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Xiaofeng Yang

TitleProfessor
InstitutionUniversity of Chicago
DepartmentRadiation and Cellular Oncology
AddressChicago IL 60637
ORCID ORCID Icon0000-0001-9023-5855 Additional info
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    Dr. Xiaofeng Yang is Professor, Vice Chair, and Chief of Medical Physics in the Department of Radiation and Cellular Oncology at the University of Chicago. He is also a board-certified therapeutic medical physicist. His research focuses on artificial intelligence, quantitative medical imaging, and image-guided radiation therapy, with the overarching goal of improving the precision, efficiency, and personalization of cancer care. His Deep Biomedical Imaging Laboratory develops machine learning, deep learning, and foundation models for fast, low-dose, and high-quality medical imaging; image segmentation, synthesis, and registration; real-time tumor tracking and motion management; and quantitative imaging for disease diagnosis and treatment response assessment. A major focus of his research is translating these computational and imaging innovations into clinical applications, particularly AI-enabled image-guided and adaptive radiotherapy across photon therapy, proton therapy, and brachytherapy.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wildman VL, Qiu RLJ, Luca K, Gaonkar MP, Safari M, Del Balzo L, Yang X, Kesarwala AH. Cardiac Substructure Dose Quantification and Optimization in Left-Sided Lung Cancer Radiotherapy. Pract Radiat Oncol. 2026 Sep 11. PMID: 42727773.
      Citations:    
    2. Li D, Bamishaye O, Li S, Qiao J, Akinlotan F, Dorabadizare F, Chen X, Fan Y, Yuan Y, Gui Z, Hekmatyar K, Tóth É, Pallier A, Xu Y, Zhang Y, Ke X, Farris AB, Yang H, Wang JX, Carlisle J, Ramalingam SS, Kirberger M, Grossniklaus H, Yang X, Liu Z, Zhou W, Yang JJ. Early detection of invasive lung cancer and multiorgan metastasis by a collagen-targeted protein MRI contrast agent. Sci Adv. 2026 Sep 11; 12(37):eadz6815. PMID: 42715331; PMCID: PMC13557066.
      Citations:    
    3. Duong AH, Kaur M, Dutta SW, Gebru T, Adams J, Cicchino M, Jagsi R, Hanasoge S, Kayode O, Schreibmann E, Al-Hallaq H, Thomas M, Yang X, Momin S, Roper J, Luca K, Ding J. Dosimetric impact of aperture-restricted VMAT on heart dose in breast cancer treated with regional nodal irradiation. J Appl Clin Med Phys. 2026 Sep; 27(9):e70775. PMID: 42643153; PMCID: PMC13507928.
      Citations:    
    4. Lam A, Luca K, Kaur M, Shah KD, Seng J, Benner K, Thomas M, Shu HK, Yang X, Chang CW, Roper J, Ding J. Beam geometry optimization and convergence mode evaluation for knowledge-based planning of hippocampal avoidance whole-brain radiotherapy: A cross-platform study with quantitative scorecard assessment. J Appl Clin Med Phys. 2026 Sep; 27(9):e70771. PMID: 42638463; PMCID: PMC13504367.
      Citations:    
    5. Rajendran P, Safari M, He W, Hu M, Shah K, Wang S, Zhou J, Yang X. Foundation models in medical image analysis: A systematic review and quantitative analysis. Med Image Anal. 2026 Aug 27; 115:104293. PMID: 42696936.
      Citations:    
    6. Wang T, Beaudry J, Aramburu Núñez D, Patel P, Gorovets D, Kollmeier M, Damato AL, Yang X. Automatic treatment planning using reinforcement learning for high-dose-rate prostate brachytherapy. Phys Med Biol. 2026 Aug 19; 71(16). PMID: 42562017.
      Citations:    Fields:    
    7. Qi XS, Wang Y, Yang X, Ren L, Liu W, Benedict SH, Xiao Y, Xing L, El Naqa IM. Generative AI, foundation models and large language models in radiation therapy physics: Clinical applications, challenges, and future directions. Med Phys. 2026 Aug; 53(8):e70616. PMID: 42563397; PMCID: PMC13448089.
      Citations:    Fields:    Translation:Humans
    8. Li Q, Safari M, Wang S, Xie H, Ding J, Wang T, Yang X. Low-dose CT imaging using a regularization-enhanced efficient diffusion probabilistic model. Med Phys. 2026 Aug; 53(8):e70626. PMID: 42563368; PMCID: PMC13447869.
      Citations:    Fields:    Translation:HumansCells
    9. Haji-Seyed-Javadi R, Koyen AE, Rath SK, Wu B, Madden MZ, Hou Y, Kapoor-Vazirani P, Roshika R, Aiello M, Luong NC, Tseng WC, Sesay F, Kim JS, Tan T, Kim S, Gao B, Song BS, Kenney AM, Connolly EC, Yang L, Xhemalce B, Li X, Switchenko JM, Yang X, Buchwald ZS, Deng X, Miller KM, Yao B, Lan L, Zhao W, Yu DS. HELZ is a RNA-DNA helicase that resolves R loops to facilitate homologous recombination repair. Nat Commun. 2026 07 23; 17(1). PMID: 42493500; PMCID: PMC13396810.
      Citations:    Fields:    Translation:HumansCells
    10. Pan S, Luca KJ, Gao Y, Wang S, Hu M, Sanford R, Safari M, Roper J, Tian Z, Wang T, Yang X. One-for-All Adaptive Radiotherapy Planning Agent: A Foundation Framework for Daily CBCT-guided Radiotherapy. ArXiv. 2026 Jul 16. PMID: 42523498; PMCID: PMC13405419.
      Citations:    
    11. Chang CW, Safari M, Akkineni SS, Hu M, Shah K, Gao Y, Patel P, Jani AB, Agasthya G, Zhou J, Yang X. A digital twin framework for adaptive treatment planning in radiotherapy. Phys Med Biol. 2026 Jul 10; 71(13). PMID: 42361838.
      Citations:    Fields:    Translation:Humans
    12. Gao Y, Hu M, Pan S, Peng J, Xie H, Chang CW, Remick J, Bradshaw B, Kapoor P, Qiu RLJ, Roper J, Tian Z, Yang X. Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy. Med Phys. 2026 Jul; 53(7):e70550. PMID: 42384553.
      Citations:    Fields:    Translation:Humans
    13. Wang S, Jin Z, Hu M, Safari M, Gao Y, Zhao F, Chang CW, Qiu RL, Roper J, Yu DS, Baciak JE, Yang X. A generalist biomedical vision-language model via multi-CLIP knowledge distillation. Nat Commun. 2026 06 10; 17(1). PMID: 42270629; PMCID: PMC13402289.
      Citations:    Fields:    Translation:Humans
    14. Li Y, Wildman VL, Balzo LD, Qiu R, Kesarwala AH, Yang X. Domain-adapted foundation model for automated cardiac CT substructure segmentation for thoracic radiotherapy. Radiother Oncol. 2026 Aug; 221:111619. PMID: 42242380.
      Citations:    Fields:    Translation:Humans
    15. Shah KD, Zhou J, Wildman VL, Roper J, Kesarwala AH, Al-Hallaq H, Murthy VL, Jagsi R, Yang X. Imaging-based detection and prediction of radiation-induced cardiac toxicity: a narrative review. BJR Open. 2026 Jan; 8(1):tzag008. PMID: 42524537; PMCID: PMC13412164.
      Citations:    
    16. Safari M, Wang S, Wildman VL, Hu M, Eidex Z, Chang CW, Middlebrooks EH, Qiu RLJ, Patel P, Jani AB, Mao H, Tian Z, Yang X. Efficient Vision Mamba for MRI Super-Resolution via Hybrid Selective Scanning. ArXiv. 2026 Mar 07. PMID: 41479458; PMCID: PMC12755253.
      Citations:    
    17. Chang CW, Wang T, Qiu RLJ, Li X, Cammin J, Yang K, Hu YH, Ren L, Xia P, Sawant A, Scott J, Buchsbaum J, Yang X. Patient outcome prognosis for external beam radiation therapy using CBCT-based radiomics: a systematic review. Biomed Phys Eng Express. 2026 Jan 06; 12(1). PMID: 41435426; PMCID: PMC13193058.
      Citations:    Fields:    Translation:Humans
    18. Chen X, Qiu RLJ, Wildman V, Sanford RJ, Shah KD, Wang T, Li Y, Chang CW, Shelton JW, Kesarwala AH, Yang X. Patient and fraction specific model adaptation for cone beam computed tomography (CBCT) multi-organ segmentation. Med Phys. 2026 Jan; 53(1):e70251. PMID: 41452348.
      Citations:    Fields:    Translation:Humans
    19. Safari M, Eidex Z, Qiu RLJ, Goette M, Wang T, Yang X. Systematic review and meta-analysis of AI-driven MRI motion artifact detection and correction. Phys Med. 2026 Jan; 141:105704. PMID: 41442850; PMCID: PMC12910474.
      Citations:    Fields:    Translation:Humans
    20. Safari M, Wang S, Eidex Z, Qiu RLJ, Chang CW, Yu DS, Yang X. A physics-informed deep learning model for MRI brain motion correction. Med Phys. 2025 Dec; 52(12):e70197. PMID: 41395855.
      Citations:    Fields:    Translation:Humans
    21. Wu J, Chen Z, Chen Y, Cui Z, Du S, Yang X, Xin J. Frequency-aware domain randomization for single-source domain generalization in medical image segmentation. Med Phys. 2025 Dec; 52(12):e70118. PMID: 41318360.
      Citations:    Fields:    Translation:Humans
    22. Hu M, Pan S, Chang CW, Qiu RLJ, Peng J, Wang T, Roper J, Mao H, Yu D, Yang X. Cross-modality 3D MRI synthesis via cycle-guided denoising diffusion probability model. J Med Imaging (Bellingham). 2025 Nov; 12(6):064003. PMID: 41292517; PMCID: PMC12643384.
      Citations:    
    23. Li Q, Safari M, Wang S, Xie H, Ding J, Wang T, Yang X. Low-Dose CT Imaging Using a Regularization-Enhanced Efficient Diffusion Probabilistic Model. ArXiv. 2025 Oct 27. PMID: 41281195; PMCID: PMC12636755.
      Citations:    
    24. Safari M, Wang S, Li Q, Eidex Z, Qiu RLJ, Chang CW, Mao H, Yang X. Res-MoCoDiff: residual-guided diffusion models for motion artifact correction in brain MRI. Phys Med Biol. 2025 10 17; 70(20). PMID: 41061726; PMCID: PMC12532098.
      Citations:    Fields:    Translation:HumansCells
    25. Shah KD, Chamseddine I, Yuan X, Tian S, Qiu R, Zhou J, Dhabaan A, Al-Hallaq H, Yu DS, Paganetti H, Yang X. Clinically Interpretable Survival Risk Stratification in Head and Neck Cancer Using Bayesian Networks and Markov Blankets. Int J Radiat Oncol Biol Phys. 2026 03 01; 124(3):856-867. PMID: 41083026; PMCID: PMC12661651.
      Citations: 1     Fields:    Translation:Humans
    26. Li Q, Wang S, Safari M, Hu X, Qiu R, Roper J, Lin M, Lin J, Torres MA, Yang X. Foundation model based multimodal transformer framework for survival analysis in HER2 stratified breast cancer. Phys Med Biol. 2025 10 08; 70(20). PMID: 40997874.
      Citations:    Fields:    Translation:HumansCells
    27. Safari M, Eidex Z, Qiu RLJ, Goette M, Wang T, Yang X. Systematic Review and Meta-analysis of AI-driven MRI Motion Artifact Detection and Correction. ArXiv. 2025 Sep 05. PMID: 40949764; PMCID: PMC12425023.
      Citations:    
    28. Safari M, Wang S, Li Q, Eidex Z, Qiu RLJ, Chang CW, Mao H, Yang X. Res-MoCoDiff: Residual-guided diffusion models for motion artifact correction in brain MRI. ArXiv. 2025 Sep 04. PMID: 40386577; PMCID: PMC12083705.
      Citations:    
    29. Shah KD, Bohannon DH, Patel SA, Chang CW, Dhere VR, Wang Y, Dhabaan A, Al-Hallaq H, Yang X, Zhou J. The effect of interfractional variation on delivered dose with ultrahypofractionated pencil beam scanning proton therapy for localized prostate cancer. J Appl Clin Med Phys. 2025 Sep; 26(9):e70223. PMID: 40946222; PMCID: PMC12433594.
      Citations:    Fields:    Translation:Humans
    30. Zafar AJ, Yang X, Diamond Z, Sibo T, Yu D, Patel PR, Zhou J. An adaptive proton FLASH therapy using modularized pin ridge filter. Med Phys. 2025 Sep; 52(9):e18109. PMID: 40940290.
      Citations:    Fields:    Translation:Humans
    31. Zhao F, Wu Y, Hu M, Chang CW, Liu R, Qiu R, Yang X. Current progress of digital twin construction using medical imaging. J Appl Clin Med Phys. 2025 Sep; 26(9):e70226. PMID: 40841176; PMCID: PMC12370374.
      Citations: 3     Fields:    Translation:Humans
    32. Hu M, Gao Y, Li Y, Qiu RL, Chang CW, Shah KD, Kapoor P, Bradshaw B, Shao Y, Roper J, Remick J, Tian Z, Yang X. Large-scale convolutional neural network for clinical target and multi-organ segmentation in gynecologic brachytherapy via multi-stage learning. Med Phys. 2025 Aug; 52(8):e18067. PMID: 40817425; PMCID: PMC12681083.
      Citations:    Fields:    Translation:Humans
    33. Momin S, Luca K, Lei Y, Chang CW, Xie H, Kei T, Adams J, Davis T, Yang X, Jani A, Roper J, Zhang J. A novel inverse treatment planning training method for inexperienced treatment planners. Phys Eng Sci Med. 2025 Sep; 48(3):965-970. PMID: 40549137.
      Citations:    Fields:    Translation:Humans
    34. Chen X, Qiu RLJ, Pan S, Shelton JW, Yang X, Kesarwala AH. CT-guided CBCT multi-organ segmentation using a multi-channel conditional consistency diffusion model for lung cancer radiotherapy. Biomed Phys Eng Express. 2025 Jun 20; 11(4). PMID: 40393462.
      Citations:    Fields:    Translation:HumansCells
    35. Safari M, Wang S, Eidex Z, Li Q, Qiu RLJ, Middlebrooks EH, Yu DS, Yang X. MRI super-resolution reconstruction using efficient diffusion probabilistic model with residual shifting. Phys Med Biol. 2025 06 16; 70(12). PMID: 40460850; PMCID: PMC12167925.
      Citations: 2     Fields:    Translation:HumansCells
    36. Shah KD, Zhou J, Roper J, Dhabaan A, Al-Hallaq H, Pourmorteza A, Yang X. Photon-counting CT in cancer radiotherapy: technological advances and clinical benefits. Phys Med Biol. 2025 05 16; 70(10). PMID: 40328288; PMCID: PMC12086776.
      Citations: 3     Fields:    Translation:Humans
    37. Safari M, Wang S, Eidex Z, Li Q, Qiu RLJ, Middlebrooks EH, Yu DS, Yang X. MRI super-resolution reconstruction using efficient diffusion probabilistic model with residual shifting. ArXiv. 2025 Apr 26. PMID: 40093364; PMCID: PMC11908366.
      Citations:    
    38. Wang S, Safari M, Li Q, Chang CW, Qiu RL, Roper J, Yu DS, Yang X. Triad: Vision Foundation Model for 3D Magnetic Resonance Imaging. Res Sq. 2025 Mar 10. PMID: 40162210; PMCID: PMC11952655.
      Citations:    
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