The University of Chicago Header Logo

Federico Salas-Lucia

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Endocrinology
AddressChicago IL 60637
ORCID ORCID Icon0000-0003-4141-5790 Additional info
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    My research integrates neurobiology and endocrinology to delineate intracellular mechanisms that customize thyroid hormone action during human brain development and function. We use human iPSCs-derived models, transgenic mice, multi-omics, in vivo, confocal fluorescence microscopy, and molecular and biochemical assays to help understand the clinical findings that abnormal maternal/perinatal thyroid hormone levels correlate with neurodevelopment.
    Collapse webpage

    Collapse Biography 
    Collapse education and training
    University of AlicanteBS2012Biology
    University Miguel HernandezMSc2014Neuroscience
    University Miguel HernandezPhD2018Neuroscience
    Collapse awards and honors
    2025Emerging Group Leader Award, International Society for Neurochemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rampy J, Torres-Manzo AP, Hoffsmith K, Loberg MA, Sheng Q, Salas-Lucia F, Bianco AC, Arrojo E Drigo R, Wang H, Weiss VL, Carrasco N. Overnutrition in mice impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations. J Clin Invest. 2026 Apr 15; 136(8). PMID: 41983397; PMCID: PMC13078877.
      Citations:    Fields:    Translation:HumansAnimals
    2. Escamilla S, Avilés-Granados C, Peralta FA, Paternain AV, Cortés-Gómez MÁ, Zetterberg H, de la Peña E, Salas-Lucia F, Sáez-Valero J, Cuchillo-Ibáñez I. GluN2A-mediated currents and calcium signal in human iPSC-derived neurons. Sci Rep. 2026 Feb 18; 16(1). PMID: 41708752; PMCID: PMC13013697.
      Citations: 1     Fields:    Translation:HumansCells
    3. Wiersema J, Mohácsik P, Gereben B, Hernandez A, Leeuwenburgh S, Meima M, Visser WE, Refetoff S, Bianco A, Salas-Lucia F, Boelen A. Measuring deiodinase activity: a need for standardization? Eur Thyroid J. 2026 02 01; 15(2). PMID: 41778896; PMCID: PMC13015784.
      Citations:    Fields:    Translation:Humans
    4. Jiang H, Escamilla S, Beestrum M, Salas-Lucia F. Cost-effectiveness of testing biofluid biomarkers to diagnose Alzheimer's disease: a systematic review. Eur J Health Econ. 2026 Jul; 27(5):1103-1115. PMID: 41385058; PMCID: PMC13451286.
      Citations:    Fields:    Translation:Humans
    5. Salas-Lucia F, Escamilla S, Charest A, Jiang H, Stout R, Bianco AC. Thyroid hormone promotes fetal neurogenesis. JCI Insight. 2025 10 08; 10(19). PMID: 40906530; PMCID: PMC12513484.
      Citations: 1     Fields:    Translation:HumansCells
    6. Salas-Lucia F, Escamilla S, Charest A, Jiang H, Stout R, Bianco AC. Thyroid Hormone Promotes Fetal Neurogenesis. bioRxiv. 2025 May 14. PMID: 40463237; PMCID: PMC12132436.
      Citations:    
    7. Rampy J, Torres-Manzo AP, Hoffsmith K, Loberg MA, Sheng Q, Salas-Lucia F, Bianco AC, Arrojo E Drigo R, Wang H, Weiss VL, Carrasco N. Overnutrition directly impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations. bioRxiv. 2025 Apr 15. PMID: 40236234; PMCID: PMC11996416.
      Citations:    
    8. Batistuzzo A, Zhang X, Bocco BMLC, McAninch EA, Salas-Lucia F, Ribeiro MO, Arvan P, Bianco AC, Fonseca TL. FVB But Not B6 Mice Carrying the Thr92Ala-Dio2 Polymorphism Have Impaired Thyroid Hormonogenesis and Goiter. Endocrinology. 2025 03 24; 166(5). PMID: 40085762; PMCID: PMC11932088.
      Citations:    Fields:    Translation:Animals
    9. Sinkó R, Salas-Lucia F, Mohácsik P, Halmos E, Wittmann G, Egri P, Bocco BMLC, Batistuzzo A, Fonseca TL, Fekete C, Bianco AC, Gereben B. Variable transduction of thyroid hormone signaling in structures of the mouse brain. Proc Natl Acad Sci U S A. 2025 Feb 11; 122(6):e2415970122. PMID: 39903117; PMCID: PMC11831203.
      Citations: 6     Fields:    Translation:AnimalsCells
    10. Hidalgo-Álvarez J, Fonseca TL, Salas-Lucia F, Bianco AC. Integrative Protocol for Generation of iPSC-Derived 3D Human Hepatic Organoids. J Vis Exp. 2024 12 06; (214). PMID: 39714036.
      Citations: 2     Fields:    Translation:HumansCells
    11. Escamilla S, Salas-Lucia F. Thyroid Hormone and Alzheimer Disease: Bridging Epidemiology to Mechanism. Endocrinology. 2024 Aug 27; 165(10). PMID: 39276028.
      Citations: 3     Fields:    Translation:HumansAnimals
    12. Salas-Lucia F. Mapping Thyroid Hormone Action in the Human Brain. Thyroid. 2024 07; 34(7):815-826. PMID: 38757586; PMCID: PMC11295854.
      Citations: 11     Fields:    Translation:HumansCells
    13. Salas-Lucia F, Escamilla S, Bianco AC, Dumitrescu A, Refetoff S. Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome. JCI Insight. 2024 02 20; 9(7). PMID: 38376950; PMCID: PMC11128209.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    14. Hidalgo-Álvarez J, Salas-Lucia F, Vera Cruz D, Fonseca TL, Bianco AC. Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids. JCI Insight. 2023 12 08; 8(23). PMID: 37856222; PMCID: PMC10795825.
      Citations: 7     Fields:    Translation:HumansCells
    15. Batistuzzo A, Salas-Lucia F, Gereben B, Ribeiro MO, Bianco AC. Sustained Pituitary T3 Production Explains the T4-mediated TSH Feedback Mechanism. Endocrinology. 2023 11 02; 164(12). PMID: 37864846; PMCID: PMC10637099.
      Citations: 8     Fields:    Translation:HumansAnimals
    16. Penna GC, Salas-Lucia F, Ribeiro MO, Bianco AC. Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism. Endocrine. 2024 05; 84(2):309-319. PMID: 37740833; PMCID: PMC10959761.
      Citations: 9     Fields:    Translation:HumansCells
    17. Salas-Lucia F, Stan MN, James H, Rajwani A, Liao XH, Dumitrescu AM, Refetoff S. Effect of the Fetal THRB Genotype on the Placenta. J Clin Endocrinol Metab. 2023 09 18; 108(10):e944-e948. PMID: 37149816; PMCID: PMC10505537.
      Citations: 8     Fields:    Translation:Humans
    18. Salas-Lucia F, Liao XH, Jiang H, Dumitrescu AM, Refetoff S, Anselmo J. The Relationship Between Fetal THRB Genotype and Maternal Thyroid Function. Thyroid. 2023 10; 33(10):1255-1258. PMID: 37597194; PMCID: PMC10611961.
      Citations:    Fields:    Translation:Humans
    19. Fekete C, Ruska Y, Egri P, Rada K, Salas-Lucia F, Sinkó R, Gereben B, Bianco AC. Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain. Elife. 2023 05 19; 12. PMID: 37204837; PMCID: PMC10241515.
      Citations: 15     Fields:    Translation:AnimalsCells
    20. Alikhani P, Alcaina Y, Salas-Lucia F, Liao XH, Bertolini A, Martin D, Moratilla A, Mora R, Mani AR, Saba A, Refetoff S, Zucchi R, González-Guerrero C, Borsò M, García-Giménez J, Buño-Soto A, Bernal J, de Miguel MP, Moreno JC. Iodotyrosines Are Biomarkers for Preclinical Stages of Iodine-Deficient Hypothyroidism in Dehal1-Knockout Mice. Thyroid. 2023 06; 33(6):752-761. PMID: 36879468; PMCID: PMC10280220.
      Citations: 4     Fields:    Translation:Animals
    21. Seetharaman S, Quintos JB, Salas-Lucia F. Resistance to Thyroid Hormone Beta in a Patient Born to a Mother With Undiagnosed Graves' Disease. AACE Clin Case Rep. 2023 May-Jun; 9(3):63-66. PMID: 37251972; PMCID: PMC10213604.
      Citations: 5     
    22. Salas-Lucia F, Bianco AC. T3 levels and thyroid hormone signaling. Front Endocrinol (Lausanne). 2022; 13:1044691. PMID: 36387853; PMCID: PMC9646642.
      Citations: 33     Fields:    Translation:HumansAnimals
    23. Sánchez Martínez DA, Salas-Lucia F, Jiang H, Ruiz-Carreño P, Alonso Romero JL. Drug cost avoidance analysis of cancer clinical trials in Spain: a study on cost contributors and their impact. BMC Health Serv Res. 2022 Jul 26; 22(1):948. PMID: 35883128; PMCID: PMC9316356.
      Citations: 1     Fields:    Translation:Humans
    24. Boucai L, Salas-Lucia F, Krishnamoorthy GP, Sherman E, Rudin CM, Drilon A, Bianco AC, Fagin JA. Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type 2 Iodothyronine Deiodinase. JCO Precis Oncol. 2022 06; 6:e2100496. PMID: 35704797; PMCID: PMC9384953.
      Citations: 11     Fields:    Translation:Humans
    25. Salas-Lucia F, Amrhein JA, Weir JE, Dumitrescu AM, Refetoff S, França MM. Severe Resistance to Thyroid Hormone Beta in a Patient with Athyreosis. Thyroid. 2022 03; 32(3):336-339. PMID: 34969265; PMCID: PMC8971974.
      Citations: 8     Fields:    Translation:Humans
    26. Russo SC, Salas-Lucia F, Bianco AC. Deiodinases and the Metabolic Code for Thyroid Hormone Action. Endocrinology. 2021 08 01; 162(8). PMID: 33720335; PMCID: PMC8237994.
      Citations: 44     Fields:    Translation:HumansAnimals
    27. Salas-Lucia F, Pacheco-Torres J, González-Granero S, García-Verdugo JM, Berbel P. Transient Hypothyroidism During Lactation Alters the Development of the Corpus Callosum in Rats. An in vivo Magnetic Resonance Image and Electron Microscopy Study. Front Neuroanat. 2020; 14:33. PMID: 32676012; PMCID: PMC7333461.
      Citations: 10     
    28. Navarro D, Alvarado M, Figueroa A, Gonzalez-Liencres C, Salas-Lucia F, Pacheco P, Sanchez-Vives MV, Berbel P. Distribution of GABAergic Neurons and VGluT1 and VGAT Immunoreactive Boutons in the Ferret (Mustela putorius) Piriform Cortex and Endopiriform Nucleus. Comparison With Visual Areas 17, 18 and 19. Front Neuroanat. 2019; 13:54. PMID: 31213994; PMCID: PMC6554450.
      Citations: 7     
    29. Lucia FS, Pacheco-Torres J, González-Granero S, Canals S, Obregón MJ, García-Verdugo JM, Berbel P. Transient Hypothyroidism During Lactation Arrests Myelination in the Anterior Commissure of Rats. A Magnetic Resonance Image and Electron Microscope Study. Front Neuroanat. 2018; 12:31. PMID: 29755326; PMCID: PMC5935182.
      Citations: 11     
    Salas-Lucia's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (84)
    Explore
    _
    Co-Authors (3)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _