"Hexokinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC 2.7.1.1.
| Descriptor ID |
D006593
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| MeSH Number(s) |
D08.811.913.696.620.300
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hexokinase".
Below are MeSH descriptors whose meaning is more specific than "Hexokinase".
This graph shows the total number of publications written about "Hexokinase" by people in this website by year, and whether "Hexokinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 1 | 0 | 1 |
| 1996 | 2 | 0 | 2 |
| 1997 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2010 | 2 | 0 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 2 | 3 |
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Below are the most recent publications written about "Hexokinase" by people in Profiles.
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Photoproximity Profiling of Protein-Protein Interactions in Cells. J Am Chem Soc. 2020 01 08; 142(1):146-153.
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Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell. 2019 05 16; 177(5):1201-1216.e19.
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De novo variants in HK1 associated with neurodevelopmental abnormalities and visual impairment. Eur J Hum Genet. 2019 07; 27(7):1081-1089.
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S100B impairs glycolysis via enhanced poly(ADP-ribosyl)ation of glyceraldehyde-3-phosphate dehydrogenase in rodent muscle cells. Am J Physiol Endocrinol Metab. 2017 06 01; 312(6):E471-E481.
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Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells. Neoplasia. 2015 Sep; 17(9):723-734.
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Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production. EMBO Mol Med. 2012 Jul; 4(7):633-46.
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Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle's cycle. J Mol Med (Berl). 2012 Jan; 90(1):31-43.
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Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury. Circ Res. 2011 Jan 07; 108(1):60-9.
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Regulation and cytoprotective role of hexokinase III. PLoS One. 2010 Nov 03; 5(11):e13823.
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Mammalian target of rapamycin promotes vincristine resistance through multiple mechanisms independent of maintained glycolytic rate. Mol Cancer Res. 2005 Nov; 3(11):635-44.