"beta 2-Microglobulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.
| Descriptor ID |
D001613
|
| MeSH Number(s) |
D12.776.124.790.223.100 D12.776.377.715.182.100
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "beta 2-Microglobulin".
Below are MeSH descriptors whose meaning is more specific than "beta 2-Microglobulin".
This graph shows the total number of publications written about "beta 2-Microglobulin" by people in this website by year, and whether "beta 2-Microglobulin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 3 | 1 | 4 |
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 2000 | 1 | 1 | 2 |
| 2001 | 2 | 0 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "beta 2-Microglobulin" by people in Profiles.
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The molecular basis for recognition of CD1d/a-galactosylceramide by a human non-Va24 T cell receptor. PLoS Biol. 2012; 10(10):e1001412.
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Solute kinetics with short-daily home hemodialysis using slow dialysate flow rate. Hemodial Int. 2010 Jan; 14(1):39-46.
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Beta2-microglobulin stimulates osteoclast formation. Kidney Int. 2008 Jun; 73(11):1275-81.
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2B4 inhibits NK-cell fratricide. Blood. 2007 Sep 15; 110(6):2020-3.
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Changes in salivary proteome following allogeneic hematopoietic stem cell transplantation. Exp Hematol. 2007 Feb; 35(2):184-92.
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2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice. Blood. 2005 Aug 15; 106(4):1337-40.
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Assessment of the stability of an immunoadsorbent for the extracorporeal removal of Beta-2-microglobulin from blood. Blood Purif. 2005; 23(4):287-97.
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Clinical efficacy of high-dose dexamethasone with maintenance dexamethasone/alpha interferon in patients with primary systemic amyloidosis: results of United States Intergroup Trial Southwest Oncology Group (SWOG) S9628. Blood. 2004 Dec 01; 104(12):3520-6.
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Dialysis-related amyloidosis. Minerva Urol Nefrol. 2003 Jun; 55(2):121-9.
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Temperature non-homogeneity in rapid airflow-based cycler significantly affects real-time PCR. Biotechniques. 2002 Sep; 33(3):508, 510, 512.