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Institution

Richard Quigg

TitleEmeritus/Emerita, Professor
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mastellos DC, Reis ES, Biglarnia AR, Waldman M, Quigg RJ, Huber-Lang M, Seelen MA, Daha MR, Lambris JD. Taming hemodialysis-induced inflammation: Are complement C3 inhibitors a viable option? Clin Immunol. 2019 01; 198:102-105. PMID: 30472267.
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    2. Alexander JJ, Sankaran JS, Seldeen KL, Thiyagarajan R, Jacob A, Quigg RJ, Troen BR, Judex S. Absence of complement factor H alters bone architecture and dynamics. Immunobiology. 2018 12; 223(12):761-771. PMID: 30107932.
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    3. Alexander JJ, Quigg RJ. Muscle, myeloid cells, and complement: a complex interaction. Cell Mol Immunol. 2018 11; 15(11):992-993. PMID: 29872116.
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    4. Chaves LD, McSkimming DI, Bryniarski MA, Honan AM, Abyad S, Thomas SA, Wells S, Buck M, Sun Y, Genco RJ, Quigg RJ, Yacoub R. Chronic kidney disease, uremic milieu, and its effects on gut bacterial microbiota dysbiosis. Am J Physiol Renal Physiol. 2018 09 01; 315(3):F487-F502. PMID: 29693447.
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    5. Yacoub R, Jacob A, Wlaschin J, McGregor M, Quigg RJ, Alexander JJ. Lupus: The microbiome angle. Immunobiology. 2018 Jun - Jul; 223(6-7):460-465. PMID: 29478734.
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    6. Mahajan SD, Aalinkeel R, Parikh NU, Jacob A, Cwiklinski K, Sandhu P, Le K, Loftus AW, Schwartz SA, Quigg RJ, Alexander JJ. Immunomodulatory Role of Complement Proteins in the Neuropathology Associated with Opiate Abuse and HIV-1 Co-Morbidity. Immunol Invest. 2017 Nov; 46(8):816-832. PMID: 29058550.
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    7. Yacoub R, Nugent M, Cai W, Nadkarni GN, Chaves LD, Abyad S, Honan AM, Thomas SA, Zheng W, Valiyaparambil SA, Bryniarski MA, Sun Y, Buck M, Genco RJ, Quigg RJ, He JC, Uribarri J. Advanced glycation end products dietary restriction effects on bacterial gut microbiota in peritoneal dialysis patients; a randomized open label controlled trial. PLoS One. 2017; 12(9):e0184789. PMID: 28931089.
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    8. Mahajan SD, Tutino VM, Redae Y, Meng H, Siddiqui A, Woodruff TM, Jarvis JN, Hennon T, Schwartz S, Quigg RJ, Alexander JJ. C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus. Immunology. 2016 08; 148(4):407-19. PMID: 27213693.
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    9. Zhu J, Chaki M, Lu D, Ren C, Wang SS, Rauhauser A, Li B, Zimmerman S, Jun B, Du Y, Vadnagara K, Wang H, Elhadi S, Quigg RJ, Topham MK, Mohan C, Ozaltin F, Zhou XJ, Marciano DK, Bazan NG, Attanasio M. Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE2 production. Am J Physiol Renal Physiol. 2016 05 01; 310(9):F895-908. PMID: 26887830.
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    10. Gupta A, Quigg RJ. Glomerular Diseases Associated With Hepatitis B and C. Adv Chronic Kidney Dis. 2015 Sep; 22(5):343-51. PMID: 26311595.
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    11. Mahajan SD, Parikh NU, Woodruff TM, Jarvis JN, Lopez M, Hennon T, Cunningham P, Quigg RJ, Schwartz SA, Alexander JJ. C5a alters blood-brain barrier integrity in a human in vitro model of systemic lupus erythematosus. Immunology. 2015 Sep; 146(1):130-43. PMID: 26059553.
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    12. Alexander JJ, Chaves LD, Chang A, Dighe S, Jacob A, Quigg RJ. Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor. Cell Mol Immunol. 2016 09; 13(5):651-7. PMID: 26166765.
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    13. Bao L, Cunningham PN, Quigg RJ. Complement in Lupus Nephritis: New Perspectives. Kidney Dis (Basel). 2015 Sep; 1(2):91-9. PMID: 27536669.
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    14. Alexander JJ, Chaves LD, Chang A, Jacob A, Ritchie M, Quigg RJ. CD11b is protective in complement-mediated immune complex glomerulonephritis. Kidney Int. 2015 May; 87(5):930-9. PMID: 25565310.
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    15. Eadon MT, Jacob A, Cunningham PN, Quigg RJ, Garcia JG, Alexander JJ. Transcriptional profiling reveals that C5a alters microRNA in brain endothelial cells. Immunology. 2014 Nov; 143(3):363-73. PMID: 24801999.
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    16. Brar JE, Quigg RJ. Complement activation in the tubulointerstitium: AKI, CKD, and in between. Kidney Int. 2014 Oct; 86(4):663-6. PMID: 25265946.
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    17. Chaves LD, Mathew L, Shakaib M, Chang A, Quigg RJ, Puri TS. Contrasting effects of systemic monocyte/macrophage and CD4+ T cell depletion in a reversible ureteral obstruction mouse model of chronic kidney disease. Clin Dev Immunol. 2013; 2013:836989. PMID: 24489579.
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    18. Naik A, Sharma S, Quigg RJ. Complement regulation in renal disease models. Semin Nephrol. 2013 Nov; 33(6):575-85. PMID: 24161042.
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    19. Jacob A, Chaves L, Eadon MT, Chang A, Quigg RJ, Alexander JJ. Curcumin alleviates immune-complex-mediated glomerulonephritis in factor-H-deficient mice. Immunology. 2013 Jul; 139(3):328-37. PMID: 23347386.
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    20. Foxley S, Zamora M, Hack B, Alexander RR, Roman B, Quigg RJ, Alexander JJ. Curcumin aggravates CNS pathology in experimental systemic lupus erythematosus. Brain Res. 2013 Apr 04; 1504:85-96. PMID: 23410788.
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    21. Ozaltin F, Li B, Rauhauser A, An SW, Soylemezoglu O, Gonul II, Taskiran EZ, Ibsirlioglu T, Korkmaz E, Bilginer Y, Duzova A, Ozen S, Topaloglu R, Besbas N, Ashraf S, Du Y, Liang C, Chen P, Lu D, Vadnagara K, Arbuckle S, Lewis D, Wakeland B, Quigg RJ, Ransom RF, Wakeland EK, Topham MK, Bazan NG, Mohan C, Hildebrandt F, Bakkaloglu A, Huang CL, Attanasio M. DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN. J Am Soc Nephrol. 2013 Feb; 24(3):377-84. PMID: 23274426.
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    22. Alexander JJ, Chaves L, Chang A, Quigg RJ. The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice. Kidney Int. 2012 Nov; 82(9):961-8. PMID: 22832515.
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    23. Thurman JM, Tchepeleva SN, Haas M, Panzer S, Boackle SA, Glogowska MJ, Quigg RJ, Holers VM. Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis. Am J Physiol Renal Physiol. 2012 Jun 15; 302(12):F1529-36. PMID: 22492944.
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    24. Jacob A, Hack B, Chen P, Quigg RJ, Alexander JJ. C5a/CD88 signaling alters blood-brain barrier integrity in lupus through nuclear factor-?B. J Neurochem. 2011 Dec; 119(5):1041-51. PMID: 21929539.
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    25. Bao L, Wang Y, Haas M, Quigg RJ. Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury. Kidney Int. 2011 Sep; 80(5):524-34. PMID: 21677637.
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    26. Quigg RJ. If oxidized LDL immune complexes are relevant in diabetic atherosclerosis, shouldn't they also be relevant in diabetic nephropathy? Clin Immunol. 2011 Jun; 139(3):233-4. PMID: 21470915.
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    27. Chang A, Henderson SG, Brandt D, Liu N, Guttikonda R, Hsieh C, Kaverina N, Utset TO, Meehan SM, Quigg RJ, Meffre E, Clark MR. In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis. J Immunol. 2011 Feb 01; 186(3):1849-60. PMID: 21187439.
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    28. Bao L, Haas M, Quigg RJ. Complement factor H deficiency accelerates development of lupus nephritis. J Am Soc Nephrol. 2011 Feb; 22(2):285-95. PMID: 21148254.
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    29. Alexander JJ, Hack BK, Jacob A, Chang A, Haas M, Finberg RW, Quigg RJ. Abnormal immune complex processing and spontaneous glomerulonephritis in complement factor H-deficient mice with human complement receptor 1 on erythrocytes. J Immunol. 2010 Sep 15; 185(6):3759-67. PMID: 20702729.
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    30. Wang ZG, Puri TS, Quigg RJ. Characterization of novel VEGF (vascular endothelial growth factor)-C splicing isoforms from mouse. Biochem J. 2010 May 27; 428(3):347-54. PMID: 20415667.
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    31. Jacob A, Hack B, Bai T, Brorson JR, Quigg RJ, Alexander JJ. Inhibition of C5a receptor alleviates experimental CNS lupus. J Neuroimmunol. 2010 Apr 15; 221(1-2):46-52. PMID: 20207017.
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    32. Puri TS, Shakaib MI, Chang A, Mathew L, Olayinka O, Minto AW, Sarav M, Hack BK, Quigg RJ. Chronic kidney disease induced in mice by reversible unilateral ureteral obstruction is dependent on genetic background. Am J Physiol Renal Physiol. 2010 Apr; 298(4):F1024-32. PMID: 20089676.
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    33. Jacob A, Hack B, Chiang E, Garcia JG, Quigg RJ, Alexander JJ. C5a alters blood-brain barrier integrity in experimental lupus. FASEB J. 2010 Jun; 24(6):1682-8. PMID: 20065106.
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    34. Jacob A, Bao L, Brorson J, Quigg RJ, Alexander JJ. C3aR inhibition reduces neurodegeneration in experimental lupus. Lupus. 2010 Jan; 19(1):73-82. PMID: 19900981.
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    35. Qiao G, Li Z, Minto AW, Shia J, Yang L, Bao L, Tschopp J, Gao JX, Wang J, Quigg RJ, Zhang J. Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain. Cell Death Differ. 2010 Mar; 17(3):522-33. PMID: 19816511.
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    36. Sarav M, Wang Y, Hack BK, Chang A, Jensen M, Bao L, Quigg RJ. Renal FcRn reclaims albumin but facilitates elimination of IgG. J Am Soc Nephrol. 2009 Sep; 20(9):1941-52. PMID: 19661163.
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    37. Bao L, Haas M, Pippin J, Wang Y, Miwa T, Chang A, Minto AW, Petkova M, Qiao G, Song WC, Alpers CE, Zhang J, Shankland SJ, Quigg RJ. Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells. J Clin Invest. 2009 May; 119(5):1264-74. PMID: 19349693.
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    38. Kulik L, Fleming SD, Moratz C, Reuter JW, Novikov A, Chen K, Andrews KA, Markaryan A, Quigg RJ, Silverman GJ, Tsokos GC, Holers VM. Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury. J Immunol. 2009 May 01; 182(9):5363-73. PMID: 19380783.
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    39. Bao L, Wang Y, Chen P, Sarav M, Haas M, Minto AW, Petkova M, Quigg RJ. Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis. Immunology. 2009 Sep; 128(1 Suppl):e895-904. PMID: 19740350.
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    40. Li X, Quigg RJ, Zhou J, Gu W, Nagesh Rao P, Reed EF. Clinical utility of microarrays: current status, existing challenges and future outlook. Curr Genomics. 2008 Nov; 9(7):466-74. PMID: 19506735.
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    41. Wang Q, Wang Y, Minto AW, Wang J, Shi Q, Li X, Quigg RJ. MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J. 2008 Dec; 22(12):4126-35. PMID: 18716028.
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    42. Wang Q, Li YC, Wang J, Kong J, Qi Y, Quigg RJ, Li X. miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):2889-94. PMID: 18287052.
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    43. Takase O, Marumo T, Hishikawa K, Fujita T, Quigg RJ, Hayashi M. NF-kappaB-dependent genes induced by proteinuria and identified using DNA microarrays. Clin Exp Nephrol. 2008 Jun; 12(3):181-8. PMID: 18274700.
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    44. Takase O, Minto AW, Puri TS, Cunningham PN, Jacob A, Hayashi M, Quigg RJ. Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis. Kidney Int. 2008 Mar; 73(5):567-77. PMID: 18075502.
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    45. Zhang Z, Sun L, Wang Y, Ning G, Minto AW, Kong J, Quigg RJ, Li YC. Renoprotective role of the vitamin D receptor in diabetic nephropathy. Kidney Int. 2008 Jan; 73(2):163-71. PMID: 17928826.
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    46. Jacob A, Hensley LK, Safratowich BD, Quigg RJ, Alexander JJ. The role of the complement cascade in endotoxin-induced septic encephalopathy. Lab Invest. 2007 Dec; 87(12):1186-94. PMID: 17922019.
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    47. Qiao G, Lei M, Li Z, Sun Y, Minto A, Fu YX, Ying H, Quigg RJ, Zhang J. Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B. J Immunol. 2007 Oct 01; 179(7):4473-9. PMID: 17878343.
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    48. Li X, Wang H, Touma E, Qi Y, Rousseau E, Quigg RJ, Ryaby JT. TP508 accelerates fracture repair by promoting cell growth over cell death. Biochem Biophys Res Commun. 2007 Dec 07; 364(1):187-93. PMID: 17942078.
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    49. Alexander JJ, Zwingmann C, Jacob A, Quigg R. Alteration in kidney glucose and amino acids are implicated in renal pathology in MRL/lpr mice. Biochim Biophys Acta. 2007 Oct; 1772(10):1143-9. PMID: 17942282.
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    50. Alexander JJ, Jacob A, Cunningham P, Hensley L, Quigg RJ. TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1. Neurochem Int. 2008 Feb; 52(3):447-56. PMID: 17884256.
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    51. Smith RJ, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, de Córdoba SR, Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, Tully SP, van der Vlag J, Walker PD, Würzner R, Zipfel PF. New approaches to the treatment of dense deposit disease. J Am Soc Nephrol. 2007 Sep; 18(9):2447-56. PMID: 17675665.
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    52. Alexander JJ, Jacob A, Vezina P, Sekine H, Gilkeson GS, Quigg RJ. Absence of functional alternative complement pathway alleviates lupus cerebritis. Eur J Immunol. 2007 Jun; 37(6):1691-701. PMID: 17523212.
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    53. Puri TS, Quigg RJ. The many effects of complement C3- and C5-binding proteins in renal injury. Semin Nephrol. 2007 May; 27(3):321-37. PMID: 17533009.
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    54. Alexander JJ, Wang Y, Chang A, Jacob A, Minto AW, Karmegam M, Haas M, Quigg RJ. Mouse podocyte complement factor H: the functional analog to human complement receptor 1. J Am Soc Nephrol. 2007 Apr; 18(4):1157-66. PMID: 17344423.
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    55. Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RJ, Holers VM. C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion. J Immunol. 2007 Feb 01; 178(3):1819-28. PMID: 17237432.
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    56. Li X, Wang H, Touma E, Rousseau E, Quigg RJ, Ryaby JT. Genetic network and pathway analysis of differentially expressed proteins during critical cellular events in fracture repair. J Cell Biochem. 2007 Feb 01; 100(2):527-43. PMID: 16960878.
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    57. Bao L, Haas M, Minto AW, Quigg RJ. Decay-accelerating factor but not CD59 limits experimental immune-complex glomerulonephritis. Lab Invest. 2007 Apr; 87(4):357-64. PMID: 17259999.
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    58. Bao L, Wang Y, Chang A, Minto AW, Zhou J, Kang H, Haas M, Quigg RJ. Unrestricted C3 activation occurs in Crry-deficient kidneys and rapidly leads to chronic renal failure. J Am Soc Nephrol. 2007 Mar; 18(3):811-22. PMID: 17229915.
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    59. Bao L, Quigg RJ. Complement in lupus nephritis: the good, the bad, and the unknown. Semin Nephrol. 2007 Jan; 27(1):69-80. PMID: 17336690.
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    60. Chang A, Aneziokoro O, Meehan SM, Quigg RJ. Membranous and crescentic glomerulonephritis in a patient with anti-nuclear and anti-neutrophil cytoplasmic antibodies. Kidney Int. 2007 Feb; 71(4):360-5. PMID: 17035938.
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    61. Alexander JJ, Quigg RJ. Systemic lupus erythematosus and the brain: what mice are telling us. Neurochem Int. 2007 Jan; 50(1):5-11. PMID: 16989923.
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    62. Alexander JJ, Quigg RJ. The simple design of complement factor H: Looks can be deceiving. Mol Immunol. 2007 Jan; 44(1-3):123-32. PMID: 16919753.
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    63. Wang Y, Zhou J, Minto AW, Hack BK, Alexander JJ, Haas M, Li YC, Heilig CW, Quigg RJ. Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy. Kidney Int. 2006 Sep; 70(5):882-91. PMID: 16820793.
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    64. Alexander JJ, Aneziokoro OG, Chang A, Hack BK, Markaryan A, Jacob A, Luo R, Thirman M, Haas M, Quigg RJ. Distinct and separable roles of the complement system in factor H-deficient bone marrow chimeric mice with immune complex disease. J Am Soc Nephrol. 2006 May; 17(5):1354-61. PMID: 16597679.
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    65. Alexander JJ, Jacob A, Bao L, Macdonald RL, Quigg RJ. Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis. J Immunol. 2005 Dec 15; 175(12):8312-9. PMID: 16339572.
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    66. Cybulsky AV, Quigg RJ, Salant DJ. Experimental membranous nephropathy redux. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F660-71. PMID: 16159900.
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    67. Bao L, Osawe I, Haas M, Quigg RJ. Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis. J Immunol. 2005 Aug 01; 175(3):1947-55. PMID: 16034139.
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    68. Bao L, Osawe I, Puri T, Lambris JD, Haas M, Quigg RJ. C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist. Eur J Immunol. 2005 Aug; 35(8):2496-506. PMID: 16052609.
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    69. Alexander JJ, Zwingmann C, Quigg R. MRL/lpr mice have alterations in brain metabolism as shown with [1H-13C] NMR spectroscopy. Neurochem Int. 2005 Jul; 47(1-2):143-51. PMID: 15893408.
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    70. Javaid B, Quigg RJ. Treatment of glomerulonephritis: will we ever have options other than steroids and cytotoxics? Kidney Int. 2005 May; 67(5):1692-703. PMID: 15840015.
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    71. Li X, Quigg RJ, Zhou J, Ryaby JT, Wang H. Early signals for fracture healing. J Cell Biochem. 2005 May 01; 95(1):189-205. PMID: 15759269.
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    72. He C, Imai M, Song H, Quigg RJ, Tomlinson S. Complement inhibitors targeted to the proximal tubule prevent injury in experimental nephrotic syndrome and demonstrate a key role for C5b-9. J Immunol. 2005 May 01; 174(9):5750-7. PMID: 15843577.
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    73. Cunningham PN, Quigg RJ. Contrasting roles of complement activation and its regulation in membranous nephropathy. J Am Soc Nephrol. 2005 May; 16(5):1214-22. PMID: 15800113.
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    74. Li X, Quigg RJ. An integrated strategy for the optimization of microarray data interpretation. Gene Expr. 2005; 12(4-6):223-30. PMID: 16355722.
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    75. Guo R, Wang Y, Minto AW, Quigg RJ, Cunningham PN. Acute renal failure in endotoxemia is dependent on caspase activation. J Am Soc Nephrol. 2004 Dec; 15(12):3093-102. PMID: 15579512.
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    76. Alexander JJ, Pickering MC, Haas M, Osawe I, Quigg RJ. Complement factor h limits immune complex deposition and prevents inflammation and scarring in glomeruli of mice with chronic serum sickness. J Am Soc Nephrol. 2005 Jan; 16(1):52-7. PMID: 15574507.
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    77. Xie JT, Mehendale SR, Li X, Quigg R, Wang X, Wang CZ, Wu JA, Aung HH, A Rue P, Bell GI, Yuan CS. Anti-diabetic effect of ginsenoside Re in ob/ob mice. Biochim Biophys Acta. 2005 Jun 10; 1740(3):319-25. PMID: 15949698.
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    78. Mühlfeld AS, Segerer S, Hudkins K, Farr AG, Bao L, Kraus D, Holers VM, Quigg RJ, Alpers CE. Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis. Kidney Int. 2004 Apr; 65(4):1214-23. PMID: 15086460.
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    79. Boackle SA, Culhane KK, Brown JM, Haas M, Bao L, Quigg RJ, Holers VM. CR1/CR2 deficiency alters IgG3 autoantibody production and IgA glomerular deposition in the MRL/lpr model of SLE. Autoimmunity. 2004 Mar; 37(2):111-23. PMID: 15293881.
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    80. Cunningham PN, Wang Y, Guo R, He G, Quigg RJ. Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol. 2004 Feb 15; 172(4):2629-35. PMID: 14764737.
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    81. Minto AW, Wilson HM, Rees AJ, Quigg RJ, Brown PA. Selective expression of TGF-beta2 and TGF-beta3 isoforms in early mesangioproliferative glomerulonephritis. Nephron Exp Nephrol. 2004; 96(4):e111-8. PMID: 15122060.
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    82. Quigg RJ. Complement and autoimmune glomerular diseases. Curr Dir Autoimmun. 2004; 7:165-80. PMID: 14719380.
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    83. Quigg RJ. Why study membranous nephropathy in rats? Kidney Int. 2003 Dec; 64(6):2318-9. PMID: 14633157.
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    84. Alexander JJ, Bao L, Jacob A, Kraus DM, Holers VM, Quigg RJ. Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis. Biochim Biophys Acta. 2003 Nov 20; 1639(3):169-76. PMID: 14636948.
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    85. Quigg RJ. Complement and the kidney. J Immunol. 2003 Oct 01; 171(7):3319-24. PMID: 14500622.
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    86. Bao L, Zhou J, Holers VM, Quigg RJ. Excessive matrix accumulation in the kidneys of MRL/lpr lupus mice is dependent on complement activation. J Am Soc Nephrol. 2003 Oct; 14(10):2516-25. PMID: 14514729.
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    87. Ren G, Doshi M, Hack BK, Alexander JJ, Quigg RJ. Rat glomerular epithelial cells produce and bear factor H on their surface that is up-regulated under complement attack. Kidney Int. 2003 Sep; 64(3):914-22. PMID: 12911541.
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    88. Aslam M, Guthridge JM, Hack BK, Quigg RJ, Holers VM, Perkins SJ. The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy. J Mol Biol. 2003 Jun 06; 329(3):525-50. PMID: 12767833.
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    89. Quigg RJ. Role of complement and complement regulatory proteins in glomerulonephritis. Springer Semin Immunopathol. 2003 May; 24(4):395-410. PMID: 12778335.
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    90. Anders RA, Yerian LM, Tretiakova M, Davison JM, Quigg RJ, Domer PH, Hoberg J, Hart J. cDNA microarray analysis of macroregenerative and dysplastic nodules in end-stage hepatitis C virus-induced cirrhosis. Am J Pathol. 2003 Mar; 162(3):991-1000. PMID: 12598331.
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    91. Bao L, Haas M, Kraus DM, Hack BK, Rakstang JK, Holers VM, Quigg RJ. Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice. J Am Soc Nephrol. 2003 Mar; 14(3):670-9. PMID: 12595503.
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    92. Alexander JJ, Saxena AK, Bao L, Jacob A, Haas M, Quigg RJ. Prominent renal expression of a murine leukemia retrovirus in experimental systemic lupus erythematosus. J Am Soc Nephrol. 2002 Dec; 13(12):2869-77. PMID: 12444205.
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    93. Bao L, Spiller OB, St John PL, Haas M, Hack BK, Ren G, Cunningham PN, Doshi M, Abrahamson DR, Morgan BP, Quigg RJ. Decay-accelerating factor expression in the rat kidney is restricted to the apical surface of podocytes. Kidney Int. 2002 Dec; 62(6):2010-21. PMID: 12427125.
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    94. Ghosh S, Sica D, Schoolwerth AC, Quigg RJ, Haas M, Fakhry I, Gehr TW. The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury. Am J Med Sci. 2002 Dec; 324(6):296-304. PMID: 12495295.
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    95. Ren G, Doshi M, Hack BK, Alexander JJ, Quigg RJ. Isolation and characterization of a novel rat factor H-related protein that is up-regulated in glomeruli under complement attack. J Biol Chem. 2002 Dec 13; 277(50):48351-8. PMID: 12374811.
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    96. Quigg RJ. Use of complement inhibitors in tissue injury. Trends Mol Med. 2002 Sep; 8(9):430-6. PMID: 12223314.
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    97. Wyss-Coray T, Yan F, Lin AH, Lambris JD, Alexander JJ, Quigg RJ, Masliah E. Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10837-42. PMID: 12119423.
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    98. Cunningham PN, Dyanov HM, Park P, Wang J, Newell KA, Quigg RJ. Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney. J Immunol. 2002 Jun 01; 168(11):5817-23. PMID: 12023385.
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    99. Bao L, Haas M, Boackle SA, Kraus DM, Cunningham PN, Park P, Alexander JJ, Anderson RK, Culhane K, Holers VM, Quigg RJ. Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice. J Immunol. 2002 Apr 01; 168(7):3601-7. PMID: 11907125.
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    100. Ren G, Hack BK, Minto AW, Cunningham PN, Alexander JJ, Haas M, Quigg RJ. A complement-dependent model of thrombotic thrombocytopenic purpura induced by antibodies reactive with endothelial cells. Clin Immunol. 2002 Apr; 103(1):43-53. PMID: 11987984.
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    101. Park P, Haas M, Cunningham PN, Bao L, Alexander JJ, Quigg RJ. Injury in renal ischemia-reperfusion is independent from immunoglobulins and T lymphocytes. Am J Physiol Renal Physiol. 2002 Feb; 282(2):F352-7. PMID: 11788450.
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    102. Cunningham PN, Hack BK, Ren G, Minto AW, Morgan BP, Quigg RJ. Glomerular complement regulation is overwhelmed in passive Heymann nephritis. Kidney Int. 2001 Sep; 60(3):900-9. PMID: 11532085.
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    103. Park P, Haas M, Cunningham PN, Alexander JJ, Bao L, Guthridge JM, Kraus DM, Holers VM, Quigg RJ. Inhibiting the complement system does not reduce injury in renal ischemia reperfusion. J Am Soc Nephrol. 2001 Jul; 12(7):1383-90. PMID: 11423567.
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    104. Alexander JJ, Hack BK, Cunningham PN, Quigg RJ. A protein with characteristics of factor H is present on rodent platelets and functions as the immune adherence receptor. J Biol Chem. 2001 Aug 24; 276(34):32129-35. PMID: 11406620.
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    105. Schiller B, Cunningham PN, Alexander JJ, Bao L, Holers VM, Quigg RJ. Expression of a soluble complement inhibitor protects transgenic mice from antibody-induced acute renal failure. J Am Soc Nephrol. 2001 Jan; 12(1):71-9. PMID: 11134252.
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    106. Cunningham PN, Holers VM, Alexander JJ, Guthridge JM, Carroll MC, Quigg RJ. Complement is activated in kidney by endotoxin but does not cause the ensuing acute renal failure. Kidney Int. 2000 Oct; 58(4):1580-7. PMID: 11012892.
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    107. Quigg RJ, He C, Hack BK, Alexander JJ, Morgan BP. Production and functional analysis of rat CD59 and chimeric CD59-Crry as active soluble proteins in Pichia pastoris. Immunology. 2000 Jan; 99(1):46-53. PMID: 10651940.
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    108. Alexander JJ, Lim A, He C, MacDonald RL, Holers VM, Quigg RJ. Renal, central nervous system and pancreatic overexpression of recombinant soluble Crry in transgenic mice. A novel means of protection from complement-mediated injury. Immunopharmacology. 1999 May; 42(1-3):245-54. PMID: 10408385.
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    109. Quigg RJ, He C, Lim A, Berthiaume D, Alexander JJ, Kraus D, Holers VM. Transgenic mice overexpressing the complement inhibitor crry as a soluble protein are protected from antibody-induced glomerular injury. J Exp Med. 1998 Oct 05; 188(7):1321-31. PMID: 9763611.
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    110. Schiller B, He C, Salant DJ, Lim A, Alexander JJ, Quigg RJ. Inhibition of complement regulation is key to the pathogenesis of active Heymann nephritis. J Exp Med. 1998 Oct 05; 188(7):1353-8. PMID: 9763614.
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    111. Quigg RJ, Kozono Y, Berthiaume D, Lim A, Salant DJ, Weinfeld A, Griffin P, Kremmer E, Holers VM. Blockade of antibody-induced glomerulonephritis with Crry-Ig, a soluble murine complement inhibitor. J Immunol. 1998 May 01; 160(9):4553-60. PMID: 9574562.
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    112. Quigg RJ, Lim A, Haas M, Alexander JJ, He C, Carroll MC. Immune complex glomerulonephritis in C4- and C3-deficient mice. Kidney Int. 1998 Feb; 53(2):320-30. PMID: 9461092.
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    113. Quigg RJ, Alexander JJ, Lo CF, Lim A, He C, Holers VM. Characterization of C3-binding proteins on mouse neutrophils and platelets. J Immunol. 1997 Sep 01; 159(5):2438-44. PMID: 9278336.
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    114. He C, Alexander JJ, Lim A, Quigg RJ. Production of the rat complement regulator, Crry, as an active soluble protein in Pichia pastoris. Arch Biochem Biophys. 1997 May 15; 341(2):347-52. PMID: 9169025.
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    115. Alexander JJ, He C, Adler S, Holers VM, Quigg RJ. Characterization of C3 receptors on cultured rat glomerular endothelial cells. Kidney Int. 1997 Apr; 51(4):1124-32. PMID: 9083278.
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    116. Quigg RJ, Holers VM. Characterization of rat complement receptors and regulatory proteins. CR2 and Crry are conserved, and the C3b receptor of neutrophils and platelets is distinct from CR1. J Immunol. 1995 Aug 01; 155(3):1481-8. PMID: 7636211.
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    117. Quigg RJ, Morgan BP, Holers VM, Adler S, Sneed AE, Lo CF. Complement regulation in the rat glomerulus: Crry and CD59 regulate complement in glomerular mesangial and endothelial cells. Kidney Int. 1995 Aug; 48(2):412-21. PMID: 7564108.
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    118. Quigg RJ, Holers VM, Morgan BP, Sneed AE. Crry and CD59 regulate complement in rat glomerular epithelial cells and are inhibited by the nephritogenic antibody of passive Heymann nephritis. J Immunol. 1995 Apr 01; 154(7):3437-43. PMID: 7534798.
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    119. Quigg RJ, Lo CF, Alexander JJ, Sneed AE, Moxley G. Molecular characterization of rat Crry: widespread distribution of two alternative forms of Crry mRNA. Immunogenetics. 1995; 42(5):362-7. PMID: 7590969.
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