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Anning Lin

TitleProfessor
InstitutionUniversity of Chicago
DepartmentBen May Department of Cancer Research
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Signaling mechanism in inflammation, cancer and neuronal degenerative disease

    My laboratory has a long-standing interest in understanding how the intracellular signaling network is integrated in response to a variety of extracellular signals, thereby controlling proliferation, programmed cell death and transformation. Our recent work focuses on elucidating the signaling mechanism in inflammatory disease, such as severe sepsis and colitis-associated cancer, and neuronal degenerative disease like Alzheimer’s disease, using a multifaceted experimental approach involving biochemistry, molecular cell biology, proteomics, computational modeling and animal models. Our long-term goal is to identify potential therapeutic targets for prevention and treatment of inflammatory and infectious disease, cancer and neuronal degenerative disease.


    Collapse Biography 
    Collapse education and training
    University of Alabama at Birmingham (UAB)Ph.D.
    University of California, San DiegoPostdoctoral Fellow

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Yan J, Xiang J, Lin Y, Ma J, Zhang J, Zhang H, Sun J, Danial NN, Liu J, Lin A. Inactivation of BAD by IKK inhibits TNFa-induced apoptosis independently of NF-?B activation. Cell. 2013 Jan 17; 152(1-2):304-15. PMID: 23332762.
      View in: PubMed
    2. Liu J, Yan J, Jiang S, Wen J, Chen L, Zhao Y, Lin A. Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-a-induced JNK activation and inflammation. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):191-6. PMID: 22184250.
      View in: PubMed
    3. Lin A. ATIA: a link between inflammation and hypoxia. Mol Cell. 2011 Jun 10; 42(5):557-8. PMID: 21658597.
      View in: PubMed
    4. Lin A. Temporal control of TNFa signaling by Miz1. Adv Exp Med Biol. 2011; 691:127-8. PMID: 21153316.
      View in: PubMed
    5. Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, Chang YH, Tsai SF, Li LY, Hung MC. KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell. 2009 Oct 09; 36(1):131-40. PMID: 19818716.
      View in: PubMed
    6. Liu J, Zhao Y, Eilers M, Lin A. Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18279-84. PMID: 19815509.
      View in: PubMed
    7. Tang F, Kokontis J, Lin Y, Liao S, Lin A, Xiang J. Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis. J Biol Chem. 2009 Nov 20; 284(47):32353-8. PMID: 19723627.
      View in: PubMed
    8. Deng H, Yu F, Chen J, Zhao Y, Xiang J, Lin A. Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1. J Biol Chem. 2008 Jul 25; 283(30):20754-60. PMID: 18469002.
      View in: PubMed
    9. Lin A. A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action. Dev Cell. 2006 Mar; 10(3):277-8. PMID: 16516830.
      View in: PubMed
    10. Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A. NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell. 2006 Feb 17; 21(4):467-80. PMID: 16483929.
      View in: PubMed
    11. Zhang J, Bui TN, Xiang J, Lin A. Cyclic AMP inhibits p38 activation via CREB-induced dynein light chain. Mol Cell Biol. 2006 Feb; 26(4):1223-34. PMID: 16449637.
      View in: PubMed
    12. Zhang J, Liu J, Yu C, Lin A. BAD Ser128 is not phosphorylated by c-Jun NH2-terminal kinase for promoting apoptosis. Cancer Res. 2005 Sep 15; 65(18):8372-8. PMID: 16166315.
      View in: PubMed
    13. Liu J, Lin A. Role of JNK activation in apoptosis: a double-edged sword. Cell Res. 2005 Jan; 15(1):36-42. PMID: 15686625.
      View in: PubMed
    14. Liu J, Minemoto Y, Lin A. c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis. Mol Cell Biol. 2004 Dec; 24(24):10844-56. PMID: 15572687.
      View in: PubMed
    15. Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN, Xiang J, Lin A. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell. 2004 Feb 13; 13(3):329-40. PMID: 14967141.
      View in: PubMed
    16. Liu H, Ma Y, Pagliari LJ, Perlman H, Yu C, Lin A, Pope RM. TNF-alpha-induced apoptosis of macrophages following inhibition of NF-kappa B: a central role for disruption of mitochondria. J Immunol. 2004 Feb 01; 172(3):1907-15. PMID: 14734776.
      View in: PubMed
    17. Lin A, Karin M. NF-kappaB in cancer: a marked target. Semin Cancer Biol. 2003 Apr; 13(2):107-14. PMID: 12654254.
      View in: PubMed
    18. Lin A. Activation of the JNK signaling pathway: breaking the brake on apoptosis. Bioessays. 2003 Jan; 25(1):17-24. PMID: 12508278.
      View in: PubMed
    19. Lin A, Dibling B. The true face of JNK activation in apoptosis. Aging Cell. 2002 Dec; 1(2):112-6. PMID: 12882340.
      View in: PubMed
    20. Tang F, Tang G, Xiang J, Dai Q, Rosner MR, Lin A. The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol. 2002 Dec; 22(24):8571-9. PMID: 12446776.
      View in: PubMed
    21. Li J, Johnson XD, Iazvovskaia S, Tan A, Lin A, Hershenson MB. Signaling intermediates required for NF-kappa B activation and IL-8 expression in CF bronchial epithelial cells. . 2003 Feb; 284(2):L307-15. PMID: 12388360.
      View in: PubMed
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