID: 12588752.
      Citations: 5     Fields:    Translation:Humans
    179. Simoncini T, Rabkin E, Liao JK. Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells. Arterioscler Thromb Vasc Biol. 2003 Feb 01; 23(2):198-203. PMID: 12588759.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    180. Liao JK. Cross-coupling between the oestrogen receptor and phosphoinositide 3-kinase. Biochem Soc Trans. 2003 Feb; 31(Pt 1):66-70. PMID: 12546655.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    181. Nakagami H, Jensen KS, Liao JK. A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms. Ann Med. 2003; 35(6):398-403. PMID: 14572163; PMCID: PMC2662041.
      Citations: 26     Fields:    Translation:HumansCells
    182. Ho KJ, Liao JK. Nonnuclear actions of estrogen. Arterioscler Thromb Vasc Biol. 2002 Dec 01; 22(12):1952-61. PMID: 12482819.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    183. Limbourg FP, Huang Z, Plumier JC, Simoncini T, Fujioka M, Tuckermann J, Moskowitz MA, Liao JK, Schütz G. Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. J Clin Invest. 2002 Dec; 110(11):1729-38. PMID: 12464678; PMCID: PMC151626.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    184. Sakata Y, Kamei CN, Nakagami H, Bronson R, Liao JK, Chin MT, Sakata Y, Kamei CN, Nakagami H, Bronson R, Liao JK, Chin MT. Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16197-202. PMID: 12454287; PMCID: PMC138588.
      Citations: 66     Fields:    Translation:Animals
    185. Liao JK, Liao JK. Beyond lipid lowering: the role of statins in vascular protection. Int J Cardiol. 2002 Nov; 86(1):5-18. PMID: 12243846.
      Citations: 61     Fields:    Translation:HumansAnimals
    186. Sun J, Liao JK. Functional interaction of endothelial nitric oxide synthase with a voltage-dependent anion channel. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):13108-13. PMID: 12228731; PMCID: PMC130594.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    187. Prorock AJ, Hafezi-Moghadam A, Laubach VE, Liao JK, Ley K, Prorock AJ, Hafezi-Moghadam A, Laubach VE, Liao JK, Ley K. Vascular protection by estrogen in ischemia-reperfusion injury requires endothelial nitric oxide synthase. Am J Physiol Heart Circ Physiol. 2003 Jan; 284(1):H133-40. PMID: 12388253.
      Citations: 8     Fields:    Translation:AnimalsCells
    188. Liao JK. Isoprenoids as mediators of the biological effects of statins. J Clin Invest. 2002 Aug; 110(3):285-8. PMID: 12163444; PMCID: PMC151100.
      Citations: 136     Fields:    Translation:HumansCells
    189. Rebsamen MC, Sun J, Norman AW, Liao JK. 1alpha,25-dihydroxyvitamin D3 induces vascular smooth muscle cell migration via activation of phosphatidylinositol 3-kinase. Circ Res. 2002 Jul 12; 91(1):17-24. PMID: 12114317.
      Citations: 39     Fields:    Translation:AnimalsCells
    190. Takemoto M, Sun J, Hiroki J, Shimokawa H, Liao JK. Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation. 2002 Jul 02; 106(1):57-62. PMID: 12093770.
      Citations: 140     Fields:    Translation:HumansCells
    191. Ho KJ, Liao JK. Non-nuclear actions of estrogen: new targets for prevention and treatment of cardiovascular disease. Mol Interv. 2002 Jul; 2(4):219-28. PMID: 14993393; PMCID: PMC2633129.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    192. Sun J, Sui X, Bradbury JA, Zeldin DC, Conte MS, Liao JK. Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids. Circ Res. 2002 May 17; 90(9):1020-7. PMID: 12016269.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    193. Grimm M, Spiecker M, De Caterina R, Shin WS, Liao JK. Inhibition of major histocompatibility complex class II gene transcription by nitric oxide and antioxidants. J Biol Chem. 2002 Jul 19; 277(29):26460-7. PMID: 12006557.
      Citations: 5     Fields:    Translation:HumansCells
    194. Hafezi-Moghadam A, Simoncini T, Yang Z, Limbourg FP, Plumier JC, Rebsamen MC, Hsieh CM, Chui DS, Thomas KL, Prorock AJ, Laubach VE, Moskowitz MA, French BA, Ley K, Liao JK. Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med. 2002 May; 8(5):473-9. PMID: 11984591; PMCID: PMC2668717.
      Citations: 157     Fields:    Translation:HumansAnimalsCells
    195. Liao JK, Liao JK. Statins and ischemic stroke. Atheroscler Suppl. 2002 May; 3(1):21-5. PMID: 12044582.
      Citations: 3     Fields:    Translation:HumansCells
    196. Simoncini T, Genazzani AR, Liao JK. Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene. Circulation. 2002 Mar 19; 105(11):1368-73. PMID: 11901050.
      Citations: 32     Fields:    Translation:HumansCells
    197. Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol. 2001 Nov; 21(11):1712-9. PMID: 11701455.
      Citations: 272     Fields:    Translation:HumansAnimalsCells
    198. Marra DE, Liao JK. Salicylates and vascular smooth muscle cell proliferation: molecular mechanisms for cell cycle arrest. Trends Cardiovasc Med. 2001 Nov; 11(8):339-44. PMID: 11728884.
      Citations: 6     Fields:    Translation:HumansCells
    199. Takemoto M, Node K, Nakagami H, Liao Y, Grimm M, Takemoto Y, Kitakaze M, Liao JK. Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy. J Clin Invest. 2001 Nov; 108(10):1429-37. PMID: 11714734; PMCID: PMC209420.
      Citations: 118     Fields:    Translation:AnimalsCells
    200. Amin-Hanjani S, Stagliano NE, Yamada M, Huang PL, Liao JK, Moskowitz MA. Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke. 2001 Apr; 32(4):980-6. PMID: 11283400.
      Citations: 82     Fields:    Translation:AnimalsCells
    201. Node K, Ruan XL, Dai J, Yang SX, Graham L, Zeldin DC, Liao JK. Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. J Biol Chem. 2001 May 11; 276(19):15983-9. PMID: 11279071.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    202. Sun J, Kamei CN, Layne MD, Jain MK, Liao JK, Lee ME, Chin MT. Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2. J Biol Chem. 2001 May 25; 276(21):18591-6. PMID: 11279181.
      Citations: 27     Fields:    Translation:Animals
    203. De Caterina R, Bourcier T, Laufs U, La Fata V, Lazzerini G, Neish AS, Libby P, Liao JK. Induction of endothelial-leukocyte interaction by interferon-gamma requires coactivation of nuclear factor-kappaB. Arterioscler Thromb Vasc Biol. 2001 Feb; 21(2):227-32. PMID: 11156857.
      Citations: 4     Fields:    Translation:AnimalsCells
    204. Laufs U, Endres M, Custodis F, Gertz K, Nickenig G, Liao JK, Böhm M. Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription. Circulation. 2000 Dec 19; 102(25):3104-10. PMID: 11120702.
      Citations: 51     Fields:    Translation:AnimalsCells
    205. Marra DE, Simoncini T, Liao JK. Inhibition of vascular smooth muscle cell proliferation by sodium salicylate mediated by upregulation of p21(Waf1) and p27(Kip1). Circulation. 2000 Oct 24; 102(17):2124-30. PMID: 11044431.
      Citations: 31     Fields:    Translation:HumansCells
    206. Laufs U, Liao JK. Targeting Rho in cardiovascular disease. Circ Res. 2000 Sep 29; 87(7):526-8. PMID: 11009552.
      Citations: 30     Fields:    Translation:HumansCells
    207. Simoncini T, Hafezi-Moghadam A, Brazil DP, Ley K, Chin WW, Liao JK. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature. 2000 Sep 28; 407(6803):538-41. PMID: 11029009; PMCID: PMC2670482.
      Citations: 362     Fields:    Translation:HumansAnimalsCells
    208. Simoncini T, Maffei S, Basta G, Barsacchi G, Genazzani AR, Liao JK, De Caterina R. Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms. Circ Res. 2000 Jul 07; 87(1):19-25. PMID: 10884367.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    209. Laufs U, Endres M, Stagliano N, Amin-Hanjani S, Chui DS, Yang SX, Simoncini T, Yamada M, Rabkin E, Allen PG, Huang PL, Schoen FJ, Moskowitz MA, Liao JK, Böhm M. Neuroprotection mediated by changes in the endothelial actin cytoskeleton. J Clin Invest. 2000 Jul; 106(1):15-24. PMID: 10880044; PMCID: PMC314365.
      Citations: 76     Fields:    Translation:AnimalsCells
    210. Liao JK, Laufs U. Direct vascular effects of HMG-CoA reductase inhibitors. Trends Cardiovasc Med. 2000 May; 10(4):143-8. PMID: 11239793.
      Citations: 20     Fields:    Translation:Humans
    211. Yamada M, Huang Z, Dalkara T, Endres M, Laufs U, Waeber C, Huang PL, Liao JK, Moskowitz MA. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr; 20(4):709-17. PMID: 10779015.
      Citations: 37     Fields:    Translation:Animals
    212. Spiecker M, Darius H, Liao JK. A functional role of I kappa B-epsilon in endothelial cell activation. J Immunol. 2000 Mar 15; 164(6):3316-22. PMID: 10706725.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    213. Node K, Huo Y, Ruan X, Yang B, Spiecker M, Ley K, Zeldin DC, Liao JK. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science. 1999 Aug 20; 285(5431):1276-9. PMID: 10455056; PMCID: PMC2720027.
      Citations: 496     Fields:    Translation:HumansAnimalsCells
    214. Laufs U, Marra D, Node K, Liao JK. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1). J Biol Chem. 1999 Jul 30; 274(31):21926-31. PMID: 10419514.
      Citations: 68     Fields:    Translation:HumansCells
    215. Lu M, Perez VL, Ma N, Miyamoto K, Peng HB, Liao JK, Adamis AP. VEGF increases retinal vascular ICAM-1 expression in vivo. Invest Ophthalmol Vis Sci. 1999 Jul; 40(8):1808-12. PMID: 10393052.
      Citations: 72     Fields:    Translation:HumansAnimals
    216. Rajavashisth TB, Liao JK, Galis ZS, Tripathi S, Laufs U, Tripathi J, Chai NN, Xu XP, Jovinge S, Shah PK, Libby P. Inflammatory cytokines and oxidized low density lipoproteins increase endothelial cell expression of membrane type 1-matrix metalloproteinase. J Biol Chem. 1999 Apr 23; 274(17):11924-9. PMID: 10207013.
      Citations: 49     Fields:    Translation:HumansCells
    217. Miyamoto A, Yang SX, Laufs U, Ruan XL, Liao JK. Activation of guanine nucleotide-binding proteins and induction of endothelial tissue-type plasminogen activator gene transcription by alcohol. J Biol Chem. 1999 Apr 23; 274(17):12055-60. PMID: 10207029.
      Citations:    Fields:    Translation:HumansAnimalsCells
    218. Endres M, Liao JK, Laufs U. [Regulation of endothelial NO production by Rho GTPase]. Med Klin (Munich). 1999 Apr 15; 94(4):211-8. PMID: 10373757.
      Citations: 3     Fields:    Translation:HumansAnimals
    219. Liao JK, Laufs U. Nuclear run-on assay to study gene transcription in vascular cells. Methods Mol Med. 1999; 30:151-7. PMID: 21341023.
      Citations:    Fields:    
    220. Laufs U, Liao JK. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem. 1998 Sep 11; 273(37):24266-71. PMID: 9727051.
      Citations: 263     Fields:    Translation:HumansCells
    221. Peng HB, Spiecker M, Liao JK. Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation. J Immunol. 1998 Aug 15; 161(4):1970-6. PMID: 9712068.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    222. Endres M, Laufs U, Huang Z, Nakamura T, Huang P, Moskowitz MA, Liao JK. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8880-5. PMID: 9671773; PMCID: PMC21171.
      Citations: 219     Fields:    Translation:HumansAnimalsCells
    223. Spiecker M, Darius H, Kaboth K, Liao JK, Hübner F. Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants. J Leukoc Biol. 1998 Jun; 63(6):732-9. PMID: 9620666.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    224. Laufs U, La Fata V, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation. 1998 Mar 31; 97(12):1129-35. PMID: 9537338.
      Citations: 382     Fields:    Translation:HumansAnimalsCells
    225. Laufs U, Fata VL, Liao JK. Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase. J Biol Chem. 1997 Dec 12; 272(50):31725-9. PMID: 9395516.
      Citations: 92     Fields:    Translation:HumansCells
    226. Spiecker M, Peng HB, Liao JK. Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaBalpha. J Biol Chem. 1997 Dec 05; 272(49):30969-74. PMID: 9388244.
      Citations: 42     Fields:    Translation:HumansCells
    227. Laufs U, Liao JK, Böhm M. [New findings on the action of HMG-CoA-reductase inhibitors]. Dtsch Med Wochenschr. 1997 Oct 10; 122(41):1255-9. PMID: 9378055.
      Citations: 2     Fields:    Translation:HumansAnimals
    228. Hong YH, Peng HB, La Fata V, Liao JK. Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulating factor by TGF-beta1. J Immunol. 1997 Sep 01; 159(5):2418-23. PMID: 9278333.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    229. Miyamoto A, Laufs U, Pardo C, Liao JK. Modulation of bradykinin receptor ligand binding affinity and its coupled G-proteins by nitric oxide. J Biol Chem. 1997 Aug 01; 272(31):19601-8. PMID: 9235967.
      Citations: 17     Fields:    Translation:AnimalsCells
    230. Liao JK, Zulueta JJ, Yu FS, Peng HB, Cote CG, Hassoun PM. Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen. J Clin Invest. 1995 Dec; 96(6):2661-6. PMID: 8675632; PMCID: PMC185972.
      Citations: 36     Fields:    Translation:AnimalsCells
    231. De Caterina R, Libby P, Peng HB, Thannickal VJ, Rajavashisth TB, Gimbrone MA, Shin WS, Liao JK. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest. 1995 Jul; 96(1):60-8. PMID: 7542286; PMCID: PMC185173.
      Citations: 375     Fields:    Translation:HumansCells
    232. Liao JK, Clark SL. Regulation of G-protein alpha i2 subunit expression by oxidized low-density lipoprotein. J Clin Invest. 1995 Apr; 95(4):1457-63. PMID: 7706449; PMCID: PMC295627.
      Citations: 12     Fields:    Translation:AnimalsCells
    233. Liao JK, Homcy CJ. The G proteins of the G alpha i and G alpha q family couple the bradykinin receptor to the release of endothelium-derived relaxing factor. J Clin Invest. 1993 Nov; 92(5):2168-72. PMID: 8227332; PMCID: PMC288395.
      Citations: 16     Fields:    Translation:AnimalsCells
    234. Liao JK, Homcy CJ. Specific receptor-guanine nucleotide binding protein interaction mediates the release of endothelium-derived relaxing factor. Circ Res. 1992 May; 70(5):1018-26. PMID: 1314714.
      Citations: 9     Fields:    Translation:AnimalsCells
    235. Liao JK, Cockrill BA, Yurchak PM. Acute myocardial infarction after ergonovine administration for uterine bleeding. Am J Cardiol. 1991 Sep 15; 68(8):823-4. PMID: 1892101.
      Citations: 3     Fields:    Translation:Humans
    236. Liao JK, Bettmann MA, Sandor T, Tucker JI, Coleman SM, Creager MA. Differential impairment of vasodilator responsiveness of peripheral resistance and conduit vessels in humans with atherosclerosis. Circ Res. 1991 Apr; 68(4):1027-34. PMID: 2009605.
      Citations: 37     Fields:    Translation:Humans
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