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Richard Quigg

TitleEmeritus/Emerita, Professor
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
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    Collapse Research 
    Collapse research activities and funding
    R21DK074012     (QUIGG, RICHARD J)Jul 1, 2006 - Jun 30, 2008
    NIH
    Targeting complement inhibitors to the human proximal tubule
    Role: Principal Investigator
    U24DK058820     (QUIGG, RICHARD J)Jun 25, 2001 - May 31, 2005
    NIH
    Massively Parallel Gene Expression Analysis
    Role: Principal Investigator
    R21DK057684     (QUIGG, RICHARD J)Jul 1, 2000 - May 31, 2002
    NIH
    GENETIC AND PATHOLOGIC ALTERATIONS IN MURINE DIABETES
    Role: Principal Investigator
    R01DK055357     (QUIGG, RICHARD J.)Aug 15, 1999 - Mar 31, 2010
    NIH
    Pathogenic role of the complement system in murine lupus
    Role: Principal Investigator
    R01DK041873     (QUIGG, RICHARD J)Aug 15, 1989 - Jul 31, 2012
    NIH
    Role of the Complement System in Renal Disease
    Role: Principal Investigator
    R56DK041873     (QUIGG, RICHARD J)Aug 15, 1989 - Apr 30, 2007
    NIH
    Role of the complement system in renal disease
    Role: Principal Investigator
    R29DK041873     (QUIGG, RICHARD J)Aug 15, 1989 - Jun 30, 1994
    NIH
    COMPLEMENT ACTIVATION OF THE GLOMERULER EPITHELIAL CELL
    Role: Principal Investigator
    T32DK007510     (COE, FREDERIC L)Sep 29, 1986 - Jun 30, 2014
    NIH
    Nephrology Research Training Grant
    Role: Co-Principal Investigator
    F32DK007730     (QUIGG, RICHARD J)Aug 1, 1986
    NIH
    ANTIBODY-INDUCED GLOMERULAR BASEMENT MEMBRANE INJURY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kareem S, Jacob A, Mathew J, Quigg RJ, Alexander JJ. Complement: Functions, location and implications. Immunology. 2023 10; 170(2):180-192. PMID: 37222083; PMCID: PMC10524990.
      Citations: 6     Fields:    
    2. Jacob A, Phelps M, Fraher S, Lopez M, Chang A, Quigg RJ, Alexander JJ. Macrophage Depletion Reduces Disease Pathology in Factor H-Dependent Immune Complex-Mediated Glomerulonephritis. J Immunol Res. 2022; 2022:1737419. PMID: 35097132; PMCID: PMC8794693.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Bomback AS, Appel GB, Gipson DS, Hladunewich MA, Lafayette R, Nester CM, Parikh SV, Smith RJH, Trachtman H, Heeger PS, Ram S, Rovin BH, Ali S, Arceneaux N, Ashoor I, Bailey-Wickins L, Barratt J, Beck L, Cattran DC, Cravedi P, Erkan E, Fervenza F, Frazer-Abel AA, Fuller L, Gbadegesin R, Hogan JJ, Kiryluk K, le Quintrec-Donnette M, Licht C, Mahan JD, Pickering MC, Quigg R, Rheault M, Sarwal MM, Sethna C, Spino C, Stegall M, Vivarelli M, Feldman DL, Thurman JM, Fremeaux-Bacchi V, Ronco P. Improving Clinical Trials for Anticomplement Therapies in Complement-Mediated Glomerulopathies: Report of a Scientific Workshop Sponsored by the National Kidney Foundation. Am J Kidney Dis. 2022 04; 79(4):570-581. PMID: 34571062.
      Citations: 8     Fields:    Translation:Humans
    4. Mahajan S, Jacob A, Kelkar A, Chang A, Mcskimming D, Neelamegham S, Quigg RJ, Alexander JJ. Local complement factor H protects kidney endothelial cell structure and function. Kidney Int. 2021 10; 100(4):824-836. PMID: 34139209.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    5. Chaves LD, Abyad S, Honan AM, Bryniarski MA, McSkimming DI, Stahura CM, Wells SC, Ruszaj DM, Morris ME, Quigg RJ, Yacoub R. Unconjugated p-cresol activates macrophage macropinocytosis leading to increased LDL uptake. JCI Insight. 2021 06 08; 6(11). PMID: 33914709; PMCID: PMC8262368.
      Citations: 6     Fields:    Translation:AnimalsCells
    6. Seldeen KL, Thiyagarajan R, Redae Y, Jacob A, Troen BR, Quigg RJ, Alexander JJ. Absence of complement factor H reduces physical performance in C57BL6 mice. Immunobiology. 2020 09; 225(5):152003. PMID: 32962822; PMCID: PMC9844077.
      Citations: 2     Fields:    Translation:Animals
    7. Alexander JJ, Jacob A, Chang A, Quigg RJ, Jarvis JN. Double negative T cells, a potential biomarker for systemic lupus erythematosus. Precis Clin Med. 2020 Mar; 3(1):34-43. PMID: 32257532; PMCID: PMC7093895.
      Citations: 20     
    8. Mastellos DC, Reis ES, Waldman M, Quigg RJ, Huber-Lang M, Seelen MA, Daha MR, Lambris JD, Biglarnia AR. Taming hemodialysis-induced inflammation: Are complement C3 inhibitors a viable option? Clin Immunol. 2019 01; 198:102-105. PMID: 30472267; PMCID: PMC7366512.
      Citations: 6     Fields:    Translation:Humans
    9. Alexander JJ, Sankaran JS, Seldeen KL, Thiyagarajan R, Jacob A, Quigg RJ, Troen BR, Judex S. Absence of complement factor H alters bone architecture and dynamics. Immunobiology. 2018 12; 223(12):761-771. PMID: 30107932.
      Citations: 4     Fields:    Translation:AnimalsCells
    10. Alexander JJ, Quigg RJ. Muscle, myeloid cells, and complement: a complex interaction. Cell Mol Immunol. 2018 11; 15(11):992-993. PMID: 29872116; PMCID: PMC6207701.
      Citations:    Fields:    Translation:Cells
    11. Chaves LD, McSkimming DI, Bryniarski MA, Honan AM, Abyad S, Thomas SA, Wells S, Buck M, Sun Y, Genco RJ, Quigg RJ, Yacoub R. Chronic kidney disease, uremic milieu, and its effects on gut bacterial microbiota dysbiosis. Am J Physiol Renal Physiol. 2018 09 01; 315(3):F487-F502. PMID: 29693447; PMCID: PMC6172581.
      Citations: 24     Fields:    Translation:AnimalsCells
    12. Yacoub R, Jacob A, Wlaschin J, McGregor M, Quigg RJ, Alexander JJ. Lupus: The microbiome angle. Immunobiology. 2018 Jun - Jul; 223(6-7):460-465. PMID: 29478734.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    13. Mahajan SD, Aalinkeel R, Parikh NU, Jacob A, Cwiklinski K, Sandhu P, Le K, Loftus AW, Schwartz SA, Quigg RJ, Alexander JJ. Immunomodulatory Role of Complement Proteins in the Neuropathology Associated with Opiate Abuse and HIV-1 Co-Morbidity. Immunol Invest. 2017 Nov; 46(8):816-832. PMID: 29058550.
      Citations: 5     Fields:    Translation:HumansCells
    14. Yacoub R, Nugent M, Cai W, Nadkarni GN, Chaves LD, Abyad S, Honan AM, Thomas SA, Zheng W, Valiyaparambil SA, Bryniarski MA, Sun Y, Buck M, Genco RJ, Quigg RJ, He JC, Uribarri J. Advanced glycation end products dietary restriction effects on bacterial gut microbiota in peritoneal dialysis patients; a randomized open label controlled trial. PLoS One. 2017; 12(9):e0184789. PMID: 28931089; PMCID: PMC5607175.
      Citations: 59     Fields:    Translation:Humans
    15. Mahajan SD, Tutino VM, Redae Y, Meng H, Siddiqui A, Woodruff TM, Jarvis JN, Hennon T, Schwartz S, Quigg RJ, Alexander JJ. C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus. Immunology. 2016 08; 148(4):407-19. PMID: 27213693; PMCID: PMC4948033.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    16. Zhu J, Chaki M, Lu D, Ren C, Wang SS, Rauhauser A, Li B, Zimmerman S, Jun B, Du Y, Vadnagara K, Wang H, Elhadi S, Quigg RJ, Topham MK, Mohan C, Ozaltin F, Zhou XJ, Marciano DK, Bazan NG, Attanasio M. Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE2 production. Am J Physiol Renal Physiol. 2016 05 01; 310(9):F895-908. PMID: 26887830; PMCID: PMC4867310.
      Citations: 12     Fields:    Translation:AnimalsCells
    17. Gupta A, Quigg RJ. Glomerular Diseases Associated With Hepatitis B and C. Adv Chronic Kidney Dis. 2015 Sep; 22(5):343-51. PMID: 26311595.
      Citations: 40     Fields:    Translation:Humans
    18. Mahajan SD, Parikh NU, Woodruff TM, Jarvis JN, Lopez M, Hennon T, Cunningham P, Quigg RJ, Schwartz SA, Alexander JJ. C5a alters blood-brain barrier integrity in a human in vitro model of systemic lupus erythematosus. Immunology. 2015 Sep; 146(1):130-43. PMID: 26059553; PMCID: PMC4552508.
      Citations: 34     Fields:    Translation:HumansCells
    19. Alexander JJ, Chaves LD, Chang A, Dighe S, Jacob A, Quigg RJ. Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor. Cell Mol Immunol. 2016 09; 13(5):651-7. PMID: 26166765; PMCID: PMC5037280.
      Citations: 5     Fields:    Translation:Animals
    20. Bao L, Cunningham PN, Quigg RJ. Complement in Lupus Nephritis: New Perspectives. Kidney Dis (Basel). 2015 Sep; 1(2):91-9. PMID: 27536669; PMCID: PMC4934819.
      Citations: 38     
    21. Alexander JJ, Chaves LD, Chang A, Jacob A, Ritchie M, Quigg RJ. CD11b is protective in complement-mediated immune complex glomerulonephritis. Kidney Int. 2015 May; 87(5):930-9. PMID: 25565310; PMCID: PMC4424815.
      Citations: 14     Fields:    Translation:AnimalsCells
    22. Eadon MT, Jacob A, Cunningham PN, Quigg RJ, Garcia JG, Alexander JJ. Transcriptional profiling reveals that C5a alters microRNA in brain endothelial cells. Immunology. 2014 Nov; 143(3):363-73. PMID: 24801999; PMCID: PMC4212950.
      Citations: 8     Fields:    Translation:AnimalsCells
    23. Brar JE, Quigg RJ. Complement activation in the tubulointerstitium: AKI, CKD, and in between. Kidney Int. 2014 Oct; 86(4):663-6. PMID: 25265946.
      Citations: 7     Fields:    Translation:Animals
    24. Chaves LD, Mathew L, Shakaib M, Chang A, Quigg RJ, Puri TS. Contrasting effects of systemic monocyte/macrophage and CD4+ T cell depletion in a reversible ureteral obstruction mouse model of chronic kidney disease. Clin Dev Immunol. 2013; 2013:836989. PMID: 24489579; PMCID: PMC3892942.
      Citations: 8     Fields:    Translation:AnimalsCells
    25. Naik A, Sharma S, Quigg RJ. Complement regulation in renal disease models. Semin Nephrol. 2013 Nov; 33(6):575-85. PMID: 24161042; PMCID: PMC4234068.
      Citations: 15     Fields:    Translation:HumansAnimals
    26. Jacob A, Chaves L, Eadon MT, Chang A, Quigg RJ, Alexander JJ. Curcumin alleviates immune-complex-mediated glomerulonephritis in factor-H-deficient mice. Immunology. 2013 Jul; 139(3):328-37. PMID: 23347386; PMCID: PMC3701179.
      Citations: 19     Fields:    Translation:HumansAnimals
    27. Foxley S, Zamora M, Hack B, Alexander RR, Roman B, Quigg RJ, Alexander JJ. Curcumin aggravates CNS pathology in experimental systemic lupus erythematosus. Brain Res. 2013 Apr 04; 1504:85-96. PMID: 23410788.
      Citations: 6     Fields:    Translation:Animals
    28. Ozaltin F, Li B, Rauhauser A, An SW, Soylemezoglu O, Gonul II, Taskiran EZ, Ibsirlioglu T, Korkmaz E, Bilginer Y, Duzova A, Ozen S, Topaloglu R, Besbas N, Ashraf S, Du Y, Liang C, Chen P, Lu D, Vadnagara K, Arbuckle S, Lewis D, Wakeland B, Quigg RJ, Ransom RF, Wakeland EK, Topham MK, Bazan NG, Mohan C, Hildebrandt F, Bakkaloglu A, Huang CL, Attanasio M. DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN. J Am Soc Nephrol. 2013 Feb; 24(3):377-84. PMID: 23274426; PMCID: PMC3582208.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    29. Alexander JJ, Chaves L, Chang A, Quigg RJ. The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice. Kidney Int. 2012 Nov; 82(9):961-8. PMID: 22832515; PMCID: PMC3472160.
      Citations: 11     Fields:    Translation:AnimalsCells
    30. Thurman JM, Tchepeleva SN, Haas M, Panzer S, Boackle SA, Glogowska MJ, Quigg RJ, Holers VM. Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis. Am J Physiol Renal Physiol. 2012 Jun 15; 302(12):F1529-36. PMID: 22492944; PMCID: PMC3378099.
      Citations: 4     Fields:    Translation:Animals
    31. Jacob A, Hack B, Chen P, Quigg RJ, Alexander JJ. C5a/CD88 signaling alters blood-brain barrier integrity in lupus through nuclear factor-?B. J Neurochem. 2011 Dec; 119(5):1041-51. PMID: 21929539; PMCID: PMC3217097.
      Citations: 28     Fields:    Translation:AnimalsCells
    32. Bao L, Wang Y, Haas M, Quigg RJ. Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury. Kidney Int. 2011 Sep; 80(5):524-34. PMID: 21677637.
      Citations: 26     Fields:    Translation:AnimalsCells
    33. Quigg RJ. If oxidized LDL immune complexes are relevant in diabetic atherosclerosis, shouldn't they also be relevant in diabetic nephropathy? Clin Immunol. 2011 Jun; 139(3):233-4. PMID: 21470915.
      Citations: 3     Fields:    Translation:Humans
    34. Chang A, Henderson SG, Brandt D, Liu N, Guttikonda R, Hsieh C, Kaverina N, Utset TO, Meehan SM, Quigg RJ, Meffre E, Clark MR. In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis. J Immunol. 2011 Feb 01; 186(3):1849-60. PMID: 21187439; PMCID: PMC3124090.
      Citations: 157     Fields:    Translation:HumansCells
    35. Bao L, Haas M, Quigg RJ. Complement factor H deficiency accelerates development of lupus nephritis. J Am Soc Nephrol. 2011 Feb; 22(2):285-95. PMID: 21148254; PMCID: PMC3029901.
      Citations: 61     Fields:    Translation:Animals
    36. Alexander JJ, Hack BK, Jacob A, Chang A, Haas M, Finberg RW, Quigg RJ. Abnormal immune complex processing and spontaneous glomerulonephritis in complement factor H-deficient mice with human complement receptor 1 on erythrocytes. J Immunol. 2010 Sep 15; 185(6):3759-67. PMID: 20702729.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    37. Wang ZG, Puri TS, Quigg RJ. Characterization of novel VEGF (vascular endothelial growth factor)-C splicing isoforms from mouse. Biochem J. 2010 May 27; 428(3):347-54. PMID: 20415667.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    38. Jacob A, Hack B, Bai T, Brorson JR, Quigg RJ, Alexander JJ. Inhibition of C5a receptor alleviates experimental CNS lupus. J Neuroimmunol. 2010 Apr 15; 221(1-2):46-52. PMID: 20207017; PMCID: PMC2902239.
      Citations: 21     Fields:    Translation:AnimalsCells
    39. Puri TS, Shakaib MI, Chang A, Mathew L, Olayinka O, Minto AW, Sarav M, Hack BK, Quigg RJ. Chronic kidney disease induced in mice by reversible unilateral ureteral obstruction is dependent on genetic background. Am J Physiol Renal Physiol. 2010 Apr; 298(4):F1024-32. PMID: 20089676; PMCID: PMC2853313.
      Citations: 44     Fields:    Translation:Animals
    40. Jacob A, Hack B, Chiang E, Garcia JG, Quigg RJ, Alexander JJ. C5a alters blood-brain barrier integrity in experimental lupus. FASEB J. 2010 Jun; 24(6):1682-8. PMID: 20065106; PMCID: PMC2874478.
      Citations: 50     Fields:    Translation:AnimalsCells
    41. Jacob A, Bao L, Brorson J, Quigg RJ, Alexander JJ. C3aR inhibition reduces neurodegeneration in experimental lupus. Lupus. 2010 Jan; 19(1):73-82. PMID: 19900981; PMCID: PMC2952506.
      Citations: 20     Fields:    Translation:AnimalsCells
    42. Qiao G, Li Z, Minto AW, Shia J, Yang L, Bao L, Tschopp J, Gao JX, Wang J, Quigg RJ, Zhang J. Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain. Cell Death Differ. 2010 Mar; 17(3):522-33. PMID: 19816511; PMCID: PMC2822025.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    43. Sarav M, Wang Y, Hack BK, Chang A, Jensen M, Bao L, Quigg RJ. Renal FcRn reclaims albumin but facilitates elimination of IgG. J Am Soc Nephrol. 2009 Sep; 20(9):1941-52. PMID: 19661163; PMCID: PMC2736763.
      Citations: 56     Fields:    Translation:AnimalsCells
    44. Kulik L, Fleming SD, Moratz C, Reuter JW, Novikov A, Chen K, Andrews KA, Markaryan A, Quigg RJ, Silverman GJ, Tsokos GC, Holers VM. Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury. J Immunol. 2009 May 01; 182(9):5363-73. PMID: 19380783; PMCID: PMC2820395.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    45. Bao L, Haas M, Pippin J, Wang Y, Miwa T, Chang A, Minto AW, Petkova M, Qiao G, Song WC, Alpers CE, Zhang J, Shankland SJ, Quigg RJ. Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells. J Clin Invest. 2009 May; 119(5):1264-74. PMID: 19349693; PMCID: PMC2673859.
      Citations: 27     Fields:    Translation:AnimalsCells
    46. Bao L, Wang Y, Chen P, Sarav M, Haas M, Minto AW, Petkova M, Quigg RJ. Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis. Immunology. 2009 Sep; 128(1 Suppl):e895-904. PMID: 19740350; PMCID: PMC2753953.
      Citations: 2     Fields:    Translation:AnimalsCells
    47. Li X, Quigg RJ, Zhou J, Gu W, Nagesh Rao P, Reed EF. Clinical utility of microarrays: current status, existing challenges and future outlook. Curr Genomics. 2008 Nov; 9(7):466-74. PMID: 19506735; PMCID: PMC2691672.
      Citations: 16     
    48. Wang Q, Wang Y, Minto AW, Wang J, Shi Q, Li X, Quigg RJ. MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J. 2008 Dec; 22(12):4126-35. PMID: 18716028; PMCID: PMC2614610.
      Citations: 199     Fields:    Translation:HumansAnimalsCells
    49. Wang Q, Li YC, Wang J, Kong J, Qi Y, Quigg RJ, Li X. miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):2889-94. PMID: 18287052; PMCID: PMC2268555.
      Citations: 160     Fields:    Translation:AnimalsCells
    50. Takase O, Marumo T, Hishikawa K, Fujita T, Quigg RJ, Hayashi M. NF-kappaB-dependent genes induced by proteinuria and identified using DNA microarrays. Clin Exp Nephrol. 2008 Jun; 12(3):181-8. PMID: 18274700.
      Citations: 5     Fields:    Translation:Animals
    51. Takase O, Minto AW, Puri TS, Cunningham PN, Jacob A, Hayashi M, Quigg RJ. Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis. Kidney Int. 2008 Mar; 73(5):567-77. PMID: 18075502.
      Citations: 34     Fields:    Translation:Animals
    52. Zhang Z, Sun L, Wang Y, Ning G, Minto AW, Kong J, Quigg RJ, Li YC. Renoprotective role of the vitamin D receptor in diabetic nephropathy. Kidney Int. 2008 Jan; 73(2):163-71. PMID: 17928826.
      Citations: 129     Fields:    Translation:Animals
    53. Jacob A, Hensley LK, Safratowich BD, Quigg RJ, Alexander JJ. The role of the complement cascade in endotoxin-induced septic encephalopathy. Lab Invest. 2007 Dec; 87(12):1186-94. PMID: 17922019.
      Citations: 29     Fields:    Translation:AnimalsCells
    54. Qiao G, Lei M, Li Z, Sun Y, Minto A, Fu YX, Ying H, Quigg RJ, Zhang J. Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B. J Immunol. 2007 Oct 01; 179(7):4473-9. PMID: 17878343.
      Citations: 25     Fields:    Translation:AnimalsCells
    55. Li X, Wang H, Touma E, Qi Y, Rousseau E, Quigg RJ, Ryaby JT. TP508 accelerates fracture repair by promoting cell growth over cell death. Biochem Biophys Res Commun. 2007 Dec 07; 364(1):187-93. PMID: 17942078.
      Citations: 12     Fields:    Translation:Animals
    56. Alexander JJ, Zwingmann C, Jacob A, Quigg R. Alteration in kidney glucose and amino acids are implicated in renal pathology in MRL/lpr mice. Biochim Biophys Acta. 2007 Oct; 1772(10):1143-9. PMID: 17942282.
      Citations: 3     Fields:    Translation:AnimalsCells
    57. Alexander JJ, Jacob A, Cunningham P, Hensley L, Quigg RJ. TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1. Neurochem Int. 2008 Feb; 52(3):447-56. PMID: 17884256; PMCID: PMC3191465.
      Citations: 95     Fields:    Translation:AnimalsCells
    58. Smith RJ, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, Tully SP, van der Vlag J, Walker PD, Zipfel PF, Dense Deposit Disease Focus Group, de Córdoba SR, Würzner R. New approaches to the treatment of dense deposit disease. J Am Soc Nephrol. 2007 Sep; 18(9):2447-56. PMID: 17675665; PMCID: PMC4853920.
      Citations: 114     Fields:    Translation:HumansAnimals
    59. Alexander JJ, Jacob A, Vezina P, Sekine H, Gilkeson GS, Quigg RJ. Absence of functional alternative complement pathway alleviates lupus cerebritis. Eur J Immunol. 2007 Jun; 37(6):1691-701. PMID: 17523212.
      Citations: 27     Fields:    Translation:AnimalsCells
    60. Puri TS, Quigg RJ. The many effects of complement C3- and C5-binding proteins in renal injury. Semin Nephrol. 2007 May; 27(3):321-37. PMID: 17533009.
      Citations: 8     Fields:    Translation:HumansAnimals
    61. Alexander JJ, Wang Y, Chang A, Jacob A, Minto AW, Karmegam M, Haas M, Quigg RJ. Mouse podocyte complement factor H: the functional analog to human complement receptor 1. J Am Soc Nephrol. 2007 Apr; 18(4):1157-66. PMID: 17344423.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    62. Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RJ, Holers VM. C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion. J Immunol. 2007 Feb 01; 178(3):1819-28. PMID: 17237432.
      Citations: 62     Fields:    Translation:AnimalsCells
    63. Li X, Wang H, Touma E, Rousseau E, Quigg RJ, Ryaby JT. Genetic network and pathway analysis of differentially expressed proteins during critical cellular events in fracture repair. J Cell Biochem. 2007 Feb 01; 100(2):527-43. PMID: 16960878.
      Citations: 8     Fields:    Translation:AnimalsCells
    64. Bao L, Haas M, Minto AW, Quigg RJ. Decay-accelerating factor but not CD59 limits experimental immune-complex glomerulonephritis. Lab Invest. 2007 Apr; 87(4):357-64. PMID: 17259999.
      Citations: 8     Fields:    Translation:AnimalsCells
    65. Bao L, Wang Y, Chang A, Minto AW, Zhou J, Kang H, Haas M, Quigg RJ. Unrestricted C3 activation occurs in Crry-deficient kidneys and rapidly leads to chronic renal failure. J Am Soc Nephrol. 2007 Mar; 18(3):811-22. PMID: 17229915.
      Citations: 23     Fields:    Translation:Animals
    66. Bao L, Quigg RJ. Complement in lupus nephritis: the good, the bad, and the unknown. Semin Nephrol. 2007 Jan; 27(1):69-80. PMID: 17336690.
      Citations: 22     Fields:    Translation:HumansAnimals
    67. Chang A, Aneziokoro O, Meehan SM, Quigg RJ. Membranous and crescentic glomerulonephritis in a patient with anti-nuclear and anti-neutrophil cytoplasmic antibodies. Kidney Int. 2007 Feb; 71(4):360-5. PMID: 17035938.
      Citations: 6     Fields:    Translation:Humans
    68. Alexander JJ, Quigg RJ. Systemic lupus erythematosus and the brain: what mice are telling us. Neurochem Int. 2007 Jan; 50(1):5-11. PMID: 16989923.
      Citations: 15     Fields:    Translation:Animals
    69. Alexander JJ, Quigg RJ. The simple design of complement factor H: Looks can be deceiving. Mol Immunol. 2007 Jan; 44(1-3):123-32. PMID: 16919753.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    70. Wang Y, Zhou J, Minto AW, Hack BK, Alexander JJ, Haas M, Li YC, Heilig CW, Quigg RJ. Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy. Kidney Int. 2006 Sep; 70(5):882-91. PMID: 16820793.
      Citations: 34     Fields:    Translation:AnimalsCells
    71. Alexander JJ, Aneziokoro OG, Chang A, Hack BK, Markaryan A, Jacob A, Luo R, Thirman M, Haas M, Quigg RJ. Distinct and separable roles of the complement system in factor H-deficient bone marrow chimeric mice with immune complex disease. J Am Soc Nephrol. 2006 May; 17(5):1354-61. PMID: 16597679.
      Citations: 14     Fields:    Translation:AnimalsCells
    72. Alexander JJ, Jacob A, Bao L, Macdonald RL, Quigg RJ. Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis. J Immunol. 2005 Dec 15; 175(12):8312-9. PMID: 16339572.
      Citations: 35     Fields:    Translation:AnimalsCells
    73. Cybulsky AV, Quigg RJ, Salant DJ. Experimental membranous nephropathy redux. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F660-71. PMID: 16159900; PMCID: PMC1325222.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    74. Bao L, Osawe I, Haas M, Quigg RJ. Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis. J Immunol. 2005 Aug 01; 175(3):1947-55. PMID: 16034139.
      Citations: 42     Fields:    Translation:AnimalsCells
    75. Bao L, Osawe I, Puri T, Lambris JD, Haas M, Quigg RJ. C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist. Eur J Immunol. 2005 Aug; 35(8):2496-506. PMID: 16052609.
      Citations: 47     Fields:    Translation:Animals
    76. Alexander JJ, Zwingmann C, Quigg R. MRL/lpr mice have alterations in brain metabolism as shown with [1H-13C] NMR spectroscopy. Neurochem Int. 2005 Jul; 47(1-2):143-51. PMID: 15893408.
      Citations: 11     Fields:    Translation:AnimalsCells
    77. Li X, Quigg RJ, Zhou J, Ryaby JT, Wang H. Early signals for fracture healing. J Cell Biochem. 2005 May 01; 95(1):189-205. PMID: 15759269.
      Citations: 7     Fields:    Translation:AnimalsCells
    78. Javaid B, Quigg RJ. Treatment of glomerulonephritis: will we ever have options other than steroids and cytotoxics? Kidney Int. 2005 May; 67(5):1692-703. PMID: 15840015.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    79. He C, Imai M, Song H, Quigg RJ, Tomlinson S. Complement inhibitors targeted to the proximal tubule prevent injury in experimental nephrotic syndrome and demonstrate a key role for C5b-9. J Immunol. 2005 May 01; 174(9):5750-7. PMID: 15843577.
      Citations: 28     Fields:    Translation:Animals
    80. Cunningham PN, Quigg RJ. Contrasting roles of complement activation and its regulation in membranous nephropathy. J Am Soc Nephrol. 2005 May; 16(5):1214-22. PMID: 15800113.
      Citations: 33     Fields:    Translation:HumansAnimals
    81. Li X, Quigg RJ. An integrated strategy for the optimization of microarray data interpretation. Gene Expr. 2005; 12(4-6):223-30. PMID: 16355722; PMCID: PMC6009125.
      Citations: 1     Fields:    Translation:HumansAnimals
    82. Guo R, Wang Y, Minto AW, Quigg RJ, Cunningham PN. Acute renal failure in endotoxemia is dependent on caspase activation. J Am Soc Nephrol. 2004 Dec; 15(12):3093-102. PMID: 15579512.
      Citations: 53     Fields:    Translation:AnimalsCells
    83. Alexander JJ, Pickering MC, Haas M, Osawe I, Quigg RJ. Complement factor h limits immune complex deposition and prevents inflammation and scarring in glomeruli of mice with chronic serum sickness. J Am Soc Nephrol. 2005 Jan; 16(1):52-7. PMID: 15574507.
      Citations: 24     Fields:    Translation:AnimalsCells
    84. Xie JT, Mehendale SR, Li X, Quigg R, Wang X, Wang CZ, Wu JA, Aung HH, A Rue P, Bell GI, Yuan CS. Anti-diabetic effect of ginsenoside Re in ob/ob mice. Biochim Biophys Acta. 2005 Jun 10; 1740(3):319-25. PMID: 15949698.
      Citations: 53     Fields:    Translation:Animals
    85. Segerer S, Hudkins K, Farr AG, Bao L, Kraus D, Holers VM, Quigg RJ, Alpers CE, Mühlfeld AS. Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis. Kidney Int. 2004 Apr; 65(4):1214-23. PMID: 15086460.
      Citations: 4     Fields:    Translation:AnimalsCells
    86. Boackle SA, Culhane KK, Brown JM, Haas M, Bao L, Quigg RJ, Holers VM. CR1/CR2 deficiency alters IgG3 autoantibody production and IgA glomerular deposition in the MRL/lpr model of SLE. Autoimmunity. 2004 Mar; 37(2):111-23. PMID: 15293881.
      Citations: 15     Fields:    Translation:Animals
    87. Cunningham PN, Wang Y, Guo R, He G, Quigg RJ. Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol. 2004 Feb 15; 172(4):2629-35. PMID: 14764737.
      Citations: 106     Fields:    Translation:Animals
    88. Minto AW, Wilson HM, Rees AJ, Quigg RJ, Brown PA. Selective expression of TGF-beta2 and TGF-beta3 isoforms in early mesangioproliferative glomerulonephritis. Nephron Exp Nephrol. 2004; 96(4):e111-8. PMID: 15122060.
      Citations:    Fields:    Translation:AnimalsCells
    89. Quigg RJ. Complement and autoimmune glomerular diseases. Curr Dir Autoimmun. 2004; 7:165-80. PMID: 14719380.
      Citations: 13     Fields:    Translation:HumansAnimals
    90. Quigg RJ. Why study membranous nephropathy in rats? Kidney Int. 2003 Dec; 64(6):2318-9. PMID: 14633157.
      Citations: 1     Fields:    Translation:Animals
    91. Alexander JJ, Bao L, Jacob A, Kraus DM, Holers VM, Quigg RJ. Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis. Biochim Biophys Acta. 2003 Nov 20; 1639(3):169-76. PMID: 14636948.
      Citations: 25     Fields:    Translation:AnimalsCells
    92. Quigg RJ. Complement and the kidney. J Immunol. 2003 Oct 01; 171(7):3319-24. PMID: 14500622.
      Citations: 13     Fields:    Translation:HumansAnimals
    93. Bao L, Zhou J, Holers VM, Quigg RJ. Excessive matrix accumulation in the kidneys of MRL/lpr lupus mice is dependent on complement activation. J Am Soc Nephrol. 2003 Oct; 14(10):2516-25. PMID: 14514729.
      Citations: 16     Fields:    Translation:AnimalsCells
    94. Ren G, Doshi M, Hack BK, Alexander JJ, Quigg RJ. Rat glomerular epithelial cells produce and bear factor H on their surface that is up-regulated under complement attack. Kidney Int. 2003 Sep; 64(3):914-22. PMID: 12911541.
      Citations: 6     Fields:    Translation:AnimalsCells
    95. Aslam M, Guthridge JM, Hack BK, Quigg RJ, Holers VM, Perkins SJ. The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy. J Mol Biol. 2003 Jun 06; 329(3):525-50. PMID: 12767833.
      Citations: 10     Fields:    Translation:AnimalsCells
    96. Quigg RJ. Role of complement and complement regulatory proteins in glomerulonephritis. Springer Semin Immunopathol. 2003 May; 24(4):395-410. PMID: 12778335.
      Citations: 2     Fields:    Translation:HumansAnimals
    97. Anders RA, Yerian LM, Tretiakova M, Davison JM, Quigg RJ, Domer PH, Hoberg J, Hart J. cDNA microarray analysis of macroregenerative and dysplastic nodules in end-stage hepatitis C virus-induced cirrhosis. Am J Pathol. 2003 Mar; 162(3):991-1000. PMID: 12598331; PMCID: PMC1868091.
      Citations: 10     Fields:    Translation:HumansCells
    98. Bao L, Haas M, Kraus DM, Hack BK, Rakstang JK, Holers VM, Quigg RJ. Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice. J Am Soc Nephrol. 2003 Mar; 14(3):670-9. PMID: 12595503.
      Citations: 32     Fields:    Translation:Animals
    99. Alexander JJ, Saxena AK, Bao L, Jacob A, Haas M, Quigg RJ. Prominent renal expression of a murine leukemia retrovirus in experimental systemic lupus erythematosus. J Am Soc Nephrol. 2002 Dec; 13(12):2869-77. PMID: 12444205.
      Citations: 4     Fields:    Translation:AnimalsCells
    100. Bao L, Spiller OB, St John PL, Haas M, Hack BK, Ren G, Cunningham PN, Doshi M, Abrahamson DR, Morgan BP, Quigg RJ. Decay-accelerating factor expression in the rat kidney is restricted to the apical surface of podocytes. Kidney Int. 2002 Dec; 62(6):2010-21. PMID: 12427125.
      Citations: 13     Fields:    Translation:AnimalsCells
    101. Ghosh S, Sica D, Schoolwerth AC, Quigg RJ, Haas M, Fakhry I, Gehr TW. The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury. Am J Med Sci. 2002 Dec; 324(6):296-304. PMID: 12495295.
      Citations: 2     Fields:    Translation:HumansAnimals
    102. Ren G, Doshi M, Hack BK, Alexander JJ, Quigg RJ. Isolation and characterization of a novel rat factor H-related protein that is up-regulated in glomeruli under complement attack. J Biol Chem. 2002 Dec 13; 277(50):48351-8. PMID: 12374811.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    103. Quigg RJ. Use of complement inhibitors in tissue injury. Trends Mol Med. 2002 Sep; 8(9):430-6. PMID: 12223314.
      Citations: 5     Fields:    Translation:HumansAnimals
    104. Wyss-Coray T, Yan F, Lin AH, Lambris JD, Alexander JJ, Quigg RJ, Masliah E. Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10837-42. PMID: 12119423; PMCID: PMC125059.
      Citations: 199     Fields:    Translation:HumansAnimalsCells
    105. Cunningham PN, Dyanov HM, Park P, Wang J, Newell KA, Quigg RJ. Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney. J Immunol. 2002 Jun 01; 168(11):5817-23. PMID: 12023385.
      Citations: 131     Fields:    Translation:AnimalsCells
    106. Bao L, Haas M, Boackle SA, Kraus DM, Cunningham PN, Park P, Alexander JJ, Anderson RK, Culhane K, Holers VM, Quigg RJ. Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice. J Immunol. 2002 Apr 01; 168(7):3601-7. PMID: 11907125.
      Citations: 25     Fields:    Translation:Animals
    107. Ren G, Hack BK, Minto AW, Cunningham PN, Alexander JJ, Haas M, Quigg RJ. A complement-dependent model of thrombotic thrombocytopenic purpura induced by antibodies reactive with endothelial cells. Clin Immunol. 2002 Apr; 103(1):43-53. PMID: 11987984.
      Citations: 4     Fields:    Translation:Animals
    108. Park P, Haas M, Cunningham PN, Bao L, Alexander JJ, Quigg RJ. Injury in renal ischemia-reperfusion is independent from immunoglobulins and T lymphocytes. Am J Physiol Renal Physiol. 2002 Feb; 282(2):F352-7. PMID: 11788450.
      Citations: 45     Fields:    Translation:AnimalsCells
    109. Cunningham PN, Hack BK, Ren G, Minto AW, Morgan BP, Quigg RJ. Glomerular complement regulation is overwhelmed in passive Heymann nephritis. Kidney Int. 2001 Sep; 60(3):900-9. PMID: 11532085.
      Citations: 8     Fields:    Translation:Animals
    110. Park P, Haas M, Cunningham PN, Alexander JJ, Bao L, Guthridge JM, Kraus DM, Holers VM, Quigg RJ. Inhibiting the complement system does not reduce injury in renal ischemia reperfusion. J Am Soc Nephrol. 2001 Jul; 12(7):1383-1390. PMID: 11423567.
      Citations: 25     Fields:    Translation:Animals
    111. Alexander JJ, Hack BK, Cunningham PN, Quigg RJ. A protein with characteristics of factor H is present on rodent platelets and functions as the immune adherence receptor. J Biol Chem. 2001 Aug 24; 276(34):32129-35. PMID: 11406620.
      Citations: 20     Fields:    Translation:AnimalsCells
    112. Schiller B, Cunningham PN, Alexander JJ, Bao L, Holers VM, Quigg RJ. Expression of a soluble complement inhibitor protects transgenic mice from antibody-induced acute renal failure. J Am Soc Nephrol. 2001 Jan; 12(1):71-79. PMID: 11134252.
      Citations: 2     Fields:    Translation:AnimalsCells
    113. Cunningham PN, Holers VM, Alexander JJ, Guthridge JM, Carroll MC, Quigg RJ. Complement is activated in kidney by endotoxin but does not cause the ensuing acute renal failure. Kidney Int. 2000 Oct; 58(4):1580-7. PMID: 11012892.
      Citations: 11     Fields:    Translation:Animals
    114. Quigg RJ, He C, Hack BK, Alexander JJ, Morgan BP. Production and functional analysis of rat CD59 and chimeric CD59-Crry as active soluble proteins in Pichia pastoris. Immunology. 2000 Jan; 99(1):46-53. PMID: 10651940; PMCID: PMC2327136.
      Citations: 4     Fields:    Translation:AnimalsCells
    115. Alexander JJ, Lim A, He C, MacDonald RL, Holers VM, Quigg RJ. Renal, central nervous system and pancreatic overexpression of recombinant soluble Crry in transgenic mice. A novel means of protection from complement-mediated injury. Immunopharmacology. 1999 May; 42(1-3):245-54. PMID: 10408385.
      Citations: 1     Fields:    Translation:Animals
    116. Quigg RJ, He C, Lim A, Berthiaume D, Alexander JJ, Kraus D, Holers VM. Transgenic mice overexpressing the complement inhibitor crry as a soluble protein are protected from antibody-induced glomerular injury. J Exp Med. 1998 Oct 05; 188(7):1321-31. PMID: 9763611; PMCID: PMC2212499.
      Citations: 18     Fields:    Translation:Animals
    117. Schiller B, He C, Salant DJ, Lim A, Alexander JJ, Quigg RJ. Inhibition of complement regulation is key to the pathogenesis of active Heymann nephritis. J Exp Med. 1998 Oct 05; 188(7):1353-8. PMID: 9763614; PMCID: PMC2212493.
      Citations: 17     Fields:    Translation:Animals
    118. Quigg RJ, Kozono Y, Berthiaume D, Lim A, Salant DJ, Weinfeld A, Griffin P, Kremmer E, Holers VM. Blockade of antibody-induced glomerulonephritis with Crry-Ig, a soluble murine complement inhibitor. J Immunol. 1998 May 01; 160(9):4553-60. PMID: 9574562.
      Citations: 38     Fields:    Translation:HumansAnimals
    119. Quigg RJ, Lim A, Haas M, Alexander JJ, He C, Carroll MC. Immune complex glomerulonephritis in C4- and C3-deficient mice. Kidney Int. 1998 Feb; 53(2):320-30. PMID: 9461092.
      Citations: 27     Fields:    Translation:AnimalsPHPublic Health
    120. Quigg RJ, Alexander JJ, Lo CF, Lim A, He C, Holers VM. Characterization of C3-binding proteins on mouse neutrophils and platelets. J Immunol. 1997 Sep 01; 159(5):2438-44. PMID: 9278336.
      Citations: 6     Fields:    Translation:AnimalsCells
    121. He C, Alexander JJ, Lim A, Quigg RJ. Production of the rat complement regulator, Crry, as an active soluble protein in Pichia pastoris. Arch Biochem Biophys. 1997 May 15; 341(2):347-52. PMID: 9169025.
      Citations: 5     Fields:    Translation:AnimalsCells
    122. Alexander JJ, He C, Adler S, Holers VM, Quigg RJ. Characterization of C3 receptors on cultured rat glomerular endothelial cells. Kidney Int. 1997 Apr; 51(4):1124-32. PMID: 9083278.
      Citations:    Fields:    Translation:HumansAnimalsCells
    123. Quigg RJ, Holers VM. Characterization of rat complement receptors and regulatory proteins. CR2 and Crry are conserved, and the C3b receptor of neutrophils and platelets is distinct from CR1. J Immunol. 1995 Aug 01; 155(3):1481-8. PMID: 7636211.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    124. Quigg RJ, Morgan BP, Holers VM, Adler S, Sneed AE, Lo CF. Complement regulation in the rat glomerulus: Crry and CD59 regulate complement in glomerular mesangial and endothelial cells. Kidney Int. 1995 Aug; 48(2):412-21. PMID: 7564108.
      Citations: 10     Fields:    Translation:AnimalsCells
    125. Quigg RJ, Holers VM, Morgan BP, Sneed AE. Crry and CD59 regulate complement in rat glomerular epithelial cells and are inhibited by the nephritogenic antibody of passive Heymann nephritis. J Immunol. 1995 Apr 01; 154(7):3437-43. PMID: 7534798.
      Citations: 17     Fields:    Translation:AnimalsCells
    126. Quigg RJ, Lo CF, Alexander JJ, Sneed AE, Moxley G. Molecular characterization of rat Crry: widespread distribution of two alternative forms of Crry mRNA. Immunogenetics. 1995; 42(5):362-7. PMID: 7590969.
      Citations: 9     Fields:    Translation:AnimalsCells
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