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Institution

James Howard Tonsgard

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentPediatrics-Neurology
AddressChicago IL 60637
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Plotkin SR, Duda DG, Muzikansky A, Allen J, Blakeley J, Rosser T, Campian JL, Clapp DW, Fisher MJ, Tonsgard J, Ullrich N, Thomas C, Cutter G, Korf B, Packer R, Karajannis MA. Multicenter, Prospective, Phase II and Biomarker Study of High-Dose Bevacizumab as Induction Therapy in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannoma. J Clin Oncol. 2019 Oct 18; JCO1901367. PMID: 31626572.
      View in: PubMed
    2. Polster SP, Dougherty MC, Zeineddine HA, Lyne SB, Smith HL, MacKenzie C, Pytel P, Yang CW, Tonsgard JH, Warnke PC, Frim DM. Dural Ectasia in Neurofibromatosis 1: Case Series, Management, and Review. Neurosurgery. 2019 Jul 27. PMID: 31350851.
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    3. Payne JM, Barton B, Ullrich NJ, Cantor A, Hearps SJ, Cutter G, Rosser T, Walsh KS, Gioia GA, Wolters PL, Tonsgard J, Schorry E, Viskochil D, Klesse L, Fisher M, Gutmann DH, Silva AJ, Hunter SJ, Rey-Casserly C, Cantor NL, Byars AW, Stavinoha PL, Ackerson JD, Armstrong CL, Isenberg J, O'Neil SH, Packer RJ, Korf B, Acosta MT, North KN. Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1. Neurology. 2016 Dec 13; 87(24):2575-2584. PMID: 27956565.
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    4. Wolters PL, Martin S, Merker VL, Tonsgard JH, Solomon SE, Baldwin A, Bergner AL, Walsh K, Thompson HL, Gardner KL, Hingtgen CM, Schorry E, Dudley WN, Franklin B. Patient-reported outcomes of pain and physical functioning in neurofibromatosis clinical trials. Neurology. 2016 Aug 16; 87(7 Suppl 1):S4-S12. PMID: 27527648.
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    5. Rojnueangnit K, Xie J, Gomes A, Sharp A, Callens T, Chen Y, Liu Y, Cochran M, Abbott MA, Atkin J, Babovic-Vuksanovic D, Barnett CP, Crenshaw M, Bartholomew DW, Basel L, Bellus G, Ben-Shachar S, Bialer MG, Bick D, Blumberg B, Cortes F, David KL, Destree A, Duat-Rodriguez A, Earl D, Escobar L, Eswara M, Ezquieta B, Frayling IM, Frydman M, Gardner K, Gripp KW, Hernández-Chico C, Heyrman K, Ibrahim J, Janssens S, Keena BA, Llano-Rivas I, Leppig K, McDonald M, Misra VK, Mulbury J, Narayanan V, Orenstein N, Galvin-Parton P, Pedro H, Pivnick EK, Powell CM, Randolph L, Raskin S, Rosell J, Rubin K, Seashore M, Schaaf CP, Scheuerle A, Schultz M, Schorry E, Schnur R, Siqveland E, Tkachuk A, Tonsgard J, Upadhyaya M, Verma IC, Wallace S, Williams C, Zackai E, Zonana J, Lazaro C, Claes K, Korf B, Martin Y, Legius E, Messiaen L. High Incidence of Noonan Syndrome Features Including Short Stature and Pulmonic Stenosis in Patients carrying NF1 Missense Mutations Affecting p.Arg1809: Genotype-Phenotype Correlation. Hum Mutat. 2015 Nov; 36(11):1052-63. PMID: 26178382.
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    6. Weiss B, Widemann BC, Wolters P, Dombi E, Vinks A, Cantor A, Perentesis J, Schorry E, Ullrich N, Gutmann DH, Tonsgard J, Viskochil D, Korf B, Packer RJ, Fisher MJ. Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study. Neuro Oncol. 2015 Apr; 17(4):596-603. PMID: 25314964.
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    7. Wolters PL, Martin S, Merker VL, Gardner KL, Hingtgen CM, Tonsgard JH, Schorry EK, Baldwin A. Patient-reported outcomes in neurofibromatosis and schwannomatosis clinical trials. Neurology. 2013 Nov 19; 81(21 Suppl 1):S6-14. PMID: 24249806.
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    8. Klein-Tasman BP, Janke KM, Luo W, Casnar CL, Hunter SJ, Tonsgard J, Trapane P, van der Fluit F, Kais LA. Cognitive and psychosocial phenotype of young children with neurofibromatosis-1. J Int Neuropsychol Soc. 2014 Jan; 20(1):88-98. PMID: 24229851.
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    9. Stricker TP, Henriksen KJ, Tonsgard JH, Montag AG, Krausz TN, Pytel P. Expression profiling of 519 kinase genes in matched malignant peripheral nerve sheath tumor/plexiform neurofibroma samples is discriminatory and identifies mitotic regulators BUB1B, PBK and NEK2 as overexpressed with transformation. Mod Pathol. 2013 Jul; 26(7):930-43. PMID: 23370767.
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    10. Pytel P, Karrison T. Neoplasms with schwannian differentiation express transcription factors known to regulate normal schwann cell development. Int J Surg Pathol. 2010 Dec; 18(6):449-57. PMID: 20034979.
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    11. Evans DG, Kalamarides M, Hunter-Schaedle K, Blakeley J, Allen J, Babovic-Vuskanovic D, Belzberg A, Bollag G, Chen R, DiTomaso E, Golfinos J, Harris G, Jacob A, Kalpana G, Karajannis M, Korf B, Kurzrock R, Law M, McClatchey A, Packer R, Roehm P, Rubenstein A, Slattery W, Tonsgard JH, Welling DB, Widemann B, Yohay K, Giovannini M. Consensus recommendations to accelerate clinical trials for neurofibromatosis type 2. Clin Cancer Res. 2009 Aug 15; 15(16):5032-5039. PMID: 19671848.
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    12. Tonsgard JH. Clinical manifestations and management of neurofibromatosis type 1. Semin Pediatr Neurol. 2006 Mar; 13(1):2-7. PMID: 16818170.
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    13. Lee MC, Frank JI, Kahana M, Tonsgard JH, Frim DM. Decompressive hemicraniectomy in a 6-year-old male after unilateral hemispheric stroke. Case report and review. Pediatr Neurosurg. 2003 Apr; 38(4):181-5. PMID: 12646736.
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    14. Miller MB, Tonsgard JH, Soltani K. Late-onset neurofibromatosis in a liver transplant recipient. Int J Dermatol. 2000 May; 39(5):376-9. PMID: 10849133.
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    15. Nadig M, Munshi I, Short MP, Tonsgard JH, Sullivan C, Frim DM. A child with neurofibromatosis-1 and a lumbar epidural arteriovenous malformation. J Child Neurol. 2000 Apr; 15(4):273-5. PMID: 10805199.
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    16. Stevenson DA, Birch PH, Friedman JM, Viskochil DH, Balestrazzi P, Boni S, Buske A, Korf BR, Niimura M, Pivnick EK, Schorry EK, Short MP, Tenconi R, Tonsgard JH, Carey JC. Descriptive analysis of tibial pseudarthrosis in patients with neurofibromatosis 1. Am J Med Genet. 1999 Jun 11; 84(5):413-9. PMID: 10360395.
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    17. Tonsgard JH, Kwak SM, Short MP, Dachman AH. CT imaging in adults with neurofibromatosis-1: frequent asymptomatic plexiform lesions. Neurology. 1998 Jun; 50(6):1755-60. PMID: 9633723.
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    18. Alexander JJ, Snyder A, Tonsgard JH. Omega-oxidation of monocarboxylic acids in rat brain. Neurochem Res. 1998 Feb; 23(2):227-33. PMID: 9475518.
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    19. Tonsgard JH, Yelavarthi KK, Cushner S, Short MP, Lindgren V. Do NF1 gene deletions result in a characteristic phenotype? Am J Med Genet. 1997 Nov 28; 73(1):80-6. PMID: 9375928.
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    20. Alexander JJ, Banerjee P, Dawson G, Tonsgard JH. Hyperammonemia increases serotonin 1A receptor expression in both rat hippocampus and a transfected hippocampal cell line, HN2-5. J Neurosci Res. 1995 May 01; 41(1):105-10. PMID: 7674372.
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    21. Kossak BD, Schmidt-Sommerfeld E, Schoeller DA, Rinaldo P, Penn D, Tonsgard JH. Impaired fatty acid oxidation in children on valproic acid and the effect of L-carnitine. Neurology. 1993 Nov; 43(11):2362-8. PMID: 8232957.
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    22. Tonsgard JH, Oesterle CS. The ophthalmologic presentation of NF-2 in childhood. J Pediatr Ophthalmol Strabismus. 1993 Sep-Oct; 30(5):327-30. PMID: 8254451.
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    23. Kundu RK, Getz GS, Tonsgard JH. Induction of (omega-1)-oxidation of monocarboxylic acids by acetylsalicylic acid. J Lipid Res. 1993 Jul; 34(7):1187-99. PMID: 8371066.
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    24. Taravath S, Tonsgard JH. Cerebral malformations in Carpenter syndrome. Pediatr Neurol. 1993 May-Jun; 9(3):230-4. PMID: 8352858.
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    25. Aoyama T, Uchida Y, Kelley RI, Marble M, Hofman K, Tonsgard JH, Rhead WJ, Hashimoto T. A novel disease with deficiency of mitochondrial very-long-chain acyl-CoA dehydrogenase. Biochem Biophys Res Commun. 1993 Mar 31; 191(3):1369-72. PMID: 8466512.
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    26. Maselli RA, Burnett ME, Tonsgard JH. In vitro microelectrode study of neuromuscular transmission in a case of botulism. Muscle Nerve. 1992 Mar; 15(3):273-6. PMID: 1313544.
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    27. Kundu RK, Tonsgard JH, Getz GS. Induction of omega-oxidation of monocarboxylic acids in rats by acetylsalicylic acid. J Clin Invest. 1991 Dec; 88(6):1865-72. PMID: 1752948.
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    28. Tonsgard JH, Meredith SC. Characterization of the binding sites for dicarboxylic acids on bovine serum albumin. Biochem J. 1991 Jun 15; 276 ( Pt 3):569-75. PMID: 2064600.
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    29. Tonsgard JH, Stephens JK, Rhead WJ, Penn D, Horwitz AL, Kirschner BS, Whitington PF, Berger S, Tripp ME. Defect in fatty acid oxidation: laboratory and pathologic findings in a patient. Pediatr Neurol. 1991 Mar-Apr; 7(2):125-30. PMID: 2059253.
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    30. Tonsgard JH, Tung B, Kornafel KS, Getz GS. Environmentally induced differential amplification of mitochondrial populations. Biochem J. 1990 Sep 01; 270(2):511-8. PMID: 2144730.
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    31. Hammond DN, Lee HJ, Tonsgard JH, Wainer BH. Development and characterization of clonal cell lines derived from septal cholinergic neurons. Brain Res. 1990 Apr 02; 512(2):190-200. PMID: 2354356.
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    32. Tonsgard JH. Effect of Reye's syndrome serum on the ultrastructure of isolated liver mitochondria. Lab Invest. 1989 Apr; 60(4):568-73. PMID: 2496274.
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    33. Tonsgard JH, Mendelson SA, Meredith SC. Binding of straight-chain saturated dicarboxylic acids to albumin. J Clin Invest. 1988 Nov; 82(5):1567-73. PMID: 3183053.
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    34. Tonsgard JH, Harwicke N, Levine SC. Kluver-Bucy syndrome in children. Pediatr Neurol. 1987 May-Jun; 3(3):162-5. PMID: 3508062.
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    35. Hammond DN, Wainer BH, Tonsgard JH, Heller A. Neuronal properties of clonal hybrid cell lines derived from central cholinergic neurons. Science. 1986 Dec 05; 234(4781):1237-40. PMID: 3775382.
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    36. Tonsgard JH. Serum dicarboxylic acids in patients with Reye syndrome. J Pediatr. 1986 Sep; 109(3):440-5. PMID: 3746531.
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    37. Tonsgard JH, Getz GS. Effect of Reye's syndrome serum on isolated chinchilla liver mitochondria. J Clin Invest. 1985 Aug; 76(2):816-25. PMID: 4031073.
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    38. Tonsgard JH. Urinary dicarboxylic acids in Reye syndrome. J Pediatr. 1985 Jul; 107(1):79-84. PMID: 4009343.
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    39. Tonsgard JH, Huttenlocher PR, Thisted RA. Lactic acidemia in Reye's syndrome. Pediatrics. 1982 Jan; 69(1):64-9. PMID: 7054762.
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    40. Tonsgard JH, Huttenlocher PR. Salicylates and Reye's syndrome. Pediatrics. 1981 Nov; 68(5):747-8. PMID: 7312481.
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