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Maria-Luisa Alegre

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Rheumatology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.


    Collapse Biography 
    Collapse education and training
    Universite Libre de Bruxelles, Brussels, BelgiumMD06/1985Medicine
    University of Chicago, Chicago, IllinoisPhD08/1993Immunology
    Universite Libre de Bruxelles, Brussels, BelgiumPhD06/1994Medical Sciences
    Collapse awards and honors
    2019Established Investigator Award, American Society of Transplantation
    2018Paul S. Russell Visiting Professor, Massachussetts General Hospital and Harvard Medical School
    2011Basic Science Investigator Award, American Society of Transplantation
    2008Leif B. Sorenson Faculty Research Award, The University of Chicago
    2005Basic Science Career Development Award, American Society of Transplantation
    1994Best PhD Dissertation, The University of Chicago
    1994Intensive Care Competence Summa Cum Laude, Universite Libre de Bruxelles
    1985MD Summa Cum Laude, Universite Libre de Bruxelles

    Collapse Research 
    Collapse research activities and funding
    P01AI097113     (ALEGRE, MARIA-LUISA)Jul 17, 2012 - Jun 30, 2022
    NIH
    Infections and the Stability of Transplantation Tolerance
    Role: Principal Investigator

    R01AI115716     (ALEGRE, MARIA-LUISA)Nov 3, 2014 - Oct 31, 2019
    NIH
    Impact of Microbiota on Alloimmune Responses in Transplantation
    Role: Principal Investigator

    U01AI132898     (TULLIUS, STEFAN GUNTHER)Jul 1, 2017 - Jun 30, 2022
    NIH
    The microbiota and allograft rejection: novel investigations into the consequences of obesity
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Sepulveda M, Pirozzolo I, Alegre ML. Impact of the microbiota on solid organ transplant rejection. Curr Opin Organ Transplant. 2019 Dec; 24(6):679-686. PMID: 31577594.
      View in: PubMed
    2. Miller ML, McIntosh CM, Wang Y, Chen L, Wang P, Lei YM, Daniels MD, Watkins E, Mora Solano C, Chong AS, Alegre ML. Resilience of T cell-intrinsic dysfunction in transplantation tolerance. Proc Natl Acad Sci U S A. 2019 Nov 19; 116(47):23682-23690. PMID: 31685610.
      View in: PubMed
    3. Alegre ML. DeTOXifying exhausted T cells. Am J Transplant. 2019 Nov; 19(11):2965. PMID: 31742914.
      View in: PubMed
    4. Alegre ML. Innate lymphoid cells coming of age. Am J Transplant. 2019 Oct; 19(10):2669. PMID: 31557416.
      View in: PubMed
    5. Alegre ML. Fibroblasts can have subsets too! Am J Transplant. 2019 Sep; 19(9):2397. PMID: 31454175.
      View in: PubMed
    6. McIntosh CM, Alegre ML. Teamwork by IL-10+ and IL-35+ Tregs. Am J Transplant. 2019 Aug; 19(8):2147. PMID: 31343849.
      View in: PubMed
    7. Lei YM, Sepulveda M, Chen L, Wang Y, Pirozzolo I, Theriault B, Chong AS, Belkaid Y, Alegre ML. Skin-restricted commensal colonization accelerates skin graft rejection. JCI Insight. 2019 Jul 16; 5. PMID: 31310590.
      View in: PubMed
    8. Alegre ML. Lymph node segregation for tolerance or inflammation. Am J Transplant. 2019 Jul; 19(7):1873. PMID: 31233678.
      View in: PubMed
    9. Alegre ML. Neuroimmunology and the control of T cell migration. Am J Transplant. 2019 Jun; 19(6):1605. PMID: 31136699.
      View in: PubMed
    10. Alegre ML. Mouse microbiomes: overlooked culprits of experimental variability. Genome Biol. 2019 05 29; 20(1):108. PMID: 31142368.
      View in: PubMed
    11. Sepulveda M, Alegre ML. Harnessing the commensal microbiota to improve immune responses. Am J Transplant. 2019 May; 19(5):1257. PMID: 31018049.
      View in: PubMed
    12. Azzi J, Alegre ML. Outstanding questions in transplantation: An introduction to this minireview series. Am J Transplant. 2019 Aug; 19(8):2149-2150. PMID: 30903734.
      View in: PubMed
    13. Alegre ML. Treg Respiration. Am J Transplant. 2019 Apr; 19(4):969. PMID: 30908828.
      View in: PubMed
    14. Rael VE, Chen L, McIntosh CM, Alegre ML. Exercise increases skin graft resistance to rejection. Am J Transplant. 2019 May; 19(5):1560-1567. PMID: 30659772.
      View in: PubMed
    15. Alegre ML. A New Ligand for LAG-3. Am J Transplant. 2019 Mar; 19(3):617. PMID: 30802371.
      View in: PubMed
    16. Gupta PK, McIntosh CM, Chong AS, Alegre ML. The pursuit of transplantation tolerance: new mechanistic insights. Cell Mol Immunol. 2019 Apr; 16(4):324-333. PMID: 30760917.
      View in: PubMed
    17. Rigat F, Bartolini E, Dalsass M, Kumar N, Marchi S, Speziale P, Maione D, Chen L, Romano MR, Alegre ML, Bagnoli F, Daum RS, David MZ. Retrospective Identification of a Broad IgG Repertoire Differentiating Patients With S. aureus Skin and Soft Tissue Infections From Controls. Front Immunol. 2019; 10:114. PMID: 30792711.
      View in: PubMed
    18. Alegre ML. A molecular pathway for indirect presentation? Am J Transplant. 2019 Feb; 19(2):311. PMID: 30690908.
      View in: PubMed
    19. Alegre ML. B cells, CMV, and stem cell transplant. Science. 2019 01 18; 363(6424):232-233. PMID: 30655432.
      View in: PubMed
    20. Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson MS, August A, Marson A, Zheng Y, Williams CB, Farrar MA. Thymic regulatory T cells arise via two distinct developmental programs. Nat Immunol. 2019 02; 20(2):195-205. PMID: 30643267.
      View in: PubMed
    21. Wu Q, Turturice B, Wagner S, Huang Y, Gupta PK, Schott C, Metwally A, Ranjan R, Perkins D, Alegre ML, Finn P, Budinger GRS, Shilling R, Bharat A. Gut Microbiota Can Impact Chronic Murine Lung Allograft Rejection. Am J Respir Cell Mol Biol. 2019 01; 60(1):131-134. PMID: 30592445.
      View in: PubMed
    22. Alegre ML. The Importance of Inflammation-induced NETS. Am J Transplant. 2019 Jan; 19(1):3. PMID: 30592568.
      View in: PubMed
    23. Gupta PK, Alegre ML. Th17 Cells Changing Colors. Am J Transplant. 2018 Dec; 18(12):2841. PMID: 30476364.
      View in: PubMed
    24. Alegre ML. Creating a Niche. Am J Transplant. 2018 Nov; 18(11):2617. PMID: 30372597.
      View in: PubMed
    25. Alegre ML. Danger, Metabolism and T Cell Memory. Am J Transplant. 2018 Oct; 18(10):2375. PMID: 30261133.
      View in: PubMed
    26. Alegre ML. The Adaptive NK Cell Response. Am J Transplant. 2018 Sep; 18(9):2105. PMID: 30161299.
      View in: PubMed
    27. Miller ML, McIntosh CM, Williams JB, Wang Y, Hollinger MK, Isaad NJ, Moon JJ, Gajewski TF, Chong AS, Alegre ML. Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance. Cell Rep. 2018 08 21; 24(8):2112-2126. PMID: 30134172.
      View in: PubMed
    28. Mcintosh CM, Alegre ML. Metabolic Control of T Cell Memory. Am J Transplant. 2018 Aug; 18(8):1835. PMID: 30134007.
      View in: PubMed
    29. Alegre ML. Preventing PTLD? Am J Transplant. 2018 Jul; 18(7):1583. PMID: 29979834.
      View in: PubMed
    30. Young JS, Yin D, Vannier AGL, Alegre ML, Chong AS. Equal Expansion of Endogenous Transplant-Specific Regulatory T Cell and Recruitment Into the Allograft During Rejection and Tolerance. Front Immunol. 2018; 9:1385. PMID: 29973932.
      View in: PubMed
    31. Alegre ML. A Cause for Leaky Guts. Am J Transplant. 2018 Jun; 18(6):1299. PMID: 29878639.
      View in: PubMed
    32. McIntosh CM, Chen L, Shaiber A, Eren AM, Alegre ML. Gut microbes contribute to variation in solid organ transplant outcomes in mice. Microbiome. 2018 05 25; 6(1):96. PMID: 29793539.
      View in: PubMed
    33. Alegre ML. Immune Regulation of Lung Fibrosis. Am J Transplant. 2018 May; 18(5):1039. PMID: 29677392.
      View in: PubMed
    34. Tu E, Chia CPZ, Chen W, Zhang D, Park SA, Jin W, Wang D, Alegre ML, Zhang YE, Sun L, Chen W. T Cell Receptor-Regulated TGF-ß Type I Receptor Expression Determines T Cell Quiescence and Activation. Immunity. 2018 04 17; 48(4):745-759.e6. PMID: 29669252.
      View in: PubMed
    35. Alegre ML. Sweet T Cell Dysfunction. Am J Transplant. 2018 Apr; 18(4):775. PMID: 29603604.
      View in: PubMed
    36. Alegre ML. Mind the GAP, for Tolerance to Gut Bacteria. Am J Transplant. 2018 Mar; 18(3):533. PMID: 29462513.
      View in: PubMed
    37. Alegre ML. What's new in transplantation tolerance? Curr Opin Organ Transplant. 2018 02; 23(1):63-65. PMID: 29189414.
      View in: PubMed
    38. Alegre ML. DC Metabolism Controls Lung T Cell Polarization. Am J Transplant. 2018 02; 18(2):285. PMID: 29381270.
      View in: PubMed
    39. Matson V, Fessler J, Bao R, Chongsuwat T, Zha Y, Alegre ML, Luke JJ, Gajewski TF. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science. 2018 01 05; 359(6371):104-108. PMID: 29302014.
      View in: PubMed
    40. Riella LV, Alegre ML. Novel Role of Calcineurin Inhibitors in Curbing T Cells' Sweet Tooth. Am J Transplant. 2018 Jan; 18(1):3. PMID: 29267999.
      View in: PubMed
    41. Alegre ML. Stealing Tregs' Identity (by Deleting NF-?B). Am J Transplant. 2017 Dec; 17(12):2997. PMID: 29145695.
      View in: PubMed
    42. Young JS, McIntosh C, Alegre ML, Chong AS. Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans. Transplantation. 2017 11; 101(11):2671-2681. PMID: 28604446.
      View in: PubMed
    43. Alegre ML. Making Therapeutic Antibodies in Vitro. Am J Transplant. 2017 Nov; 17(11):2753. PMID: 29083551.
      View in: PubMed
    44. Miller ML, Chong AS, Alegre ML. Fifty Shades of Tolerance: Beyond a Binary Tolerant/Non-Tolerant Paradigm. Curr Transplant Rep. 2017 Dec; 4(4):262-269. PMID: 31098340.
      View in: PubMed
    45. Alegre ML. Predicting TCR specificity? Am J Transplant. 2017 Oct; 17(10):2501. PMID: 28960937.
      View in: PubMed
    46. Young JS, Khiew SH, Yang J, Vannier A, Yin D, Sciammas R, Alegre ML, Chong AS. Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice. Front Immunol. 2017; 8:1169. PMID: 28970838.
      View in: PubMed
    47. Azzi J, Raimondi G, Mas V, Riella LV, Elfadawy N, Safa K, Wojciechowski D, Kanak M, Nog R, Maltzman JS, Ford ML, Pober JS, Luo XR, Rothstein D, Miller ML, Matthews D, Burlingham W, Levings M, Heeger P, Higdon L, Gill J, Gill RG, Alegre ML. The outstanding questions in transplantation: It's about time…. Am J Transplant. 2018 01; 18(1):271-272. PMID: 28758364.
      View in: PubMed
    48. Alegre ML. The Unbearable Lightness of Breathing. Am J Transplant. 2017 Sep; 17(9):2233. PMID: 28846838.
      View in: PubMed
    49. Alegre ML. Immune-Electrical Connection. Am J Transplant. 2017 Aug; 17(8):1965. PMID: 28724207.
      View in: PubMed
    50. Alegre ML. The Bugs That Keep Us Safe. Am J Transplant. 2017 Jul; 17(7):1699. PMID: 28658537.
      View in: PubMed
    51. Alegre ML. Timing Is Everything. Am J Transplant. 2017 Jun; 17(6):1433. PMID: 28544282.
      View in: PubMed
    52. Riella LV, Bagley J, Iacomini J, Alegre ML. Impact of environmental factors on alloimmunity and transplant fate. J Clin Invest. 2017 Jun 30; 127(7):2482-2491. PMID: 28481225.
      View in: PubMed
    53. Khiew SH, Yang J, Young JS, Chen J, Wang Q, Yin D, Vu V, Miller ML, Sciammas R, Alegre ML, Chong AS. CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients. JCI Insight. 2017 May 04; 2(9). PMID: 28469082.
      View in: PubMed
    54. Alegre ML. Anti-Inflammatory Effects of Nonprofessional Phagocyte. Am J Transplant. 2017 May; 17(5):1151. PMID: 28453227.
      View in: PubMed
    55. Alegre ML. The Tpm Subset of the CD8+ T Cell Memory Family. Am J Transplant. 2017 Apr; 17(4):849. PMID: 28371536.
      View in: PubMed
    56. Alegre ML. Dendritic Cell Identification for Dummies. Am J Transplant. 2017 Mar; 17(3):593. PMID: 28240828.
      View in: PubMed
    57. Alegre ML. The Multiple Molecular Paths of Antibody Suppression by TFR Cells. Am J Transplant. 2017 Feb; 17(2):311. PMID: 28122170.
      View in: PubMed
    58. Miller ML, Alegre ML, Chong AS. Transplantation tolerance after allograft rejection. Curr Opin Organ Transplant. 2017 Feb; 22(1):64-70. PMID: 27898463.
      View in: PubMed
    59. Miller ML, Alegre ML. Super-MANF to the Rescue: Immunomodulation Improves Retinal Repair and Regenerative Cell Therapy. Am J Transplant. 2017 Jan; 17(1):3. PMID: 28029735.
      View in: PubMed
    60. Alegre ML. Ionic Checkpoint: Potassium-Driven T Cell Immunosuppression. Am J Transplant. 2016 Dec; 16(12):3313. PMID: 28267261.
      View in: PubMed
    61. Alegre ML, Lakkis FG, Morelli AE. Antigen Presentation in Transplantation. Trends Immunol. 2016 12; 37(12):831-843. PMID: 27743777.
      View in: PubMed
    62. Alegre ML. Select Effects of IL-13 in Driving Tissue Repair and Fibrosis. Am J Transplant. 2016 Oct; 16(10):2771. PMID: 28497904.
      View in: PubMed
    63. Alegre ML. Standardizing Mouse Models to Account for Host-Microbial Interactions. Am J Transplant. 2016 Sep; 16(9):2503. PMID: 27575723.
      View in: PubMed
    64. Young JS, Daniels MD, Miller ML, Wang T, Zhong R, Yin D, Alegre ML, Chong AS. Erosion of Transplantation Tolerance After Infection. Am J Transplant. 2017 01; 17(1):81-90. PMID: 27273890.
      View in: PubMed
    65. Alegre ML, Chen L, David MZ, Bartman C, Boyle-Vavra S, Kumar N, Chong AS, Daum RS. Impact of Staphylococcus aureus USA300 Colonization and Skin Infections on Systemic Immune Responses in Humans. J Immunol. 2016 08 15; 197(4):1118-26. PMID: 27402695.
      View in: PubMed
    66. Lei YM, Chen L, Wang Y, Stefka AT, Molinero LL, Theriault B, Aquino-Michaels K, Sivan AS, Nagler CR, Gajewski TF, Chong AS, Bartman C, Alegre ML. The composition of the microbiota modulates allograft rejection. J Clin Invest. 2016 07 01; 126(7):2736-44. PMID: 27322054.
      View in: PubMed
    67. Arina A, Idel C, Hyjek EM, Alegre ML, Wang Y, Bindokas VP, Weichselbaum RR, Schreiber H. Tumor-associated fibroblasts predominantly come from local and not circulating precursors. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7551-6. PMID: 27317748.
      View in: PubMed
    68. Miller ML, Chen J, Daniels MD, McKeague MG, Wang Y, Yin D, Vu V, Chong AS, Alegre ML. Adoptive Transfer of Tracer-Alloreactive CD4+ T Cell Receptor Transgenic T Cells Alters the Endogenous Immune Response to an Allograft. Am J Transplant. 2016 10; 16(10):2842-2853. PMID: 27063351.
      View in: PubMed
    69. Miller ML, Daniels MD, Wang T, Wang Y, Xu J, Yin D, Chong AS, Alegre ML. Tracking of TCR-Transgenic T Cells Reveals That Multiple Mechanisms Maintain Cardiac Transplant Tolerance in Mice. Am J Transplant. 2016 10; 16(10):2854-2864. PMID: 27091509.
      View in: PubMed
    70. Molinero LL, Yin D, Lei YM, Chen L, Wang Y, Chong AS, Alegre ML. High-Fat Diet-Induced Obesity Enhances Allograft Rejection. Transplantation. 2016 05; 100(5):1015-21. PMID: 27007226.
      View in: PubMed
    71. Young JS, Chen J, Miller ML, Vu V, Tian C, Moon JJ, Alegre ML, Sciammas R, Chong AS. Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection. Am J Transplant. 2016 08; 16(8):2312-23. PMID: 26928966.
      View in: PubMed
    72. Alegre ML, Gajewski TF. Germ Warfare. Sci Am. 2016 Apr; 314(4):50. PMID: 27082192.
      View in: PubMed
    73. Evaristo C, Spranger S, Barnes SE, Miller ML, Molinero LL, Locke FL, Gajewski TF, Alegre ML. Cutting Edge: Engineering Active IKKß in T Cells Drives Tumor Rejection. J Immunol. 2016 Apr 01; 196(7):2933-8. PMID: 26903482.
      View in: PubMed
    74. Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre ML, Chang EB, Gajewski TF. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. 2015 Nov 27; 350(6264):1084-9. PMID: 26541606.
      View in: PubMed
    75. Theriault B, Wang Y, Chen L, Vest A, Bartman C, Alegre ML. Long-term Maintenance of Sterility Following Skin Transplantation in Germ-free Mice. Transplant Direct. 2015 Sep; 1(8). PMID: 26609546.
      View in: PubMed
    76. Zhao F, Cheng BL, Boyle-Vavra S, Alegre ML, Daum RS, Chong AS, Montgomery CP. Proteomic Identification of saeRS-Dependent Targets Critical for Protective Humoral Immunity against Staphylococcus aureus Skin Infection. Infect Immun. 2015 Sep; 83(9):3712-21. PMID: 26169277.
      View in: PubMed
    77. Miller ML, Daniels MD, Wang T, Chen J, Young J, Xu J, Wang Y, Yin D, Vu V, Husain AN, Alegre ML, Chong AS. Spontaneous restoration of transplantation tolerance after acute rejection. Nat Commun. 2015 Jul 07; 6:7566. PMID: 26151823.
      View in: PubMed
    78. Xu Y, Evaristo C, Alegre ML, Gurbuxani S, Kee BL. Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage. PLoS One. 2015; 10(4):e0125211. PMID: 25923440.
      View in: PubMed
    79. Bartman C, Chong AS, Alegre ML. The influence of the microbiota on the immune response to transplantation. Curr Opin Organ Transplant. 2015 Feb; 20(1):1-7. PMID: 25563985.
      View in: PubMed
    80. Alegre ML. I spy alloreactive T cells. Sci Transl Med. 2015 Jan 28; 7(272):272fs3. PMID: 25632032.
      View in: PubMed
    81. Barnes SE, Wang Y, Chen L, Molinero LL, Gajewski TF, Evaristo C, Alegre ML. T cell-NF-?B activation is required for tumor control in vivo. J Immunother Cancer. 2015; 3(1):1. PMID: 25648675.
      View in: PubMed
    82. Lei YM, Nair L, Alegre ML. The interplay between the intestinal microbiota and the immune system. Clin Res Hepatol Gastroenterol. 2015 Feb; 39(1):9-19. PMID: 25481240.
      View in: PubMed
    83. Woo SR, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MY, Duggan R, Wang Y, Barber GN, Fitzgerald KA, Alegre ML, Gajewski TF. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity. 2014 Nov 20; 41(5):830-42. PMID: 25517615.
      View in: PubMed
    84. Alegre ML, Mannon RB, Mannon PJ. The microbiota, the immune system and the allograft. Am J Transplant. 2014 Jun; 14(6):1236-48. PMID: 24840316.
      View in: PubMed
    85. Miller ML, Mashayekhi M, Chen L, Zhou P, Liu X, Michelotti M, Tramontini Gunn N, Powers S, Zhu X, Evaristo C, Alegre ML, Molinero LL. Basal NF-?B controls IL-7 responsiveness of quiescent naïve T cells. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7397-402. PMID: 24799710.
      View in: PubMed
    86. Montgomery CP, Daniels M, Zhao F, Alegre ML, Chong AS, Daum RS. Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A. Infect Immun. 2014 May; 82(5):2125-34. PMID: 24614654.
      View in: PubMed
    87. Chong AS, Alegre ML. Transplantation tolerance and its outcome during infections and inflammation. Immunol Rev. 2014 Mar; 258(1):80-101. PMID: 24517427.
      View in: PubMed
    88. Alegre ML, Bartman C, Chong AS. Microbes and allogeneic transplantation. Transplantation. 2014 Jan 15; 97(1):5-11. PMID: 23903013.
      View in: PubMed
    89. Chong AS, Alegre ML, Miller ML, Fairchild RL. Lessons and limits of mouse models. Cold Spring Harb Perspect Med. 2013 Dec 01; 3(12):a015495. PMID: 24296351.
      View in: PubMed
    90. Evaristo C, Alegre ML. IFN-?: The Dr. Jekyll and Mr. Hyde of immunology? Am J Transplant. 2013 Dec; 13(12):3057-8. PMID: 24148260.
      View in: PubMed
    91. Molinero LL, Cubre A, Mora-Solano C, Wang Y, Alegre ML. T cell receptor/CARMA1/NF-?B signaling controls T-helper (Th) 17 differentiation. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18529-34. PMID: 23091043.
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    92. Alegre ML, Bromberg JS, Bromberg JS. Commensal microbiota determine intestinal iTreg. Am J Transplant. 2012 Aug; 12(8):1967. PMID: 22845904.
      View in: PubMed
    93. Alegre ML, Molinero LL. The inside story of dendritic cell immunotherapy. Am J Transplant. 2012 Jun; 12(6):1363-4. PMID: 22642470.
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    94. Porras DL, Wang Y, Zhou P, Molinero LL, Alegre ML. Role of T-cell-specific nuclear factor ?B in islet allograft rejection. Transplantation. 2012 May 27; 93(10):976-82. PMID: 22437847.
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    95. Chong AS, Alegre ML. The impact of infection and tissue damage in solid-organ transplantation. Nat Rev Immunol. 2012 May 25; 12(6):459-71. PMID: 22627862.
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    96. Alegre ML, Bromberg JS. Literature watch implications for transplantation. The anti-infectious role of the IL-17 pathway. Am J Transplant. 2012 Jan; 12(1):3. PMID: 22244121.
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    97. Alegre ML, Chong AS. "Tip-toeing" to an assay for transplantation tolerance? Am J Transplant. 2012 Mar; 12(3):519-20. PMID: 22151375.
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    98. Alegre ML, Fu YX. Attenuation by targeting the B- and T-cell attenuator. Transplantation. 2011 Nov 27; 92(10):1075-6. PMID: 21956204.
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    99. Molinero LL, Alegre ML. Role of T cell-nuclear factor ?B in transplantation. Transplant Rev (Orlando). 2012 Jul; 26(3):189-200. PMID: 22074783.
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    100. Ahmed EB, Wang T, Daniels M, Alegre ML, Chong AS. IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice. Am J Transplant. 2011 May; 11(5):936-46. PMID: 21449942.
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    101. Molinero LL, Miller ML, Evaristo C, Alegre ML. High TCR stimuli prevent induced regulatory T cell differentiation in a NF-?B-dependent manner. J Immunol. 2011 Apr 15; 186(8):4609-17. PMID: 21411734.
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    102. Ahmed EB, Daniels M, Alegre ML, Chong AS. Bacterial infections, alloimmunity, and transplantation tolerance. Transplant Rev (Orlando). 2011 Jan; 25(1):27-35. PMID: 21126661.
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    103. Bhorade SM, Chen H, Molinero L, Liao C, Garrity ER, Vigneswaran WT, Shilling R, Sperling A, Chong A, Alegre ML. Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome. Transplantation. 2010 Sep 15; 90(5):540-6. PMID: 20628341.
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    104. Wang T, Ahmed EB, Chen L, Xu J, Tao J, Wang CR, Alegre ML, Chong AS. Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model. Am J Transplant. 2010 Jul; 10(7):1524-33. PMID: 20642679.
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    105. Sweiss NJ, Salloum R, Gandhi S, Ghandi S, Alegre ML, Sawaqed R, Badaracco M, Pursell K, Pitrak D, Baughman RP, Moller DR, Garcia JG, Niewold TB. Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations. PLoS One. 2010 Feb 05; 5(2):e9088. PMID: 20140091.
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    106. Molinero LL, Yang J, Gajewski T, Abraham C, Farrar MA, Alegre ML. CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells. J Immunol. 2009 Jun 01; 182(11):6736-43. PMID: 19454668.
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    107. Alegre ML, Chong A. Toll-like receptors (TLRs) in transplantation. Front Biosci (Elite Ed). 2009 Jun 01; 1:36-43. PMID: 19482622.
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    108. Chen L, Ahmed E, Wang T, Wang Y, Ochando J, Chong AS, Alegre ML. TLR signals promote IL-6/IL-17-dependent transplant rejection. J Immunol. 2009 May 15; 182(10):6217-25. PMID: 19414775.
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    109. Alegre ML, Chen L, Wang T, Ahmed E, Wang CR, Chong A. Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance. Transplantation. 2009 May 15; 87(9 Suppl):S77-9. PMID: 19424015.
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    110. Molinero LL, Wang Y, Zhou P, Yagita H, Alegre ML. Fas mediates cardiac allograft acceptance in mice with impaired T-cell-intrinsic NF-kappaB signaling. Transpl Int. 2009 Aug; 22(8):845-52. PMID: 19351347.
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    111. O'Neill SK, Veselits ML, Zhang M, Labno C, Cao Y, Finnegan A, Uccellini M, Alegre ML, Cambier JC, Clark MR. Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6262-7. PMID: 19332776.
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    112. Zimmer MI, Nguyen HP, Wang B, Xu H, Colmone A, Felio K, Choi HJ, Zhou P, Alegre ML, Wang CR. Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1909-14. PMID: 19179286.
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    113. Song J, Volkov S, Shea CR, Alegre ML, Salgia R, Gregg K, Curran JJ, Woodruff J, Krausz T, Levine JS, Sweiss NJ. Nephrogenic systemic fibrosis associated with stromal and vascular calcification, report of two cases. J Cutan Pathol. 2009 Oct; 36 Suppl 1:31-4. PMID: 19210585.
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    114. Alegre ML, Goldstein DR, Chong AS. Toll-like receptor signaling in transplantation. Curr Opin Organ Transplant. 2008 Aug; 13(4):358-65. PMID: 18685330.
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    115. Alegre ML, Leemans J, Le Moine A, Florquin S, De Wilde V, Chong A, Goldman M. The multiple facets of toll-like receptors in transplantation biology. Transplantation. 2008 Jul 15; 86(1):1-9. PMID: 18622268.
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    116. Wang T, Chen L, Ahmed E, Ma L, Yin D, Zhou P, Shen J, Xu H, Wang CR, Alegre ML, Chong AS. Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes. J Immunol. 2008 May 01; 180(9):5991-9. PMID: 18424719.
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    117. Ahmed EB, Alegre ML, Chong AS. Role of bacterial infections in allograft rejection. Expert Rev Clin Immunol. 2008 Mar; 4(2):281-93. PMID: 20477057.
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    118. Qiao G, Li Z, Molinero L, Alegre ML, Ying H, Sun Z, Penninger JM, Zhang J. T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol Cell Biol. 2008 Apr; 28(7):2470-80. PMID: 18227156.
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    119. Chen L, Hussien Y, Hwang KW, Wang Y, Zhou P, Alegre ML. Overexpression of program death-1 in T cells has mild impact on allograft survival. Transpl Int. 2008 Jan; 21(1):21-9. PMID: 18076633.
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    120. Molinero LL, Zhou P, Wang Y, Harlin H, Kee B, Abraham C, Alegre ML. Epidermal Langerhans cells promote skin allograft rejection in mice with NF-kappa B-impaired T cells. Am J Transplant. 2008 Jan; 8(1):21-31. PMID: 18021281.
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    121. Alegre ML, Florquin S, Goldman M. Cellular mechanisms underlying acute graft rejection: time for reassessment. Curr Opin Immunol. 2007 Oct; 19(5):563-8. PMID: 17720467.
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    122. Alegre ML, McNerney ME. Natural killer cell subsets in allograft rejection and tolerance. Curr Opin Organ Transplant. 2007 Feb; 12(1):10-16. PMID: 27792083.
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    123. Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, Thompson B, Spaulding C, Macaroun S, Alegre ML, Kee BL, Ferrando A, Miele L, Aifantis I. Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med. 2007 Jan; 13(1):70-7. PMID: 17173050.
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    124. Alegre ML, Najafian N. Costimulatory molecules as targets for the induction of transplantation tolerance. Curr Mol Med. 2006 Dec; 6(8):843-57. PMID: 17168736.
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    125. Chen L, Wang T, Zhou P, Ma L, Yin D, Shen J, Molinero L, Nozaki T, Phillips T, Uematsu S, Akira S, Wang CR, Fairchild RL, Alegre ML, Chong A. TLR engagement prevents transplantation tolerance. Am J Transplant. 2006 Oct; 6(10):2282-91. PMID: 16970798.
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    126. McNerney ME, Lee KM, Zhou P, Molinero L, Mashayekhi M, Guzior D, Sattar H, Kuppireddi S, Wang CR, Kumar V, Alegre ML. Role of natural killer cell subsets in cardiac allograft rejection. Am J Transplant. 2006 Mar; 6(3):505-13. PMID: 16468959.
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    127. Alegre ML, Fallarino F. Mechanisms of CTLA-4-Ig in tolerance induction. Curr Pharm Des. 2006; 12(2):149-60. PMID: 16454732.
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    128. Lo JC, Basak S, James ES, Quiambo RS, Kinsella MC, Alegre ML, Weih F, Franzoso G, Hoffmann A, Fu YX. Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues. Blood. 2006 Feb 01; 107(3):1048-55. PMID: 16195333.
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    129. Zhou P, Balin SJ, Mashayekhi M, Hwang KW, Palucki DA, Alegre ML. Transplantation tolerance in NF-kappaB-impaired mice is not due to regulation but is prevented by transgenic expression of Bcl-xL. J Immunol. 2005 Mar 15; 174(6):3447-53. PMID: 15749879.
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    130. Subudhi SK, Alegre ML, Fu YX. The balance of immune responses: costimulation verse coinhibition. J Mol Med (Berl). 2005 Mar; 83(3):193-202. PMID: 15630593.
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    131. Brown IE, Mashayekhi M, Markiewicz M, Alegre ML, Gajewski TF. Peripheral survival of naïve CD8+ T cells. Apoptosis. 2005 Jan; 10(1):5-11. PMID: 15711917.
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    132. Li D, Gál I, Vermes C, Alegre ML, Chong AS, Chen L, Shao Q, Adarichev V, Xu X, Koreny T, Mikecz K, Finnegan A, Glant TT, Zhang J. Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. J Immunol. 2004 Dec 15; 173(12):7135-9. PMID: 15585834.
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    133. Hwang KW, Sweatt WB, Mashayekhi M, Palucki DA, Sattar H, Chuang E, Alegre ML. Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice. J Immunol. 2004 Nov 01; 173(9):5415-24. PMID: 15494488.
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    134. O'Keefe JP, Blaine K, Alegre ML, Gajewski TF. Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9351-6. PMID: 15192143.
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    135. Subudhi SK, Zhou P, Yerian LM, Chin RK, Lo JC, Anders RA, Sun Y, Chen L, Wang Y, Alegre ML, Fu YX. Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J Clin Invest. 2004 Mar; 113(5):694-700. PMID: 14991067.
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    136. Rivas FV, O'Keefe JP, Alegre ML, Gajewski TF. Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration. Mol Cell Biol. 2004 Feb; 24(4):1628-39. PMID: 14749378.
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    137. Fallarino F, Grohmann U, Hwang KW, Orabona C, Vacca C, Bianchi R, Belladonna ML, Fioretti MC, Alegre ML, Puccetti P. Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol. 2003 Dec; 4(12):1206-12. PMID: 14578884.
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    138. Kaufman CK, Zhou P, Pasolli HA, Rendl M, Bolotin D, Lim KC, Dai X, Alegre ML, Fuchs E. GATA-3: an unexpected regulator of cell lineage determination in skin. Genes Dev. 2003 Sep 01; 17(17):2108-22. PMID: 12923059.
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    139. Zhou P, Hwang KW, Palucki D, Kim O, Newell KA, Fu YX, Alegre ML. Secondary lymphoid organs are important but not absolutely required for allograft responses. Am J Transplant. 2003 Mar; 3(3):259-66. PMID: 12614279.
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    140. Tang Q, Smith JA, Szot GL, Zhou P, Alegre ML, Henriksen KJ, Thompson CB, Bluestone JA. CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo. J Immunol. 2003 Feb 01; 170(3):1510-6. PMID: 12538715.
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    141. Zhou P, Hwang KW, Palucki DA, Guo Z, Boothby M, Newell KA, Alegre ML. Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts. Am J Transplant. 2003 Feb; 3(2):139-47. PMID: 12603209.
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    142. Harlin H, Podack E, Boothby M, Alegre ML. TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism. J Immunol. 2002 Sep 01; 169(5):2451-9. PMID: 12193714.
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    143. Utset TO, Auger JA, Peace D, Zivin RA, Xu D, Jolliffe L, Alegre ML, Bluestone JA, Clark MR. Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial. J Rheumatol. 2002 Sep; 29(9):1907-13. PMID: 12233885.
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    144. Harlin H, Hwang KW, Palucki DA, Kim O, Thompson CB, Boothby M, Alegre ML. CTLA-4 engagement regulates NF-kappaB activation in vivo. Eur J Immunol. 2002 Aug; 32(8):2095-104. PMID: 12209621.
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    145. Hwang KW, Sweatt WB, Brown IE, Blank C, Gajewski TF, Bluestone JA, Alegre ML. Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells. J Immunol. 2002 Jul 15; 169(2):633-7. PMID: 12097362.
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    146. Alegre ML, Frauwirth KA, Thompson CB. T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol. 2001 Dec; 1(3):220-8. PMID: 11905831.
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    147. Guo Z, Meng L, Kim O, Wang J, Hart J, He G, Alegre ML, Thistlethwaite JR, Pearson TC, Larsen CP, Newell KA. CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway. Transplantation. 2001 May 15; 71(9):1351-4. PMID: 11403253.
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    148. Szot GL, Zhou P, Rulifson I, Wang J, Guo Z, Kim O, Newel KA, Thistlethwaite JR, Bluestone JA, Alegre ML. Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice. Am J Transplant. 2001 May; 1(1):38-46. PMID: 12095035.
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    149. Gajewski TF, Fallarino F, Fields PE, Rivas F, Alegre ML. Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase. J Immunol. 2001 Mar 15; 166(6):3900-7. PMID: 11238634.
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    150. Alegre M, Fallarino F, Zhou P, Frauwirth K, Thistlethwaite J, Newell K, Gajewski T, Bluestone J. Transplantation and the CD28/CTLA4/B7 pathway. Transplant Proc. 2001 Feb-Mar; 33(1-2):209-11. PMID: 11266782.
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    151. Zhou P, Szot G, Guo Z, Kim O, He G, Wang J, Grusby M, Newell K, Thistlethwaite J, Bluestone J, Alegre M. Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig. Transplant Proc. 2001 Feb-Mar; 33(1-2):214-6. PMID: 11266784.
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    152. Kouki T, Sawai Y, Gardine CA, Fisfalen ME, Alegre ML, DeGroot LJ. CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease. J Immunol. 2000 Dec 01; 165(11):6606-11. PMID: 11086105.
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    153. Zhou P, Szot GL, Guo Z, Kim O, He G, Wang J, Grusby MJ, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol. 2000 Nov 15; 165(10):5580-7. PMID: 11067913.
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    154. Chuang E, Lee KM, Robbins MD, Duerr JM, Alegre ML, Hambor JE, Neveu MJ, Bluestone JA, Thompson CB. Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. J Immunol. 1999 Feb 01; 162(3):1270-7. PMID: 9973379.
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    155. Alegre ML. Costimulatory molecules as targets for the induction of transplantation tolerance. Nephrol Dial Transplant. 1999 Feb; 14(2):322-32. PMID: 10069184.
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    156. Alegre ML, Shiels H, Thompson CB, Gajewski TF. Expression and function of CTLA-4 in Th1 and Th2 cells. J Immunol. 1998 Oct 01; 161(7):3347-56. PMID: 9759851.
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    157. Noel PJ, Alegre ML, Reiner SL, Thompson CB. Impaired negative selection in CD28-deficient mice. Cell Immunol. 1998 Aug 01; 187(2):131-8. PMID: 9732701.
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    158. Lin H, Rathmell JC, Gray GS, Thompson CB, Leiden JM, Alegre ML. Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. J Exp Med. 1998 Jul 06; 188(1):199-204. PMID: 9653096.
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    159. Mandal M, Chen XR, Alegre ML, Chiu NM, Chen YH, Castaño AR, Wang CR. Tissue distribution, regulation and intracellular localization of murine CD1 molecules. Mol Immunol. 1998 Jun; 35(9):525-36. PMID: 9809580.
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    160. Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J Immunol. 1997 Jul 01; 159(1):144-51. PMID: 9200449.
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    161. Alegre ML, Noel PJ, Eisfelder BJ, Chuang E, Clark MR, Reiner SL, Thompson CB. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J Immunol. 1996 Dec 01; 157(11):4762-70. PMID: 8943377.
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    162. Cozzi PJ, Padrid P, Tompkins MB, Alegre ML, Takeda J, Leff AR. Bioactivity of recombinant feline interleukin-2 on human and feline leukocytes. Vet Immunol Immunopathol. 1995 Sep; 48(1-2):27-33. PMID: 8533314.
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    163. Alegre ML, Tso JY, Sattar HA, Smith J, Desalle F, Cole M, Bluestone JA. An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity. J Immunol. 1995 Aug 01; 155(3):1544-55. PMID: 7636216.
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    164. Alegre ML, Lenschow DJ, Bluestone JA. Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors. Dig Dis Sci. 1995 Jan; 40(1):58-64. PMID: 7821120.
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    165. Alegre ML, Peterson LJ, Jeyarajah DR, Weiser M, Bluestone JA, Thistlethwaite JR. Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts. J Immunol. 1994 Sep 15; 153(6):2738-49. PMID: 8077678.
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    166. Alegre ML, Sattar HA, Herold KC, Smith J, Tepper MA, Bluestone JA. Prevention of the humoral response induced by an anti-CD3 monoclonal antibody by deoxyspergualin in a murine model. Transplantation. 1994 Jun 27; 57(12):1786-94. PMID: 8016885.
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    167. Alegre ML, Peterson LJ, Xu D, Sattar HA, Jeyarajah DR, Kowalkowski K, Thistlethwaite JR, Zivin RA, Jolliffe L, Bluestone JA. A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo. Transplantation. 1994 Jun 15; 57(11):1537-43. PMID: 8009586.
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    168. Cozzi PJ, Padrid PA, Takeda J, Alegre ML, Yuhki N, Leff AR. Sequence and functional characterization of feline interleukin 2. Biochem Biophys Res Commun. 1993 Aug 16; 194(3):1038-43. PMID: 8352761.
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    169. Alegre ML, Collins AM, Pulito VL, Brosius RA, Olson WC, Zivin RA, Knowles R, Thistlethwaite JR, Jolliffe LK, Bluestone JA. Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody. J Immunol. 1992 Jun 01; 148(11):3461-8. PMID: 1534096.
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    170. Woodle ES, Thistlethwaite JR, Jolliffe LK, Zivin RA, Collins A, Adair JR, Bodmer M, Athwal D, Alegre ML, Bluestone JA. Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression. J Immunol. 1992 May 01; 148(9):2756-63. PMID: 1533410.
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