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Boris Reizis

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Rheumatology
AddressChicago IL 60637
ORCID ORCID Icon0000-0003-1140-7853 Additional info
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    Collapse Overview 
    Collapse overview
    Dr. Reizis joined UChicago in 2025 from the NYU Grossman School of Medicine, where he has been the Samuel A. Brown Professor of Medicine and a founding director of the Translational Immunology Center. His lab is studying fundamental mechanisms of immune system development, immunological tolerance and autoimmunity.

    One major area of research is dendritic cells (DCs), innate sentinel cells that comprise the antigen-presenting classical DCs (cDCs) and interferon-producing plasmacytoid DC (pDCs). The Reizis lab has identified several key transcriptional regulators and signaling pathways that control the DC lineage, such as the "master regulator" of pDC development (TCF4/E2-2), the driver of cDC differentiation in the periphery (NOTCH2) and the common regulator of pDC and cDC development (TRIM33). Recent studies have characterized the role of 3D chromatin organization in the differentiation and/or function of cDCs and pDCs. Finally, the lab has identified transcription factor ETV3 as a specific regulator of cDC maturation that enables the tolerogenic function of DC in the steady state. These genetic insights are used to better characterize the role of DCs in immune response to infections, immune homeostasis and autoimmunity.

    The lab also studies systemic autoimmune diseases such as systemic lupus erythematosus (SLE), which is characterized by autoreactivity to nuclear antigens including ribonucleoproteins and DNA. Of particular interest are antibody responses to self DNA, which are prevalent and pathogenic in SLE. The lab has defined the extracellular nuclease DNASE1L3 as an essential gatekeeper of tolerance to self-DNA, and revealed its autoantibody-mediated blockade in more than half of human patients with severe SLE. Current studies include the mechanisms that cause the breakdown of tolerance and propagation of autoreactivity in SLE and its animal models.

    Collapse Research 
    Collapse research activities and funding
    R21AR085741     (REIZIS, BORIS)May 1, 2025 - Jan 31, 2027
    NIH
    The Mechanism of Hematological Abnormalities in Systemic Autoimmunity
    Role: Principal Investigator
    R01AI164728     (REIZIS, BORIS)Mar 17, 2022 - Feb 28, 2027
    NIH
    Chromatin architecture as a regulator of dendritic cell function
    Role: Principal Investigator
    R01HL152637     (REIZIS, BORIS)Sep 20, 2021 - Aug 31, 2025
    NIH
    Intravital analysis of hematopoietic stem cells in their bone marrow niche - Resubmission - 1
    Role: Principal Investigator
    R21AI161772     (REIZIS, BORIS)Mar 16, 2021 - Feb 28, 2023
    NIH
    A novel regulator of extracellular nucleic acid sensing
    Role: Principal Investigator
    R21AI154864     (REIZIS, BORIS)Jun 11, 2020 - May 31, 2022
    NIH
    A novel regulator of dendritic cell differentiation
    Role: Principal Investigator
    R21AI147501     (REIZIS, BORIS)Jul 10, 2019 - Jun 30, 2021
    NIH
    Novel genetic tools for the analysis of plasmacytoid dendritic cell function in vivo
    Role: Principal Investigator
    R01AR071703     (REIZIS, BORIS)Jun 1, 2018 - Mar 31, 2029
    NIH
    Mechanisms of DNA-Specific Autoimmunity in Systemic Lupus Erythematosus
    Role: Principal Investigator
    R21AI128730     (REIZIS, BORIS)Dec 8, 2016 - Nov 30, 2018
    NIH
    Studying immune development at single-cell resolution by DNA barcoding
    Role: Principal Investigator
    R21AI115382     (REIZIS, BORIS)Jul 1, 2015 - Jun 30, 2017
    NIH
    Analyzing dendritic cell development by inducible lineage tracing
    Role: Principal Investigator
    R01AG049074     (REIZIS, BORIS)Jan 15, 2015 - Dec 31, 2020
    NIH
    Dissecting the aging of hematopoietic stem cells by genetic tracing in vivo
    Role: Principal Investigator
    R21AR064460     (REIZIS, BORIS)Jul 3, 2013 - Jun 30, 2015
    NIH
    A Novel Genetic Model of Systemic Lupus Erythematosus
    Role: Principal Investigator
    T32AI100853     (SCHWAB, SUSAN RUTH)Jul 1, 2012 - Jun 30, 2027
    NIH
    Training Program in Immunology and Inflammation
    Role: Co-Principal Investigator
    R21HL113678     (REIZIS, BORIS)Jul 1, 2012 - Jun 30, 2014
    NIH
    Visualization and Lineage Tracing of Hematopoietic Stem Cell Heterogeneity
    Role: Principal Investigator
    R21AI085439     (REIZIS, BORIS)Apr 1, 2010 - Mar 31, 2012
    NIH
    Genetic Approaches to the Study of Plasmacytoid Dendritic Cell Function
    Role: Principal Investigator
    R37AI072571     (REIZIS, BORIS)Dec 15, 2007 - Jul 31, 2028
    NIH
    Molecular Control of Plasmacytoid Dendritic Cell Development and Function
    Role: Principal Investigator
    R01AI072571     (REIZIS, BORIS)Dec 15, 2007 - Aug 10, 2018
    NIH
    Molecular Control of Plasmacytoid Dendritic Cell Development and Function
    Role: Principal Investigator
    R21AI067804     (REIZIS, BORIS)Jun 1, 2006 - Nov 30, 2008
    NIH
    Dendritic Cell-Specific Gene Targeting and Expression
    Role: Principal Investigator
    R01HL084353     (REIZIS, BORIS)Apr 1, 2006 - Mar 31, 2015
    NIH
    Zfx, a novel transcriptional regulator of hematopoiesis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Adams NM, Martinez-Krams D, Esteva E, Ra AC, Alexiou AI, Jin H, Yun TJ, Tellaoui RS, Mudianto T, Vollmer E, Novikova E, Tan Y, Huntley W, Krichevsky O, Dolgalev I, Izmirly P, Buyon JP, Moreira AL, Lund AW, Reizis B. Transcription factor Etv3 controls the tolerogenic function of dendritic cells. Science. 2026 Feb 12; 391(6786):eads1246. PMID: 41678619; PMCID: PMC12977282.
      Citations:    
    2. Adams NM, Galitsyna A, Tiniakou I, Esteva E, Ra AC, Ullrich S, Yeung ST, Tan Y, Pucella JN, Dolgalev I, Levy DE, Khanna KM, Solovei I, Mirny LA, Reizis B. Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells. Immunity. 2026 Feb 10; 59(2):270-287.e11. PMID: 41672043.
      Citations:    
    3. Adams NM, Galitsyna A, Tiniakou I, Esteva E, Ra AC, Martinez-Krams D, Lau CM, Reyes J, Abdennur N, Shkolikov A, Yap GS, Khodadadi-Jamayran A, Dolgalev I, Mirny LA, Reizis B. Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells. Sci Immunol. 2026 Feb 06; 11(116):eadx4622. PMID: 41650249; PMCID: PMC12964587.
      Citations:    
    4. Triaille C, Makita S, Côté K, Benoit G, Campeau PM, De Bruycker JJ, Ra A, McCord JJ, Sayasith K, Sutton RB, Touzot F, Haddad E, Reizis B, Morin MP. Early-onset systemic lupus erythematosus-ANCA-associated vasculitis overlap syndrome caused by DNASE1L3 deficiency. Rheumatology (Oxford). 2025 Dec 01; 64(12):6432-6434. PMID: 40880305; PMCID: PMC12671870.
      Citations:    Fields:    
    5. Pucella JN, Maqueda-Alfaro RA, Ni H, Bandeira Sulczewski F, Eichinger A, Esteva E, Ra AC, Das A, Perez OA, Feng J, Stoeckius M, Smibert P, Khodadadi-Jamayran A, Dolgalev I, Ivanova E, Sota S, Cadwell K, Koralov SB, Zhong J, Soni C, Stetson DB, Weisberg SP, Farber DL, Idoyaga J, Reizis B. Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells. Nat Immunol. 2025 Nov; 26(11):1946-1961. PMID: 41087726; PMCID: PMC12662804.
      Citations: 1     Fields:    Translation:AnimalsCells
    6. Saglimbeni J, Esteva E, Canales J, Perez OA, Eichinger A, Huntley W, Khanna KM, Dolgalev I, Klar N, Adams S, Reizis B. Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer. Proc Natl Acad Sci U S A. 2025 Sep 23; 122(38):e2504645122. PMID: 40953260; PMCID: PMC12478179.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    7. Koshkin A, Tanagala KKK, Eichinger A, Chait M, Young A, Shakil S, Yoshikawa J, Sakamoto Y, Wells SB, Chen X, Reizis B, Farber DL, Weisberg SP. Dynamic remodeling of the pancreas immune landscape in obesity. Res Sq. 2025 Aug 27. PMID: 40909804; PMCID: PMC12408010.
      Citations:    
    8. Koshkin A, Tanagala KKK, Eichinger A, Chait M, Young A, Shakil S, Yoshikawa J, Sakamoto Y, Wells SB, Chen X, Reizis B, Farber DL, Weisberg SP. Dynamic remodeling of the pancreas immune landscape in obesity. bioRxiv. 2025 Jul 18. PMID: 40791478; PMCID: PMC12338670.
      Citations:    
    9. Smith D, Eichinger A, Fennell É, Xu-Monette ZY, Rech A, Wang J, Esteva E, Seyedian A, Yang X, Zhang M, Martinez D, Tan K, Luo M, Young KJ, Murray PG, Park C, Reizis B, Pillai V. Spatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathways. Nat Commun. 2025 Jul 01; 16(1):6009. PMID: 40593805; PMCID: PMC12217310.
      Citations: 5     Fields:    Translation:HumansCells
    10. Chan RWY, Serpas L, Ni M, Volpi S, Hiraki LT, Tam LS, Rashidfarrokhi A, Wong PCH, Tam LHP, Wang Y, Jiang P, Cheng ASH, Peng W, Han DSC, Tse PPP, Lau PK, Lee WS, Magnasco A, Buti E, Sisirak V, AlMutairi N, Chan KCA, Chiu RWK, Reizis B, Lo YMD. Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction. Am J Hum Genet. 2025 May 01; 112(5):1247. PMID: 40315821; PMCID: PMC12120170.
      Citations:    Fields:    
    11. Jang G, Park R, Esteva E, Hsu PF, Feng J, Upadhaya S, Sawai CM, Aifantis I, Fooksman DR, Reizis B. Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system. J Exp Med. 2025 Jun 02; 222(6). PMID: 40072317; PMCID: PMC11899982.
      Citations:    Fields:    Translation:AnimalsCells
    12. Romanov A, Knappe GA, Ronsard L, Suh H, Omer M, Chapman AP, Lewis VR, Spivakovsky K, Canales J, Reizis B, Tingle RD, Cottrell CA, Schiffner T, Lingwood D, Bathe M, Irvine DJ. DNA origami vaccines program antigen-focused germinal centers. bioRxiv. 2025 Mar 01. PMID: 40060683; PMCID: PMC11888200.
      Citations:    
    13. Adams NM, Galitsyna A, Tiniakou I, Esteva E, Lau CM, Reyes J, Abdennur N, Shkolikov A, Yap GS, Khodadadi-Jamayran A, Mirny LA, Reizis B. Cohesin-mediated chromatin remodeling controls the differentiation and function of conventional dendritic cells. bioRxiv. 2024 Oct 30. PMID: 39345451; PMCID: PMC11430140.
      Citations: 1     
    14. Smith D, Eichinger A, Rech A, Wang J, Esteva E, Seyedian A, Yang X, Zhang M, Martinez D, Tan K, Luo M, Park C, Reizis B, Pillai V. Spatial and Single Cell Mapping of Castleman Disease Reveals Key Stromal Cell Types and Cytokine Pathways. bioRxiv. 2024 Sep 09. PMID: 39314418; PMCID: PMC11419132.
      Citations:    
    15. Adams NM, Das A, Yun TJ, Reizis B. Ontogeny and Function of Plasmacytoid Dendritic Cells. Annu Rev Immunol. 2024 06; 42(1):347-373. PMID: 38941603.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    16. Tiniakou I, Hsu PF, Lopez-Zepeda LS, Garipler G, Esteva E, Adams NM, Jang G, Soni C, Lau CM, Liu F, Khodadadi-Jamayran A, Rodrick TC, Jones D, Tsirigos A, Ohler U, Bedford MT, Nimer SD, Kaartinen V, Mazzoni EO, Reizis B. Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation. Sci Immunol. 2024 04 12; 9(94):eadi1023. PMID: 38608038; PMCID: PMC11182672.
      Citations: 5     Fields:    Translation:Cells
    17. Feng J, Jang G, Esteva E, Adams NM, Jin H, Reizis B. Clonal barcoding of endogenous adult hematopoietic stem cells reveals a spectrum of lineage contributions. Proc Natl Acad Sci U S A. 2024 Jan 23; 121(4):e2317929121. PMID: 38227649; PMCID: PMC10823160.
      Citations: 5     Fields:    Translation:AnimalsCells
    18. Soni C, Makita S, Eichinger A, Serpas L, Sisirak V, Reizis B. Cutting Edge: TLR2 Signaling in B Cells Promotes Autoreactivity to DNA via IL-6 Secretion. J Immunol. 2023 11 15; 211(10):1475-1480. PMID: 37800687; PMCID: PMC10841863.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    19. Feng J, Hsu PF, Esteva E, Labella R, Wang Y, Khodadadi-Jamayran A, Pucella J, Liu CZ, Arbini AA, Tsirigos A, Kousteni S, Reizis B. Haplodeficiency of the 9p21 tumor suppressor locus causes myeloid disorders driven by the bone marrow microenvironment. Blood. 2023 08 03; 142(5):460-476. PMID: 37267505; PMCID: PMC12022840.
      Citations: 3     Fields:    Translation:AnimalsCells
    20. Sulczewski FB, Maqueda-Alfaro RA, Alcántara-Hernández M, Perez OA, Saravanan S, Yun TJ, Seong D, Arroyo Hornero R, Raquer-McKay HM, Esteva E, Lanzar ZR, Leylek RA, Adams NM, Das A, Rahman AH, Gottfried-Blackmore A, Reizis B, Idoyaga J. Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses. Nat Immunol. 2023 08; 24(8):1265-1280. PMID: 37414907; PMCID: PMC10683792.
      Citations: 47     Fields:    Translation:AnimalsCells
    21. Jang G, Contreras Castillo S, Esteva E, Upadhaya S, Feng J, Adams NM, Richard E, Awatramani R, Sawai CM, Reizis B. Stem cell decoupling underlies impaired lymphoid development during aging. Proc Natl Acad Sci U S A. 2023 05 30; 120(22):e2302019120. PMID: 37216517; PMCID: PMC10236001.
      Citations: 5     Fields:    Translation:AnimalsCells
    22. Reizis B, Idoyaga J, Dalod M, Barrat F, Naik S, Trinchieri G, Tussiwand R, Cella M, Colonna M. Reclassification of plasmacytoid dendritic cells as innate lymphocytes is premature. Nat Rev Immunol. 2023 05; 23(5):336-337. PMID: 36959479.
      Citations: 19     Fields:    Translation:HumansCells
    23. Lacey KA, Serpas L, Makita S, Wang Y, Rashidfarrokhi A, Soni C, Gonzalez S, Moreira A, Torres VJ, Reizis B. Secreted mammalian DNases protect against systemic bacterial infection by digesting biofilms. J Exp Med. 2023 06 05; 220(6). PMID: 36928522; PMCID: PMC10037111.
      Citations: 14     Fields:    Translation:AnimalsCells
    24. Kirkling ME, Reizis B. In Vitro Generation of Murine CD8a+ DEC205+ XCR1+ Cross-Presenting Dendritic Cells from Bone Marrow-Derived Hematopoietic Progenitors. Methods Mol Biol. 2023; 2618:109-119. PMID: 36905512.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    25. Villar J, Cros A, De Juan A, Alaoui L, Bonte PE, Lau CM, Tiniakou I, Reizis B, Segura E. ETV3 and ETV6 enable monocyte differentiation into dendritic cells by repressing macrophage fate commitment. Nat Immunol. 2023 01; 24(1):84-95. PMID: 36543959; PMCID: PMC9810530.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    26. Papadaki G, Goutakoli P, Tiniakou I, Grün JR, Grützkau A, Pavlopoulos GA, Iliopoulos I, Bertsias G, Boumpas D, Ospelt C, Reizis B, Sidiropoulos P, Verginis P. IL-6 Signaling Attenuates TNF-a Production by Plasmacytoid Dendritic Cells in Rheumatoid Arthritis. J Immunol. 2022 11 15; 209(10):1906-1917. PMID: 36426957.
      Citations: 8     Fields:    Translation:HumansCells
    27. Feng J, Pucella JN, Jang G, Alcántara-Hernández M, Upadhaya S, Adams NM, Khodadadi-Jamayran A, Lau CM, Stoeckius M, Hao S, Smibert P, Tsirigos A, Idoyaga J, Reizis B. Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells. Immunity. 2022 03 08; 55(3):405-422.e11. PMID: 35180378; PMCID: PMC9344860.
      Citations: 46     Fields:    Translation:AnimalsCells
    28. Tong H, Li X, Zhang J, Gong L, Sun W, Calderon V, Zhang X, Li Y, Gadzinski A, Langdon WY, Reizis B, Zou Y, Gu H. Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells. Front Immunol. 2021; 12:757231. PMID: 34630435; PMCID: PMC8494778.
      Citations: 10     Fields:    Translation:AnimalsCells
    29. Casanova-Acebes M, Dalla E, Leader AM, LeBerichel J, Nikolic J, Morales BM, Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park MD, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Schober M, Brown BD, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch P, Aguirre-Ghiso JA, Merad M. Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature. 2021 07; 595(7868):578-584. PMID: 34135508; PMCID: PMC8923521.
      Citations: 308     Fields:    Translation:HumansAnimalsCells
    30. Shariq M, Sahasrabuddhe V, Krishna S, Radha S, Bellampalli R, Dwivedi A, Cheramangalam R, Reizis B, Hébert J, Ghosh HS. Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis. Sci Adv. 2021 05; 7(21). PMID: 34020954; PMCID: PMC8139598.
      Citations: 13     Fields:    Translation:AnimalsCells
    31. Hartl J, Serpas L, Wang Y, Rashidfarrokhi A, Perez OA, Sally B, Sisirak V, Soni C, Khodadadi-Jamayran A, Tsirigos A, Caiello I, Bracaglia C, Volpi S, Ghiggeri GM, Chida AS, Sanz I, Kim MY, Belmont HM, Silverman GJ, Clancy RM, Izmirly PM, Buyon JP, Reizis B. Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus. J Exp Med. 2021 05 03; 218(5). PMID: 33783474; PMCID: PMC8020718.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    32. Yun TJ, Igarashi S, Zhao H, Perez OA, Pereira MR, Zorn E, Shen Y, Goodrum F, Rahman A, Sims PA, Farber DL, Reizis B. Human plasmacytoid dendritic cells mount a distinct antiviral response to virus-infected cells. Sci Immunol. 2021 04 02; 6(58). PMID: 33811059; PMCID: PMC8221820.
      Citations: 37     Fields:    
    33. Vanderkerken M, Maes B, Vandersarren L, Toussaint W, Deswarte K, Vanheerswynghels M, Pouliot P, Martens L, Van Gassen S, Arthur CM, Kirkling ME, Reizis B, Conrad D, Stowell S, Hammad H, Lambrecht BN. TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31331-31342. PMID: 33214146; PMCID: PMC7733863.
      Citations: 12     Fields:    Translation:AnimalsCells
    34. Chan RWY, Serpas L, Ni M, Volpi S, Hiraki LT, Tam LS, Rashidfarrokhi A, Wong PCH, Tam LHP, Wang Y, Jiang P, Cheng ASH, Peng W, Han DSC, Tse PPP, Lau PK, Lee WS, Magnasco A, Buti E, Sisirak V, AlMutairi N, Chan KCA, Chiu RWK, Reizis B, Lo YMD. Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction. Am J Hum Genet. 2020 11 05; 107(5):882-894. PMID: 33022220; PMCID: PMC7674998.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    35. Upadhaya S, Krichevsky O, Akhmetzyanova I, Sawai CM, Fooksman DR, Reizis B. Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche. Cell Stem Cell. 2020 08 06; 27(2):336-345.e4. PMID: 32589864; PMCID: PMC7415613.
      Citations: 39     Fields:    Translation:AnimalsCells
    36. Pucella JN, Upadhaya S, Reizis B. The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing. Annu Rev Cell Dev Biol. 2020 10 06; 36:529-550. PMID: 32580566.
      Citations: 32     Fields:    Translation:HumansCells
    37. Maier B, Leader AM, Chen ST, Tung N, Chang C, LeBerichel J, Chudnovskiy A, Maskey S, Walker L, Finnigan JP, Kirkling ME, Reizis B, Ghosh S, D'Amore NR, Bhardwaj N, Rothlin CV, Wolf A, Flores R, Marron T, Rahman AH, Kenigsberg E, Brown BD, Merad M. Author Correction: A conserved dendritic-cell regulatory program limits antitumour immunity. Nature. 2020 Jun; 582(7813):E17. PMID: 32499658.
      Citations: 9     Fields:    
    38. Soni C, Perez OA, Voss WN, Pucella JN, Serpas L, Mehl J, Ching KL, Goike J, Georgiou G, Ippolito GC, Sisirak V, Reizis B. Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA. Immunity. 2020 06 16; 52(6):1022-1038.e7. PMID: 32454024; PMCID: PMC7306002.
      Citations: 104     Fields:    Translation:AnimalsCells
    39. Ural BB, Yeung ST, Damani-Yokota P, Devlin JC, de Vries M, Vera-Licona P, Samji T, Sawai CM, Jang G, Perez OA, Pham Q, Maher L, Loke P, Dittmann M, Reizis B, Khanna KM. Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties. Sci Immunol. 2020 03 27; 5(45). PMID: 32220976; PMCID: PMC7717505.
      Citations: 148     Fields:    Translation:AnimalsCells
    40. Maier B, Leader AM, Chen ST, Tung N, Chang C, LeBerichel J, Chudnovskiy A, Maskey S, Walker L, Finnigan JP, Kirkling ME, Reizis B, Ghosh S, D'Amore NR, Bhardwaj N, Rothlin CV, Wolf A, Flores R, Marron T, Rahman AH, Kenigsberg E, Brown BD, Merad M. A conserved dendritic-cell regulatory program limits antitumour immunity. Nature. 2020 04; 580(7802):257-262. PMID: 32269339; PMCID: PMC7787191.
      Citations: 473     Fields:    Translation:HumansAnimalsCells
    41. Uhde M, Yu X, Bunin A, Brauner C, Lewis SK, Lebwohl B, Krishnareddy S, Alaedini A, Reizis B, Ghosh S, Green PH, Bhagat G. Phenotypic shift of small intestinal intra-epithelial type 1 innate lymphoid cells in celiac disease is associated with enhanced cytotoxic potential. Clin Exp Immunol. 2020 05; 200(2):163-175. PMID: 31907928; PMCID: PMC7160661.
      Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
    42. Leylek R, Alcántara-Hernández M, Lanzar Z, Lüdtke A, Perez OA, Reizis B, Idoyaga J. Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population. Cell Rep. 2019 12 10; 29(11):3736-3750.e8. PMID: 31825848; PMCID: PMC6951814.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    43. Reizis B. The Specificity of Conditional Gene Targeting: A Case for Cre Reporters. Immunity. 2019 10 15; 51(4):593-594. PMID: 31618647.
      Citations: 6     Fields:    
    44. Soni C, Reizis B. Self-DNA at the Epicenter of SLE: Immunogenic Forms, Regulation, and Effects. Front Immunol. 2019; 10:1601. PMID: 31354738; PMCID: PMC6637313.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    45. Ou P, Wen L, Liu X, Huang J, Huang X, Su C, Wang L, Ni H, Reizis B, Yang CY. Thioesterase PPT1 balances viral resistance and efficient T cell crosspriming in dendritic cells. J Exp Med. 2019 09 02; 216(9):2091-2112. PMID: 31262842; PMCID: PMC6719428.
      Citations: 22     Fields:    Translation:AnimalsCells
    46. Reizis B. Plasmacytoid Dendritic Cells: Development, Regulation, and Function. Immunity. 2019 01 15; 50(1):37-50. PMID: 30650380; PMCID: PMC6342491.
      Citations: 362     Fields:    Translation:HumansAnimalsCells
    47. Sawai CM, Serpas L, Neto AG, Jang G, Rashidfarrokhi A, Kolbeck R, Sanjuan MA, Reizis B, Sisirak V. Plasmacytoid Dendritic Cells Are Largely Dispensable for the Pathogenesis of Experimental Inflammatory Bowel Disease. Front Immunol. 2018; 9:2475. PMID: 30410494; PMCID: PMC6209677.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    48. Upadhaya S, Sawai CM, Papalexi E, Rashidfarrokhi A, Jang G, Chattopadhyay P, Satija R, Reizis B. Kinetics of adult hematopoietic stem cell differentiation in vivo. J Exp Med. 2018 11 05; 215(11):2815-2832. PMID: 30291161; PMCID: PMC6219744.
      Citations: 37     Fields:    Translation:AnimalsCells
    49. Soni C, Reizis B. DNA as a self-antigen: nature and regulation. Curr Opin Immunol. 2018 12; 55:31-37. PMID: 30261321; PMCID: PMC6317730.
      Citations: 23     Fields:    Translation:Humans
    50. Lau CM, Tiniakou I, Perez OA, Kirkling ME, Yap GS, Hock H, Reizis B. Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cells. J Exp Med. 2018 09 03; 215(9):2265-2278. PMID: 30087163; PMCID: PMC6122974.
      Citations: 21     Fields:    Translation:AnimalsCells
    51. Smith-Raska MR, Arenzana TL, D'Cruz LM, Khodadadi-Jamayran A, Tsirigos A, Goldrath AW, Reizis B. The Transcription Factor Zfx Regulates Peripheral T Cell Self-Renewal and Proliferation. Front Immunol. 2018; 9:1482. PMID: 30022979; PMCID: PMC6039547.
      Citations: 8     Fields:    
    52. Kirkling ME, Cytlak U, Lau CM, Lewis KL, Resteu A, Khodadadi-Jamayran A, Siebel CW, Salmon H, Merad M, Tsirigos A, Collin M, Bigley V, Reizis B. Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells. Cell Rep. 2018 06 19; 23(12):3658-3672.e6. PMID: 29925006; PMCID: PMC6063084.
      Citations: 107     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    53. Kratchmarov R, Viragova S, Kim MJ, Rothman NJ, Liu K, Reizis B, Reiner SL. Metabolic control of cell fate bifurcations in a hematopoietic progenitor population. Immunol Cell Biol. 2018 09; 96(8):863-871. PMID: 29570858; PMCID: PMC6146018.
      Citations: 28     Fields:    Translation:AnimalsCells
    54. Upadhaya S, Reizis B, Sawai CM. New genetic tools for the in vivo study of hematopoietic stem cell function. Exp Hematol. 2018 05; 61:26-35. PMID: 29501466; PMCID: PMC5899657.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    55. Döhler A, Schneider T, Eckert I, Ribechini E, Andreas N, Riemann M, Reizis B, Weih F, Lutz MB. RelB+ Steady-State Migratory Dendritic Cells Control the Peripheral Pool of the Natural Foxp3+ Regulatory T Cells. Front Immunol. 2017; 8:726. PMID: 28690613; PMCID: PMC5479892.
      Citations: 13     Fields:    
    56. Hua Y, Yang Y, Sun S, Iwanowycz S, Westwater C, Reizis B, Li Z, Liu B. Gut homeostasis and regulatory T cell induction depend on molecular chaperone gp96 in CD11c+ cells. Sci Rep. 2017 05 19; 7(1):2171. PMID: 28526855; PMCID: PMC5438351.
      Citations: 7     Fields:    Translation:AnimalsCells
    57. Morvan MG, Champsaur M, Reizis B, Lanier LL. Chronic In Vivo Interaction of Dendritic Cells Expressing the Ligand Rae-1e with NK Cells Impacts NKG2D Expression and Function. Immunohorizons. 2017 May 01; 1(3):10-19. PMID: 28815225; PMCID: PMC5555644.
      Citations: 12     Fields:    
    58. Bradford BM, Reizis B, Mabbott NA. Oral Prion Disease Pathogenesis Is Impeded in the Specific Absence of CXCR5-Expressing Dendritic Cells. J Virol. 2017 05 15; 91(10). PMID: 28275192; PMCID: PMC5411578.
      Citations: 18     Fields:    Translation:AnimalsCells
    59. Granot T, Senda T, Carpenter DJ, Matsuoka N, Weiner J, Gordon CL, Miron M, Kumar BV, Griesemer A, Ho SH, Lerner H, Thome JJC, Connors T, Reizis B, Farber DL. Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life. Immunity. 2017 03 21; 46(3):504-515. PMID: 28329707; PMCID: PMC5415308.
      Citations: 163     Fields:    Translation:HumansCells
    60. Lukas D, Yogev N, Kel JM, Regen T, Mufazalov IA, Tang Y, Wanke F, Reizis B, Müller W, Kurschus FC, Prinz M, Kleiter I, Clausen BE, Waisman A. TGF-ß inhibitor Smad7 regulates dendritic cell-induced autoimmunity. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1480-E1489. PMID: 28167776; PMCID: PMC5338403.
      Citations: 23     Fields:    Translation:AnimalsCells
    61. Grajkowska LT, Ceribelli M, Lau CM, Warren ME, Tiniakou I, Nakandakari Higa S, Bunin A, Haecker H, Mirny LA, Staudt LM, Reizis B. Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification. Immunity. 2017 01 17; 46(1):65-77. PMID: 27986456; PMCID: PMC5243153.
      Citations: 65     Fields:    Translation:AnimalsCells
    62. Spaulding E, Fooksman D, Moore JM, Saidi A, Feintuch CM, Reizis B, Chorro L, Daily J, Lauvau G. STING-Licensed Macrophages Prime Type I IFN Production by Plasmacytoid Dendritic Cells in the Bone Marrow during Severe Plasmodium yoelii Malaria. PLoS Pathog. 2016 Oct; 12(10):e1005975. PMID: 27792766; PMCID: PMC5085251.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    63. Sawai CM, Babovic S, Upadhaya S, Knapp DJHF, Lavin Y, Lau CM, Goloborodko A, Feng J, Fujisaki J, Ding L, Mirny LA, Merad M, Eaves CJ, Reizis B. Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals. Immunity. 2016 09 20; 45(3):597-609. PMID: 27590115; PMCID: PMC5054720.
      Citations: 215     Fields:    Translation:AnimalsCells
    64. Sisirak V, Sally B, D'Agati V, Martinez-Ortiz W, Özçakar ZB, David J, Rashidfarrokhi A, Yeste A, Panea C, Chida AS, Bogunovic M, Ivanov II, Quintana FJ, Sanz I, Elkon KB, Tekin M, Yalçinkaya F, Cardozo TJ, Clancy RM, Buyon JP, Reizis B. Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity. Cell. 2016 Jun 30; 166(1):88-101. PMID: 27293190; PMCID: PMC5030815.
      Citations: 266     Fields:    Translation:HumansAnimalsCells
    65. Lau CM, Nish SA, Yogev N, Waisman A, Reiner SL, Reizis B. Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses. J Exp Med. 2016 Mar 07; 213(3):415-31. PMID: 26903243; PMCID: PMC4813676.
      Citations: 36     Fields:    Translation:AnimalsCells
    66. Hansen L, Schmidt-Christensen A, Gupta S, Fransén-Pettersson N, Hannibal TD, Reizis B, Santamaria P, Holmberg D. E2-2 Dependent Plasmacytoid Dendritic Cells Control Autoimmune Diabetes. PLoS One. 2015; 10(12):e0144090. PMID: 26624013; PMCID: PMC4666626.
      Citations: 10     Fields:    Translation:AnimalsCells
    67. Bunin A, Sisirak V, Ghosh HS, Grajkowska LT, Hou ZE, Miron M, Yang C, Ceribelli M, Uetani N, Chaperot L, Plumas J, Hendriks W, Tremblay ML, Häcker H, Staudt LM, Green PH, Bhagat G, Reizis B. Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells. Immunity. 2015 Aug 18; 43(2):277-88. PMID: 26231120; PMCID: PMC4547994.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    68. Sage AP, Murphy D, Maffia P, Masters LM, Sabir SR, Baker LL, Cambrook H, Finigan AJ, Ait-Oufella H, Grassia G, Harrison JE, Ludewig B, Reith W, Hansson GK, Reizis B, Hugues S, Mallat Z. MHC Class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity. Circulation. 2014 Oct 14; 130(16):1363-73. PMID: 25223984; PMCID: PMC4428652.
      Citations: 49     Fields:    Translation:AnimalsCells
    69. Sisirak V, Ganguly D, Lewis KL, Couillault C, Tanaka L, Bolland S, D'Agati V, Elkon KB, Reizis B. Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus. J Exp Med. 2014 Sep 22; 211(10):1969-76. PMID: 25180061; PMCID: PMC4172218.
      Citations: 138     Fields:    Translation:AnimalsCells
    70. Palmer CJ, Galan-Caridad JM, Weisberg SP, Lei L, Esquilin JM, Croft GF, Wainwright B, Canoll P, Owens DM, Reizis B. Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway. Cancer Res. 2014 Oct 15; 74(20):5914-24. PMID: 25164012; PMCID: PMC4199880.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    71. Ghosh HS, Ceribelli M, Matos I, Lazarovici A, Bussemaker HJ, Lasorella A, Hiebert SW, Liu K, Staudt LM, Reizis B. ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2. J Exp Med. 2014 Jul 28; 211(8):1623-35. PMID: 24980046; PMCID: PMC4113936.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    72. Weisberg SP, Smith-Raska MR, Esquilin JM, Zhang J, Arenzana TL, Lau CM, Churchill M, Pan H, Klinakis A, Dixon JE, Mirny LA, Mukherjee S, Reizis B. ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia. Cell Rep. 2014 Feb 13; 6(3):528-40. PMID: 24485662; PMCID: PMC3936793.
      Citations: 20     Fields:    Translation:AnimalsCells
    73. Rhee I, Zhong MC, Reizis B, Cheong C, Veillette A. Control of dendritic cell migration, T cell-dependent immunity, and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells. Mol Cell Biol. 2014 Mar; 34(5):888-99. PMID: 24366546; PMCID: PMC4023833.
      Citations: 28     Fields:    Translation:AnimalsCells
    74. Hurdayal R, Nieuwenhuizen NE, Revaz-Breton M, Smith L, Hoving JC, Parihar SP, Reizis B, Brombacher F. Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection. PLoS Pathog. 2013 Oct; 9(10):e1003699. PMID: 24204259; PMCID: PMC3812013.
      Citations: 43     Fields:    Translation:AnimalsCells
    75. Sawai CM, Sisirak V, Ghosh HS, Hou EZ, Ceribelli M, Staudt LM, Reizis B. Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells. J Exp Med. 2013 Oct 21; 210(11):2151-9. PMID: 24101375; PMCID: PMC3804932.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    76. Sparber F, Scheffler JM, Amberg N, Tripp CH, Heib V, Hermann M, Zahner SP, Clausen BE, Reizis B, Huber LA, Stoitzner P, Romani N. The late endosomal adaptor molecule p14 (LAMTOR2) represents a novel regulator of Langerhans cell homeostasis. Blood. 2014 Jan 09; 123(2):217-27. PMID: 24092934; PMCID: PMC3888288.
      Citations: 36     Fields:    Translation:AnimalsCells
    77. Ganguly D, Haak S, Sisirak V, Reizis B. The role of dendritic cells in autoimmunity. Nat Rev Immunol. 2013 Aug; 13(8):566-77. PMID: 23827956; PMCID: PMC4160805.
      Citations: 253     Fields:    Translation:HumansAnimalsCells
    78. Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, Charrier-Hisamuddin L, Chau L, Zhang Q, Bittinger K, Bushman FD, Turka LA, Shen H, Reizis B, Defranco AL, Wu GD, Choi Y. Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity. 2013 Jun 27; 38(6):1211-22. PMID: 23791643; PMCID: PMC3715143.
      Citations: 56     Fields:    Translation:AnimalsCells
    79. Wohn C, Ober-Blöbaum JL, Haak S, Pantelyushin S, Cheong C, Zahner SP, Onderwater S, Kant M, Weighardt H, Holzmann B, Reizis B, Becher B, Prens EP, Clausen BE. Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):10723-8. PMID: 23754427; PMCID: PMC3696803.
      Citations: 88     Fields:    Translation:AnimalsCells
    80. Young JA, He TH, Reizis B, Winoto A. Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells. Cell Rep. 2013 Jun 27; 3(6):1932-44. PMID: 23727238; PMCID: PMC3699966.
      Citations: 18     Fields:    Translation:AnimalsCells
    81. Persson EK, Uronen-Hansson H, Semmrich M, Rivollier A, Hägerbrand K, Marsal J, Gudjonsson S, Håkansson U, Reizis B, Kotarsky K, Agace WW. IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation. Immunity. 2013 May 23; 38(5):958-69. PMID: 23664832.
      Citations: 336     Fields:    Translation:HumansAnimalsCells
    82. Bell BD, Kitajima M, Larson RP, Stoklasek TA, Dang K, Sakamoto K, Wagner KU, Kaplan DH, Reizis B, Hennighausen L, Ziegler SF. The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol. 2013 Apr; 14(4):364-71. PMID: 23435120; PMCID: PMC4161284.
      Citations: 93     Fields:    Translation:AnimalsCells
    83. Yogev N, Frommer F, Lukas D, Kautz-Neu K, Karram K, Ielo D, von Stebut E, Probst HC, van den Broek M, Riethmacher D, Birnberg T, Blank T, Reizis B, Korn T, Wiendl H, Jung S, Prinz M, Kurschus FC, Waisman A. Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells. Immunity. 2012 Aug 24; 37(2):264-75. PMID: 22902234.
      Citations: 104     Fields:    Translation:AnimalsCells
    84. Harel S, Tu EY, Weisberg S, Esquilin M, Chambers SM, Liu B, Carson CT, Studer L, Reizis B, Tomishima MJ. ZFX controls the self-renewal of human embryonic stem cells. PLoS One. 2012; 7(8):e42302. PMID: 22879936; PMCID: PMC3411758.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    85. Lewis KL, Reizis B. Dendritic cells: arbiters of immunity and immunological tolerance. Cold Spring Harb Perspect Biol. 2012 Aug 01; 4(8):a007401. PMID: 22855722; PMCID: PMC3405856.
      Citations: 61     Fields:    Translation:HumansCells
    86. Kernbauer E, Maier V, Stoiber D, Strobl B, Schneckenleithner C, Sexl V, Reichart U, Reizis B, Kalinke U, Jamieson A, Müller M, Decker T. Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection. PLoS Pathog. 2012; 8(6):e1002763. PMID: 22719255; PMCID: PMC3375314.
      Citations: 36     Fields:    Translation:AnimalsCells
    87. Reizis B. Classical dendritic cells as a unique immune cell lineage. J Exp Med. 2012 Jun 04; 209(6):1053-6. PMID: 22665701; PMCID: PMC3375637.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    88. Köhler T, Reizis B, Johnson RS, Weighardt H, Förster I. Influence of hypoxia-inducible factor 1a on dendritic cell differentiation and migration. Eur J Immunol. 2012 May; 42(5):1226-36. PMID: 22539295; PMCID: PMC6592818.
      Citations: 66     Fields:    Translation:AnimalsCells
    89. Cervantes-Barragan L, Lewis KL, Firner S, Thiel V, Hugues S, Reith W, Ludewig B, Reizis B. Plasmacytoid dendritic cells control T-cell response to chronic viral infection. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3012-7. PMID: 22315415; PMCID: PMC3286988.
      Citations: 129     Fields:    Translation:AnimalsCells
    90. Wang Y, Huang G, Vogel P, Neale G, Reizis B, Chi H. Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):E343-52. PMID: 22308391; PMCID: PMC3277515.
      Citations: 37     Fields:    Translation:AnimalsCells
    91. Hoshi N, Schenten D, Nish SA, Walther Z, Gagliani N, Flavell RA, Reizis B, Shen Z, Fox JG, Iwasaki A, Medzhitov R. MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun. 2012; 3:1120. PMID: 23047678; PMCID: PMC3521499.
      Citations: 88     Fields:    Translation:AnimalsCells
    92. Ghosh HS, Reizis B, Robbins PD. SIRT1 associates with eIF2-alpha and regulates the cellular stress response. Sci Rep. 2011; 1:150. PMID: 22355666; PMCID: PMC3252071.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    93. Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol. 2011 Oct 23; 12(12):1184-93. PMID: 22019834; PMCID: PMC3419270.
      Citations: 141     Fields:    Translation:HumansAnimalsCells
    94. Lewis KL, Caton ML, Bogunovic M, Greter M, Grajkowska LT, Ng D, Klinakis A, Charo IF, Jung S, Gommerman JL, Ivanov II, Liu K, Merad M, Reizis B. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity. 2011 Nov 23; 35(5):780-91. PMID: 22018469; PMCID: PMC3225703.
      Citations: 294     Fields:    Translation:AnimalsCells
    95. Girard-Madoux MJ, Kel JM, Reizis B, Clausen BE. IL-10 controls dendritic cell-induced T-cell reactivation in the skin to limit contact hypersensitivity. J Allergy Clin Immunol. 2012 Jan; 129(1):143-50.e1-10. PMID: 21975175.
      Citations: 26     Fields:    Translation:AnimalsCells
    96. Kim SJ, Zou YR, Goldstein J, Reizis B, Diamond B. Tolerogenic function of Blimp-1 in dendritic cells. J Exp Med. 2011 Oct 24; 208(11):2193-9. PMID: 21948081; PMCID: PMC3201204.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    97. Reizis B. Intracellular pathogens and CD8(+) dendritic cells: dangerous liaisons. Immunity. 2011 Aug 26; 35(2):153-5. PMID: 21867923.
      Citations: 4     Fields:    
    98. Reizis B, Colonna M, Trinchieri G, Barrat F, Gilliet M. Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? Nat Rev Immunol. 2011 07 22; 11(8):558-65. PMID: 21779033; PMCID: PMC4157822.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    99. Kool M, van Loo G, Waelput W, De Prijck S, Muskens F, Sze M, van Praet J, Branco-Madeira F, Janssens S, Reizis B, Elewaut D, Beyaert R, Hammad H, Lambrecht BN. The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity. Immunity. 2011 Jul 22; 35(1):82-96. PMID: 21723156.
      Citations: 141     Fields:    Translation:HumansAnimalsCells
    100. Reizis B, Bunin A, Ghosh HS, Lewis KL, Sisirak V. Plasmacytoid dendritic cells: recent progress and open questions. Annu Rev Immunol. 2011; 29:163-83. PMID: 21219184; PMCID: PMC4160806.
      Citations: 322     Fields:    Translation:HumansAnimalsCells
    101. Teichmann LL, Ols ML, Kashgarian M, Reizis B, Kaplan DH, Shlomchik MJ. Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage. Immunity. 2010 Dec 14; 33(6):967-78. PMID: 21167752; PMCID: PMC3010763.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    102. Ghosh HS, Cisse B, Bunin A, Lewis KL, Reizis B. Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells. Immunity. 2010 Dec 14; 33(6):905-16. PMID: 21145760; PMCID: PMC3010277.
      Citations: 153     Fields:    Translation:AnimalsCells
    103. Sathaliyawala T, O'Gorman WE, Greter M, Bogunovic M, Konjufca V, Hou ZE, Nolan GP, Miller MJ, Merad M, Reizis B. Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity. 2010 Oct 29; 33(4):597-606. PMID: 20933441; PMCID: PMC2966531.
      Citations: 96     Fields:    Translation:AnimalsCells
    104. Frenz T, Waibler Z, Hofmann J, Hamdorf M, Lantermann M, Reizis B, Tovey MG, Aichele P, Sutter G, Kalinke U. Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion. Eur J Immunol. 2010 Oct; 40(10):2769-77. PMID: 20821729.
      Citations: 18     Fields:    Translation:AnimalsCells
    105. Kel JM, Girard-Madoux MJ, Reizis B, Clausen BE. TGF-beta is required to maintain the pool of immature Langerhans cells in the epidermis. J Immunol. 2010 Sep 15; 185(6):3248-55. PMID: 20713882.
      Citations: 87     Fields:    Translation:AnimalsCells
    106. Manicassamy S, Reizis B, Ravindran R, Nakaya H, Salazar-Gonzalez RM, Wang YC, Pulendran B. Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science. 2010 Aug 13; 329(5993):849-53. PMID: 20705860; PMCID: PMC3732486.
      Citations: 288     Fields:    Translation:AnimalsCells
    107. Bar-On L, Birnberg T, Lewis KL, Edelson BT, Bruder D, Hildner K, Buer J, Murphy KM, Reizis B, Jung S. CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14745-50. PMID: 20679228; PMCID: PMC2930429.
      Citations: 92     Fields:    Translation:AnimalsCells
    108. Colonna L, Catalano G, Chew C, D'Agati V, Thomas JW, Wong FS, Schmitz J, Masuda ES, Reizis B, Tarakhovsky A, Clynes R. Therapeutic targeting of Syk in autoimmune diabetes. J Immunol. 2010 Aug 01; 185(3):1532-43. PMID: 20601600; PMCID: PMC2981095.
      Citations: 31     Fields:    Translation:AnimalsCells
    109. Reizis B. Regulation of plasmacytoid dendritic cell development. Curr Opin Immunol. 2010 Apr; 22(2):206-11. PMID: 20144853; PMCID: PMC2854232.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    110. Melillo JA, Song L, Bhagat G, Blazquez AB, Plumlee CR, Lee C, Berin C, Reizis B, Schindler C. Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function. J Immunol. 2010 Mar 01; 184(5):2638-45. PMID: 20124100; PMCID: PMC3099405.
      Citations: 134     Fields:    Translation:AnimalsCells
    111. Mortier E, Advincula R, Kim L, Chmura S, Barrera J, Reizis B, Malynn BA, Ma A. Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets. Immunity. 2009 Nov 20; 31(5):811-22. PMID: 19913445.
      Citations: 124     Fields:    Translation:AnimalsCells
    112. Cucak H, Yrlid U, Reizis B, Kalinke U, Johansson-Lindbom B. Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity. 2009 Sep 18; 31(3):491-501. PMID: 19733096.
      Citations: 116     Fields:    Translation:AnimalsCells
    113. Repass JF, Laurent MN, Carter C, Reizis B, Bedford MT, Cardenas K, Narang P, Coles M, Richie ER. IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells. Genesis. 2009 Apr; 47(4):281-7. PMID: 19263498.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    114. Arenzana TL, Smith-Raska MR, Reizis B. Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes. Blood. 2009 Jun 04; 113(23):5857-67. PMID: 19329779; PMCID: PMC2700322.
      Citations: 19     Fields:    Translation:AnimalsCells
    115. Cervantes-Barragán L, Kalinke U, Züst R, König M, Reizis B, López-Macías C, Thiel V, Ludewig B. Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection. J Immunol. 2009 Jan 15; 182(2):1099-106. PMID: 19124753.
      Citations: 88     Fields:    Translation:AnimalsCells
    116. Kang SJ, Liang HE, Reizis B, Locksley RM. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity. 2008 Nov 14; 29(5):819-33. PMID: 19006696; PMCID: PMC2858430.
      Citations: 98     Fields:    Translation:AnimalsCells
    117. Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, Holmberg D, Zweier C, den Hollander NS, Kant SG, Holter W, Rauch A, Zhuang Y, Reizis B. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell. 2008 Oct 03; 135(1):37-48. PMID: 18854153; PMCID: PMC2631034.
      Citations: 359     Fields:    Translation:HumansAnimalsCells
    118. Hou B, Reizis B, DeFranco AL. Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms. Immunity. 2008 Aug 15; 29(2):272-82. PMID: 18656388; PMCID: PMC2847796.
      Citations: 222     Fields:    Translation:AnimalsCells
    119. Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature. 2007 Sep 20; 449(7160):361-5. PMID: 17694047; PMCID: PMC2670239.
      Citations: 292     Fields:    Translation:AnimalsCells
    120. Caton ML, Smith-Raska MR, Reizis B. Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. J Exp Med. 2007 Jul 09; 204(7):1653-64. PMID: 17591855; PMCID: PMC2118632.
      Citations: 508     Fields:    Translation:AnimalsCells
    121. Galan-Caridad JM, Harel S, Arenzana TL, Hou ZE, Doetsch FK, Mirny LA, Reizis B. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell. 2007 Apr 20; 129(2):345-57. PMID: 17448993; PMCID: PMC1899089.
      Citations: 135     Fields:    Translation:AnimalsCells
    122. Babbe H, Chester N, Leder P, Reizis B. The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Mol Cell Biol. 2007 Mar; 27(5):1947-59. PMID: 17210642; PMCID: PMC1820471.
      Citations: 18     Fields:    Translation:AnimalsCells
    123. Shigematsu H, Reizis B, Iwasaki H, Mizuno S, Hu D, Traver D, Leder P, Sakaguchi N, Akashi K. Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity. 2004 Jul; 21(1):43-53. PMID: 15345219.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    124. Martin CH, Aifantis I, Scimone ML, von Andrian UH, Reizis B, von Boehmer H, Gounari F. Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat Immunol. 2003 Sep; 4(9):866-73. PMID: 12925850.
      Citations: 60     Fields:    Translation:AnimalsCells
    125. Miyamoto T, Iwasaki H, Reizis B, Ye M, Graf T, Weissman IL, Akashi K. Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell. 2002 Jul; 3(1):137-47. PMID: 12110174.
      Citations: 171     Fields:    Translation:AnimalsCells
    126. Gounari F, Aifantis I, Martin C, Fehling HJ, Hoeflinger S, Leder P, von Boehmer H, Reizis B. Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. Nat Immunol. 2002 May; 3(5):489-96. PMID: 11927910.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    127. Reizis B, Leder P. Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev. 2002 Feb 01; 16(3):295-300. PMID: 11825871; PMCID: PMC155334.
      Citations: 70     Fields:    Translation:AnimalsCells
    128. Reizis B, Leder P. The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes. J Exp Med. 2001 Oct 01; 194(7):979-90. PMID: 11581319; PMCID: PMC2193489.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    129. Reizis B, Lee JT, Leder P. Homologous genomic fragments in the mouse pre-T cell receptor alpha (pTa) and Xist loci. Genomics. 2000 Jan 01; 63(1):149-52. PMID: 10662556.
      Citations: 2     Fields:    Translation:AnimalsCells
    130. Reizis B, Leder P. Expression of the mouse pre-T cell receptor alpha gene is controlled by an upstream region containing a transcriptional enhancer. J Exp Med. 1999 May 17; 189(10):1669-78. PMID: 10330446; PMCID: PMC2193641.
      Citations: 12     Fields:    Translation:AnimalsCells
    131. Reizis B, Altmann DM, Cohen IR. Biochemical characterization of the human diabetes-associated HLA-DQ8 allelic product: similarity to the major histocompatibility complex class II I-A(g)7 protein of non-obese diabetic mice. Eur J Immunol. 1997 Oct; 27(10):2478-83. PMID: 9368599.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    132. Reizis B, Eisenstein M, Bocková J, Könen-Waisman S, Mor F, Elias D, Cohen IR. Molecular characterization of the diabetes-associated mouse MHC class II protein, I-Ag7. Int Immunol. 1997 Jan; 9(1):43-51. PMID: 9043946.
      Citations: 16     Fields:    Translation:AnimalsCells
    133. Reizis B, Schild H, Stefanovic S, Mor F, Rammensee H, Cohen IR. Peptide binding motifs of the MHC class I molecules (RT1.Al) of the Lewis rat. Immunogenetics. 1997; 45(4):278-9. PMID: 9002449.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    134. Mor F, Reizis B, Cohen IR, Steinman L. IL-2 and TNF receptors as targets of regulatory T-T interactions: isolation and characterization of cytokine receptor-reactive T cell lines in the Lewis rat. J Immunol. 1996 Dec 01; 157(11):4855-61. PMID: 8943388.
      Citations: 8     Fields:    Translation:AnimalsCells
    135. Reizis B, Mor F, Cohen IR. Functional activation of encephalitogenic T cells in the absence of antigen-presenting cells. Int Immunol. 1995 Aug; 7(8):1375-9. PMID: 7495744.
      Citations:    Fields:    Translation:AnimalsCells
    136. Reizis B, Schramm C, Cohen IR, Mor F. Expression of major histocompatibility complex class II molecules in rat T cells. Eur J Immunol. 1994 Nov; 24(11):2796-802. PMID: 7525305.
      Citations: 9     Fields:    Translation:AnimalsCells
    137. Alon R, Cahalon L, Hershkoviz R, Elbaz D, Reizis B, Wallach D, Akiyama SK, Yamada KM, Lider O. TNF-alpha binds to the N-terminal domain of fibronectin and augments the beta 1-integrin-mediated adhesion of CD4+ T lymphocytes to the glycoprotein. J Immunol. 1994 Feb 01; 152(3):1304-13. PMID: 7905501.
      Citations: 35     Fields:    Translation:HumansCells
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