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George Perry

Title
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    R01GM115656     (PERRY, GEORGE HERBERT)Jun 20, 2016 - May 31, 2021
    NIH
    Hunter-gatherer vs. agriculturalist growth and immune system functional genomics
    Role: Principal Investigator
    F32GM085998     (PERRY, GEORGE HERBERT)Aug 11, 2008 - Aug 10, 2011
    NIH
    Studying the evolution of gene regulation at the protein level in primates
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Elbatrawy AA, Ademoye TA, Alnakhala H, Tripathi A, Zhu X, Plascencia-Villa G, Perry G, Dettmer U, Fortin JS. Inspecting the Triazole Scaffold as Powerful Antifibril Agents against 2N4R Tau and a-Synuclein Aggregates. ACS Omega. 2025 Feb 25; 10(7):6721-6734. PMID: 40028124; PMCID: PMC11866179.
      Citations:    
    2. Orkin JD, Kuderna LFK, Hermosilla-Albala N, Fontsere C, Aylward ML, Janiak MC, Andriaholinirina N, Balaresque P, Blair ME, Fausser JL, Gut IG, Gut M, Hahn MW, Harris RA, Horvath JE, Keyser C, Kitchener AC, Le MD, Lizano E, Merker S, Nadler T, Perry GH, Rabarivola CJ, Rasmussen L, Raveendran M, Roos C, Wu DD, Zaramody A, Zhang G, Zinner D, Pozzi L, Rogers J, Farh KK, Marques Bonet T. Ecological and anthropogenic effects on the genomic diversity of lemurs in Madagascar. Nat Ecol Evol. 2025 Jan; 9(1):42-56. PMID: 39730835.
      Citations: 1     Fields:    Translation:Animals
    3. Castellani RJ, Jamshidi P, Plascencia-Villa G, Perry G, Castellani RJ, Jamshidi P, Plascencia-Villa G, Perry G. The Amyloid Cascade Hypothesis: A Conclusion in Search of Support. Am J Pathol. 2024 Nov 10. PMID: 39532243.
      Citations:    Fields:    
    4. Elbatrawy AA, Ademoye TA, Alnakhala H, Tripathi A, Plascencia-Villa G, Zhu X, Perry G, Dettmer U, Fortin JS. Exploring the rhodanine universe: Design and synthesis of fluorescent rhodanine-based derivatives as anti-fibrillar and anti-oligomer agents against a-synuclein and 2N4R tau. Bioorg Med Chem. 2024 Dec 15; 116:117990. PMID: 39550891; PMCID: PMC11645236.
      Citations:    Fields:    Translation:HumansCells
    5. Ganegamage SK, Ademoye TA, Patel H, Alnakhala H, Tripathi A, Nguyen CCD, Pham K, Plascencia-Villa G, Zhu X, Perry G, Tian S, Dettmer U, Lasagna-Reeves C, Fortin JS. Evaluation of Alpha-Synuclein and Tau Antiaggregation Activity of Urea and Thiourea-Based Small Molecules for Neurodegenerative Disease Therapeutics. ACS Chem Neurosci. 2024 11 06; 15(21):3915-3931. PMID: 39436010; PMCID: PMC11587513.
      Citations: 1     Fields:    Translation:HumansCells
    6. Plascencia-Villa G, Castellani RJ, Perry G. Central role of brain regulatory T cells in the inflammatory cascade in Alzheimer's disease. Proc Natl Acad Sci U S A. 2024 Aug 06; 121(32):e2412255121. PMID: 39074294; PMCID: PMC11317600.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    7. Avila J, Marco J, Plascencia-Villa G, Bajic VP, Perry G. Could there be an experimental way to link consciousness and quantum computations of brain microtubules? Front Neurosci. 2024; 18:1430432. PMID: 38979125; PMCID: PMC11228156.
      Citations:    
    8. Everett J, Brooks J, Tjendana Tjhin V, Lermyte F, Hands-Portman I, Plascencia-Villa G, Perry G, Sadler PJ, O'Connor PB, Collingwood JF, Telling ND. Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues. ACS Chem Neurosci. 2024 04 03; 15(7):1469-1483. PMID: 38501754; PMCID: PMC10995949.
      Citations: 3     Fields:    Translation:Humans
    9. Diaz-Lasprilla AM, McKee M, Jimenez-Vergara AC, Ravi S, Bellamy D, Ortega W, Crosby CO, Steele J, Plascencia-Villa G, Perry G, Munoz-Pinto DJ. Fabrication and Characterization of Quad-Component Bioinspired Hydrogels to Model Elevated Fibrin Levels in Central Nervous Tissue Scaffolds. Gels. 2024 Mar 17; 10(3). PMID: 38534621; PMCID: PMC10969996.
      Citations:    
    10. Moreira PI, Avila J, Galimberti D, Pappolla MA, Plascencia-Villa G, Sorensen AA, Zhu X, Perry G. Therapeutic Trials in Alzheimer's Disease: Where Are We Now? J Alzheimers Dis. 2024; 101(s1):S1-S2. PMID: 39422966.
      Citations:    Fields:    
    11. Ramirez E, Ganegamage SK, Min S, Patel H, Ogunware A, Plascencia-Villa G, Alnakhala H, Shimanaka K, Tripathi A, Wang KW, Zhu X, Rochet JC, Kuo MH, Counts SE, Perry G, Dettmer U, Lasagna-Reeves CA, Fortin JS. Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on a-Synuclein and Tau Aggregation. ACS Chem Neurosci. 2023 11 01; 14(21):3913-3927. PMID: 37818657; PMCID: PMC10624178.
      Citations: 3     Fields:    Translation:Humans
    12. Plascencia-Villa G, Perry G. Roles of Oxidative Stress in Synaptic Dysfunction and Neuronal Cell Death in Alzheimer's Disease. Antioxidants (Basel). 2023 Aug 17; 12(8). PMID: 37627623; PMCID: PMC10451948.
      Citations: 28     
    13. Plascencia-Villa G, Perry G. Exploring Molecular Targets for Mitochondrial Therapies in Neurodegenerative Diseases. Int J Mol Sci. 2023 Aug 06; 24(15). PMID: 37569861; PMCID: PMC10419704.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    14. Castellani RJ, Perry G. The Teflon hypothesis. Brain Commun. 2023; 5(4):fcad203. PMID: 37492487; PMCID: PMC10365830.
      Citations: 1     
    15. Veilleux CC, Garrett EC, Pajic P, Saitou M, Ochieng J, Dagsaan LD, Dominy NJ, Perry GH, Gokcumen O, Melin AD. Human subsistence and signatures of selection on chemosensory genes. Commun Biol. 2023 07 03; 6(1):683. PMID: 37400713; PMCID: PMC10317983.
      Citations: 1     Translation:Humans
    16. Plascencia-Villa G, Perry G. Lessons from antiamyloid-ß immunotherapies in Alzheimer's disease. Handb Clin Neurol. 2023; 193:267-292. PMID: 36803816.
      Citations: 10     Fields:    Translation:Humans
    17. Plascencia-Villa G, Perry G. Neuropathologic Changes Provide Insights into Key Mechanisms of Alzheimer Disease and Related Dementia. Am J Pathol. 2022 10; 192(10):1340-1346. PMID: 35931209; PMCID: PMC9552032.
      Citations: 10     Fields:    Translation:HumansCells
    18. Marciniak S, Mughal MR, Godfrey LR, Bankoff RJ, Randrianatoandro H, Crowley BE, Bergey CM, Muldoon KM, Schuster SC, Malhi RS, Yoder AD, Louis EE, Kistler L, Perry GH, Randrianasy J, Raharivololona BM. Evolutionary and phylogenetic insights from a nuclear genome sequence of the extinct, giant, "subfossil" koala lemur Megaladapis edwardsi. Proc Natl Acad Sci U S A. 2021 06 29; 118(26). PMID: 34162703; PMCID: PMC8255780.
      Citations: 7     Fields:    Translation:AnimalsCells
    19. Everett J, Lermyte F, Brooks J, Tjendana-Tjhin V, Plascencia-Villa G, Hands-Portman I, Donnelly JM, Billimoria K, Perry G, Zhu X, Sadler PJ, O'Connor PB, Collingwood JF, Telling ND. Biogenic metallic elements in the human brain? Sci Adv. 2021 06; 7(24). PMID: 34108207; PMCID: PMC8189590.
      Citations: 33     Fields:    
    20. Hernandez M, Perry GH. Scanning the human genome for "signatures" of positive selection: Transformative opportunities and ethical obligations. Evol Anthropol. 2021 Mar; 30(2):113-121. PMID: 33788352.
      Citations: 5     Fields:    Translation:Humans
    21. Orkin JD, Montague MJ, Tejada-Martinez D, de Manuel M, Del Campo J, Di Fiore A, Fontsere C, Hodgson JA, Janiak MC, Kuderna LFK, Lizano E, Martin MP, Niimura Y, Perry GH, Valverde CS, Tang J, Warren WC, Kawamura S, Krawetz R, Melin AD, Cheves Hernandez S, de Magalhães JP, Marquès-Bonet T. The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS. Proc Natl Acad Sci U S A. 2021 02 16; 118(7). PMID: 33574059; PMCID: PMC7896301.
      Citations: 25     Fields:    Translation:Animals
    22. Plascencia-Villa G, Perry G. Status and future directions of clinical trials in Alzheimer's disease. Int Rev Neurobiol. 2020; 154:3-50. PMID: 32739008.
      Citations: 15     Fields:    Translation:Humans
    23. Plascencia-Villa G, Perry G. Preventive and Therapeutic Strategies in Alzheimer's Disease: Focus on Oxidative Stress, Redox Metals, and Ferroptosis. Antioxid Redox Signal. 2021 03 10; 34(8):591-610. PMID: 32486897; PMCID: PMC8098758.
      Citations: 65     Fields:    Translation:HumansCells
    24. Perry GH. How human behavior can impact the evolution of genetically-mediated behavior in wild non-human species. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2020 05; 206(3):337-342. PMID: 32201915; PMCID: PMC7196034.
      Citations: 1     Fields:    Translation:HumansAnimals
    25. Grogan KE, Perry GH. Studying human and nonhuman primate evolutionary biology with powerful in vitro and in vivo functional genomics tools. Evol Anthropol. 2020 May; 29(3):143-158. PMID: 32142200; PMCID: PMC10574139.
      Citations: 6     Fields:    Translation:HumansAnimals
    26. Singh SK, Srivastav S, Castellani RJ, Plascencia-Villa G, Perry G. Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders. Neurotherapeutics. 2019 07; 16(3):666-674. PMID: 31376068; PMCID: PMC6694352.
      Citations: 115     Fields:    Translation:HumansAnimals
    27. Makarewicz CA, Perry GH. Horse Paleogenomes and Human-Animal Interactions in Prehistory. Trends Genet. 2019 07; 35(7):473-475. PMID: 31109769.
      Citations: 1     Fields:    Translation:HumansAnimals
    28. Castellani RJ, Plascencia-Villa G, Perry G. The amyloid cascade and Alzheimer's disease therapeutics: theory versus observation. Lab Invest. 2019 07; 99(7):958-970. PMID: 30760863.
      Citations: 51     Fields:    Translation:Humans
    29. Rodriguez RA, Liang H, Chen LY, Plascencia-Villa G, Perry G. Single-channel permeability and glycerol affinity of human aquaglyceroporin AQP3. Biochim Biophys Acta Biomembr. 2019 04 01; 1861(4):768-775. PMID: 30659792; PMCID: PMC6382548.
      Citations: 10     Fields:    Translation:HumansCells
    30. Tripathy A, Shade A, Erskine B, Bailey K, Grande A, deLong JJ, Perry G, Castellani RJ. No Evidence of Increased Chronic Traumatic Encephalopathy Pathology or Neurodegenerative Proteinopathy in Former Military Service Members: A Preliminary Study. J Alzheimers Dis. 2019; 67(4):1277-1289. PMID: 30741674.
      Citations: 5     Fields:    Translation:Humans
    31. Castellani RJ, Perry G. Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges. J Alzheimers Dis. 2019; 67(2):447-467. PMID: 30584140; PMCID: PMC6398540.
      Citations: 40     Fields:    Translation:HumansAnimals
    32. Castellani RJ, Smith M, Bailey K, Perry G, deJong JL. Neuropathology in Consecutive Forensic Consultation Cases with a History of Remote Traumatic Brain Injury. J Alzheimers Dis. 2019; 72(3):683-691. PMID: 31609691.
      Citations: 2     Fields:    Translation:Humans
    33. Aylward ML, Sullivan AP, Perry GH, Johnson SE, Louis EE. An environmental DNA sampling method for aye-ayes from their feeding traces. Ecol Evol. 2018 Sep; 8(18):9229-9240. PMID: 30377496; PMCID: PMC6194247.
      Citations: 8     
    34. Everett J, Collingwood JF, Tjendana-Tjhin V, Brooks J, Lermyte F, Plascencia-Villa G, Hands-Portman I, Dobson J, Perry G, Telling ND. Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects. Nanoscale. 2018 Jul 05; 10(25):11782-11796. PMID: 29688240; PMCID: PMC6034173.
      Citations: 42     Fields:    Translation:Humans
    35. Plascencia-Villa G, Perry G. Iron·ic facts about dementia. J Neurol Neurosurg Psychiatry. 2018 05; 89(5):446-447. PMID: 29353235.
      Citations: 1     Fields:    Translation:Humans
    36. Rodriguez RA, Chen LY, Plascencia-Villa G, Perry G. Thermodynamics of Amyloid-ß Fibril Elongation: Atomistic Details of the Transition State. ACS Chem Neurosci. 2018 04 18; 9(4):783-789. PMID: 29239603; PMCID: PMC5911799.
      Citations: 15     Fields:    Translation:HumansCells
    37. Kistler L, Johnson SM, Irwin MT, Louis EE, Ratan A, Perry GH. A massively parallel strategy for STR marker development, capture, and genotyping. Nucleic Acids Res. 2017 Sep 06; 45(15):e142. PMID: 28666376; PMCID: PMC5587753.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    38. Trizzino M, Park Y, Holsbach-Beltrame M, Aracena K, Mika K, Caliskan M, Perry GH, Lynch VJ, Brown CD. Transposable elements are the primary source of novelty in primate gene regulation. Genome Res. 2017 10; 27(10):1623-1633. PMID: 28855262; PMCID: PMC5630026.
      Citations: 126     Fields:    Translation:HumansAnimalsCells
    39. Bankoff RJ, Jerjos M, Hohman B, Lauterbur ME, Kistler L, Perry GH. Testing Convergent Evolution in Auditory Processing Genes between Echolocating Mammals and the Aye-Aye, a Percussive-Foraging Primate. Genome Biol Evol. 2017 07 01; 9(7):1978-1989. PMID: 28810710; PMCID: PMC5553384.
      Citations: 2     Fields:    Translation:Animals
    40. Sullivan AP, Perry GH, de Manuel M, Marques-Bonet T. An evolutionary medicine perspective on Neandertal extinction. J Hum Evol. 2017 07; 108:62-71. PMID: 28622932.
      Citations: 8     Fields:    Translation:HumansAnimals
    41. Rodriguez RA, Chen LY, Plascencia-Villa G, Perry G. Elongation affinity, activation barrier, and stability of Aß42 oligomers/fibrils in physiological saline. Biochem Biophys Res Commun. 2017 05 27; 487(2):444-449. PMID: 28427941; PMCID: PMC5489073.
      Citations: 6     Fields:    Translation:Cells
    42. Moritz GL, Ong PS, Perry GH, Dominy NJ. Functional preservation and variation in the cone opsin genes of nocturnal tarsiers. Philos Trans R Soc Lond B Biol Sci. 2017 Apr 05; 372(1717). PMID: 28193820; PMCID: PMC5312025.
      Citations: 4     Fields:    Translation:Animals
    43. Lei R, Frasier CL, Hawkins MT, Engberg SE, Bailey CA, Johnson SE, McLain AT, Groves CP, Perry GH, Nash SD, Mittermeier RA, Louis EE. Phylogenomic Reconstruction of Sportive Lemurs (genus Lepilemur) Recovered from Mitogenomes with Inferences for Madagascar Biogeography. J Hered. 2017 03 01; 108(2):107-119. PMID: 28173059.
      Citations: 10     Fields:    Translation:Animals
    44. Castellani RJ, Perry G. Dementia Pugilistica Revisited. J Alzheimers Dis. 2017; 60(4):1209-1221. PMID: 29036831; PMCID: PMC5676846.
      Citations: 15     Fields:    Translation:HumansAnimals
    45. Castellani RJ, Mojica G, Perry G. The Role of the Iron Stain in Assessing Intracranial Hemorrhage. Open Neurol J. 2016; 10:136-142. PMID: 27857815; PMCID: PMC5090778.
      Citations: 1     
    46. Garoon J, Engelman M, Gitlin L, Szanton S. Where does the neighborhood go? Trust, social engagement, and health among older adults in Baltimore City. Health Place. 2016 09; 41:58-66. PMID: 27552723; PMCID: PMC5465432.
      Citations: 3     Fields:    Translation:Humans
    47. Plascencia-Villa G, Ponce A, Collingwood JF, Arellano-Jiménez MJ, Zhu X, Rogers JT, Betancourt I, José-Yacamán M, Perry G. High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer's disease. Sci Rep. 2016 04 28; 6:24873. PMID: 27121137; PMCID: PMC4848473.
      Citations: 56     Fields:    Translation:Humans
    48. Federman S, Dornburg A, Daly DC, Downie A, Perry GH, Yoder AD, Sargis EJ, Richard AF, Donoghue MJ, Baden AL. Implications of lemuriform extinctions for the Malagasy flora. Proc Natl Acad Sci U S A. 2016 May 03; 113(18):5041-6. PMID: 27071108; PMCID: PMC4983841.
      Citations: 15     Fields:    Translation:Animals
    49. Melin AD, Wells K, Moritz GL, Kistler L, Orkin JD, Timm RM, Bernard H, Lakim MB, Perry GH, Kawamura S, Dominy NJ. Euarchontan Opsin Variation Brings New Focus to Primate Origins. Mol Biol Evol. 2016 Apr; 33(4):1029-41. PMID: 26739880; PMCID: PMC4776711.
      Citations: 9     Fields:    Translation:HumansAnimals
    50. Furr-Holden DM, Milam AJ, Nesoff ED, Garoon J, Smart MJ, Duncan A, Warren GC. Triangulating Syndemic Services and Drug Treatment Policy: Improving Drug Treatment Portal Locations in Baltimore City. Prog Community Health Partnersh. 2016; 10(2):319-27. PMID: 27346779; PMCID: PMC6931040.
      Citations: 3     Fields:    Translation:Humans
    51. Lynch VJ, Bedoya-Reina OC, Ratan A, Sulak M, Drautz-Moses DI, Perry GH, Miller W, Schuster SC. Elephantid Genomes Reveal the Molecular Bases of Woolly Mammoth Adaptations to the Arctic. Cell Rep. 2015 Jul 14; 12(2):217-28. PMID: 26146078.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    52. Castellani RJ, Perry G, Iverson GL. Chronic effects of mild neurotrauma: putting the cart before the horse? J Neuropathol Exp Neurol. 2015 Jun; 74(6):493-9. PMID: 25933385; PMCID: PMC4433573.
      Citations: 15     Fields:    Translation:Humans
    53. Rodriguez AR, Plascencia-Villa G, Witt CM, Yu JJ, José-Yacamán M, Chambers JP, Perry G, Guentzel MN, Arulanandam BP. Chlamydia pneumoniae promotes dysfunction of pancreatic beta cells. Cell Immunol. 2015 Jun; 295(2):83-91. PMID: 25863744; PMCID: PMC4533996.
      Citations: 5     Fields:    Translation:AnimalsCells
    54. Pelcovits A, Marriotti R, Heath J, Perry G, Castellani RJ. Simultaneous onset of Alzheimer's disease in a husband and wife in their mid-fifties: what do we really know about environmental factors? Open Neurol J. 2015; 9:1-3. PMID: 25932054; PMCID: PMC4391217.
      Citations:    
    55. Carvalho C, Correia SC, Perry G, Castellani RJ, Moreira PI. Cerebrovascular and mitochondrial abnormalities in Alzheimer's disease: a brief overview. J Neural Transm (Vienna). 2016 Feb; 123(2):107-11. PMID: 25608860.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    56. Perry GH, Orlando L. Ancient DNA and human evolution. J Hum Evol. 2015 Feb; 79:1-3. PMID: 25619123.
      Citations:    Fields:    Translation:HumansAnimals
    57. Perry GH, Kistler L, Kelaita MA, Sams AJ. Insights into hominin phenotypic and dietary evolution from ancient DNA sequence data. J Hum Evol. 2015 Feb; 79:55-63. PMID: 25563409.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    58. Kistler L, Ratan A, Godfrey LR, Crowley BE, Hughes CE, Lei R, Cui Y, Wood ML, Muldoon KM, Andriamialison H, McGraw JJ, Tomsho LP, Schuster SC, Miller W, Louis EE, Yoder AD, Malhi RS, Perry GH. Comparative and population mitogenomic analyses of Madagascar's extinct, giant 'subfossil' lemurs. J Hum Evol. 2015 Feb; 79:45-54. PMID: 25523037.
      Citations: 31     Fields:    Translation:Animals
    59. Fornicola W, Pelcovits A, Li BX, Heath J, Perry G, Castellani RJ. Alzheimer Disease Pathology in Middle Age Reveals a Spatial-Temporal Disconnect Between Amyloid-ß and Phosphorylated Tau. Open Neurol J. 2014; 8:22-6. PMID: 25628768; PMCID: PMC4303956.
      Citations: 4     
    60. Kim HL, Ratan A, Perry GH, Miller W, Schuster SC, Montenegro A. Khoisan hunter-gatherers have been the largest population throughout most of modern-human demographic history. Nat Commun. 2014 Dec 04; 5:5692. PMID: 25471224; PMCID: PMC4268704.
      Citations: 27     Fields:    Translation:Humans
    61. Hodgson JA, Pickrell JK, Pearson LN, Quillen EE, Soodyall H, Shriver MD, Perry GH, Prista A, Rocha J. Natural selection for the Duffy-null allele in the recently admixed people of Madagascar. Proc Biol Sci. 2014 Aug 22; 281(1789):20140930. PMID: 24990677; PMCID: PMC4100512.
      Citations: 31     Fields:    Translation:Humans
    62. Perry GH, Grenier JC, Patin E, Pacis A, Barakatt M, Gravel S, Zhou X, Nsobya SL, Excoffier L, Quintana-Murci L, Dominy NJ, Barreiro LB, Foll M, Nédélec Y. Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers. Proc Natl Acad Sci U S A. 2014 09 02; 111(35):E3596-603. PMID: 25136101; PMCID: PMC4156716.
      Citations: 48     Fields:    Translation:Humans
    63. Blekhman R, Perry GH, Shahbaz S, Fiehn O, Clark AG, Gilad Y. Comparative metabolomics in primates reveals the effects of diet and gene regulatory variation on metabolic divergence. Sci Rep. 2014 Jul 28; 4:5809. PMID: 25069065; PMCID: PMC4894427.
      Citations: 13     Fields:    Translation:HumansAnimals
    64. Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA, Perry G, Zhu X, Lee HG. Accumulation of intraneuronal amyloid-ß is common in normal brain. Curr Alzheimer Res. 2014 May; 11(4):317-24. PMID: 24597504.
      Citations: 8     Fields:    Translation:Humans
    65. Perry G, Castellani R. Plaques and tangles: birthmarks of the aging soul. Preface. Biochem Pharmacol. 2014 Apr 15; 88(4):423-5. PMID: 24486570.
      Citations:    Fields:    Translation:HumansCells
    66. Castellani RJ, Perry G. The complexities of the pathology-pathogenesis relationship in Alzheimer disease. Biochem Pharmacol. 2014 Apr 15; 88(4):671-6. PMID: 24447936.
      Citations: 36     Fields:    Translation:Humans
    67. Patin E, Siddle KJ, Laval G, Harmant C, Froment A, Dominy NJ, Perry GH, Quach H, Becker N, Régnault B, Lemée L, Gravel S, Hombert JM, Van der Veen L, Barreiro LB, Verdu P, Heyer E, Quintana-Murci L. The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists. Nat Commun. 2014; 5:3163. PMID: 24495941.
      Citations: 46     Fields:    
    68. Bedoya-Reina OC, Ratan A, Burhans R, Kim HL, Giardine B, Riemer C, Li Q, Olson TL, Loughran TP, Vonholdt BM, Perry GH, Schuster SC, Miller W. Galaxy tools to study genome diversity. Gigascience. 2013 Dec 30; 2(1):17. PMID: 24377391; PMCID: PMC3877877.
      Citations: 11     Fields:    
    69. Fujioka H, Phelix CF, Friedland RP, Zhu X, Perry EA, Castellani RJ, Perry G. Apolipoprotein E4 prevents growth of malaria at the intraerythrocyte stage: implications for differences in racial susceptibility to Alzheimer's disease. J Health Care Poor Underserved. 2013 Nov; 24(4 Suppl):70-8. PMID: 24241262; PMCID: PMC4909051.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    70. Williams WM, Torres S, Siedlak SL, Castellani RJ, Perry G, Smith MA, Zhu X. Antimicrobial peptide ß-defensin-1 expression is upregulated in Alzheimer's brain. J Neuroinflammation. 2013 Oct 18; 10:127. PMID: 24139179; PMCID: PMC3817866.
      Citations: 28     Fields:    Translation:HumansCells
    71. Correia SC, Perry G, Castellani R, Moreira PI. Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease? J Neurochem. 2013 Oct; 127(1):4-6. PMID: 24074055; PMCID: PMC3831604.
      Citations: 1     Fields:    Translation:HumansAnimals
    72. Perry GH, Louis EE, Ratan A, Bedoya-Reina OC, Burhans RC, Lei R, Johnson SE, Schuster SC, Miller W. Aye-aye population genomic analyses highlight an important center of endemism in northern Madagascar. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):5823-8. PMID: 23530231; PMCID: PMC3625347.
      Citations: 19     Fields:    Translation:Animals
    73. Santos RX, Correia SC, Zhu X, Smith MA, Moreira PI, Castellani RJ, Nunomura A, Perry G. Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease. Antioxid Redox Signal. 2013 Jun 20; 18(18):2444-57. PMID: 23216311; PMCID: PMC3671662.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    74. Castellani RJ, Perry G. Pathogenesis and disease-modifying therapy in Alzheimer's disease: the flat line of progress. Arch Med Res. 2012 Nov; 43(8):694-8. PMID: 23085451.
      Citations: 38     Fields:    Translation:HumansCells
    75. Villanea FA, Perry GH, Dominy NJ, Gutiérrez-Espeleta GA. ASPM and the evolution of cerebral cortical size in a community of New World monkeys. PLoS One. 2012; 7(9):e44928. PMID: 23028686; PMCID: PMC3459963.
      Citations:    Fields:    Translation:HumansAnimals
    76. Iskow RC, Gokcumen O, Abyzov A, Malukiewicz J, Zhu Q, Sukumar AT, Pai AA, Mills RE, Habegger L, Cusanovich DA, Rubel MA, Perry GH, Gerstein M, Stone AC, Gilad Y, Lee C. Regulatory element copy number differences shape primate expression profiles. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12656-61. PMID: 22797897; PMCID: PMC3411951.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    77. Nunomura A, Moreira PI, Castellani RJ, Lee HG, Zhu X, Smith MA, Perry G. Oxidative damage to RNA in aging and neurodegenerative disorders. Neurotox Res. 2012 Oct; 22(3):231-48. PMID: 22669748.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    78. Williams WM, Castellani RJ, Weinberg A, Perry G, Smith MA. Do ß-defensins and other antimicrobial peptides play a role in neuroimmune function and neurodegeneration? ScientificWorldJournal. 2012; 2012:905785. PMID: 22606066; PMCID: PMC3346844.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    79. Castellani RJ, Moreira PI, Perry G, Zhu X. The role of iron as a mediator of oxidative stress in Alzheimer disease. Biofactors. 2012 Mar-Apr; 38(2):133-8. PMID: 22447715.
      Citations: 30     Fields:    Translation:HumansAnimals
    80. Zhu X, Castellani RJ, Ziats NP, Petersen RB, Gon Lee H, Perry G. Mark A. Smith: neurocytochemistry innovator. J Neurochem. 2012 Mar; 120(6):1139-40. PMID: 22268813.
      Citations:    Fields:    Translation:HumansCells
    81. Perry G, Phelix CF, Nunomura A, Colom LV, Castellani RJ, Petersen RB, Lee HG, Zhu X. Untangling the vascular web from Alzheimer disease and oxidative stress. Can J Neurol Sci. 2012 Jan; 39(1):4. PMID: 22384486.
      Citations:    Fields:    Translation:Humans
    82. Perry GH, Marioni JC, Wang Y, Bainer R, Pickrell JK, Michelini K, Zehr S, Yoder AD, Stephens M, Pritchard JK, Gilad Y, Melsted P. Comparative RNA sequencing reveals substantial genetic variation in endangered primates. Genome Res. 2012 Apr; 22(4):602-10. PMID: 22207615; PMCID: PMC3317143.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    83. Perry GH, Reeves D, Ratan A, Miller W, Michelini K, Louis EE, Pritchard JK, Mason CE, Gilad Y, Melsted P. A genome sequence resource for the aye-aye (Daubentonia madagascariensis), a nocturnal lemur from Madagascar. Genome Biol Evol. 2012; 4(2):126-35. PMID: 22155688; PMCID: PMC3273163.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    84. Zhu X, Castellani RJ, Moreira PI, Aliev G, Shenk JC, Siedlak SL, Harris PLR, Fujioka H, Sayre LM, Szweda PA, Szweda LI, Smith MA, Perry G. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover. Free Radic Biol Med. 2012 Feb 01; 52(3):699-704. PMID: 22137893; PMCID: PMC3268699.
      Citations: 20     Fields:    Translation:HumansCells
    85. Ziats NP, Petersen RB, Lee HG, Castellani RJ, Perry G, Zhu X. Mark A. Smith, 1965-2010: consummate student of pathogenesis. Int J Clin Exp Pathol. 2011; 4(7):731-2. PMID: 22076176; PMCID: PMC3209616.
      Citations:    Fields:    Translation:HumansAnimals
    86. Castellani RJ, Gupta Y, Sheng B, Siedlak SL, Harris PL, Coller JM, Perry G, Lee HG, Tabaton M, Smith MA, Wang X, Zhu X. A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules. Lab Invest. 2011 Dec; 91(12):1777-86. PMID: 21968813; PMCID: PMC3428037.
      Citations: 19     Fields:    Translation:HumansCells
    87. Castellani RJ, Petersen RB, Lee HG, Zhu X, Perry G. Mark A. Smith: the scientist, the man. Int J Exp Pathol. 2011 Oct; 92(5):297-8. PMID: 21917030; PMCID: PMC3193142.
      Citations:    Fields:    
    88. Stone JG, Siedlak SL, Tabaton M, Hirano A, Castellani RJ, Santocanale C, Perry G, Smith MA, Zhu X, Lee HG. The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies. J Neuropathol Exp Neurol. 2011 Jul; 70(7):578-87. PMID: 21666500; PMCID: PMC3122485.
      Citations: 15     Fields:    Translation:HumansCells
    89. Wang X, Su B, Liu W, He X, Gao Y, Castellani RJ, Perry G, Smith MA, Zhu X. DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease. Aging Cell. 2011 Oct; 10(5):807-23. PMID: 21615675; PMCID: PMC3173562.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    90. Stone JG, Casadesus G, Gustaw-Rothenberg K, Siedlak SL, Wang X, Zhu X, Perry G, Castellani RJ, Smith MA. Frontiers in Alzheimer's disease therapeutics. Ther Adv Chronic Dis. 2011 Jan 01; 2(1):9-23. PMID: 21743833; PMCID: PMC3129861.
      Citations: 12     
    91. Heath JE, Siedlak SL, Zhu X, Lee HG, Thakur A, Yan R, Perry G, Smith MA, Castellani RJ. Widespread distribution of reticulon-3 in various neurodegenerative diseases. Neuropathology. 2010 Dec; 30(6):574-9. PMID: 20374499; PMCID: PMC2902651.
      Citations: 13     Fields:    
    92. Perry GH, Marioni JC, Gilad Y, Melsted P. Genomic-scale capture and sequencing of endogenous DNA from feces. Mol Ecol. 2010 Dec; 19(24):5332-44. PMID: 21054605; PMCID: PMC2998560.
      Citations: 46     Fields:    
    93. Stone AC, Battistuzzi FU, Kubatko LS, Perry GH, Trudeau E, Lin H, Kumar S. More reliable estimates of divergence times in Pan using complete mtDNA sequences and accounting for population structure. Philos Trans R Soc Lond B Biol Sci. 2010 Oct 27; 365(1556):3277-88. PMID: 20855302; PMCID: PMC2981963.
      Citations: 31     Fields:    Translation:AnimalsCells
    94. Castellani RJ, Nugent SL, Morrison AL, Zhu X, Lee HG, Harris PL, Bajic V, Sharma HS, Chen SG, Oettgen P, Perry G, Smith MA. CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease. J Neural Transm (Vienna). 2011 Jan; 118(1):23-6. PMID: 20972807; PMCID: PMC3090073.
      Citations: 7     Fields:    
    95. Clark TA, Lee HP, Rolston RK, Zhu X, Marlatt MW, Castellani RJ, Nunomura A, Casadesus G, Smith MA, Lee HG, Perry G. Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease. Int J Biomed Sci. 2010 Sep; 6(3):225-227. PMID: 21765811; PMCID: PMC3134937.
      Citations: 30     
    96. Luca F, Perry GH, Di Rienzo A. Evolutionary adaptations to dietary changes. Annu Rev Nutr. 2010 Aug 21; 30:291-314. PMID: 20420525; PMCID: PMC4163920.
      Citations: 78     Fields:    Translation:HumansAnimals
    97. Zou WQ, Puoti G, Xiao X, Yuan J, Qing L, Cali I, Shimoji M, Langeveld JP, Castellani R, Notari S, Crain B, Schmidt RE, Geschwind M, Dearmond SJ, Cairns NJ, Dickson D, Honig L, Torres JM, Mastrianni J, Capellari S, Giaccone G, Belay ED, Schonberger LB, Cohen M, Perry G, Kong Q, Parchi P, Tagliavini F, Gambetti P. Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein. Ann Neurol. 2010 Aug; 68(2):162-72. PMID: 20695009; PMCID: PMC3032610.
      Citations: 97     Fields:    
    98. Lee HP, Zhu X, Casadesus G, Castellani RJ, Nunomura A, Smith MA, Lee HG, Perry G. Antioxidant approaches for the treatment of Alzheimer's disease. Expert Rev Neurother. 2010 Jul; 10(7):1201-8. PMID: 20586698.
      Citations: 40     Fields:    Translation:HumansAnimals
    99. Moh CF, Siedlak SL, Tabaton M, Perry G, Castellani RJ, Smith MA. Paraffin-embedded tissue (PET) blot method: application to Alzheimer disease. J Neurosci Methods. 2010 Jul 15; 190(2):244-7. PMID: 20580647; PMCID: PMC2906114.
      Citations: 3     Fields:    
    100. Mondragón-Rodríguez S, Basurto-Islas G, Lee HG, Perry G, Zhu X, Castellani RJ, Smith MA. Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis. Expert Rev Neurother. 2010 May; 10(5):683-91. PMID: 20420489; PMCID: PMC2922904.
      Citations: 24     Fields:    
    101. Bonda DJ, Mailankot M, Stone JG, Garrett MR, Staniszewska M, Castellani RJ, Siedlak SL, Zhu X, Lee HG, Perry G, Nagaraj RH, Smith MA. Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease. Redox Rep. 2010; 15(4):161-8. PMID: 20663292; PMCID: PMC2956440.
      Citations: 57     Fields:    
    102. Perry GH, Pickrell JK. A rod cell marker of nocturnal ancestry. J Hum Evol. 2010 Feb; 58(2):207-10. PMID: 19942252; PMCID: PMC2813975.
      Citations: 2     Fields:    
    103. Su B, Liu H, Wang X, Chen SG, Siedlak SL, Kondo E, Choi R, Takeda A, Castellani RJ, Perry G, Smith MA, Zhu X, Lee HG. Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease. Mol Neurodegener. 2009 Jul 23; 4:32. PMID: 19627592; PMCID: PMC2723103.
      Citations: 23     Fields:    
    104. Friedlich AL, Rolston RK, Zhu X, Marlatt MW, Castellani RJ, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA. Treatment advances in Alzheimer's disease based on the oxidative stress model. F1000 Med Rep. 2009 Jul 08; 1. PMID: 20948726; PMCID: PMC2948307.
      Citations:    
    105. Bonda DJ, Evans TA, Santocanale C, Llosá JC, Viña J, Bajic V, Castellani RJ, Siedlak SL, Perry G, Smith MA, Lee HG. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging (Albany NY). 2009 Apr; 1(4):382-8. PMID: 19946466; PMCID: PMC2783633.
      Citations: 49     Fields:    
    106. Castellani RJ, Zhu X, Lee HG, Smith MA, Perry G. Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches. Int J Mol Sci. 2009 Mar; 10(3):1386-1406. PMID: 19399255; PMCID: PMC2672036.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    107. Perry GH. The evolutionary significance of copy number variation in the human genome. Cytogenet Genome Res. 2008; 123(1-4):283-7. PMID: 19287166; PMCID: PMC2920192.
      Citations: 16     Fields:    Translation:HumansAnimals
    108. Nunomura A, Hofer T, Moreira PI, Castellani RJ, Smith MA, Perry G. RNA oxidation in Alzheimer disease and related neurodegenerative disorders. Acta Neuropathol. 2009 Jul; 118(1):151-66. PMID: 19271225.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    109. Perry GH, Dominy NJ. Evolution of the human pygmy phenotype. Trends Ecol Evol. 2009 Apr; 24(4):218-25. PMID: 19246118.
      Citations: 52     Fields:    Translation:Humans
    110. Rolston RK, Perry G, Zhu X, Castellani RJ, Dwyer BE, Lee HG, Petersen RB, Smith MA. Iron: A Pathological Mediator of Alzheimer Disease? Agro Food Ind Hi Tech. 2009 Jan 31; 19(6):33-36. PMID: 21544251; PMCID: PMC3085186.
      Citations: 9     
    111. Lee HG, Casadesus G, Nunomura A, Zhu X, Castellani RJ, Richardson SL, Perry G, Felsher DW, Petersen RB, Smith MA. The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. Am J Pathol. 2009 Mar; 174(3):891-7. PMID: 19164506; PMCID: PMC2665749.
      Citations: 45     Fields:    
    112. Castellani RJ, Lee HG, Siedlak SL, Nunomura A, Hayashi T, Nakamura M, Zhu X, Perry G, Smith MA. Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta. J Alzheimers Dis. 2009; 18(2):447-52. PMID: 19584435; PMCID: PMC2907530.
      Citations: 53     Fields:    
    113. Lee HG, Casadesus G, Zhu X, Castellani RJ, McShea A, Perry G, Petersen RB, Bajic V, Smith MA. Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease. Neurochem Int. 2009 Feb; 54(2):84-8. PMID: 19114068; PMCID: PMC2792898.
      Citations: 66     Fields:    
    114. Stone JG, Rolston RK, Ueda M, Lee HG, Richardson SL, Castellani RJ, Perry G, Smith MA. Evidence for the novel expression of human kallikrein-related peptidase 3, prostate-specific antigen, in the brain. Int J Clin Exp Pathol. 2009; 2(3):267-74. PMID: 19079621; PMCID: PMC2600468.
      Citations: 3     Fields:    
    115. Verrelli BC, Lewis CM, Stone AC, Perry GH. Different selective pressures shape the molecular evolution of color vision in chimpanzee and human populations. Mol Biol Evol. 2008 Dec; 25(12):2735-43. PMID: 18832077; PMCID: PMC2721556.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    116. Bryan KJ, Zhu X, Harris PL, Perry G, Castellani RJ, Smith MA, Casadesus G. Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease. Mol Neurodegener. 2008 Sep 11; 3:13. PMID: 18786268; PMCID: PMC2565661.
      Citations: 42     Fields:    
    117. Perry GH, Yang F, Marques-Bonet T, Murphy C, Fitzgerald T, Lee AS, Hyland C, Stone AC, Hurles ME, Tyler-Smith C, Eichler EE, Carter NP, Lee C, Redon R. Copy number variation and evolution in humans and chimpanzees. Genome Res. 2008 Nov; 18(11):1698-710. PMID: 18775914; PMCID: PMC2577862.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
    118. Castellani RJ, Nunomura A, Lee HG, Perry G, Smith MA. Phosphorylated tau: toxic, protective, or none of the above. J Alzheimers Dis. 2008 Aug; 14(4):377-83. PMID: 18688087; PMCID: PMC2765711.
      Citations: 33     Fields:    
    119. Garoon JP, Duggan PS. Discourses of disease, discourses of disadvantage: a critical analysis of National Pandemic Influenza Preparedness Plans. Soc Sci Med. 2008 Oct; 67(7):1133-42. PMID: 18656294.
      Citations: 19     Fields:    Translation:HumansPHPublic Health
    120. Castellani RJ, Lee HG, Zhu X, Perry G, Smith MA. Alzheimer disease pathology as a host response. J Neuropathol Exp Neurol. 2008 Jun; 67(6):523-31. PMID: 18520771; PMCID: PMC2763411.
      Citations: 45     Fields:    
    121. Castellani RJ, Nunomura A, Rolston RK, Moreira PI, Takeda A, Perry G, Smith MA. Sublethal RNA oxidation as a mechanism for neurodegenerative disease. Int J Mol Sci. 2008 May; 9(5):789-806. PMID: 19325784; PMCID: PMC2635712.
      Citations: 17     Fields:    
    122. Gustaw KA, Garrett MR, Lee HG, Castellani RJ, Zagorski MG, Prakasam A, Siedlak SL, Zhu X, Perry G, Petersen RB, Friedland RP, Smith MA. Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis. J Neurochem. 2008 Aug; 106(3):1350-6. PMID: 18485104; PMCID: PMC2575068.
      Citations: 20     Fields:    
    123. Myung NH, Zhu X, Kruman II, Castellani RJ, Petersen RB, Siedlak SL, Perry G, Smith MA, Lee HG. Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. Age (Dordr). 2008 Dec; 30(4):209-15. PMID: 19424844; PMCID: PMC2585649.
      Citations: 68     Fields:    
    124. Ionita-Laza I, Perry GH, Raby BA, Klanderman B, Lee C, Laird NM, Weiss ST, Lange C. On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test. Genet Epidemiol. 2008 Apr; 32(3):273-84. PMID: 18228561.
      Citations: 28     Fields:    Translation:Humans
    125. Shah RS, Lee HG, Xiongwei Z, Perry G, Smith MA, Castellani RJ. Current approaches in the treatment of Alzheimer's disease. Biomed Pharmacother. 2008 Apr-May; 62(4):199-207. PMID: 18407457.
      Citations: 40     Fields:    Translation:HumansPHPublic Health
    126. Gonzalez-Cuyar LF, Perry G, Miyajima H, Atwood CS, Riveros-Angel M, Lyons PF, Siedlak SL, Smith MA, Castellani RJ. Redox active iron accumulation in aceruloplasminemia. Neuropathology. 2008 Oct; 28(5):466-71. PMID: 18282164.
      Citations: 15     Fields:    Translation:HumansCells
    127. Perry GH, Ben-Dor A, Tsalenko A, Sampas N, Rodriguez-Revenga L, Tran CW, Scheffer A, Steinfeld I, Tsang P, Yamada NA, Park HS, Kim JI, Seo JS, Yakhini Z, Laderman S, Bruhn L, Lee C. The fine-scale and complex architecture of human copy-number variation. Am J Hum Genet. 2008 Mar; 82(3):685-95. PMID: 18304495; PMCID: PMC2661628.
      Citations: 153     Fields:    Translation:HumansCells
    128. Lee AS, Perry GH, Vallender EJ, Johnson WE, Miller GM, Korbel JO, Lee C, Gutiérrez-Arcelus M. Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies. Hum Mol Genet. 2008 Apr 15; 17(8):1127-36. PMID: 18180252.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    129. Perry G, Castellani RJ, Moreira PI, Lee HG, Zhu X, Smith MA. Pathology's new role: defining disease process and protective responses. Int J Clin Exp Pathol. 2008 Jan 01; 1(1):1-4. PMID: 18784818; PMCID: PMC2480530.
      Citations: 1     Fields:    
    130. Castellani RJ, Perry G, Smith MA. The role of novel chitin-like polysaccharides in Alzheimer disease. Neurotox Res. 2007 Dec; 12(4):269-74. PMID: 18201954.
      Citations: 17     Fields:    Translation:HumansAnimals
    131. Perry GH, Dominy NJ, Claw KG, Lee AS, Fiegler H, Redon R, Werner J, Villanea FA, Mountain JL, Misra R, Carter NP, Lee C, Stone AC. Diet and the evolution of human amylase gene copy number variation. Nat Genet. 2007 Oct; 39(10):1256-60. PMID: 17828263; PMCID: PMC2377015.
      Citations: 525     Fields:    
    132. Uscher-Pines L, Duggan PS, Garoon JP, Karron RA, Faden RR. Social justice and disadvantaged groups. Hastings Cent Rep. 2007 Jul-Aug; 37(4):32-9. PMID: 17844922.
      Citations: 22     Fields:    Translation:HumansPHPublic Health
    133. Perry GH, Martin RD, Verrelli BC. Signatures of functional constraint at aye-aye opsin genes: the potential of adaptive color vision in a nocturnal primate. Mol Biol Evol. 2007 Sep; 24(9):1963-70. PMID: 17575304.
      Citations: 17     Fields:    Translation:Animals
    134. Castellani RJ, Moreira PI, Liu G, Dobson J, Perry G, Smith MA, Zhu X. Iron: the Redox-active center of oxidative stress in Alzheimer disease. Neurochem Res. 2007 Oct; 32(10):1640-5. PMID: 17508283.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    135. Castellani RJ, Zhu X, Lee HG, Moreira PI, Perry G, Smith MA. Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees? Expert Rev Neurother. 2007 May; 7(5):473-85. PMID: 17492899.
      Citations: 9     Fields:    Translation:HumansAnimals
    136. Parker-Katiraee L, Carson AR, Yamada T, Arnaud P, Feil R, Abu-Amero SN, Moore GE, Kaneda M, Perry GH, Stone AC, Lee C, Meguro-Horike M, Sasaki H, Kobayashi K, Nakabayashi K, Scherer SW. Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. PLoS Genet. 2007 May 04; 3(5):e65. PMID: 17480121; PMCID: PMC1865561.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    137. Lee HG, Zhu X, Castellani RJ, Nunomura A, Perry G, Smith MA. Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses. J Pharmacol Exp Ther. 2007 Jun; 321(3):823-9. PMID: 17229880.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    138. Perry GH, Tito RY, Verrelli BC. The evolutionary history of human and chimpanzee Y-chromosome gene loss. Mol Biol Evol. 2007 Mar; 24(3):853-9. PMID: 17218643.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    139. Gonzalez-Cuyar LF, Hunter B, Harris PL, Perry G, Smith MA, Castellani RJ. Cerebrotendinous xanthomatosis: case report with evidence of oxidative stress. Redox Rep. 2007; 12(3):119-24. PMID: 17623518.
      Citations: 7     Fields:    Translation:Humans
    140. Redon R, Ishikawa S, Fitch KR, Feuk L, Perry GH, Andrews TD, Fiegler H, Shapero MH, Carson AR, Chen W, Cho EK, Dallaire S, Freeman JL, Huang J, Kalaitzopoulos D, Komura D, MacDonald JR, Marshall CR, Mei R, Montgomery L, Nishimura K, Okamura K, Shen F, Somerville MJ, Tchinda J, Valsesia A, Woodwark C, Yang F, Zhang J, Zerjal T, Zhang J, Armengol L, Conrad DF, Estivill X, Tyler-Smith C, Carter NP, Aburatani H, Lee C, Jones KW, Scherer SW, Hurles ME, González JR, Gratacòs M. Global variation in copy number in the human genome. Nature. 2006 Nov 23; 444(7118):444-54. PMID: 17122850; PMCID: PMC2669898.
      Citations: 1608     Fields:    
    141. Fiegler H, Redon R, Andrews D, Scott C, Andrews R, Carder C, Clark R, Dovey O, Ellis P, Feuk L, French L, Hunt P, Kalaitzopoulos D, Larkin J, Montgomery L, Perry GH, Plumb BW, Porter K, Rigby RE, Rigler D, Valsesia A, Langford C, Humphray SJ, Scherer SW, Lee C, Hurles ME, Carter NP. Accurate and reliable high-throughput detection of copy number variation in the human genome. Genome Res. 2006 Dec; 16(12):1566-74. PMID: 17122085; PMCID: PMC1665640.
      Citations: 58     Fields:    Translation:HumansCells
    142. Previll LA, Crosby ME, Castellani RJ, Bowser R, Perry G, Smith MA, Zhu X. Increased expression of p130 in Alzheimer disease. Neurochem Res. 2007 Apr-May; 32(4-5):639-44. PMID: 17006760.
      Citations: 6     Fields:    Translation:HumansCells
    143. Lam-Himlin D, Espey MG, Perry G, Smith MA, Castellani RJ. Malignant glioma progression and nitric oxide. Neurochem Int. 2006 Dec; 49(8):764-8. PMID: 16971023.
      Citations: 20     Fields:    Translation:Humans
    144. Nunomura A, Castellani RJ, Zhu X, Moreira PI, Perry G, Smith MA. Involvement of oxidative stress in Alzheimer disease. J Neuropathol Exp Neurol. 2006 Jul; 65(7):631-41. PMID: 16825950.
      Citations: 177     Fields:    Translation:HumansAnimalsCells
    145. Freeman JL, Perry GH, Feuk L, Redon R, McCarroll SA, Altshuler DM, Aburatani H, Jones KW, Tyler-Smith C, Hurles ME, Carter NP, Scherer SW, Lee C. Copy number variation: new insights in genome diversity. Genome Res. 2006 Aug; 16(8):949-61. PMID: 16809666.
      Citations: 304     Fields:    Translation:HumansAnimals
    146. Smith MA, Zhu X, Lee HG, Harris PL, Fortino AE, Perry G, Castellani RJ. Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: pathogenic implications for ischemic cardiomyopathy. Age (Dordr). 2006 Mar; 28(1):85-91. PMID: 23598681; PMCID: PMC2464719.
      Citations:    Fields:    
    147. Perry GH, Tchinda J, McGrath SD, Zhang J, Picker SR, Iafrate AJ, Tyler-Smith C, Scherer SW, Eichler EE, Stone AC, Lee C, Cáceres AM. Hotspots for copy number variation in chimpanzees and humans. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8006-11. PMID: 16702545; PMCID: PMC1472420.
      Citations: 111     Fields:    Translation:HumansAnimalsCells
    148. Nunomura A, Castellani RJ, Lee HG, Moreira PI, Zhu X, Perry G, Smith MA. Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream. Sci Aging Knowledge Environ. 2006 May 03; 2006(8):pe10. PMID: 16672726.
      Citations: 5     Fields:    Translation:HumansCells
    149. Castellani RJ, Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Neuropathology of Alzheimer disease: pathognomonic but not pathogenic. Acta Neuropathol. 2006 Jun; 111(6):503-9. PMID: 16718346.
      Citations: 36     Fields:    Translation:Humans
    150. Castellani RJ, Lee HG, Perry G, Smith MA. Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau. Am J Alzheimers Dis Other Demen. 2006 Mar-Apr; 21(2):126-30. PMID: 16634469; PMCID: PMC10833251.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    151. Perry GH, Verrelli BC, Stone AC. Molecular evolution of the primate developmental genes MSX1 and PAX9. Mol Biol Evol. 2006 Mar; 23(3):644-54. PMID: 16326750.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    152. Castellani RJ, Siedlak SL, Fortino AE, Perry G, Ghetti B, Smith MA. Chitin-like polysaccharides in Alzheimer's disease brains. Curr Alzheimer Res. 2005 Oct; 2(4):419-23. PMID: 16248847.
      Citations: 23     Fields:    Translation:HumansCells
    153. Petersen RB, Siedlak SL, Lee HG, Kim YS, Nunomura A, Tagliavini F, Ghetti B, Cras P, Moreira PI, Castellani RJ, Guentchev M, Budka H, Ironside JW, Gambetti P, Smith MA, Perry G. Redox metals and oxidative abnormalities in human prion diseases. Acta Neuropathol. 2005 Sep; 110(3):232-8. PMID: 16096758.
      Citations: 19     Fields:    Translation:HumansCells
    154. Lee HG, Castellani RJ, Zhu X, Perry G, Smith MA. Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective? Int J Exp Pathol. 2005 Jun; 86(3):133-8. PMID: 15910547; PMCID: PMC2517413.
      Citations: 18     Fields:    Translation:Humans
    155. Moreira PI, Smith MA, Zhu X, Nunomura A, Castellani RJ, Perry G. Oxidative stress and neurodegeneration. Ann N Y Acad Sci. 2005 Jun; 1043:545-52. PMID: 16037277.
      Citations: 56     Fields:    Translation:Humans
    156. Castellani RJ, Honda K, Zhu X, Cash AD, Nunomura A, Perry G, Smith MA. Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease. Ageing Res Rev. 2004 Jul; 3(3):319-26. PMID: 15231239.
      Citations: 19     Fields:    Translation:HumansCells
    157. Castellani RJ, Smith MA, Perry G, Friedland RP. Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer's disease pathogenesis. Neurobiol Aging. 2004 May-Jun; 25(5):599-602; discussion 603-4. PMID: 15172735.
      Citations: 23     Fields:    Translation:HumansAnimals
    158. Zhu X, McShea A, Harris PL, Raina AK, Castellani RJ, Funk JO, Shah S, Atwood C, Bowen R, Bowser R, Morelli L, Perry G, Smith MA. Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease. J Neurosci Res. 2004 Mar 01; 75(5):698-703. PMID: 14991845.
      Citations: 25     Fields:    Translation:HumansCells
    159. Perry G, Smith MA, Castellani RJ. Prion disease and Alzheimer's disease: pathogenic overlap. Acta Neurobiol Exp (Wars). 2004; 64(1):11-7. PMID: 15190676.
      Citations: 6     Fields:    Translation:Humans
    160. Perry G, Castellani RJ, Smith MA, Harris PL, Kubat Z, Ghanbari K, Jones PK, Cordone G, Tabaton M, Wolozin B, Ghanbari H. Oxidative damage in the olfactory system in Alzheimer's disease. Acta Neuropathol. 2003 Dec; 106(6):552-6. PMID: 12955399.
      Citations: 11     Fields:    Translation:HumansCells
    161. Cash AD, Aliev G, Siedlak SL, Nunomura A, Fujioka H, Zhu X, Raina AK, Vinters HV, Tabaton M, Johnson AB, Paula-Barbosa M, Avíla J, Jones PK, Castellani RJ, Smith MA, Perry G. Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. Am J Pathol. 2003 May; 162(5):1623-7. PMID: 12707046; PMCID: PMC1851211.
      Citations: 106     Fields:    Translation:HumansCells
    162. Perry G, Taddeo MA, Petersen RB, Castellani RJ, Harris PL, Siedlak SL, Cash AD, Liu Q, Nunomura A, Atwood CS, Smith MA. Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease. Biometals. 2003 Mar; 16(1):77-81. PMID: 12572666.
      Citations: 32     Fields:    Translation:HumansCells
    163. Nunomura A, Chiba S, Kosaka K, Takeda A, Castellani RJ, Smith MA, Perry G. Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies. Neuroreport. 2002 Nov 15; 13(16):2035-9. PMID: 12438921.
      Citations: 29     Fields:    Translation:Humans
    164. Castellani R, Hirai K, Aliev G, Drew KL, Nunomura A, Takeda A, Cash AD, Obrenovich ME, Perry G, Smith MA. Role of mitochondrial dysfunction in Alzheimer's disease. J Neurosci Res. 2002 Nov 01; 70(3):357-60. PMID: 12391597.
      Citations: 116     Fields:    Translation:HumansAnimalsCells
    165. Guentchev M, Siedlak SL, Jarius C, Tagliavini F, Castellani RJ, Perry G, Smith MA, Budka H. Oxidative damage to nucleic acids in human prion disease. Neurobiol Dis. 2002 Apr; 9(3):275-81. PMID: 11950273.
      Citations: 19     Fields:    Translation:Humans
    166. Kikuchi A, Takeda A, Onodera H, Kimpara T, Hisanaga K, Sato N, Nunomura A, Castellani RJ, Perry G, Smith MA, Itoyama Y. Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy. Neurobiol Dis. 2002 Mar; 9(2):244-8. PMID: 11895375.
      Citations: 99     Fields:    Translation:HumansCells
    167. Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, Montine T, Sayre LM, Smith MA. Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. Neurosci Lett. 2002 Feb 08; 319(1):25-8. PMID: 11814645.
      Citations: 52     Fields:    Translation:HumansCells
    168. Zhou F, Smith MA, Castellani RJ, Stimmelmayr R, Perry G, Drew KL, Zhu X. Hibernation, a Model of Neuroprotection. ScientificWorldJournal. 2001; 1:108. PMID: 30147589; PMCID: PMC6084134.
      Citations: 2     Fields:    
    169. Perry G, Castellani RJ, Hirai K, Smith MA. Reactive Oxygen Species Mediate Cellular Damage in Alzheimer Disease. J Alzheimers Dis. 1998 Mar; 1(1):45-55. PMID: 12214011.
      Citations: 43     Fields:    
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