Insulin-Like Growth Factor II
"Insulin-Like Growth Factor II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.
| Descriptor ID |
D007335
|
| MeSH Number(s) |
D12.644.276.937.420 D12.776.124.862.425 D12.776.467.937.420 D23.529.937.420
|
| Concept/Terms |
Insulin-Like Growth Factor II- Insulin-Like Growth Factor II
- IGF-II
- Insulin Like Growth Factor II
- Insulin-Like Somatomedin Peptide II
- Insulin Like Somatomedin Peptide II
- Multiplication-Stimulating Factor
- Factor, Multiplication-Stimulating
- Multiplication Stimulating Factor
- Somatomedin A
- Somatomedin MSA
- IGF-2
- Multiplication-Stimulating Activity
- Multiplication Stimulating Activity
|
Below are MeSH descriptors whose meaning is more general than "Insulin-Like Growth Factor II".
Below are MeSH descriptors whose meaning is more specific than "Insulin-Like Growth Factor II".
This graph shows the total number of publications written about "Insulin-Like Growth Factor II" by people in this website by year, and whether "Insulin-Like Growth Factor II" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 1999 | 1 | 1 | 2 |
| 2001 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Insulin-Like Growth Factor II" by people in Profiles.
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Regulation of Insulin-Like Growth Factor 2 by Oocyte-Secreted Factors in Primary Human Granulosa Cells. J Clin Endocrinol Metab. 2020 01 01; 105(1).
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Oocyte-Secreted Factors Synergize With FSH to Promote Aromatase Expression in Primary Human Cumulus Cells. J Clin Endocrinol Metab. 2019 05 01; 104(5):1667-1676.
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Randomized phase II trial of cixutumumab alone or with cetuximab for refractory recurrent/metastatic head and neck squamous cell carcinoma. Oral Oncol. 2018 07; 82:83-90.
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A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes. Diabetes. 2017 11; 66(11):2903-2914.
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Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases. Mol Neurobiol. 2017 05; 54(4):2636-2658.
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FSH Regulates IGF-2 Expression in Human Granulosa Cells in an AKT-Dependent Manner. J Clin Endocrinol Metab. 2015 Aug; 100(8):E1046-55.
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A phase I trial of the IGF-1R antibody Cixutumumab in combination with temsirolimus in patients with metastatic breast cancer. Breast Cancer Res Treat. 2013 May; 139(1):145-53.
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Genetic variation in IGF2 and HTRA1 and breast cancer risk among BRCA1 and BRCA2 carriers. Cancer Epidemiol Biomarkers Prev. 2011 Aug; 20(8):1690-702.
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Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation. J Bone Miner Res. 2010 Nov; 25(11):2447-59.
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Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme. J Mol Biol. 2010 Jan 15; 395(2):430-43.