"Up-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015854
|
| MeSH Number(s) |
G02.111.905 G05.308.850 G07.690.773.998
|
| Concept/Terms |
Up-Regulation- Up-Regulation
- Up Regulation
- Upregulation
- Up-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Up-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Up-Regulation".
This graph shows the total number of publications written about "Up-Regulation" by people in this website by year, and whether "Up-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 4 | 4 |
| 1995 | 0 | 2 | 2 |
| 1996 | 1 | 7 | 8 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 8 | 8 |
| 1999 | 0 | 8 | 8 |
| 2000 | 1 | 8 | 9 |
| 2001 | 2 | 9 | 11 |
| 2002 | 2 | 15 | 17 |
| 2003 | 4 | 19 | 23 |
| 2004 | 7 | 42 | 49 |
| 2005 | 3 | 21 | 24 |
| 2006 | 1 | 26 | 27 |
| 2007 | 5 | 20 | 25 |
| 2008 | 1 | 24 | 25 |
| 2009 | 1 | 26 | 27 |
| 2010 | 6 | 18 | 24 |
| 2011 | 3 | 26 | 29 |
| 2012 | 3 | 30 | 33 |
| 2013 | 7 | 14 | 21 |
| 2014 | 4 | 21 | 25 |
| 2015 | 1 | 24 | 25 |
| 2016 | 3 | 13 | 16 |
| 2017 | 5 | 22 | 27 |
| 2018 | 3 | 26 | 29 |
| 2019 | 0 | 9 | 9 |
| 2020 | 2 | 19 | 21 |
| 2021 | 2 | 10 | 12 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
| 2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Up-Regulation" by people in Profiles.
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Upregulated selenoprotein I during lipopolysaccharide-induced B cell activation promotes lipidomic changes and is required for effective differentiation into IgM-secreting plasma B cells. J Leukoc Biol. 2024 Jun 28; 116(1):6-17.
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The VEGF-Hypoxia Signature Is Upregulated in Basal-like Breast Tumors from Women of African Ancestry and Associated with Poor Outcomes in Breast Cancer. Clin Cancer Res. 2024 Jun 03; 30(11):2609-2618.
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RNA-based translation activators for targeted gene upregulation. Nat Commun. 2023 10 26; 14(1):6827.
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Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing. Neuron. 2023 05 17; 111(10):1637-1650.e5.
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TLR4 activation induces inflammatory vascular permeability via Dock1 targeting and NOX4 upregulation. Biochim Biophys Acta Mol Basis Dis. 2022 12 01; 1868(12):166562.
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Targeted polyelectrolyte complex micelles treat vascular complications in vivo. Proc Natl Acad Sci U S A. 2021 12 14; 118(50).
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Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells. Cells. 2021 10 09; 10(10).
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Laminin-a4 Is Upregulated in Both Human and Murine Models of Obesity. Front Endocrinol (Lausanne). 2021; 12:698621.
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Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM). Br J Cancer. 2021 08; 125(4):582-592.
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SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis. Blood Cancer J. 2021 05 17; 11(5):93.