"DNA Polymerase III" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3'-5' and 5'-3' exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II. EC 2.7.7.7.
| Descriptor ID |
D004258
|
| MeSH Number(s) |
D08.811.913.696.445.308.300.235
|
| Concept/Terms |
DNA Polymerase III- DNA Polymerase III
- Polymerase III, DNA
- DNA Pol III
- DNA Polymerase delta
- Polymerase delta, DNA
- DNA-Dependent DNA Polymerase III
- DNA Dependent DNA Polymerase III
|
Below are MeSH descriptors whose meaning is more general than "DNA Polymerase III".
Below are MeSH descriptors whose meaning is more specific than "DNA Polymerase III".
This graph shows the total number of publications written about "DNA Polymerase III" by people in this website by year, and whether "DNA Polymerase III" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Polymerase III" by people in Profiles.
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Immune checkpoint inhibitors for POLE or POLD1 proofreading-deficient metastatic colorectal cancer. Ann Oncol. 2024 Jul; 35(7):643-655.
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DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader. Nat Genet. 2015 Jun; 47(6):677-81.
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A frameshifting stimulatory stem loop destabilizes the hybrid state and impedes ribosomal translocation. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):5538-43.
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Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nat Genet. 2012 May 27; 44(7):770-6.
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A phage-encoded inhibitor of Escherichia coli DNA replication targets the DNA polymerase clamp loader. Mol Microbiol. 2011 Mar; 79(5):1325-38.
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The crystal structure of XC847 from Xanthomonas campestris: a 3'-5' oligoribonuclease of DnaQ fold family with a novel opposingly shifted helix. Proteins. 2006 Dec 01; 65(4):1036-40.
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Cytochrome oxidase deficiency protects Escherichia coli from cell death but not from filamentation due to thymine deficiency or DNA polymerase inactivation. J Bacteriol. 2005 Apr; 187(8):2827-35.
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Cell death in Escherichia coli dnaE(Ts) mutants incubated at a nonpermissive temperature is prevented by mutation in the cydA gene. J Bacteriol. 2004 Apr; 186(7):2147-55.
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Ig gene somatic hypermutation in mice defective for DNA polymerase delta proofreading. Int Immunol. 2003 Apr; 15(4):477-81.
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Role of the dinB gene product in spontaneous mutation in Escherichia coli with an impaired replicative polymerase. J Bacteriol. 2000 Dec; 182(23):6742-50.