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Maria-Luisa Alegre

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Rheumatology
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.

    Collapse Biography 
    Collapse education and training
    Universite Libre de Bruxelles, Brussels, BelgiumMD06/1985Medicine
    University of Chicago, Chicago, IllinoisPhD08/1993Immunology
    Universite Libre de Bruxelles, Brussels, BelgiumPhD06/1994Medical Sciences
    Collapse awards and honors
    2020 - 2021Chair, Nominations Committee, American Association of Immunologists
    2020Elected to AAP, Association of American Physicians (AAP)
    2020Elected Fellow, American Society of Transplantation
    2019Established Investigator Award, American Society of Transplantation
    2018Paul S. Russell Visiting Professor, Massachussetts General Hospital and Harvard Medical School
    2016 - 2018Chair, Community of Basic Scientists, American Society of Transplantation
    2014 - 2020Section Editor, American Journal of Transplantation
    2013Chair, Autumn Immunology Conference
    2012 - 2018Member, AITC study section, NIH
    2011Basic Science Investigator Award, American Society of Transplantation
    2009 - 2014Board of Directors, Autumn Immunology Conference
    2009 - 2012Board of Directors, American Society of Transplantation
    2008Leif B. Sorenson Faculty Research Award, The University of Chicago
    2007 - 2011Section Editor, The Journal of Immunology
    2006 - 2009Member, TTT study section, NIH
    2006Elected, American Aociety for Clinical Investigation (ASCI)
    2005Basic Science Career Development Award, American Society of Transplantation
    1994Best PhD Dissertation, The University of Chicago
    1994Intensive Care Competence Summa Cum Laude, Universite Libre de Bruxelles
    1985MD Summa Cum Laude, Universite Libre de Bruxelles

    Collapse Research 
    Collapse research activities and funding
    T32AI153020     (SWARTZ, MELODY ANN)Aug 19, 2021 - Jul 31, 2026
    NIH
    Immunoengineering Postdoctoral Training Program - Resubmission - 1
    Role: Co-Principal Investigator

    U01AI132898     (TULLIUS, STEFAN GUNTHER)Jul 1, 2017 - Jun 30, 2022
    NIH
    The microbiota and allograft rejection: novel investigations into the consequences of obesity
    Role: Co-Investigator

    R01AI115716     (ALEGRE, MARIA-LUISA)Nov 3, 2014 - Nov 30, 2024
    NIH
    Impact of Microbiota on Alloimmune Responses in Transplantation
    Role: Principal Investigator

    P01AI097113     (ALEGRE, MARIA-LUISA)Jul 17, 2012 - Apr 30, 2028
    NIH
    Infections and the Stability of Transplantation Tolerance
    Role: Principal Investigator

    R01AR059414     (DAUM, ROBERT S.)Sep 1, 2010 - Apr 30, 2015
    NIH
    Epidemic CA-MRSA: Molecular Epidemiology and Immunology
    Role: Co-Principal Investigator

    R01AI071080     (ALEGRE, MARIA-LUISA)Jan 1, 2008 - Dec 31, 2012
    NIH
    Mechanisms of TLR-mediated prevention of transplantation tolerance
    Role: Principal Investigator

    R01AI052352     (ALEGRE, MARIA-LUISA)Jul 1, 2002 - Jan 31, 2015
    NIH
    Role of NF-kB Activation in Acute Allograft Rejection
    Role: Principal Investigator

    R56AI052352     (ALEGRE, MARIA-LUISA)Jul 1, 2002 - Jan 31, 2010
    NIH
    Role of NF-kB Activation in Acute Allograft Rejection
    Role: Principal Investigator

    K02AI051428     (ALEGRE, MARIA-LUISA)Apr 1, 2002 - Mar 31, 2007
    NIH
    NF-kappaBeta activation T cell function/graft rejection
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sepulveda M, Rasic M, Lei YM, Kwan M, Chen L, Chen Y, Perkins D, Alegre ML. Coordinated elimination of bacterial taxa optimally attenuates alloimmunity and prolongs allograft survival. Am J Transplant. 2024 Mar 20. PMID: 38519004.
      Citations:    Fields:    
    2. Kwan M, Alegre ML. Tiny heroes: Microbiota-modified bile acid metabolites protect against drug-induced gut damage. Am J Transplant. 2024 Mar 18. PMID: 38508318.
      Citations:    Fields:    
    3. Wang P, Chen L, Mora-Cartin R, McIntosh CM, Sattar H, Chong AS, Alegre ML. Low-affinity CD8+ T cells provide interclonal help to high-affinity CD8+ T cells to augment alloimmunity. Am J Transplant. 2024 Jan 14. PMID: 38228228.
      Citations:    Fields:    
    4. West L, AST COTS MOuse MOdels in Transplantation (MOMOT) work group, Cravedi P, Riella LV, Ford ML, Valujskikh A, Menon MC, Kirk AD, Alegre ML, Alessandrini A, Feng S, Kehn P, Najafian N, Hancock WW, Heeger PS, Maltzman JS, Mannon RB, Nadig SN, Odim J, Turnquist H, Shaw J, Luo X, Chong AS, Bromberg JS. Advancing mouse models for transplantation research. Am J Transplant. 2024 Jan 12. PMID: 38219866.
      Citations:    Fields:    
    5. McIntosh CM, Allocco JB, Wang P, McKeague ML, Cassano A, Wang Y, Xie SZ, Hynes G, Mora-Cartín R, Abbondanza D, Chen L, Sattar H, Yin D, Zhang ZJ, Chong AS, Alegre ML. Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection. J Clin Invest. 2023 11 01; 133(21). PMID: 37676735; PMCID: PMC10617766.
      Citations:    Fields:    Translation:AnimalsCells
    6. Allocco J, Alegre ML. Biological Time Travel: Tracking the Journey of Alloreactive T Cells Through Longitudinal Biobanking. Transplantation. 2023 09 01; 107(9):1862-1864. PMID: 37606904; PMCID: PMC10926360.
      Citations:    Fields:    Translation:Cells
    7. Li Z, Chen L, Sepulveda M, Wang P, Rasic M, Tullius SG, Perkins D, Alegre ML. Microbiota-dependent and -independent effects of obesity on transplant rejection and hyperglycemia. Am J Transplant. 2023 10; 23(10):1526-1535. PMID: 37356668; PMCID: PMC10543612.
      Citations: 1     Fields:    Translation:Animals
    8. Adam I, Motyka B, Tao K, Jeyakanthan M, Alegre ML, Cowan PJ, West LJ. Sex, T Cells, and the Microbiome in Natural ABO Antibody Production in Mice. Transplantation. 2023 Jun 08. PMID: 37289044; PMCID: PMC10593149.
      Citations:    Fields:    
    9. Adam I, Motyka B, Tao K, Jeyakanthan M, Alegre ML, Cowan PJ, West LJ. Sex, T Cells, and the Microbiome in Natural ABO Antibody Production in Mice. Transplantation. 2023 11 01; 107(11):2353-2363. PMID: 37871273; PMCID: PMC10593149.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Pollard J, Hynes G, Yin D, Mandal M, Gounari F, Alegre ML, Chong A. Pregnancy programs epigenetic and transcriptional exhaustion in memory CD8+ T cells. Res Sq. 2023 Apr 05. PMID: 37066154; PMCID: PMC10104270.
      Citations:    
    11. Li Z, Rasic M, Kwan M, Sepulveda M, McIntosh C, Shastry V, Chen L, Finn P, Perkins D, Alegre ML. Oral administration of the commensal Alistipes onderdonkii prolongs allograft survival. Am J Transplant. 2023 02; 23(2):272-277. PMID: 36804134; PMCID: PMC10041932.
      Citations: 1     Fields:    Translation:AnimalsCells
    12. Kwan M, Sepulveda M, Alegre ML. Methods to Study TLRs in Transplantation. Methods Mol Biol. 2023; 2700:139-149. PMID: 37603178.
      Citations:    Fields:    Translation:HumansAnimals
    13. Gupta PK, Allocco JB, Fraipont JM, McKeague ML, Wang P, Andrade MS, McIntosh C, Chen L, Wang Y, Li Y, Andrade J, Chong AS, Alegre ML, Conejo-Garcia JR. Reduced Satb1 expression predisposes CD4+ T conventional cells to Treg suppression and promotes transplant survival. Proc Natl Acad Sci U S A. 2022 10 04; 119(40):e2205062119. PMID: 36161903; PMCID: PMC9546564.
      Citations: 1     Fields:    Translation:AnimalsCells
    14. Pirozzolo I, Sepulveda M, Chen L, Wang Y, Lei YM, Li Z, Li R, Sattar H, Theriault B, Belkaid Y, Chong AS, Alegre ML. Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants. J Clin Invest. 2022 09 01; 132(17). PMID: 35834335; PMCID: PMC9435649.
      Citations: 4     Fields:    Translation:HumansAnimals
    15. Wang P, Chen L, McIntosh CM, Lane JI, Li R, Xie SZ, Sattar H, Esterhazy D, Chong AS, Alegre ML. Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor-mismatched skin transplantation. Am J Transplant. 2022 10; 22(10):2348-2359. PMID: 35633180; PMCID: PMC9547964.
      Citations: 1     Fields:    Translation:Animals
    16. Andrade MS, Young JS, Pollard JM, Yin D, Alegre ML, Chong AS. Linked sensitization by memory CD4+ T cells prevents costimulation blockade-induced transplantation tolerance. JCI Insight. 2022 06 08; 7(11). PMID: 35674134; PMCID: PMC9220839.
      Citations:    Fields:    Translation:AnimalsCells
    17. Durgam SS, Alegre ML, Chong AS. Toward an understanding of allogeneic conflict in pregnancy and transplantation. J Exp Med. 2022 05 02; 219(5). PMID: 35416935; PMCID: PMC9011201.
      Citations: 5     Fields:    Translation:Humans
    18. Quante M, Iske J, Uehara H, Minami K, Nian Y, Maenosono R, Matsunaga T, Liu Y, Azuma H, Perkins D, Alegre ML, Zhou H, Elkhal A, Tullius SG. Taurodeoxycholic acid and valine reverse obesity-associated augmented alloimmune responses and prolong allograft survival. Am J Transplant. 2022 02; 22(2):402-413. PMID: 34551205; PMCID: PMC10614103.
      Citations: 3     Fields:    Translation:HumansAnimals
    19. Chong AS, Sage PT, Alegre ML. Regulation of Alloantibody Responses. Front Cell Dev Biol. 2021; 9:706171. PMID: 34307385; PMCID: PMC8297544.
      Citations: 3     
    20. Quante M, Iske J, Heinbokel T, Desai BN, Cetina Biefer HR, Nian Y, Matsunaga T, Uehara H, Maenosono R, Azuma H, Falk CS, Lo T, Sheu E, Tavakkoli A, Abdi R, Perkins D, Alegre ML, Banks AS, Zhou H, Elkhal A, Tullius SG, Krenzien F, Pratschke J. Restored TDCA and valine levels imitate the effects of bariatric surgery. Elife. 2021 06 22; 10. PMID: 34155969; PMCID: PMC8257250.
      Citations: 6     Fields:    Translation:Animals
    21. Pirozzolo I, Li Z, Sepulveda M, Alegre ML. Influence of the microbiome on solid organ transplant survival. J Heart Lung Transplant. 2021 08; 40(8):745-753. PMID: 34030971; PMCID: PMC8319047.
      Citations: 3     Fields:    Translation:Humans
    22. Suah AN, Tran DV, Khiew SH, Andrade MS, Pollard JM, Jain D, Young JS, Yin D, Chalasani G, Alegre ML, Chong AS. Pregnancy-induced humoral sensitization overrides T cell tolerance to fetus-matched allografts in mice. J Clin Invest. 2021 01 04; 131(1). PMID: 33393512; PMCID: PMC7773355.
      Citations: 10     Fields:    Translation:AnimalsCells
    23. Cravedi P, Schold JD, Safa K, Kates OS, Elfadawy N, Mannon RB, Shah MB, Hammond SP, Avery R, Guerrero Miranda C, Riella LV, Jowsey-Gregoire S, Akalin E, Camirand G, Alegre ML, Azzi J. The COVID-19 pandemic: A community approach. Clin Transplant. 2020 11; 34(11):e14059. PMID: 32762055; PMCID: PMC7435543.
      Citations: 6     Fields:    Translation:HumansCellsPHPublic Health
    24. Khiew SH, Jain D, Chen J, Yang J, Yin D, Young JS, Dent A, Sciammas R, Alegre ML, Chong AS. Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells. J Clin Invest. 2020 07 01; 130(7):3453-3466. PMID: 32452834; PMCID: PMC7329196.
      Citations: 8     Fields:    Translation:AnimalsCells
    25. Sepulveda M, Alegre ML. Metabolomic profiling reveals clinically relevant microbiota-linked metabolites. Am J Transplant. 2020 Jul; 20(7):1763. PMID: 32596922.
      Citations:    
    26. Alegre ML. Introduction to this Cellular Immunology issue on new advances in solid organ transplantation immunology. Cell Immunol. 2020 09; 355:104156. PMID: 32619810; PMCID: PMC8114903.
      Citations:    Fields:    Translation:Humans
    27. Alegre ML. The anti-inflammatory function of the apoptotic secretome. Am J Transplant. 2020 06; 20(6):1471. PMID: 32472643.
      Citations: 2     Fields:    Translation:Cells
    28. Alegre ML. Can Diet Induce Transplantation Tolerance? J Am Soc Nephrol. 2020 07; 31(7):1417-1418. PMID: 32482687; PMCID: PMC7351008.
      Citations: 1     Fields:    
    29. Chong AS, Issa F, Leuvenink HGD, Alegre ML. The First ITS Meeting. Transplantation. 2020 06; 104(6):1114-1116. PMID: 32433230.
      Citations: 1     Fields:    Translation:Humans
    30. Alegre ML. Liver Protection by ILC1s. Am J Transplant. 2020 05; 20(5):1215. PMID: 32333517.
      Citations:    Fields:    Translation:AnimalsCells
    31. Alegre ML. Immune impact of commensals versus pathobionts. Am J Transplant. 2020 Apr; 20(4):913. PMID: 32222102.
      Citations:    
    32. Si Y, Zhao F, Beesetty P, Weiskopf D, Li Z, Tian Q, Alegre ML, Sette A, Chong AS, Montgomery CP. Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination. Sci Adv. 2020 04; 6(14):eaaw7713. PMID: 32270029; PMCID: PMC7112766.
      Citations: 10     Fields:    Translation:AnimalsCellsPHPublic Health
    33. Mcintosh CM, Alegre ML. Giving effector/memory T cells a new (suppressive) purpose. Am J Transplant. 2020 Mar; 20(3):625. PMID: 32090473.
      Citations:    
    34. Piper C, Zhou V, Komorowski R, Szabo A, Vincent B, Serody J, Alegre ML, Edelson BT, Taneja R, Drobyski WR. Pathogenic Bhlhe40+ GM-CSF+ CD4+ T cells promote indirect alloantigen presentation in the GI tract during GVHD. Blood. 2020 02 20; 135(8):568-581. PMID: 31880771; PMCID: PMC7033370.
      Citations: 24     Fields:    Translation:AnimalsCells
    35. Allocco JB, Alegre ML. Exploiting immunometabolism and T cell function for solid organ transplantation. Cell Immunol. 2020 05; 351:104068. PMID: 32139072; PMCID: PMC7150626.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    36. Allocco JB, Alegre ML. In vivo and in vitro differences in CD8+ T cell metabolism. Am J Transplant. 2020 Feb; 20(2):327. PMID: 31983082.
      Citations:    
    37. Chong AS, Issa F, Leuvenink HGD, Alegre ML. The First International Transplant Science (ITS) Meeting. Transplantation. 2020 Jan 20. PMID: 31977999.
      Citations:    
    38. Alegre ML. The initiation of graft-versus-host disease. Am J Transplant. 2020 Jan; 20(1):3. PMID: 31894910.
      Citations:    
    39. Sepulveda M, Pirozzolo I, Alegre ML. Impact of the microbiota on solid organ transplant rejection. Curr Opin Organ Transplant. 2019 12; 24(6):679-686. PMID: 31577594; PMCID: PMC7137354.
      Citations: 10     Fields:    Translation:Humans
    40. Miller ML, McIntosh CM, Wang Y, Chen L, Wang P, Lei YM, Daniels MD, Watkins E, Mora Solano C, Chong AS, Alegre ML. Resilience of T cell-intrinsic dysfunction in transplantation tolerance. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23682-23690. PMID: 31685610; PMCID: PMC6876241.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    41. Alegre ML. DeTOXifying exhausted T cells. Am J Transplant. 2019 Nov; 19(11):2965. PMID: 31742914.
      Citations:    
    42. Alegre ML. Innate lymphoid cells coming of age. Am J Transplant. 2019 Oct; 19(10):2669. PMID: 31557416.
      Citations:    
    43. Alegre ML. Fibroblasts can have subsets too! Am J Transplant. 2019 Sep; 19(9):2397. PMID: 31454175.
      Citations:    
    44. McIntosh CM, Alegre ML. Teamwork by IL-10+ and IL-35+ Tregs. Am J Transplant. 2019 Aug; 19(8):2147. PMID: 31343849.
      Citations:    
    45. Lei YM, Sepulveda M, Chen L, Wang Y, Pirozzolo I, Theriault B, Chong AS, Belkaid Y, Alegre ML. Skin-restricted commensal colonization accelerates skin graft rejection. JCI Insight. 2019 07 16; 5. PMID: 31310590; PMCID: PMC6693824.
      Citations: 10     Fields:    Translation:AnimalsCells
    46. Alegre ML. Lymph node segregation for tolerance or inflammation. Am J Transplant. 2019 Jul; 19(7):1873. PMID: 31233678.
      Citations:    
    47. Alegre ML. Neuroimmunology and the control of T cell migration. Am J Transplant. 2019 Jun; 19(6):1605. PMID: 31136699.
      Citations:    
    48. Alegre ML. Mouse microbiomes: overlooked culprits of experimental variability. Genome Biol. 2019 05 29; 20(1):108. PMID: 31142368; PMCID: PMC6540381.
      Citations: 15     Fields:    Translation:AnimalsCells
    49. Sepulveda M, Alegre ML. Harnessing the commensal microbiota to improve immune responses. Am J Transplant. 2019 May; 19(5):1257. PMID: 31018049.
      Citations:    
    50. Azzi J, Alegre ML. Outstanding questions in transplantation: An introduction to this minireview series. Am J Transplant. 2019 08; 19(8):2149-2150. PMID: 30903734.
      Citations:    Fields:    Translation:Cells
    51. Alegre ML. Treg Respiration. Am J Transplant. 2019 Apr; 19(4):969. PMID: 30908828.
      Citations:    
    52. Rael VE, Chen L, McIntosh CM, Alegre ML. Exercise increases skin graft resistance to rejection. Am J Transplant. 2019 05; 19(5):1560-1567. PMID: 30659772; PMCID: PMC7137356.
      Citations: 3     Fields:    Translation:AnimalsCells
    53. Alegre ML. A New Ligand for LAG-3. Am J Transplant. 2019 Mar; 19(3):617. PMID: 30802371.
      Citations:    
    54. Gupta PK, McIntosh CM, Chong AS, Alegre ML. The pursuit of transplantation tolerance: new mechanistic insights. Cell Mol Immunol. 2019 04; 16(4):324-333. PMID: 30760917; PMCID: PMC6461908.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    55. Rigat F, Bartolini E, Dalsass M, Kumar N, Marchi S, Speziale P, Maione D, Chen L, Romano MR, Alegre ML, Bagnoli F, Daum RS, David MZ. Retrospective Identification of a Broad IgG Repertoire Differentiating Patients With S. aureus Skin and Soft Tissue Infections From Controls. Front Immunol. 2019; 10:114. PMID: 30792711; PMCID: PMC6375365.
      Citations: 9     Fields:    Translation:HumansCells
    56. Alegre ML. A molecular pathway for indirect presentation? Am J Transplant. 2019 Feb; 19(2):311. PMID: 30690908.
      Citations:    
    57. Alegre ML. B cells, CMV, and stem cell transplant. Science. 2019 01 18; 363(6424):232-233. PMID: 30655432.
      Citations: 3     Fields:    Translation:HumansCells
    58. Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson MS, August A, Marson A, Zheng Y, Williams CB, Farrar MA. Thymic regulatory T cells arise via two distinct developmental programs. Nat Immunol. 2019 02; 20(2):195-205. PMID: 30643267; PMCID: PMC6650268.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    59. Wu Q, Turturice B, Wagner S, Huang Y, Gupta PK, Schott C, Metwally A, Ranjan R, Perkins D, Alegre ML, Finn P, Budinger GRS, Shilling R, Bharat A. Gut Microbiota Can Impact Chronic Murine Lung Allograft Rejection. Am J Respir Cell Mol Biol. 2019 01; 60(1):131-134. PMID: 30592445; PMCID: PMC6348725.
      Citations: 8     Fields:    Translation:AnimalsCells
    60. Alegre ML. The Importance of Inflammation-induced NETS. Am J Transplant. 2019 Jan; 19(1):3. PMID: 30592568.
      Citations:    
    61. Gupta PK, Alegre ML. Th17 Cells Changing Colors. Am J Transplant. 2018 Dec; 18(12):2841. PMID: 30476364.
      Citations:    
    62. Wu JF, Muthusamy A, Al-Ghalith GA, Knights D, Guo B, Wu B, Remmel RP, Schladt DP, Alegre ML, Oetting WS, Jacobson PA, Israni AK. Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients. Clin Transplant. 2018 12; 32(12):e13436. PMID: 30372560; PMCID: PMC6984979.
      Citations: 16     Fields:    Translation:Humans
    63. Alegre ML. Creating a Niche. Am J Transplant. 2018 Nov; 18(11):2617. PMID: 30372597.
      Citations:    
    64. Alegre ML. Danger, Metabolism and T Cell Memory. Am J Transplant. 2018 Oct; 18(10):2375. PMID: 30261133.
      Citations:    
    65. Alegre ML. The Adaptive NK Cell Response. Am J Transplant. 2018 Sep; 18(9):2105. PMID: 30161299.
      Citations:    
    66. Miller ML, McIntosh CM, Williams JB, Wang Y, Hollinger MK, Isaad NJ, Moon JJ, Gajewski TF, Chong AS, Alegre ML. Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance. Cell Rep. 2018 08 21; 24(8):2112-2126. PMID: 30134172; PMCID: PMC6142813.
      Citations: 15     Fields:    Translation:HumansAnimals
    67. Mcintosh CM, Alegre ML. Metabolic Control of T Cell Memory. Am J Transplant. 2018 Aug; 18(8):1835. PMID: 30134007.
      Citations:    
    68. Alegre ML. Preventing PTLD? Am J Transplant. 2018 Jul; 18(7):1583. PMID: 29979834.
      Citations:    
    69. Young JS, Yin D, Vannier AGL, Alegre ML, Chong AS. Equal Expansion of Endogenous Transplant-Specific Regulatory T Cell and Recruitment Into the Allograft During Rejection and Tolerance. Front Immunol. 2018; 9:1385. PMID: 29973932; PMCID: PMC6020780.
      Citations: 10     Fields:    
    70. Alegre ML. A Cause for Leaky Guts. Am J Transplant. 2018 Jun; 18(6):1299. PMID: 29878639.
      Citations:    
    71. McIntosh CM, Chen L, Shaiber A, Eren AM, Alegre ML. Gut microbes contribute to variation in solid organ transplant outcomes in mice. Microbiome. 2018 05 25; 6(1):96. PMID: 29793539; PMCID: PMC5968713.
      Citations: 31     Fields:    Translation:Animals
    72. Alegre ML. Immune Regulation of Lung Fibrosis. Am J Transplant. 2018 May; 18(5):1039. PMID: 29677392.
      Citations:    
    73. Tu E, Chia CPZ, Chen W, Zhang D, Park SA, Jin W, Wang D, Alegre ML, Zhang YE, Sun L, Chen W. T Cell Receptor-Regulated TGF-ß Type I Receptor Expression Determines T Cell Quiescence and Activation. Immunity. 2018 04 17; 48(4):745-759.e6. PMID: 29669252; PMCID: PMC5911925.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    74. Alegre ML. Sweet T Cell Dysfunction. Am J Transplant. 2018 Apr; 18(4):775. PMID: 29603604.
      Citations:    
    75. Alegre ML. Mind the GAP, for Tolerance to Gut Bacteria. Am J Transplant. 2018 Mar; 18(3):533. PMID: 29462513.
      Citations:    
    76. Alegre ML. What's new in transplantation tolerance? Curr Opin Organ Transplant. 2018 02; 23(1):63-65. PMID: 29189414.
      Citations: 1     Fields:    
    77. Alegre ML. DC Metabolism Controls Lung T Cell Polarization. Am J Transplant. 2018 02; 18(2):285. PMID: 29381270.
      Citations: 1     Fields:    Translation:HumansCells
    78. Matson V, Fessler J, Bao R, Chongsuwat T, Zha Y, Alegre ML, Luke JJ, Gajewski TF. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science. 2018 01 05; 359(6371):104-108. PMID: 29302014; PMCID: PMC6707353.
      Citations: 1172     Fields:    Translation:HumansAnimalsCells
    79. Riella LV, Alegre ML. Novel Role of Calcineurin Inhibitors in Curbing T Cells' Sweet Tooth. Am J Transplant. 2018 Jan; 18(1):3. PMID: 29267999.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    80. Alegre ML. Stealing Tregs' Identity (by Deleting NF-?B). Am J Transplant. 2017 Dec; 17(12):2997. PMID: 29145695.
      Citations:    
    81. Alegre ML. Making Therapeutic Antibodies in Vitro. Am J Transplant. 2017 Nov; 17(11):2753. PMID: 29083551.
      Citations:    
    82. Young JS, McIntosh C, Alegre ML, Chong AS. Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans. Transplantation. 2017 11; 101(11):2671-2681. PMID: 28604446; PMCID: PMC5653459.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    83. Miller ML, Chong AS, Alegre ML. Fifty Shades of Tolerance: Beyond a Binary Tolerant/Non-Tolerant Paradigm. Curr Transplant Rep. 2017 Dec; 4(4):262-269. PMID: 31098340; PMCID: PMC6516484.
      Citations: 5     
    84. Alegre ML. Predicting TCR specificity? Am J Transplant. 2017 Oct; 17(10):2501. PMID: 28960937.
      Citations:    
    85. Young JS, Khiew SH, Yang J, Vannier A, Yin D, Sciammas R, Alegre ML, Chong AS. Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice. Front Immunol. 2017; 8:1169. PMID: 28970838; PMCID: PMC5609110.
      Citations: 9     Fields:    
    86. Azzi J, Raimondi G, Mas V, Riella LV, Elfadawy N, Safa K, Wojciechowski D, Kanak M, Nog R, Maltzman JS, Ford ML, Pober JS, Luo XR, Rothstein D, Miller ML, Matthews D, Burlingham W, Levings M, Heeger P, Higdon L, Gill J, Gill RG, Alegre ML. The outstanding questions in transplantation: It's about time…. Am J Transplant. 2018 01; 18(1):271-272. PMID: 28758364.
      Citations: 1     Fields:    Translation:Humans
    87. Alegre ML. The Unbearable Lightness of Breathing. Am J Transplant. 2017 Sep; 17(9):2233. PMID: 28846838.
      Citations:    
    88. Alegre ML. Immune-Electrical Connection. Am J Transplant. 2017 Aug; 17(8):1965. PMID: 28724207.
      Citations:    
    89. Alegre ML. The Bugs That Keep Us Safe. Am J Transplant. 2017 Jul; 17(7):1699. PMID: 28658537.
      Citations:    
    90. Alegre ML. Timing Is Everything. Am J Transplant. 2017 Jun; 17(6):1433. PMID: 28544282.
      Citations:    
    91. Riella LV, Bagley J, Iacomini J, Alegre ML. Impact of environmental factors on alloimmunity and transplant fate. J Clin Invest. 2017 Jun 30; 127(7):2482-2491. PMID: 28481225; PMCID: PMC5490769.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    92. Khiew SH, Yang J, Young JS, Chen J, Wang Q, Yin D, Vu V, Miller ML, Sciammas R, Alegre ML, Chong AS. CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients. JCI Insight. 2017 May 04; 2(9). PMID: 28469082; PMCID: PMC5414557.
      Citations: 5     Fields:    
    93. Alegre ML. Anti-Inflammatory Effects of Nonprofessional Phagocyte. Am J Transplant. 2017 May; 17(5):1151. PMID: 28453227.
      Citations:    
    94. Alegre ML. The Tpm Subset of the CD8+ T Cell Memory Family. Am J Transplant. 2017 Apr; 17(4):849. PMID: 28371536.
      Citations:    
    95. Alegre ML. Dendritic Cell Identification for Dummies. Am J Transplant. 2017 Mar; 17(3):593. PMID: 28240828.
      Citations:    
    96. Alegre ML. The Multiple Molecular Paths of Antibody Suppression by TFR Cells. Am J Transplant. 2017 Feb; 17(2):311. PMID: 28122170.
      Citations:    
    97. Miller ML, Alegre ML, Chong AS. Transplantation tolerance after allograft rejection. Curr Opin Organ Transplant. 2017 Feb; 22(1):64-70. PMID: 27898463; PMCID: PMC5406013.
      Citations: 3     Fields:    Translation:Humans
    98. Miller ML, Alegre ML. Super-MANF to the Rescue: Immunomodulation Improves Retinal Repair and Regenerative Cell Therapy. Am J Transplant. 2017 Jan; 17(1):3. PMID: 28029735.
      Citations:    
    99. Alegre ML. Ionic Checkpoint: Potassium-Driven T Cell Immunosuppression. Am J Transplant. 2016 Dec; 16(12):3313. PMID: 28267261.
      Citations:    
    100. Alegre ML, Lakkis FG, Morelli AE. Antigen Presentation in Transplantation. Trends Immunol. 2016 12; 37(12):831-843. PMID: 27743777; PMCID: PMC5135637.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    101. Alegre ML. Select Effects of IL-13 in Driving Tissue Repair and Fibrosis. Am J Transplant. 2016 Oct; 16(10):2771. PMID: 28497904.
      Citations:    
    102. Alegre ML. Standardizing Mouse Models to Account for Host-Microbial Interactions. Am J Transplant. 2016 Sep; 16(9):2503. PMID: 27575723.
      Citations:    
    103. Young JS, Daniels MD, Miller ML, Wang T, Zhong R, Yin D, Alegre ML, Chong AS. Erosion of Transplantation Tolerance After Infection. Am J Transplant. 2017 01; 17(1):81-90. PMID: 27273890; PMCID: PMC5938732.
      Citations: 20     Fields:    Translation:AnimalsCells
    104. Alegre ML, Chen L, David MZ, Bartman C, Boyle-Vavra S, Kumar N, Chong AS, Daum RS. Impact of Staphylococcus aureus USA300 Colonization and Skin Infections on Systemic Immune Responses in Humans. J Immunol. 2016 08 15; 197(4):1118-26. PMID: 27402695; PMCID: PMC4976020.
      Citations: 8     Fields:    Translation:HumansCells
    105. Lei YM, Chen L, Wang Y, Stefka AT, Molinero LL, Theriault B, Aquino-Michaels K, Sivan AS, Nagler CR, Gajewski TF, Chong AS, Bartman C, Alegre ML. The composition of the microbiota modulates allograft rejection. J Clin Invest. 2016 07 01; 126(7):2736-44. PMID: 27322054; PMCID: PMC4922695.
      Citations: 43     Fields:    Translation:AnimalsCells
    106. Arina A, Idel C, Hyjek EM, Alegre ML, Wang Y, Bindokas VP, Weichselbaum RR, Schreiber H. Tumor-associated fibroblasts predominantly come from local and not circulating precursors. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7551-6. PMID: 27317748; PMCID: PMC4941507.
      Citations: 98     Fields:    Translation:AnimalsCells
    107. Miller ML, Chen J, Daniels MD, McKeague MG, Wang Y, Yin D, Vu V, Chong AS, Alegre ML. Adoptive Transfer of Tracer-Alloreactive CD4+ T Cell Receptor Transgenic T Cells Alters the Endogenous Immune Response to an Allograft. Am J Transplant. 2016 10; 16(10):2842-2853. PMID: 27063351; PMCID: PMC5065388.
      Citations: 8     Fields:    Translation:AnimalsCells
    108. Miller ML, Daniels MD, Wang T, Wang Y, Xu J, Yin D, Chong AS, Alegre ML. Tracking of TCR-Transgenic T Cells Reveals That Multiple Mechanisms Maintain Cardiac Transplant Tolerance in Mice. Am J Transplant. 2016 10; 16(10):2854-2864. PMID: 27091509; PMCID: PMC6241514.
      Citations: 15     Fields:    Translation:AnimalsCells
    109. Molinero LL, Yin D, Lei YM, Chen L, Wang Y, Chong AS, Alegre ML. High-Fat Diet-Induced Obesity Enhances Allograft Rejection. Transplantation. 2016 05; 100(5):1015-21. PMID: 27007226; PMCID: PMC4846555.
      Citations: 17     Fields:    Translation:AnimalsCells
    110. Young JS, Chen J, Miller ML, Vu V, Tian C, Moon JJ, Alegre ML, Sciammas R, Chong AS. Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection. Am J Transplant. 2016 08; 16(8):2312-23. PMID: 26928966; PMCID: PMC4956497.
      Citations: 23     Fields:    Translation:AnimalsCells
    111. Alegre ML, Gajewski TF. Germ Warfare. Sci Am. 2016 Apr; 314(4):50. PMID: 27082192.
      Citations:    Fields:    Translation:HumansAnimalsCells
    112. Spranger S, Barnes SE, Miller ML, Molinero LL, Locke FL, Gajewski TF, Alegre ML, Evaristo C. Cutting Edge: Engineering Active IKKß in T Cells Drives Tumor Rejection. J Immunol. 2016 Apr 01; 196(7):2933-8. PMID: 26903482; PMCID: PMC4799771.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    113. Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre ML, Chang EB, Gajewski TF. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. 2015 Nov 27; 350(6264):1084-9. PMID: 26541606; PMCID: PMC4873287.
      Citations: 1542     Fields:    Translation:HumansAnimalsCells
    114. Theriault B, Wang Y, Chen L, Vest A, Bartman C, Alegre ML. Long-term Maintenance of Sterility Following Skin Transplantation in Germ-free Mice. Transplant Direct. 2015 Sep; 1(8). PMID: 26609546; PMCID: PMC4655119.
      Citations: 11     
    115. Zhao F, Cheng BL, Boyle-Vavra S, Alegre ML, Daum RS, Chong AS, Montgomery CP. Proteomic Identification of saeRS-Dependent Targets Critical for Protective Humoral Immunity against Staphylococcus aureus Skin Infection. Infect Immun. 2015 Sep; 83(9):3712-21. PMID: 26169277; PMCID: PMC4534640.
      Citations: 8     Fields:    Translation:AnimalsCells
    116. Miller ML, Daniels MD, Wang T, Chen J, Young J, Xu J, Wang Y, Yin D, Vu V, Husain AN, Alegre ML, Chong AS. Spontaneous restoration of transplantation tolerance after acute rejection. Nat Commun. 2015 Jul 07; 6:7566. PMID: 26151823; PMCID: PMC4498267.
      Citations: 27     Fields:    Translation:AnimalsCells
    117. Xu Y, Evaristo C, Alegre ML, Gurbuxani S, Kee BL. Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage. PLoS One. 2015; 10(4):e0125211. PMID: 25923440; PMCID: PMC4414598.
      Citations: 4     Fields:    Translation:AnimalsCells
    118. Bartman C, Chong AS, Alegre ML. The influence of the microbiota on the immune response to transplantation. Curr Opin Organ Transplant. 2015 Feb; 20(1):1-7. PMID: 25563985; PMCID: PMC4423793.
      Citations: 9     Fields:    Translation:HumansAnimals
    119. Alegre ML. I spy alloreactive T cells. Sci Transl Med. 2015 Jan 28; 7(272):272fs3. PMID: 25632032.
      Citations:    Fields:    Translation:HumansCells
    120. Barnes SE, Wang Y, Chen L, Molinero LL, Gajewski TF, Evaristo C, Alegre ML. T cell-NF-?B activation is required for tumor control in vivo. J Immunother Cancer. 2015; 3(1):1. PMID: 25648675; PMCID: PMC4308877.
      Citations: 25     Fields:    
    121. Lei YM, Nair L, Alegre ML. The interplay between the intestinal microbiota and the immune system. Clin Res Hepatol Gastroenterol. 2015 Feb; 39(1):9-19. PMID: 25481240; PMCID: PMC4423786.
      Citations: 26     Fields:    Translation:HumansAnimals
    122. Woo SR, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MY, Duggan R, Wang Y, Fitzgerald KA, Alegre ML, Gajewski TF, Barber GN. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity. 2014 Nov 20; 41(5):830-42. PMID: 25517615; PMCID: PMC4384884.
      Citations: 741     Fields:    Translation:AnimalsCells
    123. Alegre ML, Mannon RB, Mannon PJ. The microbiota, the immune system and the allograft. Am J Transplant. 2014 Jun; 14(6):1236-48. PMID: 24840316; PMCID: PMC4423796.
      Citations: 21     Fields:    Translation:Humans
    124. Miller ML, Mashayekhi M, Chen L, Zhou P, Liu X, Michelotti M, Tramontini Gunn N, Powers S, Zhu X, Evaristo C, Alegre ML, Molinero LL. Basal NF-?B controls IL-7 responsiveness of quiescent naïve T cells. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7397-402. PMID: 24799710; PMCID: PMC4034246.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    125. Montgomery CP, Daniels M, Zhao F, Alegre ML, Chong AS, Daum RS. Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A. Infect Immun. 2014 May; 82(5):2125-34. PMID: 24614654; PMCID: PMC3993461.
      Citations: 73     Fields:    Translation:AnimalsCells
    126. Chong AS, Alegre ML. Transplantation tolerance and its outcome during infections and inflammation. Immunol Rev. 2014 Mar; 258(1):80-101. PMID: 24517427; PMCID: PMC3927153.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    127. Alegre ML, Bartman C, Chong AS. Microbes and allogeneic transplantation. Transplantation. 2014 Jan 15; 97(1):5-11. PMID: 23903013; PMCID: PMC3859868.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    128. Chong AS, Alegre ML, Miller ML, Fairchild RL. Lessons and limits of mouse models. Cold Spring Harb Perspect Med. 2013 Dec 01; 3(12):a015495. PMID: 24296351; PMCID: PMC3839603.
      Citations: 24     Fields:    Translation:AnimalsCells
    129. Evaristo C, Alegre ML. IFN-?: The Dr. Jekyll and Mr. Hyde of immunology? Am J Transplant. 2013 Dec; 13(12):3057-8. PMID: 24148260; PMCID: PMC3923495.
      Citations:    Fields:    Translation:AnimalsCells
    130. Molinero LL, Cubre A, Mora-Solano C, Wang Y, Alegre ML. T cell receptor/CARMA1/NF-?B signaling controls T-helper (Th) 17 differentiation. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18529-34. PMID: 23091043; PMCID: PMC3494911.
      Citations: 34     Fields:    Translation:AnimalsCells
    131. Alegre ML, Bromberg JS. Commensal microbiota determine intestinal iTreg. Am J Transplant. 2012 Aug; 12(8):1967. PMID: 22845904.
      Citations: 2     Fields:    
    132. Alegre ML, Molinero LL. The inside story of dendritic cell immunotherapy. Am J Transplant. 2012 Jun; 12(6):1363-4. PMID: 22642470; PMCID: PMC3933448.
      Citations:    Fields:    Translation:AnimalsCells
    133. Porras DL, Wang Y, Zhou P, Molinero LL, Alegre ML. Role of T-cell-specific nuclear factor ?B in islet allograft rejection. Transplantation. 2012 May 27; 93(10):976-82. PMID: 22437847; PMCID: PMC3535294.
      Citations: 5     Fields:    Translation:AnimalsCells
    134. Chong AS, Alegre ML. The impact of infection and tissue damage in solid-organ transplantation. Nat Rev Immunol. 2012 May 25; 12(6):459-71. PMID: 22627862; PMCID: PMC4053185.
      Citations: 61     Fields:    Translation:HumansAnimals
    135. Alegre ML, Bromberg JS. Literature watch implications for transplantation. The anti-infectious role of the IL-17 pathway. Am J Transplant. 2012 Jan; 12(1):3. PMID: 22244121; PMCID: PMC3922618.
      Citations:    Fields:    Translation:Humans
    136. Alegre ML, Chong AS. "Tip-toeing" to an assay for transplantation tolerance? Am J Transplant. 2012 Mar; 12(3):519-20. PMID: 22151375; PMCID: PMC3843508.
      Citations:    Fields:    Translation:HumansCells
    137. Alegre ML, Fu YX. Attenuation by targeting the B- and T-cell attenuator. Transplantation. 2011 Nov 27; 92(10):1075-6. PMID: 21956204; PMCID: PMC4425216.
      Citations: 1     Fields:    Translation:Animals
    138. Molinero LL, Alegre ML. Role of T cell-nuclear factor ?B in transplantation. Transplant Rev (Orlando). 2012 Jul; 26(3):189-200. PMID: 22074783; PMCID: PMC3309102.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    139. Ahmed EB, Wang T, Daniels M, Alegre ML, Chong AS. IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice. Am J Transplant. 2011 May; 11(5):936-46. PMID: 21449942; PMCID: PMC3083487.
      Citations: 37     Fields:    Translation:AnimalsCells
    140. Molinero LL, Miller ML, Alegre ML, Evaristo C. High TCR stimuli prevent induced regulatory T cell differentiation in a NF-?B-dependent manner. J Immunol. 2011 Apr 15; 186(8):4609-17. PMID: 21411734; PMCID: PMC3544303.
      Citations: 53     Fields:    Translation:AnimalsCells
    141. Ahmed EB, Daniels M, Alegre ML, Chong AS. Bacterial infections, alloimmunity, and transplantation tolerance. Transplant Rev (Orlando). 2011 Jan; 25(1):27-35. PMID: 21126661; PMCID: PMC2998288.
      Citations: 15     Fields:    Translation:Humans
    142. Bhorade SM, Chen H, Molinero L, Liao C, Garrity ER, Vigneswaran WT, Shilling R, Sperling A, Chong A, Alegre ML. Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome. Transplantation. 2010 Sep 15; 90(5):540-6. PMID: 20628341; PMCID: PMC4737704.
      Citations: 28     Fields:    Translation:HumansCells
    143. Wang T, Ahmed EB, Chen L, Xu J, Tao J, Wang CR, Alegre ML, Chong AS. Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model. Am J Transplant. 2010 Jul; 10(7):1524-33. PMID: 20642679; PMCID: PMC4060596.
      Citations: 52     Fields:    Translation:AnimalsCells
    144. Sweiss NJ, Salloum R, Gandhi S, Ghandi S, Alegre ML, Sawaqed R, Badaracco M, Pursell K, Pitrak D, Baughman RP, Moller DR, Garcia JG, Niewold TB. Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations. PLoS One. 2010 Feb 05; 5(2):e9088. PMID: 20140091; PMCID: PMC2816716.
      Citations: 63     Fields:    Translation:HumansCells
    145. Molinero LL, Yang J, Gajewski T, Abraham C, Farrar MA, Alegre ML. CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells. J Immunol. 2009 Jun 01; 182(11):6736-43. PMID: 19454668; PMCID: PMC2830151.
      Citations: 62     Fields:    Translation:AnimalsCells
    146. Alegre ML, Chong A. Toll-like receptors (TLRs) in transplantation. Front Biosci (Elite Ed). 2009 06 01; 1(1):36-43. PMID: 19482622; PMCID: PMC4423788.
      Citations: 7     Fields:    Translation:Humans
    147. Chen L, Ahmed E, Wang T, Wang Y, Ochando J, Chong AS, Alegre ML. TLR signals promote IL-6/IL-17-dependent transplant rejection. J Immunol. 2009 May 15; 182(10):6217-25. PMID: 19414775; PMCID: PMC2834528.
      Citations: 53     Fields:    Translation:AnimalsCells
    148. Alegre ML, Chen L, Wang T, Ahmed E, Wang CR, Chong A. Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance. Transplantation. 2009 May 15; 87(9 Suppl):S77-9. PMID: 19424015; PMCID: PMC2740905.
      Citations: 5     Fields:    Translation:HumansCells
    149. Molinero LL, Wang Y, Zhou P, Yagita H, Alegre ML. Fas mediates cardiac allograft acceptance in mice with impaired T-cell-intrinsic NF-kappaB signaling. Transpl Int. 2009 Aug; 22(8):845-52. PMID: 19351347; PMCID: PMC4423812.
      Citations: 3     Fields:    Translation:AnimalsCells
    150. O'Neill SK, Veselits ML, Zhang M, Labno C, Cao Y, Finnegan A, Uccellini M, Alegre ML, Cambier JC, Clark MR. Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6262-7. PMID: 19332776; PMCID: PMC2662959.
      Citations: 26     Fields:    Translation:AnimalsCells
    151. Zimmer MI, Nguyen HP, Wang B, Xu H, Colmone A, Felio K, Choi HJ, Zhou P, Alegre ML, Wang CR. Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1909-14. PMID: 19179286; PMCID: PMC2644137.
      Citations: 19     Fields:    Translation:AnimalsCells
    152. Song J, Volkov S, Shea CR, Alegre ML, Salgia R, Gregg K, Curran JJ, Woodruff J, Krausz T, Levine JS, Sweiss NJ. Nephrogenic systemic fibrosis associated with stromal and vascular calcification, report of two cases. J Cutan Pathol. 2009 Oct; 36 Suppl 1:31-4. PMID: 19210585.
      Citations: 7     Fields:    Translation:Humans
    153. Alegre ML, Goldstein DR, Chong AS. Toll-like receptor signaling in transplantation. Curr Opin Organ Transplant. 2008 Aug; 13(4):358-65. PMID: 18685330; PMCID: PMC2605274.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    154. Alegre ML, Leemans J, Le Moine A, Florquin S, De Wilde V, Chong A, Goldman M. The multiple facets of toll-like receptors in transplantation biology. Transplantation. 2008 Jul 15; 86(1):1-9. PMID: 18622268; PMCID: PMC4423792.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    155. Wang T, Chen L, Ahmed E, Ma L, Yin D, Zhou P, Shen J, Xu H, Wang CR, Alegre ML, Chong AS. Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes. J Immunol. 2008 May 01; 180(9):5991-9. PMID: 18424719; PMCID: PMC2597467.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    156. Ahmed EB, Alegre ML, Chong AS. Role of bacterial infections in allograft rejection. Expert Rev Clin Immunol. 2008 Mar; 4(2):281-93. PMID: 20477057.
      Citations: 8     Fields:    
    157. Qiao G, Li Z, Molinero L, Alegre ML, Ying H, Sun Z, Penninger JM, Zhang J. T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol Cell Biol. 2008 Apr; 28(7):2470-80. PMID: 18227156; PMCID: PMC2268433.
      Citations: 56     Fields:    Translation:AnimalsCells
    158. Chen L, Hussien Y, Hwang KW, Wang Y, Zhou P, Alegre ML. Overexpression of program death-1 in T cells has mild impact on allograft survival. Transpl Int. 2008 Jan; 21(1):21-9. PMID: 18076633.
      Citations: 1     Fields:    Translation:AnimalsCells
    159. Molinero LL, Zhou P, Wang Y, Harlin H, Kee B, Abraham C, Alegre ML. Epidermal Langerhans cells promote skin allograft rejection in mice with NF-kappa B-impaired T cells. Am J Transplant. 2008 Jan; 8(1):21-31. PMID: 18021281; PMCID: PMC2829624.
      Citations: 11     Fields:    Translation:AnimalsCells
    160. Alegre ML, Florquin S, Goldman M. Cellular mechanisms underlying acute graft rejection: time for reassessment. Curr Opin Immunol. 2007 Oct; 19(5):563-8. PMID: 17720467.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    161. Alegre ML, McNerney ME. Natural killer cell subsets in allograft rejection and tolerance. Curr Opin Organ Transplant. 2007 Feb; 12(1):10-16. PMID: 27792083.
      Citations:    Fields:    
    162. Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, Spaulding C, Macaroun S, Alegre ML, Kee BL, Ferrando A, Miele L, Aifantis I, Thompson B. Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med. 2007 Jan; 13(1):70-7. PMID: 17173050.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    163. Alegre ML, Najafian N. Costimulatory molecules as targets for the induction of transplantation tolerance. Curr Mol Med. 2006 Dec; 6(8):843-57. PMID: 17168736.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    164. Chen L, Wang T, Zhou P, Ma L, Yin D, Shen J, Molinero L, Nozaki T, Phillips T, Uematsu S, Akira S, Wang CR, Fairchild RL, Alegre ML, Chong A. TLR engagement prevents transplantation tolerance. Am J Transplant. 2006 Oct; 6(10):2282-91. PMID: 16970798.
      Citations: 90     Fields:    Translation:AnimalsCells
    165. McNerney ME, Lee KM, Zhou P, Molinero L, Mashayekhi M, Guzior D, Sattar H, Kuppireddi S, Wang CR, Kumar V, Alegre ML. Role of natural killer cell subsets in cardiac allograft rejection. Am J Transplant. 2006 Mar; 6(3):505-13. PMID: 16468959.
      Citations: 47     Fields:    Translation:AnimalsCells
    166. Alegre ML, Fallarino F. Mechanisms of CTLA-4-Ig in tolerance induction. Curr Pharm Des. 2006; 12(2):149-60. PMID: 16454732.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    167. Lo JC, Basak S, James ES, Quiambo RS, Kinsella MC, Alegre ML, Weih F, Franzoso G, Hoffmann A, Fu YX. Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues. Blood. 2006 Feb 01; 107(3):1048-55. PMID: 16195333; PMCID: PMC1895903.
      Citations: 51     Fields:    Translation:AnimalsCells
    168. Zhou P, Balin SJ, Mashayekhi M, Hwang KW, Palucki DA, Alegre ML. Transplantation tolerance in NF-kappaB-impaired mice is not due to regulation but is prevented by transgenic expression of Bcl-xL. J Immunol. 2005 Mar 15; 174(6):3447-53. PMID: 15749879.
      Citations: 12     Fields:    Translation:AnimalsCells
    169. Subudhi SK, Alegre ML, Fu YX. The balance of immune responses: costimulation verse coinhibition. J Mol Med (Berl). 2005 Mar; 83(3):193-202. PMID: 15630593.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    170. Brown IE, Mashayekhi M, Markiewicz M, Alegre ML, Gajewski TF. Peripheral survival of naïve CD8+ T cells. Apoptosis. 2005 Jan; 10(1):5-11. PMID: 15711917.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    171. Li D, Vermes C, Alegre ML, Chong AS, Chen L, Shao Q, Adarichev V, Xu X, Koreny T, Mikecz K, Finnegan A, Glant TT, Zhang J, Gál I. Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. J Immunol. 2004 Dec 15; 173(12):7135-9. PMID: 15585834.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    172. Hwang KW, Sweatt WB, Mashayekhi M, Palucki DA, Sattar H, Chuang E, Alegre ML. Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice. J Immunol. 2004 Nov 01; 173(9):5415-24. PMID: 15494488.
      Citations: 11     Fields:    Translation:AnimalsCells
    173. O'Keefe JP, Blaine K, Alegre ML, Gajewski TF. Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9351-6. PMID: 15192143; PMCID: PMC438980.
      Citations: 19     Fields:    Translation:AnimalsCells
    174. Subudhi SK, Zhou P, Yerian LM, Chin RK, Lo JC, Anders RA, Sun Y, Chen L, Wang Y, Alegre ML, Fu YX. Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J Clin Invest. 2004 Mar; 113(5):694-700. PMID: 14991067; PMCID: PMC351315.
      Citations: 51     Fields:    Translation:AnimalsCells
    175. Rivas FV, O'Keefe JP, Alegre ML, Gajewski TF. Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration. Mol Cell Biol. 2004 Feb; 24(4):1628-39. PMID: 14749378; PMCID: PMC344175.
      Citations: 31     Fields:    Translation:AnimalsCells
    176. Fallarino F, Grohmann U, Hwang KW, Orabona C, Vacca C, Bianchi R, Belladonna ML, Fioretti MC, Alegre ML, Puccetti P. Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol. 2003 Dec; 4(12):1206-12. PMID: 14578884.
      Citations: 458     Fields:    Translation:HumansAnimalsCells
    177. Kaufman CK, Zhou P, Pasolli HA, Rendl M, Bolotin D, Lim KC, Dai X, Alegre ML, Fuchs E. GATA-3: an unexpected regulator of cell lineage determination in skin. Genes Dev. 2003 Sep 01; 17(17):2108-22. PMID: 12923059; PMCID: PMC196453.
      Citations: 136     Fields:    Translation:Animals
    178. Zhou P, Hwang KW, Palucki D, Kim O, Newell KA, Fu YX, Alegre ML. Secondary lymphoid organs are important but not absolutely required for allograft responses. Am J Transplant. 2003 Mar; 3(3):259-66. PMID: 12614279.
      Citations: 17     Fields:    Translation:AnimalsCells
    179. Tang Q, Smith JA, Szot GL, Zhou P, Alegre ML, Henriksen KJ, Thompson CB, Bluestone JA. CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo. J Immunol. 2003 Feb 01; 170(3):1510-6. PMID: 12538715.
      Citations: 11     Fields:    Translation:AnimalsCells
    180. Zhou P, Hwang KW, Palucki DA, Guo Z, Boothby M, Newell KA, Alegre ML. Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts. Am J Transplant. 2003 Feb; 3(2):139-47. PMID: 12603209.
      Citations: 15     Fields:    Translation:AnimalsCells
    181. Harlin H, Podack E, Boothby M, Alegre ML, Harlin H, Podack E, Boothby M, Alegre ML. TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism. J Immunol. 2002 Sep 01; 169(5):2451-9. PMID: 12193714.
      Citations: 18     Fields:    Translation:AnimalsCells
    182. Utset TO, Auger JA, Peace D, Zivin RA, Xu D, Jolliffe L, Alegre ML, Bluestone JA, Clark MR. Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial. J Rheumatol. 2002 Sep; 29(9):1907-13. PMID: 12233885.
      Citations: 35     Fields:    Translation:HumansCTClinical Trials
    183. Harlin H, Hwang KW, Palucki DA, Kim O, Thompson CB, Boothby M, Alegre ML. CTLA-4 engagement regulates NF-kappaB activation in vivo. Eur J Immunol. 2002 Aug; 32(8):2095-104. PMID: 12209621.
      Citations: 13     Fields:    Translation:AnimalsCells
    184. Hwang KW, Sweatt WB, Brown IE, Blank C, Gajewski TF, Bluestone JA, Alegre ML. Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells. J Immunol. 2002 Jul 15; 169(2):633-7. PMID: 12097362.
      Citations: 8     Fields:    Translation:AnimalsCells
    185. Alegre ML, Frauwirth KA, Thompson CB. T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol. 2001 Dec; 1(3):220-8. PMID: 11905831.
      Citations: 287     Fields:    Translation:HumansAnimalsCells
    186. Guo Z, Meng L, Kim O, Wang J, Hart J, He G, Alegre ML, Thistlethwaite JR, Pearson TC, Larsen CP, Newell KA, Guo Z, Meng L, Kim O, Wang J, Hart J, He G, Alegre ML, Thistlethwaite JR, Pearson TC, Larsen CP, Newell KA. CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway. Transplantation. 2001 May 15; 71(9):1351-4. PMID: 11403253.
      Citations: 13     Fields:    Translation:AnimalsCells
    187. Szot GL, Zhou P, Rulifson I, Wang J, Guo Z, Kim O, Newel KA, Thistlethwaite JR, Bluestone JA, Alegre ML. Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice. Am J Transplant. 2001 May; 1(1):38-46. PMID: 12095035.
      Citations: 18     Fields:    Translation:AnimalsCells
    188. Gajewski TF, Fallarino F, Fields PE, Rivas F, Alegre ML. Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase. J Immunol. 2001 Mar 15; 166(6):3900-7. PMID: 11238634.
      Citations: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    189. Alegre M, Fallarino F, Zhou P, Frauwirth K, Thistlethwaite J, Newell K, Gajewski T, Bluestone J. Transplantation and the CD28/CTLA4/B7 pathway. Transplant Proc. 2001 Feb-Mar; 33(1-2):209-11. PMID: 11266782.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    190. Zhou P, Szot G, Guo Z, Kim O, He G, Wang J, Grusby M, Newell K, Thistlethwaite J, Bluestone J, Alegre M. Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig. Transplant Proc. 2001 Feb-Mar; 33(1-2):214-6. PMID: 11266784.
      Citations:    Fields:    Translation:AnimalsCells
    191. Kouki T, Sawai Y, Gardine CA, Fisfalen ME, Alegre ML, DeGroot LJ. CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease. J Immunol. 2000 Dec 01; 165(11):6606-11. PMID: 11086105.
      Citations: 131     Fields:    Translation:Cells
    192. Zhou P, Szot GL, Guo Z, Kim O, He G, Wang J, Grusby MJ, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol. 2000 Nov 15; 165(10):5580-7. PMID: 11067913.
      Citations: 16     Fields:    Translation:AnimalsCells
    193. Alegre ML. Costimulatory molecules as targets for the induction of transplantation tolerance. Nephrol Dial Transplant. 1999 Feb; 14(2):322-32. PMID: 10069184.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    194. Chuang E, Lee KM, Robbins MD, Duerr JM, Alegre ML, Hambor JE, Neveu MJ, Bluestone JA, Thompson CB. Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. J Immunol. 1999 Feb 01; 162(3):1270-7. PMID: 9973379.
      Citations: 35     Fields:    Translation:HumansCells
    195. Alegre ML, Shiels H, Thompson CB, Gajewski TF. Expression and function of CTLA-4 in Th1 and Th2 cells. J Immunol. 1998 Oct 01; 161(7):3347-56. PMID: 9759851.
      Citations: 51     Fields:    Translation:AnimalsCells
    196. Noel PJ, Alegre ML, Reiner SL, Thompson CB. Impaired negative selection in CD28-deficient mice. Cell Immunol. 1998 Aug 01; 187(2):131-8. PMID: 9732701.
      Citations: 13     Fields:    Translation:AnimalsCells
    197. Lin H, Rathmell JC, Gray GS, Thompson CB, Leiden JM, Alegre ML. Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. J Exp Med. 1998 Jul 06; 188(1):199-204. PMID: 9653096; PMCID: PMC2525553.
      Citations: 42     Fields:    Translation:AnimalsCells
    198. Mandal M, Chen XR, Alegre ML, Chiu NM, Chen YH, Wang CR, Castaño AR. Tissue distribution, regulation and intracellular localization of murine CD1 molecules. Mol Immunol. 1998 Jun; 35(9):525-36. PMID: 9809580.
      Citations: 28     Fields:    Translation:AnimalsCells
    199. Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J Immunol. 1997 Jul 01; 159(1):144-51. PMID: 9200449.
      Citations: 70     Fields:    Translation:HumansCells
    200. Alegre ML, Noel PJ, Eisfelder BJ, Chuang E, Clark MR, Reiner SL, Thompson CB. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J Immunol. 1996 Dec 01; 157(11):4762-70. PMID: 8943377.
      Citations: 104     Fields:    Translation:AnimalsCells
    201. Cozzi PJ, Padrid P, Tompkins MB, Alegre ML, Takeda J, Leff AR. Bioactivity of recombinant feline interleukin-2 on human and feline leukocytes. Vet Immunol Immunopathol. 1995 Sep; 48(1-2):27-33. PMID: 8533314.
      Citations:    Fields:    Translation:HumansAnimalsCells
    202. Alegre ML, Tso JY, Sattar HA, Smith J, Desalle F, Cole M, Bluestone JA. An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity. J Immunol. 1995 Aug 01; 155(3):1544-55. PMID: 7636216.
      Citations: 33     Fields:    Translation:AnimalsCells
    203. Alegre ML, Lenschow DJ, Bluestone JA. Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors. Dig Dis Sci. 1995 Jan; 40(1):58-64. PMID: 7821120.
      Citations: 1     Fields:    Translation:Humans
    204. Alegre ML, Peterson LJ, Jeyarajah DR, Weiser M, Bluestone JA, Thistlethwaite JR. Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts. J Immunol. 1994 Sep 15; 153(6):2738-49. PMID: 8077678.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    205. Alegre ML, Sattar HA, Herold KC, Smith J, Tepper MA, Bluestone JA. Prevention of the humoral response induced by an anti-CD3 monoclonal antibody by deoxyspergualin in a murine model. Transplantation. 1994 Jun 27; 57(12):1786-94. PMID: 8016885.
      Citations: 3     Fields:    Translation:HumansAnimalsPHPublic Health
    206. Alegre ML, Peterson LJ, Xu D, Sattar HA, Jeyarajah DR, Kowalkowski K, Thistlethwaite JR, Zivin RA, Jolliffe L, Bluestone JA. A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo. Transplantation. 1994 Jun 15; 57(11):1537-43. PMID: 8009586.
      Citations: 42     Fields:    Translation:HumansAnimals
    207. Cozzi PJ, Padrid PA, Takeda J, Alegre ML, Yuhki N, Leff AR. Sequence and functional characterization of feline interleukin 2. Biochem Biophys Res Commun. 1993 Aug 16; 194(3):1038-43. PMID: 8352761.
      Citations: 2     Fields:    Translation:AnimalsCells
    208. Alegre ML, Collins AM, Pulito VL, Brosius RA, Olson WC, Zivin RA, Knowles R, Thistlethwaite JR, Jolliffe LK, Bluestone JA. Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody. J Immunol. 1992 Jun 01; 148(11):3461-8. PMID: 1534096.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    209. Woodle ES, Thistlethwaite JR, Jolliffe LK, Zivin RA, Collins A, Adair JR, Bodmer M, Athwal D, Alegre ML, Bluestone JA. Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression. J Immunol. 1992 May 01; 148(9):2756-63. PMID: 1533410.
      Citations: 17     Fields:    Translation:HumansCells
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