-
Kaur A, Rojek AE, Symes E, Nawas MT, Patel AA, Patel JL, Sojitra P, Aqil B, Sukhanova M, McNerney ME, Wu LP, Akmatbekov A, Segal J, Tjota MY, Gurbuxani S, Cheng JX, Yeon SY, Ravisankar HV, Fitzpatrick C, Lager A, Drazer MW, Saygin C, Wanjari P, Katsonis P, Lichtarge O, Churpek JE, Ghosh SB, Patel AB, Menon MP, Arber DA, Wang P, Venkataraman G. Real world predictors of response and 24-month survival in high-grade TP53-mutated myeloid neoplasms. Blood Cancer J. 2024 Jun 18; 14(1):99.
PMID: 38890297; PMCID: PMC11189545.
Citations: Fields:
Translation:
Humans
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Saygin C, Zhang P, Stauber J, Aldoss I, Sperling AS, Weeks LD, Luskin MR, Knepper TC, Wanjari P, Wang P, Lager AM, Fitzpatrick C, Segal JP, Gharghabi M, Gurbuxani S, Venkataraman G, Cheng JX, Eisfelder BJ, Bohorquez O, Patel AA, Umesh Nagalakshmi S, Jayaram S, Odenike OM, Larson RA, Godley LA, Arber DA, Gibson CJ, Munshi NC, Marcucci G, Ebert BL, Greally JM, Steidl U, Lapalombella R, Shah BD, Stock W. Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis. Blood Cancer Discov. 2024 May 01; 5(3):164-179.
PMID: 38150184; PMCID: PMC11061587.
Citations:
5 Fields:
Translation:
Humans
-
Cohen NA, Weber CR, Cheng JX, Choi D, Garcia NM, Choi NK, Rubin DT. Ozanimod-exposed Patients with Ulcerative Colitis Undergoing Total Colectomy Exhibit Unique Lymph Node Histological Changes. J Crohns Colitis. 2024 Apr 23; 18(4):638-641.
PMID: 37879626.
Citations: Fields:
Translation:
Humans
-
Johnston H, Youshanlouei HR, Osei C, Patel AA, DuVall A, Wang P, Wanjari P, Segal J, Venkataraman G, Cheng JX, Gurbuxani S, Lager A, Fitzpatrick C, Thirman M, Nawas M, Liu H, Drazer M, Odenike O, Larson R, Stock W, Saygin C. Socioeconomic determinants of the biology and outcomes of acute lymphoblastic leukemia in adults. Blood Adv. 2024 01 09; 8(1):164-171.
PMID: 38039510; PMCID: PMC10787242.
Citations:
1 Fields:
Translation:
Humans
-
Kaumeyer BA, Fidai SS, Thakral B, Wang SA, Arber DA, Cheng JX, Gurbuxani S, Venkataraman G. GLUT1 Immunohistochemistry Is a Highly Sensitive and Relatively Specific Marker for Erythroid Lineage in Benign and Malignant Hematopoietic Tissues. Am J Clin Pathol. 2022 08 04; 158(2):228-234.
PMID: 35311938.
Citations:
1 Fields:
Translation:
Humans
-
Willbanks A, Wood S, Cheng JX. RNA Epigenetics: Fine-Tuning Chromatin Plasticity and Transcriptional Regulation, and the Implications in Human Diseases. Genes (Basel). 2021 04 22; 12(5).
PMID: 33922187; PMCID: PMC8145807.
Citations:
9 Fields:
Translation:
HumansAnimalsCells
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Eisfelder BJ, Saygin C, Wynne J, Colton MW, Fischietti M, Beauchamp EM, Cheng JX, Odenike O, Roboz G, Alachkar H, Stock W. OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia. Blood Cancer J. 2021 03 03; 11(3):48.
PMID: 33658483; PMCID: PMC7930094.
Citations:
5 Fields:
Translation:
HumansAnimalsCells
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Willbank A, Wood S, Cheng JX. Development of a Novel Flow Cytometric Technique for Quantitative Measurements of Transcriptional Addiction and Drug Resistance in Leukemia Cells. Modern Pathology. 2021; 34(2):927-1049.
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Wood S, Willbanks A, Cheng JX. The Role of RNA Modifications and RNA-modifying Proteins in Cancer Therapy and Drug Resistance. Curr Cancer Drug Targets. 2021; 21(4):326-352.
PMID: 33504307.
Citations:
14 Fields:
Translation:
HumansCells
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Wood S, Willbanks A, Cheng JX. RNA Cytosine Methyltransferases NSUN1 and NSUN2 Mediate the Lineage-Associated Resistance to Venetoclax in Leukemia. Blood. 2020; 136(Supplement):13-14.
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Stoddart A, Wang J, Fernald AA, Davis EM, Johnson CR, Hu C, Cheng JX, McNerney ME, Le Beau MM. Cytotoxic Therapy-Induced Effects on Both Hematopoietic and Marrow Stromal Cells Promotes Therapy-Related Myeloid Neoplasms. Blood Cancer Discov. 2020 07; 1(1):32-47.
PMID: 32924016; PMCID: PMC7486063.
Citations:
18 Fields:
Translation:
AnimalsCells
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Wood S, Willbanks A, Cheng JX. RNA Cytosine Methyltransferases NSUN1 and NSUN2 Mediate the Lineage-associated Resistance to Venetoclax in Leukemia (abstract). The 62th ASH annual meeting. 2020.
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Wood S, Chen L, He C, Larson RA, Vardiman JW, Cheng JX. Quantitative Imaging of Drug-Selective Chromatin Topological Domains in Hematologic Malignancies: Towards Next Generation Digital Pathology and RNA Epigenomics (abstract). The 109th USCAP annual meeting. 2020.
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. Myelodysplastic Syndromes. In Wang, E. & Lagoo, AS (Ed) Practical Lymph Node and Bone Marrow Pathology. 2020; 24:531.
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. Myelodysplastic/Myeloproliferative Neoplasms. In Wang, E. & Lagoo, AS (Ed) Practical Lymph Node and Bone Marrow Pathology. 2020; 25:559.
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Lu SL, Hsu FM, Tsai CL, Lee JM, Huang PM, Hsu CH, Lin CC, Chang YL, Hsieh MS, Cheng JC. Improved prognosis with induction chemotherapy in pathological complete responders after trimodality treatment for esophageal squamous cell carcinoma: Hypothesis generating for adjuvant treatment. Eur J Surg Oncol. 2019 Aug; 45(8):1498-1504.
PMID: 30910457.
Citations:
5 Fields:
Translation:
Humans
-
Herrou J, Willett JW, Fiebig A, Varesio LM, Czyz DM, Cheng JX, Ultee E, Briegel A, Bigelow L, Babnigg G, Kim Y, Crosson S. Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus. Mol Microbiol. 2019 03; 111(3):637-661.
PMID: 30536925; PMCID: PMC6417958.
Citations:
15 Fields:
Translation:
AnimalsCells
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Hantel A, Gabster B, Cheng JX, Golomb H, Gajewski TF. Severe hemophagocytic lymphohistiocytosis in a melanoma patient treated with ipilimumab + nivolumab. J Immunother Cancer. 2018 07 16; 6(1):73.
PMID: 30012206; PMCID: PMC6048909.
Citations:
27 Fields:
Translation:
Humans
-
Cheng JX, Chen L, Li Y, Cloe A, Yue M, Wei J, Watanabe KA, Shammo JM, Anastasi J, Shen QJ, Larson RA, He C, Le Beau MM, Vardiman JW. Author Correction: RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia. Nat Commun. 2018 06 06; 9(1):2286.
PMID: 29875356; PMCID: PMC5989218.
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Cracolici V, Grogan RH, Sukhanova M, Cheng JX, Gurbuxani S, Cipriani NA. A Herald of Plasma Cell Myeloma: A Report of Malignant Plasma Cells Identified in Parathyroid Adenoma and a Review of Non-parathyroid Malignancies in Parathyroid Glands. Head Neck Pathol. 2018 Jun; 12(2):286-290.
PMID: 29030756; PMCID: PMC5953883.
Citations: Fields:
Translation:
HumansCells
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Huang PM, Hsu FM, Lin CC, Hsu CH, Cheng JC, Lee JM. Do We Need to Add Postoperative Radiotherapy in Patients Undergoing Trimodality Therapy for Esophageal Squamous Cell Carcinoma with Positive Lymph Nodes Disease? Dig Surg. 2018; 35(2):104-110.
PMID: 28675905.
Citations:
2 Fields:
Translation:
Humans
-
Stoddart A, Wang J, Hu C, Fernald AA, Davis EM, Cheng JX, Le Beau MM. Inhibition of WNT signaling in the bone marrow niche prevents the development of MDS in the Apcdel/+ MDS mouse model. Blood. 2017 06 01; 129(22):2959-2970.
PMID: 28348148; PMCID: PMC5454335.
Citations:
35 Fields:
Translation:
HumansAnimalsCells
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Cheng JX, Chen L, Li Y, Yue M, Cloe A, Shammo JM, Larson RA, He C, Le Beau MM, Vardiman JW. RNA:m5c/Methyltransferases Mediate Chromatin Organization and 5-Azacytidine Response/Resistance in Leukemia. Blood (Supplement 1). 2017; 130:2471.
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Cheng JX, Chen L, Cole A, Parilla M, Le Beau MM, Larson RA, Vardiman JW. RNA/HnRNPK and BRD4/BET Mediate 5-Azacytidine (5-AZA) Action and Resistance in MDS/AML. Leukemia Research. 2017; 55:S122 .
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Cheng JX, Chen L, Cole A, Vardiman JA. RNA m5C methyltransferases and hnRNPK mediate disease-associated chromatin structure and drug resistance in leukemia. Cancer Res. 2017; 77:13 Suppl.
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Cheng JX, Chen L, Li Y. Yue M, Cloe A, Le Beau MM, He C, Larson RA, Vardiman JW. Bromodomain and Extra-Terminal Motif Proteins (BETs) Mediate 5-Azacitidine Resistance in Myeloid Leukemia through Recruitment of an Active RNA Polymerase II Complex. Platform presentation. The 63rd ASH annual meeting. 2016.
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Cheng JX. RNA m5C Methyltransferases and hnRNPK Mediate Lineage-Specific Chromatin Structures and Differential Responses in Leukemia Platform presentation. The Myeloid Development Symposium on the 63rd ASH annual meeting. 2016.
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Willett JW, Herrou J, Czyz DM, Cheng JX, Crosson S. Brucella abortus ?rpoE1 confers protective immunity against wild type challenge in a mouse model of brucellosis. Vaccine. 2016 09 30; 34(42):5073-5081.
PMID: 27591954; PMCID: PMC5026968.
Citations:
7 Fields:
Translation:
AnimalsCells
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Wang YJ, Huang CY, Hou WH, Wang CC, Lan KH, Yu HJ, Lai MK, Liu SP, Pu YS, Cheng JC. Dual-timing PSA as a biomarker for patients with salvage intensity modulated radiation therapy for biochemical failure after radical prostatectomy. Oncotarget. 2016 Jul 12; 7(28):44224-44235.
PMID: 27317764; PMCID: PMC5190091.
Citations:
2 Fields:
Translation:
Humans
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Hsu FM, Hou WH, Huang CY, Wang CC, Tsai CL, Tsai YC, Yu HJ, Pu YS, Cheng JC. Differences in toxicity and outcome associated with circadian variations between patients undergoing daytime and evening radiotherapy for prostate adenocarcinoma. Chronobiol Int. 2016; 33(2):210-9.
PMID: 26818960.
Citations:
17 Fields:
Translation:
Humans
-
Cloe A, Chen L, Li Y, Liu H, Cheng JX. Identification of Specific Hnrnps As Novel Therapeutic Targets and Responsive Indicators of KPT330 (selinexor) in Leukemia. Blood. 2016; 128:1657.
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Aslam MN, McClintock S, Khan SP, Perone P, Allen R, Ouillette PD, Dame MK, Cheng JX, Kunkel SL, Varani J. MDI 301 suppresses myeloid leukemia cell growth in vitro and in vivo without the toxicity associated with all-trans retinoic acid therapy. Anticancer Drugs. 2015 Aug; 26(7):763-73.
PMID: 26010252.
Citations:
1 Fields:
Translation:
HumansAnimalsCells
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Cheng JX, Anastasi J, Yue M, Shen QJ, Larson RA, Vardiman JW. Identifying distinct differentiation/lineage-specific, drug-sensitive chromatin structures and the underlying novel mutations in MDS and AML. Platform presentation. The 13th International Symposium on Myelodysplastic Syndromes. 2015.
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Wang CC, Liang JT, Tsai CL, Chen YH, Lin YL, Shun CT, Cheng JC. Neoadjuvant bevacizumab and chemoradiotherapy in locally advanced rectal cancer: early outcome and technical impact on toxicity. World J Surg Oncol. 2014 Nov 06; 12:329.
PMID: 25373828; PMCID: PMC4240843.
Citations:
3 Fields:
Translation:
Humans
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Liang HK, Wang CW, Tseng HM, Huang CY, Lan KH, Chen YH, You SL, Cheng JC, Cheng AL, Kuo SH. Preoperative prognostic neurologic index for glioblastoma patients receiving tumor resection. Ann Surg Oncol. 2014 Nov; 21(12):3992-8.
PMID: 24854491.
Citations:
3 Fields:
Translation:
Humans
-
Cheng JX, Anastasi J, Vardiman JW. Distinct Chromatin Conformations of PU.1 Dictate Differential Drug Responses in Two Different Types of Leukemia Cells: Implications in Effective Epigenetic Therapy in Leukemia. Platform presentation. The USCAP 103rd Annual Meeting. 2014.
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Perry AM, Warnke RA, Hu Q, Gaulard P, Copie-Bergman C, Alkan S, Wang HY, Cheng JX, Bacon CM, Delabie J, Ranheim E, Kucuk C, Hu X, Weisenburger DD, Jaffe ES, Chan WC. Indolent T-cell lymphoproliferative disease of the gastrointestinal tract. Blood. 2013 Nov 21; 122(22):3599-606.
PMID: 24009234; PMCID: PMC3837508.
Citations:
64 Fields:
Translation:
HumansCells
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Ple-plakon PA, Demirci H, Cheng JX, Elner VM. Orbital myeloid sarcoma in an adult with acute myeloid leukemia, FAB M1, and 12p-deletion. Ophthalmic Plast Reconstr Surg. 2013 May-Jun; 29(3):e73-5.
PMID: 23314098.
Citations:
3 Fields:
Translation:
HumansCells
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Cheng JX, Anastasi J, Watanabe K, Kleinbrink EL, Grimley E, Knibbs R, Shen QJ, Vardiman JW. Genome-wide profiling reveals epigenetic inactivation of the PU.1 pathway by histone H3 lysine 27 trimethylation in cytogenetically normal myelodysplastic syndrome. Leukemia. 2013 Jun; 27(6):1291-300.
PMID: 23411464.
Citations:
7 Fields:
Translation:
HumansCells
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Cheng JX, Anastasi J, Shen JQ, Watanabe K, Grimley E, Kleinbrink E, Knibbs R, Roulston D, Vardiman JW. Epigenetic Mechanisms Underlying the Pathogenesis of Myelodysplastic Syndrome (MDS) and Chronic Myelomonocytic Leukemia (CMML). Modern Pathology. 2012; 25(2S):329A.
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Cheng JX, Anastasi J, Shen JQ, Watanabe K, Kleinbrink E, Grimley E, Knibbs R, Roulston R, Vardiman JW. Characterizing Epigenetic Patterns and Pharmacologic Responses in Myelodysplastic Neoplasms. American Journal of Clinical Pathology. 2012; 138(Suppl 2):A338-A338.
View Publication.
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Cheng JX, Anastasi J, Vardiman JW. The 11th International Symposium on Myelodysplastic Syndromes. Profiling and Characterizing Aberrant DNA and Histone Methylations of Lineage Determining Factor Encoding Genes RUNX1, SPIB and SPI1 in Myelodysplastic Syndrome. Platform presentation. 2011.
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Cheng JX, Anastasi J, Shen JQ, Watanabe K, Kleinbrink E, Grimley E, Knibbs R, Roulston R, Vardiman JW. A Novel Epigenetic Mechanism in the Pathogenesis of Myelodysplastic Syndrome (MDS). Blood. 2011; 21(118):2783.
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Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010 May 28; 38(4):576-89.
PMID: 20513432; PMCID: PMC2898526.
Citations:
6571 Fields:
Translation:
AnimalsCells
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Spooner CJ, Cheng JX, Pujadas E, Laslo P, Singh H. A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates. Immunity. 2009 Oct 16; 31(4):576-86.
PMID: 19818654; PMCID: PMC4373467.
Citations:
93 Fields:
Translation:
AnimalsCells
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Hsu FM, Lin CC, Lee JM, Chang YL, Hsu CH, Tsai YC, Lee YC, Cheng JC. Improved local control by surgery and paclitaxel-based chemoradiation for esophageal squamous cell carcinoma: results of a retrospective non-randomized study. J Surg Oncol. 2008 Jul 01; 98(1):34-41.
PMID: 18449912.
Citations:
16 Fields:
Translation:
HumansCTClinical Trials
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Cheng JX, Anastasi J, Vardiman JW. Analysis of DNA Methylation and Histone H3 Trimethylation at Lysine 27 (H3K27me3) in Myelodysplastic Syndrome (MDS) with a Novel Sequential Methylated DNA Immunoprecipitation (SMeDIP) and Sequential Chromatin-Immunoprecipitation (SChIP) Technology: A Pilot Study of Refractory Cytopenia with Multilineage Dysplasia (RCMD). Modern Pathology. 2008; 21(1S):249A.
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Cheng JX, Tretiakova M, Gong C, Mandal S, Krausz T, Taxy JB. Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior. Mod Pathol. 2008 Jun; 21(6):647-52.
PMID: 18327209.
Citations:
67 Fields:
Translation:
Humans
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Wang CW, Kuo WH, Chang KJ, Huang CS, Cheng JC. Should adjuvant radiotherapy to the supraclavicular fossa be routinely given in patients with breast conservative treatment? J Surg Oncol. 2007 Aug 01; 96(2):144-50.
PMID: 17443743.
Citations:
2 Fields:
Translation:
Humans
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Graham WV, Wang F, Clayburgh DR, Cheng JX, Yoon B, Wang Y, Lin A, Turner JR. Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. J Biol Chem. 2006 Sep 08; 281(36):26205-15.
PMID: 16835238.
Citations:
72 Fields:
Translation:
HumansAnimalsCells
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Cheng JX, Gandolfi M, Ptashne M. Activation of the Gal1 gene of yeast by pairs of 'non-classical' activators. Curr Biol. 2004 Sep 21; 14(18):1675-9.
PMID: 15380071.
Citations:
6 Fields:
Translation:
AnimalsCells
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Cheng JC, Peng LC, Chen YH, Huang DY, Wu JK, Jian JJ. Unique role of proximal rectal dose in late rectal complications for patients with cervical cancer undergoing high-dose-rate intracavitary brachytherapy. Int J Radiat Oncol Biol Phys. 2003 Nov 15; 57(4):1010-8.
PMID: 14575832.
Citations:
9 Fields:
Translation:
HumansPHPublic Health
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Cheng JX, Floer M, Ononaji P, Bryant G, Ptashne M. Responses of four yeast genes to changes in the transcriptional machinery are determined by their promoters. Curr Biol. 2002 Oct 29; 12(21):1828-32.
PMID: 12419182.
Citations:
26 Fields:
Translation:
Cells
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Cheng JX, Nevado J, Lu Z, Ptashne M. The TBP-inhibitory domain of TAF145 limits the effects of nonclassical transcriptional activators. Curr Biol. 2002 Jun 04; 12(11):934-7.
PMID: 12062059.
Citations:
7 Fields:
Translation:
Cells
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Cheng X, Boyer JL, Juliano RL. Selection of peptides that functionally replace a zinc finger in the Sp1 transcription factor by using a yeast combinatorial library. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14120-5.
PMID: 9391163; PMCID: PMC28443.
Citations:
7 Fields:
Translation:
AnimalsCells
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Cheng X, DeLong RK, Wickstrom E, Kligshteyn M, Demirdji SH, Caruthers MH, Juliano RL. Interactions between single-stranded DNA binding protein and oligonucleotide analogs with different backbone chemistries. J Mol Recognit. 1997 Mar-Apr; 10(2):101-7.
PMID: 9376128.
Citations:
7 Fields:
Translation:
Cells
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. U.S. Patent: A Method for Identification and Characterization of Peptides That Recognize Specific DNA Sequences. Patent No. 5,869,250; Filing date: 1996/12/02; Grant date: 1999/02/09 https://pubchem.ncbi.nlm.nih.gov/patent/US-5869250-A. 1996.
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Cheng X, Kay BK, Juliano RL. Identification of a biologically significant DNA-binding peptide motif by use of a random phage display library. Gene. 1996 May 24; 171(1):1-8.
PMID: 8675015.
Citations:
5 Fields:
Translation:
Cells