"Substrate Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
| Descriptor ID |
D013379
|
| MeSH Number(s) |
G02.111.835
|
| Concept/Terms |
Substrate Specificity- Substrate Specificity
- Specificities, Substrate
- Specificity, Substrate
- Substrate Specificities
|
Below are MeSH descriptors whose meaning is more general than "Substrate Specificity".
Below are MeSH descriptors whose meaning is more specific than "Substrate Specificity".
This graph shows the total number of publications written about "Substrate Specificity" by people in this website by year, and whether "Substrate Specificity" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 3 | 3 |
| 1997 | 0 | 6 | 6 |
| 1998 | 0 | 7 | 7 |
| 1999 | 0 | 7 | 7 |
| 2000 | 0 | 6 | 6 |
| 2001 | 1 | 11 | 12 |
| 2002 | 0 | 5 | 5 |
| 2003 | 0 | 8 | 8 |
| 2004 | 0 | 15 | 15 |
| 2005 | 0 | 11 | 11 |
| 2006 | 0 | 6 | 6 |
| 2007 | 0 | 14 | 14 |
| 2008 | 0 | 10 | 10 |
| 2009 | 0 | 11 | 11 |
| 2010 | 0 | 17 | 17 |
| 2011 | 0 | 13 | 13 |
| 2012 | 0 | 11 | 11 |
| 2013 | 0 | 13 | 13 |
| 2014 | 0 | 6 | 6 |
| 2015 | 0 | 10 | 10 |
| 2016 | 0 | 14 | 14 |
| 2017 | 0 | 17 | 17 |
| 2018 | 1 | 12 | 13 |
| 2019 | 0 | 2 | 2 |
| 2020 | 1 | 9 | 10 |
| 2021 | 0 | 5 | 5 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
| 2025 | 0 | 4 | 4 |
| 2026 | 0 | 2 | 2 |
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Below are the most recent publications written about "Substrate Specificity" by people in Profiles.
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In vitro properties of large serine integrase hybrids derived from ?C31 and TG1 integrases. Nucleic Acids Res. 2026 Jul 17; 54(14).
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Discovery of a secreted Bacteroides fragilis mucinase that cleaves mucins with bis-T O-glycans through a carbohydrate binding module-dependent mechanism. Gut Microbes. 2026 Dec 31; 18(1):2644983.
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Distal Mutations Rewire Allosteric Networks to Control Substrate Specificity in PTP1B. Biochemistry. 2025 12 16; 64(24):4661-4674.
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Structural basis of drug recognition by human MATE1 transporter. Nat Commun. 2025 Oct 27; 16(1):9444.
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Arsenic regulates ALKBH1 abundance and substrate specificity to promote translation and tumorigenicity. Cell Rep. 2025 10 28; 44(10):116311.
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Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE. Nat Commun. 2025 Apr 29; 16(1):3974.
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Homologous expression, purification, and characterization of a recombinant acetylxylan esterase from Aspergillus nidulans. Int J Biol Macromol. 2024 Nov; 280(Pt 2):135816.
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New insights into RNA processing by the eukaryotic tRNA splicing endonuclease. J Biol Chem. 2023 09; 299(9):105138.
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Substrate-driven assembly of a translocon for multipass membrane proteins. Nature. 2022 11; 611(7934):167-172.
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Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition. Nat Commun. 2022 04 05; 13(1):1833.