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An epistatic ratchet constrains the direction of glucocorticoid receptor evolution.
Bridgham JT, Ortlund EA, Thornton JW. An epistatic ratchet constrains the direction of glucocorticoid receptor evolution. Nature. 2009 Sep 24; 461(7263):515-9.
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PubMed
subject areas
Animals
CHO Cells
Cricetinae
Cricetulus
Crystallography, X-Ray
Epistasis, Genetic
Evolution, Molecular
Hormones
Models, Biological
Models, Molecular
Mutation
Protein Engineering
Receptors, Glucocorticoid
Sequence Alignment
Substrate Specificity
authors with profiles
Joseph Thornton
An epistatic ratchet constrains the direction of glucocorticoid receptor evolution.