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Shasha Wu

TitleAssociate Professor
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Wu's research focuses on the investigation of EEG biomarkers for the epileptogenic tissue, such as infra slowing activity and High-Frequency Oscillations using intracranial EEG recordings. The goal of the research is to help in delineating the epileptic brain tissue for epilepsy surgery and to improve the surgical outcome.

    Collapse Biography 
    Collapse education and training
    University Hospitals Case Medical Center, Cleveland, OH06/2012Clinical Fellowship in Clinical Neurophysiology and Epilepsy
    University of Vermont, Burlington, VT06/2010Neurology Residency
    AtlantiCare Regional Medical Center, Atlantic City, NJ06/2007Medical Intership
    University of Pittsburgh, Pittsburgh, PA06/2006Research Fellow
    Peking University, Beijing, ChinaPhD06/2000Molecular Biology
    Baotou Medical College, Inner Mongolia, ChinaMD06/1994Medicine

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Satzer D, Wu S, Henry J, Doll E, Issa NP, Warnke Peter C. Ambulatory Local Field Potential Recordings from the Thalamus in Epilepsy: A Feasibility Study. Stereotact Funct Neurosurg. 2023; 101(3):195-206. PMID: 37232010.
      Citations:    Fields:    Translation:Humans
    2. Michalak AJ, Greenblatt A, Wu S, Tobochnik S, Dave H, Raghupathi R, Esengul YT, Guerra A, Tao JX, Issa NP, Cosgrove GR, Lega B, Warnke P, Chen HI, Lucas T, Sheth SA, Banks GP, Kwon CS, Feldstein N, Youngerman B, McKhann G, Davis KA, Schevon CA. Seizure onset patterns predict outcome after stereo-electroencephalography-guided laser amygdalohippocampotomy. Epilepsia. 2023 06; 64(6):1568-1581. PMID: 37013668; PMCID: PMC10247471.
      Citations: 2     Fields:    Translation:Humans
    3. Issa NP, Nunn KC, Wu S, Haider HA, Tao JX. Putative roles for homeostatic plasticity in epileptogenesis. Epilepsia. 2023 03; 64(3):539-552. PMID: 36617338; PMCID: PMC10015501.
      Citations: 4     Fields:    Translation:Humans
    4. Creery JD, Brang DJ, Arndt JD, Bassard A, Towle VL, Tao JX, Wu S, Rose S, Warnke PC, Issa NP, Paller KA. Electrophysiological markers of memory consolidation in the human brain when memories are reactivated during sleep. Proc Natl Acad Sci U S A. 2022 11; 119(44):e2123430119. PMID: 36279460; PMCID: PMC9636913.
      Citations: 6     Fields:    Translation:Humans
    5. Lee S, Henry J, Tryba AK, Esengul Y, Warnke P, Wu S, van Drongelen W. Digital reconstruction of infraslow activity in human intracranial ictal recordings using a deconvolution-based inverse filter. Sci Rep. 2022 08 11; 12(1):13701. PMID: 35953580; PMCID: PMC9372169.
      Citations:    Fields:    Translation:Humans
    6. Brang D, Plass J, Sherman A, Stacey WC, Wasade VS, Grabowecky M, Ahn E, Towle VL, Tao JX, Wu S, Issa NP, Suzuki S. Visual cortex responds to sound onset and offset during passive listening. J Neurophysiol. 2022 06 01; 127(6):1547-1563. PMID: 35507478; PMCID: PMC9190746.
      Citations: 2     Fields:    Translation:Humans
    7. Bruzzone MJ, Issa NP, Wu S, Rose S, Esengul YT, Towle VL, Nordli D, Warnke PC, Tao JX. Hippocampal spikes have heterogeneous scalp EEG correlates important for defining IEDs. Epilepsy Res. 2022 05; 182:106914. PMID: 35367692.
      Citations: 1     Fields:    Translation:Humans
    8. Karthik G, Plass J, Beltz AM, Liu Z, Grabowecky M, Suzuki S, Stacey WC, Wasade VS, Towle VL, Tao JX, Wu S, Issa NP, Brang D. Visual speech differentially modulates beta, theta, and high gamma bands in auditory cortex. Eur J Neurosci. 2021 11; 54(9):7301-7317. PMID: 34587350; PMCID: PMC8630510.
      Citations: 1     Fields:    Translation:Humans
    9. Lee S, Wu S, Tao JX, Rose S, Warnke PC, Issa NP, van Drongelen W. Manifestation of Hippocampal Interictal Discharges on Clinical Scalp EEG Recordings. J Clin Neurophysiol. 2023 Feb 01; 40(2):144-150. PMID: 34010227; PMCID: PMC8590709.
      Citations: 2     Fields:    Translation:Humans
    10. Abumurad S, Issa NP, Wu S, Rose S, Taylan Esengul Y, Nordli D, Warnke PC, Tao JX. Laser interstitial thermal therapy for NPRL3-related epilepsy with multiple seizure foci: A case report. Epilepsy Behav Rep. 2021; 16:100459. PMID: 34235417; PMCID: PMC8249776.
      Citations: 4     
    11. Wu S, Issa NP, Lacy M, Satzer D, Rose SL, Yang CW, Collins JM, Liu X, Sun T, Towle VL, Nordli DR, Warnke PC, Tao JX. Surgical Outcomes and EEG Prognostic Factors After Stereotactic Laser Amygdalohippocampectomy for Mesial Temporal Lobe Epilepsy. Front Neurol. 2021; 12:654668. PMID: 34079512; PMCID: PMC8165234.
      Citations: 3     
    12. Mera RM, Wu S, Recalde BY, Issa NP, Del Brutto OH. Epilepsy, interictal EEG abnormalities and hippocampal atrophy in patients with calcified neurocysticercosis: a population study in an endemic milieu. Epileptic Disord. 2021 Apr 01; 23(2):357-365. PMID: 33926860.
      Citations: 4     Fields:    Translation:Humans
    13. Santos de Lima F, Klein S, El Ammar F, Wu S, Rose S, Tao JX, Issa NP. Rapid development of seizures and PRES in a COVID-19 patient. Epilepsy Behav Rep. 2021; 15:100436. PMID: 33688630; PMCID: PMC7931684.
      Citations: 5     
    14. Wu S, Mera RM, Recalde BY, Issa NP, Del Brutto OH, Costa AF. Cognitive decline among individuals with history of mild symptomatic SARS-CoV-2 infection: A longitudinal prospective study nested to a population cohort. Eur J Neurol. 2021 10; 28(10):3245-3253. PMID: 33576150; PMCID: PMC8014083.
      Citations: 58     Fields:    Translation:HumansCells
    15. Santos de Lima F, Issa N, Seibert K, Davis J, Wlodarski R, Klein S, El Ammar F, Wu S, Rose S, Warnke P, Tao J. Epileptiform activity and seizures in patients with COVID-19. J Neurol Neurosurg Psychiatry. 2021 05; 92(5):565-566. PMID: 33158913.
      Citations: 17     Fields:    Translation:Humans
    16. Zheng W, Minama Reddy GK, Dai F, Chandramani A, Brang D, Hunter S, Kohrman MH, Rose S, Rossi M, Tao J, Wu S, Byrne R, Frim DM, Warnke P, Towle VL. Chasing language through the brain: Successive parallel networks. Clin Neurophysiol. 2021 01; 132(1):80-93. PMID: 33360179.
      Citations: 3     Fields:    Translation:Humans
    17. Chen Z, Issa NP, Wu S, Liu X, Sun T, Bodnya J, Rose S, Tao JX. The clinical significance of small sharp spikes: A retrospective study of 909 patients in epilepsy monitoring unit. Epilepsy Res. 2020 12; 168:106477. PMID: 33096313.
      Citations:    Fields:    Translation:Humans
    18. Sun T, Liu X, Issa NP, Rose S, Wu S, Wang Q, Martinez R, Towle VL, Jr DRN, Warnke P, Tao JX. RTTBD-like activity in association with hippocampal ictal discharges in patients with temporal lobe epilepsy. Epileptic Disord. 2020 Aug 01; 22(4):462-472. PMID: 32763870.
      Citations: 1     Fields:    Translation:Humans
    19. Arabkheradmand G, Zhou G, Noto T, Yang Q, Schuele SU, Parvizi J, Gottfried JA, Wu S, Rosenow JM, Koubeissi MZ, Lane G, Zelano C. Anticipation-induced delta phase reset improves human olfactory perception. PLoS Biol. 2020 05; 18(5):e3000724. PMID: 32453719; PMCID: PMC7250403.
      Citations: 4     Fields:    Translation:Humans
    20. Tao JX, Satzer D, Issa NP, Collins J, Wu S, Rose S, Henry J, Santos de Lima F, Nordli D, Warnke PC. Stereotactic laser anterior corpus callosotomy for Lennox-Gastaut syndrome. Epilepsia. 2020 06; 61(6):1190-1200. PMID: 32401350.
      Citations: 7     Fields:    Translation:Humans
    21. Satzer D, Tao JX, Issa NP, Chen Z, Wu S, Rose S, Collins J, Awad IA, Warnke PC. Stereotactic laser interstitial thermal therapy for epilepsy associated with solitary and multiple cerebral cavernous malformations. Neurosurg Focus. 2020 04 01; 48(4):E12. PMID: 32234994.
      Citations: 5     Fields:    Translation:Humans
    22. Issa NP, Wu S, Rose S, Tao JX. Prone position: An underrecognized and preventable risk for SUDEP. Epilepsy Behav. 2020 03; 104(Pt A):106918. PMID: 32058301.
      Citations:    Fields:    
    23. Rose S, Issa NP, Wu S, Liu X, Tao JX. Reader response: Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP). Neurology. 2019 12 03; 93(23):1020-1021. PMID: 31792108.
      Citations:    Fields:    Translation:Humans
    24. Tao JX, Issa NP, Wu S, Rose S, Collins J, Warnke PC. Interstitial Stereotactic Laser Anterior Corpus Callosotomy: A Report of 2 Cases with Operative Technique and Effectiveness. Neurosurgery. 2019 09 01; 85(3):E569-E574. PMID: 29982584.
      Citations: 3     Fields:    Translation:Humans
    25. Liu X, Wu S, Daif A, Sun T, Chauhan V, Issa NP, Rose S, Tao JX. Clinical implications of scalp ictal EEG pattern in patients with temporal lobe epilepsy. Clin Neurophysiol. 2019 09; 130(9):1604-1610. PMID: 31319289.
      Citations: 1     Fields:    Translation:Humans
    26. Lee S, Issa NP, Rose S, Tao JX, Warnke PC, Towle VL, van Drongelen W, Wu S. DC shifts, high frequency oscillations, ripples and fast ripples in relation to the seizure onset zone. Seizure. 2020 Apr; 77:52-58. PMID: 31101405; PMCID: PMC6825882.
      Citations: 11     Fields:    Translation:Humans
    27. Plass J, Ahn E, Towle VL, Stacey WC, Wasade VS, Tao J, Wu S, Issa NP, Brang D. Joint Encoding of Auditory Timing and Location in Visual Cortex. J Cogn Neurosci. 2019 07; 31(7):1002-1017. PMID: 30912728; PMCID: PMC6551606.
      Citations: 8     Fields:    Translation:Humans
    28. Liu X, Issa NP, Rose S, Wu S, Sun T, Towle LV, Warnke PC, Tao JX. The first-hour-of-the-day sleep EEG reliably identifies interictal epileptiform discharges during long-term video-EEG monitoring. Seizure. 2018 Dec; 63:48-51. PMID: 30399461.
      Citations: 3     Fields:    Translation:Humans
    29. Issa NP, Lee S, Wu S, Rose S, Towle VL, Warnke PC, van Drongelen W, Tao JX. Reply to "which small sharp spikes are benign epileptiform transients of sleep?" Clin Neurophysiol. 2018 11; 129(11):2495-2496. PMID: 30268708.
      Citations:    Fields:    Translation:Humans
    30. Bruzzone MJ, Issa N, Rose S, Warnke P, Towle VL, Tao JX, Wu S. Insights Into the Therapeutic Effect of Responsive Neurostimulation Assessed With Scalp EEG Recording: A Case Report. J Clin Neurophysiol. 2018 Sep; 35(5):438-441. PMID: 29023305.
      Citations: 2     Fields:    Translation:Humans
    31. Issa NP, Wu S, Rose S, Towle VL, Warnke PC, Tao JX. Small sharp spikes as EEG markers of mesiotemporal lobe epilepsy. Clin Neurophysiol. 2018 09; 129(9):1796-1803. PMID: 30005212.
      Citations: 4     Fields:    Translation:Humans
    32. Daif A, Lukas RV, Issa NP, Javed A, VanHaerents S, Reder AT, Tao JX, Warnke P, Rose S, Towle VL, Wu S. Antiglutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy. Epilepsy Behav. 2018 03; 80:331-336. PMID: 29433947.
      Citations: 37     Fields:    Translation:Humans
    33. Tao JX, Wu S, Lacy M, Rose S, Issa NP, Yang CW, Dorociak KE, Bruzzone M, Kim J, Daif A, Choi J, Towle VL, Warnke PC. Stereotactic EEG-guided laser interstitial thermal therapy for mesial temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 2018 05; 89(5):542-548. PMID: 29183959.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    34. Ali A, Wu S, Issa NP, Rose S, Towle VL, Warnke P, Tao JX. Association of sleep with sudden unexpected death in epilepsy. Epilepsy Behav. 2017 11; 76:1-6. PMID: 28917499.
      Citations: 20     Fields:    Translation:Humans
    35. Jiang H, Schuele S, Rosenow J, Zelano C, Parvizi J, Tao JX, Wu S, Gottfried JA. Theta Oscillations Rapidly Convey Odor-Specific Content in Human Piriform Cortex. Neuron. 2017 Apr 05; 94(1):207-219.e4. PMID: 28384472; PMCID: PMC5480455.
      Citations: 26     Fields:    Translation:Humans
    36. Tao JX, Issa N, Collins JW, Wu S, Rose S, Warnke P. Homonymous hemianopsia after MR-guided stereotactic laser amygdalohippocampectomy. Epilepsy Behav. 2017 01; 66:140-141. PMID: 27993511.
      Citations: 1     Fields:    
    37. Serafini A, Issa NP, Rose S, Wu S, Warnke P, Tao JX. TIRDA Originating From Lateral Temporal Cortex in a Patient With mTLE Is Not Related to Hippocampal Activity. J Clin Neurophysiol. 2016 Dec; 33(6):e34-e38. PMID: 27753735.
      Citations: 3     Fields:    Translation:Humans
    38. Wang S, Graf S, Xu J, Issa NP, Ali A, Rose S, Wu S, Jacobsen J, Warnke P, Tao JX. The incidence of peri-ictal prone position in patients with generalized convulsive seizures. Epilepsy Behav. 2016 08; 61:158-161. PMID: 27351726.
      Citations: 3     Fields:    Translation:Humans
    39. Serafini A, Lukas RV, VanHaerents S, Warnke P, Tao JX, Rose S, Wu S. Paraneoplastic epilepsy. Epilepsy Behav. 2016 08; 61:51-58. PMID: 27304613.
      Citations: 17     Fields:    Translation:Humans
    40. Wu S, Issa NP, Rose SL, Ali A, Tao JX. Impact of periictal nurse interventions on postictal generalized EEG suppression in generalized convulsive seizures. Epilepsy Behav. 2016 05; 58:22-5. PMID: 26994879.
      Citations: 5     Fields:    Translation:Humans
    41. Wu S, Tao XJ, Issa N, Rose S, Warnke P. MR-guided laser interstitial thermal therapy for the treatment of medically refractory epilepsy. Int J Neurol Neurother. 2016; (3):42.
    42. Tao J, Liebenthal J, Wu S, Rose S, Ebersole JS. Author response:. Neurology. 2015 Sep 29; 85(13):1185-6. PMID: 26688873.
      Citations:    Fields:    Translation:Humans
    43. Rose S, Wu S, Jiang A, Kim J, Tao JX. Neurogenic pulmonary edema: An etiological factor for SUDEP? Epilepsy Behav. 2015 Nov; 52(Pt A):76-7. PMID: 26409134.
      Citations: 2     Fields:    
    44. Brang D, Towle VL, Suzuki S, Hillyard SA, Di Tusa S, Dai Z, Tao J, Wu S, Grabowecky M. Peripheral sounds rapidly activate visual cortex: evidence from electrocorticography. J Neurophysiol. 2015 Nov; 114(5):3023-8. PMID: 26334017; PMCID: PMC4737427.
      Citations: 13     Fields:    Translation:Humans
    45. Tao JX, Sandra R, Wu S, Ebersole JS. Should the "Back to Sleep" campaign be advocated for SUDEP prevention? Epilepsy Behav. 2015 Apr; 45:79-80. PMID: 25875185.
      Citations: 8     Fields:    
    46. Liebenthal JA, Wu S, Rose S, Ebersole JS, Tao JX. Association of prone position with sudden unexpected death in epilepsy. Neurology. 2015 Feb 17; 84(7):703-9. PMID: 25609764.
      Citations: 39     Fields:    Translation:Humans
    47. Wu S, Kunhi Veedu HP, Lhatoo SD, Koubeissi MZ, Miller JP, L├╝ders HO. Role of ictal baseline shifts and ictal high-frequency oscillations in stereo-electroencephalography analysis of mesial temporal lobe seizures. Epilepsia. 2014 May; 55(5):690-698. PMID: 24725106.
      Citations: 15     Fields:    Translation:Humans
    48. Lee A, Wu S, Zhou X, Liebenthal J, Rose S, Tao JX. Periictal autonomic dysfunction and generalized postictal EEG suppression in convulsive seizures arising from sleep and wakefulness. Epilepsy Behav. 2013 Sep; 28(3):439-43. PMID: 23891764.
      Citations: 3     Fields:    Translation:Humans
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