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Allele frequencies at recessive disease genes are mainly determined by pleiotropic effects in heterozygotes.
Causal modelling of gene effects from regulators to programs to traits.
Simple scaling laws control the genetic architectures of human complex traits.
Specificity, length and luck drive gene rankings in association studies.
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Allele frequencies at recessive disease genes are mainly determined by pleiotropic effects in heterozygotes.
Allele frequencies at recessive disease genes are mainly determined by pleiotropic effects in heterozygotes. Genetics. 2026 09 02; 234(1).
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PubMed
subject areas
Gene Frequency
Genes, Recessive
Genetic Pleiotropy
Heterozygote
Humans
Loss of Function Mutation
Models, Genetic
Mutation
Selection, Genetic
authors with profiles
Jonathan K. Pritchard