"DNA Polymerase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7.
| Descriptor ID |
D004256
|
| MeSH Number(s) |
D08.811.913.696.445.308.300.225
|
| Concept/Terms |
DNA Polymerase I- DNA Polymerase I
- Polymerase I, DNA
- Klenow Fragment
- DNA-Dependent DNA Polymerase I
- DNA Dependent DNA Polymerase I
- DNA Pol I
- DNA Polymerase alpha
- Polymerase alpha, DNA
|
Below are MeSH descriptors whose meaning is more general than "DNA Polymerase I".
Below are MeSH descriptors whose meaning is more specific than "DNA Polymerase I".
This graph shows the total number of publications written about "DNA Polymerase I" by people in this website by year, and whether "DNA Polymerase I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Polymerase I" by people in Profiles.
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Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli. Biochemistry. 1999 Jan 12; 38(2):696-704.
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KGF facilitates repair of radiation-induced DNA damage in alveolar epithelial cells. Am J Physiol. 1997 Jun; 272(6 Pt 1):L1174-80.
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Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan. Cancer Res. 1994 Jul 01; 54(13):3487-93.
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Two DNA polymerases: HIV reverse transcriptase and the Klenow fragment of Escherichia coli DNA polymerase I. Cold Spring Harb Symp Quant Biol. 1993; 58:495-504.
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Differential action and differential expression of DNA polymerase I during Escherichia coli colony development. J Bacteriol. 1992 Nov; 174(22):7262-72.
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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science. 1992 Jun 26; 256(5065):1783-90.
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Use of in vitro DNA amplification to screen family members for an insulin gene mutation. Diabetes. 1988 Jul; 37(7):862-6.
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Host and phage-coded functions required for coliphage N4 DNA replication. Virology. 1986 Apr 15; 150(1):33-44.
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In vitro models for mutagenesis: a role for lesion, polymerase and sequence. Prog Clin Biol Res. 1986; 209A:149-59.