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Yan Zheng

Title
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Williams JB, Horton BL, Zheng Y, Duan Y, Powell JD, Gajewski TF. The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment. J Exp Med. 2017 02; 214(2):381-400. PMID: 28115575; PMCID: PMC5294847.
      Citations: 88     Fields:    Translation:AnimalsCells
    2. Spaapen RM, Leung MY, Fuertes MB, Kline JP, Zhang L, Zheng Y, Fu YX, Luo X, Cohen KS, Gajewski TF. Therapeutic activity of high-dose intratumoral IFN-ß requires direct effect on the tumor vasculature. J Immunol. 2014 Oct 15; 193(8):4254-60. PMID: 25217157.
      Citations: 50     Fields:    Translation:AnimalsCells
    3. Locke FL, Zha YY, Zheng Y, Driessens G, Gajewski TF. Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction. J Immunol. 2013 Aug 15; 191(4):1677-85. PMID: 23851688; PMCID: PMC3759681.
      Citations: 10     Fields:    Translation:AnimalsCells
    4. Gajewski TF, Woo SR, Zha Y, Spaapen R, Zheng Y, Corrales L, Spranger S. Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment. Curr Opin Immunol. 2013 Apr; 25(2):268-76. PMID: 23579075.
      Citations: 214     Fields:    Translation:Humans
    5. Zheng Y, Zha Y, Spaapen RM, Mathew R, Barr K, Bendelac A, Gajewski TF. Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy. Mol Immunol. 2013 Oct; 55(3-4):283-91. PMID: 23548837; PMCID: PMC3646929.
      Citations: 26     Fields:    Translation:AnimalsCells
    6. Zheng Y, Zha Y, Driessens G, Locke F, Gajewski TF. Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo. J Exp Med. 2012 Nov 19; 209(12):2157-63. PMID: 23129747; PMCID: PMC3501351.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    7. Widau RC, Zheng Y, Sung CY, Zelivianskaia A, Roach LE, Bachmeyer KM, Abramova T, Desgardin A, Rosner A, Cunningham JM, Skapek SX. p19Arf represses platelet-derived growth factor receptor ß by transcriptional and posttranscriptional mechanisms. Mol Cell Biol. 2012 Nov; 32(21):4270-82. PMID: 22907756; PMCID: PMC3486135.
      Citations: 13     Fields:    Translation:AnimalsCells
    8. Avidan MS, Jacobsohn E, Glick D, Burnside BA, Zhang L, Villafranca A, Karl L, Kamal S, Torres B, O'Connor M, Evers AS, Gradwohl S, Lin N, Palanca BJ, Mashour GA, BAG-RECALL Research Group. Prevention of intraoperative awareness in a high-risk surgical population. N Engl J Med. 2011 Aug 18; 365(7):591-600. PMID: 21848460.
      Citations: 135     Fields:    Translation:Humans
    9. Gajewski TF, Fuertes M, Spaapen R, Zheng Y, Kline J. Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment. Curr Opin Immunol. 2011 Apr; 23(2):286-92. PMID: 21185705; PMCID: PMC3070788.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    10. Driessens G, Zheng Y, Locke F, Cannon JL, Gounari F, Gajewski TF. Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-?1 phosphorylation. J Immunol. 2011 Jan 15; 186(2):784-90. PMID: 21149602; PMCID: PMC4888792.
      Citations: 31     Fields:    Translation:AnimalsCells
    11. Zheng Y, Zhao YD, Gibbons M, Abramova T, Chu PY, Ash JD, Cunningham JM, Skapek SX. Tgfbeta signaling directly induces Arf promoter remodeling by a mechanism involving Smads 2/3 and p38 MAPK. J Biol Chem. 2010 Nov 12; 285(46):35654-64. PMID: 20826783; PMCID: PMC2975190.
      Citations: 22     Fields:    Translation:AnimalsCells
    12. Leng S, Zhang W, Zheng Y, Liberman Z, Rhodes CJ, Eldar-Finkelman H, Sun XJ. Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1. J Endocrinol. 2010 Aug; 206(2):171-81. PMID: 20466847; PMCID: PMC3072280.
      Citations: 39     Fields:    Translation:AnimalsCells
    13. Zheng Y, Zhang W, Pendleton E, Leng S, Wu J, Chen R, Sun XJ. Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats. J Endocrinol. 2009 Dec; 203(3):337-47. PMID: 19801385; PMCID: PMC3050029.
      Citations: 29     Fields:    Translation:AnimalsCells
    14. Praveen K, Zheng Y, Rivas F, Gajewski TF. Protein kinase Ctheta focusing at the cSMAC is a consequence rather than cause of TCR signaling and is dependent on the MEK/ERK pathway. J Immunol. 2009 May 15; 182(10):6022-30. PMID: 19414753.
      Citations: 2     Fields:    Translation:AnimalsCells
    15. Zheng Y, Zha Y, Gajewski TF. Molecular regulation of T-cell anergy. EMBO Rep. 2008 Jan; 9(1):50-5. PMID: 18174897; PMCID: PMC2246614.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    16. Zhande R, Zhang W, Zheng Y, Pendleton E, Li Y, Polakiewicz RD, Sun XJ. Dephosphorylation by default, a potential mechanism for regulation of insulin receptor substrate-1/2, Akt, and ERK1/2. J Biol Chem. 2006 Dec 22; 281(51):39071-80. PMID: 17068339.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
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