Central Nervous System Agents
"Central Nervous System Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252)
| Descriptor ID |
D002491
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| MeSH Number(s) |
D27.505.954.427
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Central Nervous System Agents".
Below are MeSH descriptors whose meaning is more specific than "Central Nervous System Agents".
This graph shows the total number of publications written about "Central Nervous System Agents" by people in this website by year, and whether "Central Nervous System Agents" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 1 | 2 |
| 1999 | 0 | 1 | 1 |
| 2001 | 1 | 1 | 2 |
| 2003 | 3 | 0 | 3 |
| 2008 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Central Nervous System Agents" by people in Profiles.
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CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP. Neurology. 2018 01 23; 90(4):e273-e281.
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Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment. Glia. 2014 Jul; 62(7):1176-94.
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Sigma-1 receptors: potential targets for the treatment of substance abuse. Curr Pharm Des. 2012; 18(7):902-19.
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Conditioned cues and the expression of stimulant sensitization in animals and humans. Neuropharmacology. 2009; 56 Suppl 1:160-8.
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Positron emission tomography in central nervous system drug discovery and development. Neuroimaging Clin N Am. 2003 Nov; 13(4):851-6, xi.
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Neuropharmacology of TBI-induced plasticity. Brain Inj. 2003 Aug; 17(8):685-94.
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Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats. Arch Toxicol. 2003 Aug; 77(8):452-8.
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Effects of Panax quinquefolius L. on brainstem neuronal activities: comparison between Wisconsin-cultivated and Illinois-cultivated roots. Phytomedicine. 2001 May; 8(3):178-83.
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Voltage-dependent inhibition of brain Na(+) channels by American ginseng. Eur J Pharmacol. 2001 Feb 09; 413(1):47-54.
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Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol. 1999 Dec 01; 58(11):1685-93.