 Anning Lin
| Title | PROFESSOR |
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| Institution | University of Chicago |
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| Department | Ben May Department |
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| Address | Chicago IL 60637
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 Overview Signaling mechanism in inflammation, cancer and neuronal degenerative disease
My laboratory has a long-standing interest in understanding how the intracellular signaling network is integrated in response to a variety of extracellular signals, thereby controlling proliferation, programmed cell death and transformation. Our recent work focuses on elucidating the signaling mechanism in inflammatory disease, such as severe sepsis and colitis-associated cancer, and neuronal degenerative disease like Alzheimer’s disease, using a multifaceted experimental approach involving biochemistry, molecular cell biology, proteomics, computational modeling and animal models. Our long-term goal is to identify potential therapeutic targets for prevention and treatment of inflammatory and infectious disease, cancer and neuronal degenerative disease.
Biography | University of Alabama at Birmingham (UAB) | Ph.D. | | | | University of California, San Diego | Postdoctoral Fellow | | |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Yan J, Xiang J, Lin Y, Ma J, Zhang J, Zhang H, Sun J, Danial NN, Liu J, Lin A. Inactivation of BAD by IKK inhibits TNFa-induced apoptosis independently of NF-?B activation. Cell. 2013 Jan 17; 152(1-2):304-15. PMID: 23332762.
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Liu J, Yan J, Jiang S, Wen J, Chen L, Zhao Y, Lin A. Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-a-induced JNK activation and inflammation. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):191-6. PMID: 22184250.
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Lin A. ATIA: a link between inflammation and hypoxia. Mol Cell. 2011 Jun 10; 42(5):557-8. PMID: 21658597.
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Lin A. Temporal control of TNFa signaling by Miz1. Adv Exp Med Biol. 2011; 691:127-8. PMID: 21153316.
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Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, Chang YH, Tsai SF, Li LY, Hung MC. KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell. 2009 Oct 09; 36(1):131-40. PMID: 19818716.
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Liu J, Zhao Y, Eilers M, Lin A. Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18279-84. PMID: 19815509.
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Tang F, Kokontis J, Lin Y, Liao S, Lin A, Xiang J. Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis. J Biol Chem. 2009 Nov 20; 284(47):32353-8. PMID: 19723627.
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Deng H, Yu F, Chen J, Zhao Y, Xiang J, Lin A. Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1. J Biol Chem. 2008 Jul 25; 283(30):20754-60. PMID: 18469002.
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Lin A. A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action. Dev Cell. 2006 Mar; 10(3):277-8. PMID: 16516830.
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Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A. NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell. 2006 Feb 17; 21(4):467-80. PMID: 16483929.
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Zhang J, Bui TN, Xiang J, Lin A. Cyclic AMP inhibits p38 activation via CREB-induced dynein light chain. Mol Cell Biol. 2006 Feb; 26(4):1223-34. PMID: 16449637.
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Zhang J, Liu J, Yu C, Lin A. BAD Ser128 is not phosphorylated by c-Jun NH2-terminal kinase for promoting apoptosis. Cancer Res. 2005 Sep 15; 65(18):8372-8. PMID: 16166315.
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Liu J, Lin A. Role of JNK activation in apoptosis: a double-edged sword. Cell Res. 2005 Jan; 15(1):36-42. PMID: 15686625.
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Liu J, Minemoto Y, Lin A. c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis. Mol Cell Biol. 2004 Dec; 24(24):10844-56. PMID: 15572687.
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Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN, Xiang J, Lin A. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell. 2004 Feb 13; 13(3):329-40. PMID: 14967141.
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Liu H, Ma Y, Pagliari LJ, Perlman H, Yu C, Lin A, Pope RM. TNF-alpha-induced apoptosis of macrophages following inhibition of NF-kappa B: a central role for disruption of mitochondria. J Immunol. 2004 Feb 01; 172(3):1907-15. PMID: 14734776.
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Lin A, Karin M. NF-kappaB in cancer: a marked target. Semin Cancer Biol. 2003 Apr; 13(2):107-14. PMID: 12654254.
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Lin A. Activation of the JNK signaling pathway: breaking the brake on apoptosis. Bioessays. 2003 Jan; 25(1):17-24. PMID: 12508278.
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Lin A, Dibling B. The true face of JNK activation in apoptosis. Aging Cell. 2002 Dec; 1(2):112-6. PMID: 12882340.
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Tang F, Tang G, Xiang J, Dai Q, Rosner MR, Lin A. The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol. 2002 Dec; 22(24):8571-9. PMID: 12446776.
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Li J, Johnson XD, Iazvovskaia S, Tan A, Lin A, Hershenson MB. Signaling intermediates required for NF-kappa B activation and IL-8 expression in CF bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2003 Feb; 284(2):L307-15. PMID: 12388360.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2002 | 3 | | 2003 | 2 | | 2004 | 3 | | 2005 | 2 | | 2006 | 3 | | 2008 | 1 | | 2009 | 3 | | 2011 | 3 | | 2013 | 1 |
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