"Eflornithine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
| Descriptor ID |
D000518
|
| MeSH Number(s) |
D12.125.068.665.340 D12.125.095.765.340
|
| Concept/Terms |
Eflornithine- Eflornithine
- alpha-Difluoromethyl Ornithine
- Ornithine, alpha-Difluoromethyl
- alpha Difluoromethyl Ornithine
- alpha-Difluoromethylornithine
- alpha Difluoromethylornithine
Eflornithine Hydrochloride- Eflornithine Hydrochloride
- Hydrochloride, Eflornithine
- Eflornithine Monohydrochloride, Monohydrate
- Monohydrochloride, Monohydrate Eflornithine
|
Below are MeSH descriptors whose meaning is more general than "Eflornithine".
Below are MeSH descriptors whose meaning is more specific than "Eflornithine".
This graph shows the total number of publications written about "Eflornithine" by people in this website by year, and whether "Eflornithine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Eflornithine" by people in Profiles.
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Discordant Effects of Polyamine Depletion by DENSpm and DFMO on ß-cell Cytokine Stress and Diabetes Outcomes in Mice. Endocrinology. 2024 Jan 16; 165(3).
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Inhibition of polyamine biosynthesis preserves ß cell function in type 1 diabetes. Cell Rep Med. 2023 11 21; 4(11):101261.
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Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome. EMBO Mol Med. 2023 11 08; 15(11):e17833.
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Polyamine biosynthesis is critical for growth and differentiation of the pancreas. Sci Rep. 2015 Aug 24; 5:13269.
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Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy. Amino Acids. 2014 Mar; 46(3):633-42.
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Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response. Am J Physiol Gastrointest Liver Physiol. 2011 Jul; 301(1):G181-7.
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Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. Breast Cancer Res Treat. 2008 Jan; 107(1):33-40.
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Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. Breast Cancer Res Treat. 2007 Sep; 105(1):29-36.
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Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells. Clin Exp Metastasis. 2005; 22(3):255-63.
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Effects of alpha-difluoromethylornithine on local recurrence and pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice. Clin Exp Metastasis. 2003; 20(4):321-5.