FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.

FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. J Mol Med (Berl). 2013 Mar; 91(3):333-46.

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subject areas

Animals
Dichloroacetic Acid
Forkhead Box Protein O1
Forkhead Transcription Factors
Gene Expression Regulation
Glucose
Humans
Hypertension, Pulmonary
Oxidation-Reduction
Physical Conditioning, Animal
Rats
Up-Regulation
Ventricular Dysfunction, Right

authors with profiles

Stephen Archer
Lin Piao