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Crystal structure of an ancient protein: evolution by conformational epistasis.
Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW. Crystal structure of an ancient protein: evolution by conformational epistasis. Science. 2007 Sep 14; 317(5844):1544-8.
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PubMed
subject areas
Aldosterone
Amino Acid Sequence
Amino Acid Substitution
Animals
Crystallography, X-Ray
Epistasis, Genetic
Evolution, Molecular
Humans
Hydrocortisone
Ligands
Likelihood Functions
Models, Molecular
Molecular Sequence Data
Mutation
Phylogeny
Protein Conformation
Protein Structure, Secondary
Protein Structure, Tertiary
Receptors, Glucocorticoid
Receptors, Mineralocorticoid
authors with profiles
Joseph Thornton
Crystal structure of an ancient protein: evolution by conformational epistasis.